MX2008013809A - Celulas madre adultas derivadas de adiposa en regeneracion hepatica. - Google Patents

Celulas madre adultas derivadas de adiposa en regeneracion hepatica.

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Publication number
MX2008013809A
MX2008013809A MX2008013809A MX2008013809A MX2008013809A MX 2008013809 A MX2008013809 A MX 2008013809A MX 2008013809 A MX2008013809 A MX 2008013809A MX 2008013809 A MX2008013809 A MX 2008013809A MX 2008013809 A MX2008013809 A MX 2008013809A
Authority
MX
Mexico
Prior art keywords
stem cells
adult stem
hepatic
adipose derived
derived adult
Prior art date
Application number
MX2008013809A
Other languages
English (en)
Inventor
John W Ludlow
Jeffery M Gimble
Original Assignee
Univ Louisiana State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Louisiana State filed Critical Univ Louisiana State
Publication of MX2008013809A publication Critical patent/MX2008013809A/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C12N2500/62—DMSO
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    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/12—Hepatocyte growth factor [HGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/237—Oncostatin M [OSM]
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención proporciona un método para derivar células madre hepáticas de las células madre derivadas de tejido no hepático; en una modalidad de la invención; las células madre hepáticas se derivan de células madre de adiposa; la invención también proporciona un método para mejorar la producción de citocina hepática (por ejemplo, HGF) a partir de ASC, que puede ser útil en la regeneración de tejido del hígado cuando se transplanta in vivo; se proporcionan condiciones de cultivo tisular, incluyendo condiciones del medio.
MX2008013809A 2006-04-25 2007-04-23 Celulas madre adultas derivadas de adiposa en regeneracion hepatica. MX2008013809A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79450806P 2006-04-25 2006-04-25
US89412807P 2007-03-09 2007-03-09
PCT/US2007/067216 WO2007127698A2 (en) 2006-04-25 2007-04-23 Adipose derived adult stem cells in hepatic regeneration

Publications (1)

Publication Number Publication Date
MX2008013809A true MX2008013809A (es) 2009-06-05

Family

ID=38656312

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008013809A MX2008013809A (es) 2006-04-25 2007-04-23 Celulas madre adultas derivadas de adiposa en regeneracion hepatica.

Country Status (13)

Country Link
US (2) US9249393B2 (es)
EP (1) EP2019859A4 (es)
JP (1) JP2009535035A (es)
KR (1) KR20090038391A (es)
AU (1) AU2007244965A1 (es)
CA (1) CA2650594A1 (es)
CR (1) CR10438A (es)
IL (1) IL194922A0 (es)
MX (1) MX2008013809A (es)
MY (1) MY146352A (es)
RU (1) RU2008146395A (es)
TW (1) TW200831671A (es)
WO (1) WO2007127698A2 (es)

Families Citing this family (16)

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EP2471542B1 (en) * 2009-08-28 2016-04-27 Osaka Air Machine Service, Ltd. Therapeutic agent for liver-related diseases
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
EP2603579B1 (en) * 2010-08-12 2015-07-01 ABAG Verwaltungs GmbH Method for producing cells having characteristics of hepatocytes
US9555061B2 (en) 2011-04-15 2017-01-31 National University Corporation Torrori University Synthesis and analysis of compounds capable of inducing differentiation of human mesenchymal stems cells into hepatocytes
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
EP2554176B1 (en) * 2011-08-04 2016-07-27 ETHIANUM Betriebsgesellschaft mbH & Co. KG Means for liver regeneration
CN103981147B (zh) * 2013-02-08 2017-11-10 中国科学院上海生命科学研究院 一种新的制备肝实质细胞的方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
AU2014296259B2 (en) 2013-07-30 2017-04-27 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
WO2015042125A2 (en) 2013-09-19 2015-03-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for producing hepatocyte-like cells
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
KR102091442B1 (ko) 2016-07-18 2020-03-20 (주)안트로젠 건 또는 인대 손상 치유를 위한 자가 및 동종의 지방유래 중간엽줄기세포 조성물 및 이의 제조방법

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US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5426098A (en) * 1993-09-02 1995-06-20 Celtrix Pharmaceuticals, Inc. Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor beta
JP4222726B2 (ja) 1997-12-02 2009-02-12 ゼン‐バイオ，インコーポレイテッド 骨芽細胞の発生および使用
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
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ES2300320T3 (es) * 2000-02-26 2008-06-16 Artecel, Inc. Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos.
DK1490480T3 (en) 2002-03-15 2016-04-11 Univ North Carolina PRIMITIVE AND PROXIMAL Liver Stem Cells
CA2457296A1 (en) * 2003-08-19 2005-02-19 Takahiro Ochiya Methods for inducing differentiation of pluripotent cells
JP2005095138A (ja) * 2003-08-19 2005-04-14 Effector Cell Institute Inc 多分化能を有する細胞の分化誘導方法

Also Published As

Publication number Publication date
WO2007127698A2 (en) 2007-11-08
IL194922A0 (en) 2011-08-01
TW200831671A (en) 2008-08-01
US9249393B2 (en) 2016-02-02
RU2008146395A (ru) 2010-05-27
AU2007244965A1 (en) 2007-11-08
US20070249045A1 (en) 2007-10-25
CA2650594A1 (en) 2007-11-08
KR20090038391A (ko) 2009-04-20
WO2007127698A3 (en) 2008-12-11
JP2009535035A (ja) 2009-10-01
MY146352A (en) 2012-08-15
US20160237408A1 (en) 2016-08-18
EP2019859A4 (en) 2009-11-25
EP2019859A2 (en) 2009-02-04
CR10438A (es) 2009-02-26

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