ATE536347T1 - Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren - Google Patents

Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren

Info

Publication number
ATE536347T1
ATE536347T1 AT09751270T AT09751270T ATE536347T1 AT E536347 T1 ATE536347 T1 AT E536347T1 AT 09751270 T AT09751270 T AT 09751270T AT 09751270 T AT09751270 T AT 09751270T AT E536347 T1 ATE536347 T1 AT E536347T1
Authority
AT
Austria
Prior art keywords
inhibitors
heterologue
transferas
mannosyl
proteins
Prior art date
Application number
AT09751270T
Other languages
English (en)
Inventor
Ranjit Desai
Lihu Yang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE536347T1 publication Critical patent/ATE536347T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT09751270T 2008-05-20 2009-05-18 Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren ATE536347T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12825108P 2008-05-20 2008-05-20
PCT/US2009/044297 WO2009143041A1 (en) 2008-05-20 2009-05-18 Efficient production of heterologous proteins using mannosyl transferase inhibitors

Publications (1)

Publication Number Publication Date
ATE536347T1 true ATE536347T1 (de) 2011-12-15

Family

ID=40929664

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09751270T ATE536347T1 (de) 2008-05-20 2009-05-18 Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren

Country Status (9)

Country Link
US (2) US8309325B2 (de)
EP (1) EP2300446B1 (de)
JP (2) JP5411929B2 (de)
CN (1) CN102036974B (de)
AT (1) ATE536347T1 (de)
AU (1) AU2009249314A1 (de)
CA (1) CA2721459A1 (de)
MX (1) MX2010012626A (de)
WO (1) WO2009143041A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2534465T3 (es) * 2005-11-15 2015-04-23 Glycofi, Inc. Producción de glucoproteínas con O-glucosilación reducida
WO2009143041A1 (en) * 2008-05-20 2009-11-26 Merck & Co., Inc. Efficient production of heterologous proteins using mannosyl transferase inhibitors
CA2827732A1 (en) 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Yeast strain for the production of proteins with modified o-glycosylation
US20160376570A1 (en) 2013-07-04 2016-12-29 Novartis Ag O-Mannosyltransferase Deficient Filamentous Fungal Cells and Methods of Use Thereof
CN108064266A (zh) 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4318550A1 (de) 1993-06-04 1994-12-08 Boehringer Mannheim Gmbh Aryliden-4-oxo-2-thioxo-3- thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6103501A (en) 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
FR2804113B1 (fr) 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
US6506755B2 (en) 2000-02-03 2003-01-14 Hoffmann-La Roche Inc. Thiazolidinecarboxyl acids
US20030186948A1 (en) 2000-03-21 2003-10-02 Jeffrey Kudlow O-linked N-acetylglucosamine pathway in the pathogenesis of neurodegeneration and diabetes
WO2001070236A1 (en) 2000-03-21 2001-09-27 Uab Research Foundation Preventing and/or treating diabetes mellitus
GB0021419D0 (en) 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
GB0021421D0 (en) * 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
EP1456187A4 (de) 2001-11-15 2005-02-09 Incyte San Diego Inc N-substituierte heterocyclen zur behandlung von hypercholesterinämie, dyslipidämie und anderen metabolischen störungen, krebs und anderen krankheiten
WO2003070238A1 (en) 2002-02-23 2003-08-28 Oxford Glycosciences (Uk) Ltd Thiazolidine antifungal agents
GB0204252D0 (en) * 2002-02-23 2002-04-10 Oxford Glycosciences Uk Ltd Novel compounds
US7102000B2 (en) 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
AU2002953533A0 (en) 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
US7781464B2 (en) 2003-01-17 2010-08-24 Bexel Pharmaceuticals, Inc. Heterocyclic diphenyl ethers
US6794401B2 (en) 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
US7521465B2 (en) 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
US20100305174A1 (en) 2005-04-13 2010-12-02 Orchid Research Laboratories Limited Novel Heterocyclic Derivatives
JP4224046B2 (ja) 2005-08-10 2009-02-12 シプロ化成株式会社 光学記録媒体
JP2007045946A (ja) 2005-08-10 2007-02-22 Shipro Kasei Kaisha Ltd チアゾリジン誘導体を用いた有機色素
US7268364B2 (en) 2005-09-23 2007-09-11 Aculon, Inc. Hybrid devices
ES2534465T3 (es) * 2005-11-15 2015-04-23 Glycofi, Inc. Producción de glucoproteínas con O-glucosilación reducida
AU2007201027B2 (en) 2006-03-08 2009-10-22 National Institute Of Immunology 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-acp reductase of type II fatty acid synthesis pathway and other cell growth pathways
CN101605887B (zh) 2006-05-16 2012-09-05 协和发酵麒麟株式会社 蛋白的高分泌生产方法
US8877791B2 (en) 2006-08-04 2014-11-04 Beth Israel Deaconess Medical Center, Inc. Inhibitors of pyruvate kinase and methods of treating disease
WO2009143041A1 (en) * 2008-05-20 2009-11-26 Merck & Co., Inc. Efficient production of heterologous proteins using mannosyl transferase inhibitors

Also Published As

Publication number Publication date
MX2010012626A (es) 2011-02-22
CA2721459A1 (en) 2009-11-26
US20130316398A1 (en) 2013-11-28
US20110076721A1 (en) 2011-03-31
AU2009249314A1 (en) 2009-11-26
US8309325B2 (en) 2012-11-13
EP2300446A1 (de) 2011-03-30
EP2300446B1 (de) 2011-12-07
US8765409B2 (en) 2014-07-01
WO2009143041A1 (en) 2009-11-26
JP2011520968A (ja) 2011-07-21
JP5411929B2 (ja) 2014-02-12
CN102036974A (zh) 2011-04-27
CN102036974B (zh) 2014-07-23
JP2014055157A (ja) 2014-03-27

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