ATE515565T1 - Verfahren zur reklonierung von produktionszellen - Google Patents
Verfahren zur reklonierung von produktionszellenInfo
- Publication number
- ATE515565T1 ATE515565T1 AT08151018T AT08151018T ATE515565T1 AT E515565 T1 ATE515565 T1 AT E515565T1 AT 08151018 T AT08151018 T AT 08151018T AT 08151018 T AT08151018 T AT 08151018T AT E515565 T1 ATE515565 T1 AT E515565T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- recloning
- serum
- production cells
- replication
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 abstract 5
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 241000699800 Cricetinae Species 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000000151 deposition Methods 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 239000004017 serum-free culture medium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10338531A DE10338531A1 (de) | 2003-08-19 | 2003-08-19 | Verfahren zur Reklonierung von Produktionszellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE515565T1 true ATE515565T1 (de) | 2011-07-15 |
Family
ID=34201814
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08151018T ATE515565T1 (de) | 2003-08-19 | 2004-08-17 | Verfahren zur reklonierung von produktionszellen |
| AT04764194T ATE415471T1 (de) | 2003-08-19 | 2004-08-17 | Verfahren zur reklonierung von produktionszellen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04764194T ATE415471T1 (de) | 2003-08-19 | 2004-08-17 | Verfahren zur reklonierung von produktionszellen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7833787B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1658365B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5129959B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101184572B1 (cg-RX-API-DMAC7.html) |
| AT (2) | ATE515565T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2536239C (cg-RX-API-DMAC7.html) |
| DE (2) | DE10338531A1 (cg-RX-API-DMAC7.html) |
| DK (2) | DK1658365T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2317023T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI337201B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005019442A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060223183A1 (en) * | 2005-03-11 | 2006-10-05 | Bates Steven E | Gamma irradiation of frozen feeder cells |
| EP1901068A1 (en) * | 2006-09-15 | 2008-03-19 | Boehringer Ingelheim Pharma GmbH & Co. KG | Methods of selecting cell clones |
| US20080268470A1 (en) * | 2006-09-15 | 2008-10-30 | Hitto Kaufmann | Methods of selecting cell clones |
| EP2257620A1 (de) * | 2008-03-19 | 2010-12-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Methode zur steigerung der reklonierungseffizienz |
| JP5304275B2 (ja) * | 2009-01-29 | 2013-10-02 | Ｊｎｃ株式会社 | アポクライティン−ｉｉをコードするコドン最適化核酸およびその使用方法 |
| US8597943B2 (en) | 2009-04-09 | 2013-12-03 | Cellca Gmbh | Method for improved single cell cloning |
| JP5697042B2 (ja) * | 2009-11-19 | 2015-04-08 | 国立大学法人 岡山大学 | 遺伝子発現を上昇させるシステム及び該システムを保持したベクター |
| PE20141568A1 (es) | 2011-10-28 | 2014-11-21 | Neotope Biosciences Ltd | Anticuerpos humanizados que reconocen la alfa-sinucleina |
| AU2013211874B2 (en) | 2012-01-27 | 2017-11-02 | Prothena Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| CU24446B1 (es) | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
| US10513555B2 (en) | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| WO2015004632A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize iapp |
| US9951131B2 (en) | 2013-07-12 | 2018-04-24 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
| WO2015075635A2 (en) | 2013-11-19 | 2015-05-28 | Prothena Biosciences Limited | Monitoring immunotherapy of lewy body disease from constipation symptoms |
| TW201623331A (zh) | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子（ｍｃａｍ）抗體類及使用彼等之相關方法 |
| US20170158755A1 (en) | 2014-03-12 | 2017-06-08 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg1-3 |
| WO2015136472A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg4-5 |
| DK3116911T3 (da) | 2014-03-12 | 2019-09-30 | Prothena Biosciences Ltd | Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse |
| EP3129051A1 (en) | 2014-04-08 | 2017-02-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
| TWI786505B (zh) | 2015-01-28 | 2022-12-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| TWI718121B (zh) | 2015-01-28 | 2021-02-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| TWI769570B (zh) | 2015-01-28 | 2022-07-01 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| JP2018530540A (ja) | 2015-09-16 | 2018-10-18 | プロセナ バイオサイエンシーズ リミテッド | 巨細胞動脈炎、リウマチ性多発筋痛症又は高安動脈炎の処置又は予防のための抗ｍｃａｍ抗体の使用 |
| WO2017046774A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017149513A1 (en) | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2017153955A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| WO2017153953A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| BR112018072394A2 (pt) | 2016-05-02 | 2019-02-19 | Prothena Biosciences Limited | anticorpos que reconhecem a tau |
| ES2933491T3 (es) | 2016-05-02 | 2023-02-09 | Prothena Biosciences Ltd | Inmunoterapia tau |
| US10889638B2 (en) | 2016-05-02 | 2021-01-12 | Prothena Biosciences Limited | Antibodies recognizing tau |
| WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2018007922A2 (en) | 2016-07-02 | 2018-01-11 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| EP3478715A2 (en) | 2016-07-02 | 2019-05-08 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| WO2018007924A2 (en) | 2016-07-02 | 2018-01-11 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US11958896B2 (en) | 2017-05-02 | 2024-04-16 | Prothena Biosciences Limited | Antibodies recognizing tau |
| WO2019064053A1 (en) | 2017-09-28 | 2019-04-04 | Prothena Biosciences Limited | DOSAGE REGIMES FOR THE TREATMENT OF SYNUCLEINOPATHIES |
| EP3691626A4 (en) | 2017-10-06 | 2021-06-30 | Prothena Biosciences Limited | METHODS OF DETECTION OF TRANSTHYRETINE |
| PH12020550694A1 (en) | 2017-11-29 | 2021-04-12 | Prothena Biosciences Ltd | Lyophilized formulation of a monoclonal antibody against transthyretin |
| CN119409813A (zh) | 2018-11-08 | 2025-02-11 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| UA128431C2 (uk) | 2018-11-26 | 2024-07-10 | Форті Севен, Інк. | ГУМАНІЗОВАНЕ АНТИТІЛО ДО c-Kit |
| PE20212324A1 (es) | 2019-03-03 | 2021-12-14 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| US20230235048A1 (en) | 2020-06-24 | 2023-07-27 | Andriani IOANNOU | Antibodies recognizing sortilin |
| AR133829A1 (es) | 2023-09-15 | 2025-11-05 | Othair Prothena Ltd | Agentes penetrantes de células y usos de los mismos |
| TW202530253A (zh) | 2023-09-15 | 2025-08-01 | 愛爾蘭商普羅希那生物科學有限公司 | 抗ｔｄｐ－４３抗體及其用途 |
| AR133834A1 (es) | 2023-09-15 | 2025-11-05 | Prothena Biosciences Ltd | Agentes de penetración célular y sus usos |
| WO2025059491A2 (en) | 2023-09-15 | 2025-03-20 | Prothena Platform Technologies Limited | Methods, compositions, and kits including cell-penetrating agents |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
| US5008198A (en) | 1984-09-14 | 1991-04-16 | Scripps Clinic And Research Foundation | Merozoite surface glycoproteins |
| EP0557459B1 (en) | 1990-11-13 | 1997-10-22 | Immunex Corporation | Bifunctional selectable fusion genes |
| US5459058A (en) * | 1991-03-28 | 1995-10-17 | Benjamin Rich | Cell culture system |
| CA2163427A1 (en) | 1993-05-21 | 1994-12-08 | Stephen D. Lupton | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| DE19539493A1 (de) | 1995-10-24 | 1997-04-30 | Thomae Gmbh Dr K | Starker homologer Promotor aus Hamster |
| CN1299409A (zh) | 1998-04-17 | 2001-06-13 | 雀巢制品公司 | 由正常人皮肤组织衍生的无限增殖细胞系 |
| WO2000034326A1 (en) | 1998-12-11 | 2000-06-15 | Clontech Laboratories, Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| WO2000034325A1 (en) | 1998-12-11 | 2000-06-15 | Clontech Laboratories, Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| EP1135532B1 (en) | 1998-12-11 | 2011-03-16 | Clontech Laboratories Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| JP2003504059A (ja) | 1999-07-12 | 2003-02-04 | ジェネンテック・インコーポレーテッド | 発現ベクターと方法 |
| AU780810B2 (en) * | 1999-08-05 | 2005-04-21 | Baxalta GmbH | Recombinant stable cell clone, its production and use thereof |
| US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| AU783767B2 (en) | 1999-10-14 | 2005-12-01 | Takara Bio Usa, Inc. | Anthozoa derived chromophores/fluorophores and methods for using the same |
| JP2004510434A (ja) * | 2000-10-03 | 2004-04-08 | ユニバーシティ オブ ノース カロライナ | 肝前駆細胞のクローン増殖方法 |
| US20030073234A1 (en) * | 2001-10-12 | 2003-04-17 | Michal Amit | Clonal human embryonic stem cell lines and methods of generating same |
-
2003
- 2003-08-19 DE DE10338531A patent/DE10338531A1/de not_active Ceased
-
2004
- 2004-08-17 EP EP04764194A patent/EP1658365B1/de not_active Expired - Lifetime
- 2004-08-17 AT AT08151018T patent/ATE515565T1/de active
- 2004-08-17 DK DK04764194T patent/DK1658365T3/da active
- 2004-08-17 DE DE502004008542T patent/DE502004008542D1/de not_active Expired - Lifetime
- 2004-08-17 JP JP2006523593A patent/JP5129959B2/ja not_active Expired - Fee Related
- 2004-08-17 ES ES04764194T patent/ES2317023T3/es not_active Expired - Lifetime
- 2004-08-17 ES ES08151018T patent/ES2368772T3/es not_active Expired - Lifetime
- 2004-08-17 CA CA2536239A patent/CA2536239C/en not_active Expired - Fee Related
- 2004-08-17 AT AT04764194T patent/ATE415471T1/de active
- 2004-08-17 WO PCT/EP2004/009204 patent/WO2005019442A2/de not_active Ceased
- 2004-08-17 DK DK08151018.2T patent/DK1918364T3/da active
- 2004-08-17 KR KR1020067003371A patent/KR101184572B1/ko not_active Expired - Fee Related
- 2004-08-17 EP EP08151018A patent/EP1918364B1/de not_active Expired - Lifetime
- 2004-08-18 TW TW093124872A patent/TWI337201B/zh not_active IP Right Cessation
- 2004-08-19 US US10/922,577 patent/US7833787B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2536239C (en) | 2014-05-27 |
| TWI337201B (en) | 2011-02-11 |
| WO2005019442A2 (de) | 2005-03-03 |
| US20050059146A1 (en) | 2005-03-17 |
| KR101184572B1 (ko) | 2012-09-21 |
| TW200516148A (en) | 2005-05-16 |
| EP1918364A3 (de) | 2008-05-14 |
| JP2007502608A (ja) | 2007-02-15 |
| EP1918364A2 (de) | 2008-05-07 |
| DE10338531A1 (de) | 2005-04-07 |
| EP1658365A2 (de) | 2006-05-24 |
| EP1658365B1 (de) | 2008-11-26 |
| ATE415471T1 (de) | 2008-12-15 |
| US7833787B2 (en) | 2010-11-16 |
| WO2005019442A3 (de) | 2005-10-06 |
| JP5129959B2 (ja) | 2013-01-30 |
| ES2368772T3 (es) | 2011-11-22 |
| CA2536239A1 (en) | 2005-03-03 |
| EP1918364B1 (de) | 2011-07-06 |
| DE502004008542D1 (de) | 2009-01-08 |
| DK1658365T3 (da) | 2009-02-02 |
| DK1918364T3 (da) | 2011-08-29 |
| ES2317023T3 (es) | 2009-04-16 |
| KR20060065706A (ko) | 2006-06-14 |
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