ATE499377T1 - Synthese von epirubicin aus 13- dihydrodaunorubicin - Google Patents

Synthese von epirubicin aus 13- dihydrodaunorubicin

Info

Publication number
ATE499377T1
ATE499377T1 AT06846676T AT06846676T ATE499377T1 AT E499377 T1 ATE499377 T1 AT E499377T1 AT 06846676 T AT06846676 T AT 06846676T AT 06846676 T AT06846676 T AT 06846676T AT E499377 T1 ATE499377 T1 AT E499377T1
Authority
AT
Austria
Prior art keywords
produce
daunorubicinol
trifluoroacetyl
reacted
epirubicin
Prior art date
Application number
AT06846676T
Other languages
English (en)
Inventor
Alexander Zabudkin
Victor Matvienko
Alexey Matveev
Aleksandr Itkin
Original Assignee
Solux Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38174444&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE499377(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Solux Corp filed Critical Solux Corp
Application granted granted Critical
Publication of ATE499377T1 publication Critical patent/ATE499377T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
AT06846676T 2005-12-20 2006-12-19 Synthese von epirubicin aus 13- dihydrodaunorubicin ATE499377T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75176505P 2005-12-20 2005-12-20
US11/612,322 US8802830B2 (en) 2005-12-20 2006-12-18 Synthesis of epirubicin from 13-dihydrodaunorubicine
PCT/US2006/062286 WO2007076345A2 (en) 2005-12-20 2006-12-19 Synthesis of epirubicin from 13-dihydrodaunorubicine

Publications (1)

Publication Number Publication Date
ATE499377T1 true ATE499377T1 (de) 2011-03-15

Family

ID=38174444

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06846676T ATE499377T1 (de) 2005-12-20 2006-12-19 Synthese von epirubicin aus 13- dihydrodaunorubicin

Country Status (7)

Country Link
US (1) US8802830B2 (de)
EP (1) EP1963348B1 (de)
CN (1) CN101341166B (de)
AT (1) ATE499377T1 (de)
DE (1) DE602006020336D1 (de)
RU (1) RU2440363C2 (de)
WO (1) WO2007076345A2 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
PL2301943T3 (pl) * 2009-09-08 2014-06-30 Heraeus Precious Metals Gmbh Krystalizacja epidaunorubicyny x HCI
DE102011103751A1 (de) * 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103204888B (zh) * 2012-01-15 2016-08-17 山东新时代药业有限公司 一种盐酸表柔比星中间体的制备方法
US9963479B2 (en) 2013-07-02 2018-05-08 Zhejiang Hisun Pharmaceutical Co., Ltd. Method for preparing epirubicin and intermediate thereof
CN103694291B (zh) * 2013-12-24 2015-06-17 深圳万乐药业有限公司 一种戊柔比星的合成方法
CN104098628B (zh) * 2014-07-31 2017-07-18 大连大学 一类n‑三氟乙酰柔红霉素的硒代衍生物，其制备方法及应用
CN104098629B (zh) * 2014-07-31 2016-11-09 大连大学 一类表柔红霉素的硒代衍生物，其制备方法及应用
KR102155411B1 (ko) 2015-03-30 2020-09-11 메이지 세이카 파루마 가부시키가이샤 에피루비신 제조방법 및 그의 신규한 제조 중간체
CN108473523B (zh) * 2016-01-11 2022-03-15 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体
CN106749446B (zh) * 2017-01-10 2019-10-29 鲁南制药集团股份有限公司 一种盐酸表柔比星中间体化合物ⅴ
CN106749445B (zh) * 2017-01-10 2019-12-06 鲁南制药集团股份有限公司 一种盐酸表柔比星中间体化合物ⅲ
CN109293613B (zh) * 2018-11-23 2023-04-25 鲁南制药集团股份有限公司 一种表柔红霉素中间体化合物
CN112574150A (zh) * 2019-09-28 2021-03-30 鲁南制药集团股份有限公司 一种盐酸表柔比星中间体化合物ii
CN114149473B (zh) * 2020-09-08 2024-03-15 鲁南制药集团股份有限公司 一种盐酸表柔比星的合成方法及其中间体
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same

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US4254110A (en) 1979-02-02 1981-03-03 Farmitalia Carlo Erba S.P.A. Pentofuranosyl anthracyclines, intermediates in and method for their preparation and compositions and use thereof
US4345068A (en) * 1979-11-22 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, their doxorubicin analogs, and intermediates used in said process
IT1155446B (it) * 1982-12-23 1987-01-28 Erba Farmitalia Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine
JPS61502956A (ja) 1984-06-14 1986-12-18 ビオガル　ジヨジセルジヤ−ル アドリアマイシン及びそのハロゲン化塩の調整法
IT1196154B (it) 1984-06-21 1988-11-10 Erba Farmitalia Procedimento per la preparazione di 4'-epidoxorubicina
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EP1034181B1 (de) * 1997-11-28 2006-01-11 Dainippon Sumitomo Pharma Co., Ltd. Kristallines amrubicin-hydrochlorid
ES2235518T3 (es) * 1998-10-16 2005-07-01 Mercian Corporation Cristalizacion de hidrocloruro de doxorubicina.
ATE546457T1 (de) * 1999-03-19 2012-03-15 Waldemar Priebe Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika
JP4688315B2 (ja) 2001-02-28 2011-05-25 メルシャン株式会社 ４−デメトキシダウノマイシノンの製造
UA50928A (en) 2001-06-25 2002-11-15 Sinbias Pharma Method for production of chlorohydric salt of adriamycine
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
RU2341530C2 (ru) * 2003-07-02 2008-12-20 Солакс Корпорейшн Термостойкий кристаллический гидрохлорид эпирубицина и способ его получения
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
CN101331147B (zh) * 2005-12-13 2011-11-30 苏洛克股份有限公司 用于制备4-脱甲基柔红霉素的方法

Also Published As

Publication number Publication date
WO2007076345A3 (en) 2007-11-15
US20070142309A1 (en) 2007-06-21
RU2008124183A (ru) 2010-01-27
US8802830B2 (en) 2014-08-12
DE602006020336D1 (de) 2011-04-07
WO2007076345A2 (en) 2007-07-05
CN101341166A (zh) 2009-01-07
EP1963348B1 (de) 2011-02-23
RU2440363C2 (ru) 2012-01-20
EP1963348A4 (de) 2008-12-10
EP1963348A2 (de) 2008-09-03
CN101341166B (zh) 2012-10-17

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