ATE536347T1 - Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren - Google Patents

Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren

Info

Publication number
ATE536347T1
ATE536347T1 AT09751270T AT09751270T ATE536347T1 AT E536347 T1 ATE536347 T1 AT E536347T1 AT 09751270 T AT09751270 T AT 09751270T AT 09751270 T AT09751270 T AT 09751270T AT E536347 T1 ATE536347 T1 AT E536347T1
Authority
AT
Austria
Prior art keywords
inhibitors
heterologue
transferas
mannosyl
proteins
Prior art date
Application number
AT09751270T
Other languages
English (en)
Inventor
Ranjit Desai
Lihu Yang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE536347T1 publication Critical patent/ATE536347T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT09751270T 2008-05-20 2009-05-18 Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren ATE536347T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12825108P 2008-05-20 2008-05-20
PCT/US2009/044297 WO2009143041A1 (en) 2008-05-20 2009-05-18 Efficient production of heterologous proteins using mannosyl transferase inhibitors

Publications (1)

Publication Number Publication Date
ATE536347T1 true ATE536347T1 (de) 2011-12-15

Family

ID=40929664

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09751270T ATE536347T1 (de) 2008-05-20 2009-05-18 Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren

Country Status (9)

Country Link
US (2) US8309325B2 (de)
EP (1) EP2300446B1 (de)
JP (2) JP5411929B2 (de)
CN (1) CN102036974B (de)
AT (1) ATE536347T1 (de)
AU (1) AU2009249314A1 (de)
CA (1) CA2721459A1 (de)
MX (1) MX2010012626A (de)
WO (1) WO2009143041A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2628725A1 (en) * 2005-11-15 2007-05-31 Glycofi, Inc. Production of glycoproteins with reduced o-glycosylation
CN102036974B (zh) * 2008-05-20 2014-07-23 默沙东公司 利用甘露糖基转移酶抑制剂有效生产异源蛋白质
CN103764837A (zh) 2011-02-25 2014-04-30 默沙东公司 用于生产具有修饰的o-糖基化的蛋白的酵母菌株
MX364532B (es) 2013-07-04 2019-04-29 Glykos Finland Oy Celulas de hongos filamentosos deficientes de o-manosiltransferasa y metodos de uso de las mismas.
CN108064266A (zh) 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4318550A1 (de) 1993-06-04 1994-12-08 Boehringer Mannheim Gmbh Aryliden-4-oxo-2-thioxo-3- thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
FR2804113B1 (fr) * 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
US6506755B2 (en) * 2000-02-03 2003-01-14 Hoffmann-La Roche Inc. Thiazolidinecarboxyl acids
US20030186948A1 (en) * 2000-03-21 2003-10-02 Jeffrey Kudlow O-linked N-acetylglucosamine pathway in the pathogenesis of neurodegeneration and diabetes
US6589995B2 (en) * 2000-03-21 2003-07-08 Uab Research Foundation Method of inhibiting pancreatic β-cell p135 O-glycosylation
GB0021419D0 (en) * 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
GB0021421D0 (en) * 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
JP2005513026A (ja) * 2001-11-15 2005-05-12 インサイト サン ディエゴ インコーポレイテッド 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環
WO2003070238A1 (en) 2002-02-23 2003-08-28 Oxford Glycosciences (Uk) Ltd Thiazolidine antifungal agents
GB0204252D0 (en) * 2002-02-23 2002-04-10 Oxford Glycosciences Uk Ltd Novel compounds
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
AU2002953533A0 (en) 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
US7521465B2 (en) * 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
US7781464B2 (en) * 2003-01-17 2010-08-24 Bexel Pharmaceuticals, Inc. Heterocyclic diphenyl ethers
WO2006109146A2 (en) 2005-04-13 2006-10-19 Orchid Research Laboratories Limited Novel heterocyclic derivatives
JP4224046B2 (ja) 2005-08-10 2009-02-12 シプロ化成株式会社 光学記録媒体
JP2007045946A (ja) 2005-08-10 2007-02-22 Shipro Kasei Kaisha Ltd チアゾリジン誘導体を用いた有機色素
US7268364B2 (en) * 2005-09-23 2007-09-11 Aculon, Inc. Hybrid devices
CA2628725A1 (en) * 2005-11-15 2007-05-31 Glycofi, Inc. Production of glycoproteins with reduced o-glycosylation
SG153872A1 (en) * 2006-03-08 2009-07-29 Nat Inst Immunology 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-acp reductase of type ii fatty acid synthesis pathway and other cell growth pathways
KR20090031359A (ko) * 2006-05-16 2009-03-25 교와 핫꼬 기린 가부시키가이샤 단백질의 고분비 생산 방법
WO2008019139A2 (en) * 2006-08-04 2008-02-14 Beth Israel Deaconess Medical Center Inhibitors of pyruvate kinase and methods of treating disease
CN102036974B (zh) * 2008-05-20 2014-07-23 默沙东公司 利用甘露糖基转移酶抑制剂有效生产异源蛋白质

Also Published As

Publication number Publication date
AU2009249314A1 (en) 2009-11-26
WO2009143041A1 (en) 2009-11-26
US20130316398A1 (en) 2013-11-28
JP2014055157A (ja) 2014-03-27
US8309325B2 (en) 2012-11-13
US20110076721A1 (en) 2011-03-31
CN102036974B (zh) 2014-07-23
US8765409B2 (en) 2014-07-01
JP2011520968A (ja) 2011-07-21
EP2300446B1 (de) 2011-12-07
CA2721459A1 (en) 2009-11-26
MX2010012626A (es) 2011-02-22
JP5411929B2 (ja) 2014-02-12
EP2300446A1 (de) 2011-03-30
CN102036974A (zh) 2011-04-27

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