ATE496914T1 - Verfahren zur synthese von triazolen - Google Patents
Verfahren zur synthese von triazolenInfo
- Publication number
- ATE496914T1 ATE496914T1 AT06784685T AT06784685T ATE496914T1 AT E496914 T1 ATE496914 T1 AT E496914T1 AT 06784685 T AT06784685 T AT 06784685T AT 06784685 T AT06784685 T AT 06784685T AT E496914 T1 ATE496914 T1 AT E496914T1
- Authority
- AT
- Austria
- Prior art keywords
- triazoles
- synthesis
- infective
- proliferative
- inflammatory
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003852 triazoles Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002325 prokinetic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68899005P | 2005-06-08 | 2005-06-08 | |
| PCT/US2006/022424 WO2006133397A2 (en) | 2005-06-08 | 2006-06-08 | Process for the synthesis of triazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE496914T1 true ATE496914T1 (de) | 2011-02-15 |
Family
ID=37450902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06784685T ATE496914T1 (de) | 2005-06-08 | 2006-06-08 | Verfahren zur synthese von triazolen |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8399660B2 (https=) |
| EP (1) | EP1904489B1 (https=) |
| JP (2) | JP5534497B2 (https=) |
| KR (1) | KR101394307B1 (https=) |
| AT (1) | ATE496914T1 (https=) |
| DE (1) | DE602006019870D1 (https=) |
| WO (1) | WO2006133397A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| JP5534497B2 (ja) * | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス，インコーポレイテッド | トリアゾール類の合成方法 |
| WO2007133803A2 (en) * | 2006-05-15 | 2007-11-22 | Rib-X Pharmaceuticals, Inc. | Treatment of mycobacterial infections |
| WO2010005127A2 (en) * | 2008-07-09 | 2010-01-14 | Postech Academy-Industry Foundation | Heterogeneous copper nanocatalyst and manufacturing methods thereof |
| WO2010047737A2 (en) | 2008-09-02 | 2010-04-29 | Micurx Pharmaceuticals, Inc. | Antimicrobial indoline compounds for treatment of bacterial infections |
| CN103379917B (zh) * | 2010-11-01 | 2016-10-12 | 梅琳塔治疗公司 | 药物组合物 |
| US9126991B2 (en) | 2012-10-04 | 2015-09-08 | Hui-Yin Li | Radezolid salts and polymorphic forms thereof |
| CN107205989A (zh) | 2014-11-14 | 2017-09-26 | 梅琳塔治疗公司 | 治疗、预防或降低皮肤感染风险的方法 |
| WO2016088103A1 (en) * | 2014-12-05 | 2016-06-09 | Sun Pharmaceutical Industries Limited | A process for the preparation of tedizolid phosphate |
| US20170333400A1 (en) * | 2016-05-17 | 2017-11-23 | Melinta Therapeutics, Inc. | Topical formulations of biaryl heterocyclic compounds and methods of use thereof |
| CN106749074A (zh) * | 2016-11-14 | 2017-05-31 | 沈阳药科大学 | 一种联芳基噁唑烷酮中间体的制备方法 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
| US4948801A (en) | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
| US5130316A (en) * | 1988-07-29 | 1992-07-14 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| EP0610265B1 (en) * | 1991-11-01 | 1996-12-27 | PHARMACIA & UPJOHN COMPANY | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| WO1994013649A1 (en) * | 1992-12-08 | 1994-06-23 | The Upjohn Company | Tropone-substituted phenyloxazolidinone antibacterial agents |
| DE4425612A1 (de) | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| JPH08151578A (ja) | 1994-11-30 | 1996-06-11 | Canon Inc | 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置 |
| JPH08151577A (ja) | 1994-11-30 | 1996-06-11 | Canon Inc | 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子、それらを用いた液晶装置及び表示方法 |
| HRP970049A2 (en) * | 1996-02-06 | 1998-04-30 | Bayer Ag | New heteroaryl oxazolidinones |
| GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| SK156499A3 (en) | 1997-05-30 | 2000-06-12 | Upjohn Co | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| AU1694099A (en) | 1997-12-26 | 1999-07-19 | Cheil Jedang Corporation | Cephem derivatives and a method for producing the compounds and an antibacterialcomposition containing the compounds |
| BR9907183A (pt) | 1998-01-23 | 2003-06-10 | Versicor Inc | Colet neas combinatórias de oxazolidinona, composições e processos de preparação |
| US6562844B2 (en) * | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| WO1999064417A2 (en) | 1998-06-05 | 1999-12-16 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| GB9812019D0 (en) | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
| TW572757B (en) | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
| GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
| AU1379900A (en) | 1998-11-17 | 2000-06-05 | Bayer Aktiengesellschaft | Novel substituted phenyloxazolidone derivatives |
| WO2001009107A1 (en) * | 1999-07-28 | 2001-02-08 | Pharmacia & Upjohn Company | Oxazolidinones and their use as antiinfectives |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| KR20020063888A (ko) * | 1999-11-04 | 2002-08-05 | 바실리어 파마슈티카 아게 | 치환된 5-벤질-2,4-디아미노피리미딘 |
| GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| AU5889701A (en) * | 2000-06-05 | 2001-12-17 | Dong A Pharm Co Ltd | Novel oxazolidinone derivatives and a process for the preparation thereof |
| DE10034627A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Aryl-substituierte Oxazolidinone mit Cytokin inhibitorischer Wirkung |
| GB0100102D0 (en) | 2001-01-03 | 2001-02-14 | Syngenta Participations Ag | Organic compounds |
| GB0108794D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compound |
| GB0108793D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| DE60212959T2 (de) | 2001-04-07 | 2007-02-15 | Astrazeneca Ab | Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika |
| GB0108764D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| GB0113297D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
| GB0113299D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical process & intermediates |
| SI1427711T1 (sl) | 2001-09-11 | 2005-12-31 | Astrazeneca Ab | Oksazolidinonski in/ali izoksazolinski derivati kot antibakterijska sredstva |
| GB2396350A (en) | 2001-10-25 | 2004-06-23 | Astrazeneca Ab | Aryl substituted oxazolidinones with antibacterial activity |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| CN1649866A (zh) | 2002-02-28 | 2005-08-03 | 阿斯特拉曾尼卡有限公司 | 3－环状基－5－(含氮5－元环)甲基－噁唑烷酮衍生物及其作为抗菌药物的用途 |
| EP1490059A1 (en) | 2002-03-29 | 2004-12-29 | Pharmacia & Upjohn Company LLC | Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections |
| TW200420573A (en) | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
| US20040132764A1 (en) * | 2002-10-23 | 2004-07-08 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Antibiotics for the treatment of infections in acidic environments |
| MXPA05005651A (es) | 2002-11-28 | 2005-07-27 | Astrazeneca Ab | Derivados de oxazolidinona y/o isoxazolina como agentes antibacterianos. |
| GB0229521D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229518D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229526D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| TW200500360A (en) | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
| JP2006522791A (ja) | 2003-04-09 | 2006-10-05 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗微生物性［３．１．０］ビシクロヘキシルフェニルオキサゾリジノン誘導体および類似体 |
| EP1656370B1 (en) * | 2003-06-03 | 2012-08-15 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
| WO2005012271A2 (en) | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| SI1656370T1 (sl) | 2003-06-03 | 2012-12-31 | Rib-X Pharmaceuticals, Inc. | Biarilne heterociklične spojine in postopki za njihovo izdelavo in uporabo |
| WO2005003087A2 (en) | 2003-07-01 | 2005-01-13 | Orchid Chemicals And Pharmaceuticals Ltd. | Oxazole derivatives as antibacterial agents |
| ATE471937T1 (de) * | 2003-07-02 | 2010-07-15 | Merck Sharp & Dohme | Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon |
| JP2007500707A (ja) * | 2003-07-29 | 2007-01-18 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法 |
| AR046782A1 (es) | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| JP5534497B2 (ja) * | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス，インコーポレイテッド | トリアゾール類の合成方法 |
-
2006
- 2006-06-08 JP JP2008515957A patent/JP5534497B2/ja not_active Expired - Fee Related
- 2006-06-08 WO PCT/US2006/022424 patent/WO2006133397A2/en not_active Ceased
- 2006-06-08 EP EP06784685A patent/EP1904489B1/en active Active
- 2006-06-08 KR KR1020087000377A patent/KR101394307B1/ko not_active Expired - Fee Related
- 2006-06-08 AT AT06784685T patent/ATE496914T1/de not_active IP Right Cessation
- 2006-06-08 US US11/921,838 patent/US8399660B2/en active Active
- 2006-06-08 DE DE602006019870T patent/DE602006019870D1/de active Active
-
2013
- 2013-03-18 US US13/845,759 patent/US8796465B2/en active Active
- 2013-04-03 JP JP2013077419A patent/JP5923457B2/ja active Active
-
2014
- 2014-07-07 US US14/325,248 patent/US9376400B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8399660B2 (en) | 2013-03-19 |
| JP5534497B2 (ja) | 2014-07-02 |
| US20150158827A1 (en) | 2015-06-11 |
| WO2006133397A2 (en) | 2006-12-14 |
| US20140031402A1 (en) | 2014-01-30 |
| EP1904489B1 (en) | 2011-01-26 |
| US8796465B2 (en) | 2014-08-05 |
| JP2008545798A (ja) | 2008-12-18 |
| KR20080020669A (ko) | 2008-03-05 |
| KR101394307B1 (ko) | 2014-05-13 |
| US20100234615A1 (en) | 2010-09-16 |
| WO2006133397A3 (en) | 2007-05-24 |
| DE602006019870D1 (de) | 2011-03-10 |
| EP1904489A2 (en) | 2008-04-02 |
| US9376400B2 (en) | 2016-06-28 |
| JP5923457B2 (ja) | 2016-05-24 |
| JP2013129680A (ja) | 2013-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |