ATE50767T1 - Optisch aktive verbindungen mit antitassiver und zentral-sedativer wirkung, ein verfahren zu deren herstellung und diese enthaltende zusammensetzungen. - Google Patents
Optisch aktive verbindungen mit antitassiver und zentral-sedativer wirkung, ein verfahren zu deren herstellung und diese enthaltende zusammensetzungen.Info
- Publication number
- ATE50767T1 ATE50767T1 AT84116334T AT84116334T ATE50767T1 AT E50767 T1 ATE50767 T1 AT E50767T1 AT 84116334 T AT84116334 T AT 84116334T AT 84116334 T AT84116334 T AT 84116334T AT E50767 T1 ATE50767 T1 AT E50767T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- tassive
- central
- optically active
- active compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT24430/83A IT1203721B (it) | 1983-12-29 | 1983-12-29 | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
EP84116334A EP0147847B1 (de) | 1983-12-29 | 1984-12-27 | Optisch aktive Verbindungen mit antitassiver und zentral-sedativer Wirkung, ein Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE50767T1 true ATE50767T1 (de) | 1990-03-15 |
Family
ID=11213495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT84116334T ATE50767T1 (de) | 1983-12-29 | 1984-12-27 | Optisch aktive verbindungen mit antitassiver und zentral-sedativer wirkung, ein verfahren zu deren herstellung und diese enthaltende zusammensetzungen. |
Country Status (6)
Country | Link |
---|---|
US (2) | US4699911A (de) |
EP (1) | EP0147847B1 (de) |
JP (3) | JPS60252474A (de) |
AT (1) | ATE50767T1 (de) |
DE (1) | DE3481510D1 (de) |
IT (1) | IT1203721B (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837025A (en) * | 1988-03-25 | 1989-06-06 | Laboratoires D'hygiene Et De Dietetique | Self-adhesive device for the percutaneous administration of an active ingredient |
NL8801622A (nl) * | 1988-06-25 | 1990-01-16 | Stamicarbon | Bereiding van enantiomeren van dropropizine. |
IT1226570B (it) * | 1988-08-01 | 1991-01-24 | Bidachem Spa | Procedimento di preparazione della levo- e destro-dropropizina |
IT1231158B (it) * | 1989-07-20 | 1991-11-19 | Dompe Farmaceutici Spa | Procedimento per la risoluzione ottica della dropropizina. |
CA2112487C (en) * | 1991-06-26 | 2003-04-15 | James W. Young | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
EP1262182A3 (de) * | 1991-11-26 | 2003-02-26 | Sepracor Inc. | Verfahren und Zusammensetzungen zur Behandlung von Bluthochdruck, Angina und anderen Erkrankungen mit optisch reinem (-) Amlodipin |
IT1254452B (it) * | 1992-02-14 | 1995-09-25 | Dompe Farmaceutici Spa | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
IT1254993B (it) * | 1992-06-24 | 1995-10-11 | Procedimento per la preparazione degli enantiomeri della dropropizina | |
JP2002538102A (ja) | 1999-03-01 | 2002-11-12 | セプラコア インコーポレーテッド | 光学的に純粋なr(+)オンダンセトロンを使用する無呼吸および無呼吸障害の治療方法 |
IT1318650B1 (it) | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
IT1318651B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
CN102805746B (zh) * | 2011-06-02 | 2016-02-10 | 湖南九典制药股份有限公司 | 一种作用于呼吸系统疾病的复方化学药及其制备工艺与应用 |
MX2017014725A (es) * | 2017-11-16 | 2019-05-17 | Productos Farm S A De C V | Dropropizina en combinacion con ambroxol en la forma farmaceutica de jarabe y tabletas. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3163649A (en) * | 1964-12-29 | Substituteb phenyl-piperazine | ||
BE601394A (de) * | ||||
BE601794A (fr) * | 1960-03-24 | 1961-09-25 | Gabriel Co | Mécanisme distributeur |
GB938646A (en) * | 1961-03-16 | 1963-10-02 | Henri Morren | New piperazine derivatives |
NL275711A (de) * | 1962-03-15 | |||
IT1210639B (it) * | 1981-02-25 | 1989-09-14 | Menarini Sas | Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione |
-
1983
- 1983-12-29 IT IT24430/83A patent/IT1203721B/it active
-
1984
- 1984-12-27 EP EP84116334A patent/EP0147847B1/de not_active Expired - Lifetime
- 1984-12-27 AT AT84116334T patent/ATE50767T1/de not_active IP Right Cessation
- 1984-12-27 DE DE8484116334T patent/DE3481510D1/de not_active Expired - Lifetime
- 1984-12-27 JP JP59281944A patent/JPS60252474A/ja active Granted
-
1986
- 1986-09-11 US US06/906,698 patent/US4699911A/en not_active Expired - Lifetime
-
1987
- 1987-07-02 US US07/069,242 patent/US4764515A/en not_active Expired - Lifetime
-
1991
- 1991-01-24 JP JP3007236A patent/JPH0662416B2/ja not_active Expired - Lifetime
- 1991-01-24 JP JP3007235A patent/JPH0670027B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH05222019A (ja) | 1993-08-31 |
JPS60252474A (ja) | 1985-12-13 |
JPH0662416B2 (ja) | 1994-08-17 |
JPH0670027B2 (ja) | 1994-09-07 |
IT8324430A0 (it) | 1983-12-29 |
EP0147847A2 (de) | 1985-07-10 |
US4699911A (en) | 1987-10-13 |
IT1203721B (it) | 1989-02-23 |
DE3481510D1 (de) | 1990-04-12 |
EP0147847B1 (de) | 1990-03-07 |
JPH058688B2 (de) | 1993-02-02 |
US4764515A (en) | 1988-08-16 |
EP0147847A3 (en) | 1986-11-26 |
JPH05221864A (ja) | 1993-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |