ATE494389T1 - Universeller tag-assay - Google Patents
Universeller tag-assayInfo
- Publication number
- ATE494389T1 ATE494389T1 AT03781775T AT03781775T ATE494389T1 AT E494389 T1 ATE494389 T1 AT E494389T1 AT 03781775 T AT03781775 T AT 03781775T AT 03781775 T AT03781775 T AT 03781775T AT E494389 T1 ATE494389 T1 AT E494389T1
- Authority
- AT
- Austria
- Prior art keywords
- universal
- detection probes
- identifier
- target
- tag
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42465602P | 2002-11-06 | 2002-11-06 | |
| US10/424,542 US20040086892A1 (en) | 2002-11-06 | 2003-04-24 | Universal tag assay |
| PCT/US2003/035378 WO2004044549A2 (en) | 2002-11-06 | 2003-11-05 | Universal tag assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE494389T1 true ATE494389T1 (de) | 2011-01-15 |
Family
ID=32180019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03781775T ATE494389T1 (de) | 2002-11-06 | 2003-11-05 | Universeller tag-assay |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040086892A1 (de) |
| EP (1) | EP1558764B1 (de) |
| JP (1) | JP4505414B2 (de) |
| AT (1) | ATE494389T1 (de) |
| AU (1) | AU2003287533A1 (de) |
| CA (1) | CA2505254C (de) |
| DE (1) | DE60335649D1 (de) |
| WO (1) | WO2004044549A2 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| US20050118616A1 (en) * | 2002-08-16 | 2005-06-02 | Kawashima Tadashi R. | Amplification of target nucleotide sequence without polymerase chain reaction |
| US7258978B2 (en) * | 2002-11-06 | 2007-08-21 | Geneohm Sciences | Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen |
| US20040086895A1 (en) * | 2002-11-06 | 2004-05-06 | Crothers Donald M. | Method of electrochemical detection of somatic cell mutations |
| US20070099194A1 (en) * | 2005-11-02 | 2007-05-03 | Xing Yang | Quality control of probe attachment on electrodes |
| CA2545356A1 (en) * | 2003-11-10 | 2005-05-26 | Geneohm Sciences, Inc. | Nucleic acid detection method having increased sensitivity |
| DE602004023875D1 (de) | 2003-12-15 | 2009-12-10 | Geneohm Sciences Inc | Kohlenstoffelektrodenoberfläche zur bindung von dna- und proteinmolekülen daran |
| US7341834B2 (en) | 2003-12-15 | 2008-03-11 | Geneohn Sciences, Inc. | Multiplexed electrochemical detection system and method |
| SE0401270D0 (sv) * | 2004-05-18 | 2004-05-18 | Fredrik Dahl | Method for amplifying specific nucleic acids in parallel |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| WO2006065598A2 (en) * | 2004-12-13 | 2006-06-22 | Geneohm Sciences, Inc. | Fluidic cartridges for electrochemical detection of dna |
| GB0502010D0 (en) * | 2005-02-01 | 2005-03-09 | Enigma Diagnostics Ltd | Biochemical reagents and their uses |
| CN101238221B (zh) * | 2005-04-12 | 2011-11-16 | Novia公司名下的现场Rcp公司 | 新型环形探针及其在鉴定生物分子中的用途 |
| CN101213310A (zh) * | 2005-04-12 | 2008-07-02 | Novia公司名下的现场Rcp公司 | 用于产生寡核苷酸的方法 |
| DK1907583T4 (da) | 2005-06-15 | 2020-01-27 | Complete Genomics Inc | Enkeltmolekyle-arrays til genetisk og kemisk analyse |
| WO2007025594A1 (en) * | 2005-07-07 | 2007-03-08 | Pamgene Bv | Method for detection and quantification of target nucleic acids in a sample |
| US7960104B2 (en) | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
| US8986926B2 (en) * | 2005-12-23 | 2015-03-24 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
| WO2007081387A1 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices, methods of use, and kits for performing diagnostics |
| JP4989493B2 (ja) * | 2006-01-20 | 2012-08-01 | オリンパス株式会社 | 分子内プローブによる核酸配列の検出方法 |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
| WO2007133682A2 (en) * | 2006-05-11 | 2007-11-22 | Geneohm Sciences, Inc. | 100% sequence identity detection methods for variable genomes |
| US7833716B2 (en) | 2006-06-06 | 2010-11-16 | Gen-Probe Incorporated | Tagged oligonucleotides and their use in nucleic acid amplification methods |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US9551026B2 (en) * | 2007-12-03 | 2017-01-24 | Complete Genomincs, Inc. | Method for nucleic acid detection using voltage enhancement |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| EP2326732A4 (de) * | 2008-08-26 | 2012-11-14 | Fluidigm Corp | Testverfahren für erhöhten durchsatz von proben und/oder targets |
| US8691509B2 (en) | 2009-04-02 | 2014-04-08 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
| US20130296189A1 (en) * | 2009-05-08 | 2013-11-07 | Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences | Probes utilizing universal tags, a kit comprising the same and detection methods |
| JP5610258B2 (ja) * | 2009-09-09 | 2014-10-22 | 国立大学法人 筑波大学 | 送液装置 |
| US20110104693A1 (en) * | 2009-11-03 | 2011-05-05 | High Throughput Genomics, Inc. | QUANTITATIVE NUCLEASE PROTECTION SEQUENCING (qNPS) |
| ES2574055T3 (es) * | 2009-11-25 | 2016-06-14 | Gen9, Inc. | Métodos y aparatos para la reducción de errores en el ADN basada en un chip |
| US20120202704A1 (en) * | 2009-12-07 | 2012-08-09 | Illumina, Inc. | Multi-sample indexing for multiplex genotyping |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| CA2789425C (en) * | 2010-02-12 | 2020-04-28 | Raindance Technologies, Inc. | Digital analyte analysis with polymerase error correction |
| EP2622103B2 (de) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwichassays in tröpfchen |
| EP2673614B1 (de) | 2011-02-11 | 2018-08-01 | Raindance Technologies, Inc. | Verfahren zur bildung gemischter tröpfchen |
| US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
| JP5951755B2 (ja) | 2011-05-04 | 2016-07-13 | エイチティージー モレキュラー ダイアグノスティクス， インコーポレイテッド | 定量的ヌクレアーゼプロテクションアッセイ（ｑＮＰＡ）法および定量的ヌクレアーゼプロテクション配列決定（ｑＮＰＳ）法の改善 |
| SG10201605049QA (en) | 2011-05-20 | 2016-07-28 | Fluidigm Corp | Nucleic acid encoding reactions |
| EP3216872B1 (de) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzymquantifizierung |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| GB2496016B (en) | 2011-09-09 | 2016-03-16 | Univ Leland Stanford Junior | Methods for obtaining a sequence |
| US10837879B2 (en) | 2011-11-02 | 2020-11-17 | Complete Genomics, Inc. | Treatment for stabilizing nucleic acid arrays |
| US9862994B2 (en) | 2012-02-09 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Selective nucleic acid amplification from nucleic acid pools |
| JP2015519900A (ja) | 2012-05-21 | 2015-07-16 | フリューダイム・コーポレイション | 粒子集団の単粒子解析方法及び単粒子単離方法 |
| CN103014168A (zh) * | 2012-12-28 | 2013-04-03 | 北京大学 | 基于DNA hairpin和RCA的核酸检测方法 |
| AU2014290454A1 (en) | 2013-07-18 | 2016-01-28 | President And Fellows Of Harvard College | Specific nucleic acid amplification with compounded selectivity |
| PL3030682T3 (pl) | 2013-08-05 | 2020-11-16 | Twist Bioscience Corporation | Biblioteki genowe syntezowane de novo |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| DK3066219T3 (en) * | 2013-11-08 | 2019-03-11 | Ionis Pharmaceuticals Inc | METHODS FOR DETECTING OIGONUCLEOTIDES |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| JP7008407B2 (ja) | 2014-06-06 | 2022-01-25 | コーネル・ユニバーシティー | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016126987A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| US9895673B2 (en) | 2015-12-01 | 2018-02-20 | Twist Bioscience Corporation | Functionalized surfaces and preparation thereof |
| US11117113B2 (en) | 2015-12-16 | 2021-09-14 | Fluidigm Corporation | High-level multiplex amplification |
| US11649484B2 (en) | 2016-02-26 | 2023-05-16 | Abbott Diagnostics Scarborough, Inc. | Redox labeled oligonucleotide probes and their use |
| WO2018020831A1 (ja) * | 2016-07-25 | 2018-02-01 | 国立大学法人群馬大学 | 遺伝子変異を有するポリヌクレオチド配列の簡便検出法 |
| GB2568444A (en) | 2016-08-22 | 2019-05-15 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| KR102650753B1 (ko) * | 2016-10-01 | 2024-03-26 | 버클리 라잇츠, 인크. | 미세유체 장치에서 인 시츄 식별을 위한 dna 바코드 조성물 및 방법 |
| JP6346242B2 (ja) | 2016-11-04 | 2018-06-20 | 株式会社東芝 | 核酸検出方法及びアッセイキット |
| CN110366613A (zh) | 2016-12-16 | 2019-10-22 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| SG11201907713WA (en) | 2017-02-22 | 2019-09-27 | Twist Bioscience Corp | Nucleic acid based data storage |
| CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| JP2020536504A (ja) | 2017-09-11 | 2020-12-17 | ツイスト バイオサイエンス コーポレーション | Ｇｐｃｒ結合タンパク質およびその合成 |
| JP7066840B2 (ja) | 2017-10-20 | 2022-05-13 | ツイスト バイオサイエンス コーポレーション | ポリヌクレオチド合成のための加熱されたナノウェル |
| JP7191448B2 (ja) | 2018-01-04 | 2022-12-19 | ツイスト バイオサイエンス コーポレーション | Ｄｎａベースのデジタル情報ストレージ |
| US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| EP3805408B1 (de) * | 2018-06-01 | 2023-06-21 | Korea University Research and Business Foundation | Verfahren zur detektion einer zielnukleinsäure mittels rolling-circle-amplifikation und zusammensetzung einer detektion der zielnukleinsäure |
| WO2020028194A1 (en) | 2018-07-30 | 2020-02-06 | Readcoor, Inc. | Methods and systems for sample processing or analysis |
| KR20210044249A (ko) | 2018-08-08 | 2021-04-22 | 이니바타 엘티디. | 가변성 복제 다중 pcr |
| CN113766930A (zh) | 2019-02-26 | 2021-12-07 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| JP2022522668A (ja) | 2019-02-26 | 2022-04-20 | ツイスト バイオサイエンス コーポレーション | 抗体を最適化するための変異体核酸ライブラリ |
| CA3144644A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| WO2022056347A1 (en) * | 2020-09-14 | 2022-03-17 | Mayo Foundation For Medical Education And Research | Probabilistic inference for estimating tonic concentrations using multiple cyclic square wave voltammetry |
| CN112288060A (zh) * | 2020-11-09 | 2021-01-29 | 北京沃东天骏信息技术有限公司 | 用于识别标签的方法和装置 |
| AU2022227563A1 (en) | 2021-02-23 | 2023-08-24 | 10X Genomics, Inc. | Probe-based analysis of nucleic acids and proteins |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985002627A1 (en) * | 1983-12-16 | 1985-06-20 | Genetics International, Inc. | Assay for nucleic acids |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5246921A (en) * | 1990-06-26 | 1993-09-21 | The Wistar Institute Of Anatomy And Biology | Method for treating leukemias |
| US5776672A (en) * | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
| US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5412087A (en) * | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5312527A (en) * | 1992-10-06 | 1994-05-17 | Concordia University | Voltammetric sequence-selective sensor for target polynucleotide sequences |
| US6096880A (en) * | 1993-04-15 | 2000-08-01 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| US5714320A (en) * | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
| US5952172A (en) * | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| SE9400522D0 (sv) * | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5871918A (en) * | 1996-06-20 | 1999-02-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
| US5876924A (en) * | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
| US5942391A (en) * | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US5604097A (en) * | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5846719A (en) * | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US6207369B1 (en) * | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US6180346B1 (en) * | 1995-06-27 | 2001-01-30 | The Universtiy Of North Carolina At Chapel Hill | Electropolymerizable film, and method of making and use thereof |
| US5854033A (en) * | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| DK0862656T3 (da) * | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
| US6458530B1 (en) * | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| US5981297A (en) * | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
| US6221586B1 (en) * | 1997-04-09 | 2001-04-24 | California Institute Of Technology | Electrochemical sensor using intercalative, redox-active moieties |
| US6124120A (en) * | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| US6686150B1 (en) * | 1998-01-27 | 2004-02-03 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
| US6316229B1 (en) * | 1998-07-20 | 2001-11-13 | Yale University | Single molecule analysis target-mediated ligation of bipartite primers |
| US6232067B1 (en) * | 1998-08-17 | 2001-05-15 | The Perkin-Elmer Corporation | Adapter directed expression analysis |
| WO2000015779A2 (en) * | 1998-09-15 | 2000-03-23 | Yale University | Molecular cloning using rolling circle amplification |
| US6177248B1 (en) * | 1999-02-24 | 2001-01-23 | Affymetrix, Inc. | Downstream genes of tumor suppressor WT1 |
| CA2366459A1 (en) * | 1999-03-26 | 2000-10-05 | Affymetrix, Inc. | Universal arrays |
| CA2367400A1 (en) * | 1999-04-06 | 2000-10-12 | Yale University | Fixed address analysis of sequence tags |
| US20010026919A1 (en) * | 2000-02-08 | 2001-10-04 | Alex Chenchik | Nucleic acid assays employing universal arrays |
| CA2400457A1 (en) * | 2000-02-16 | 2001-08-23 | Illumina, Inc. | Parallel genotyping of multiple patient samples |
| US20030119004A1 (en) * | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
-
2003
- 2003-04-24 US US10/424,542 patent/US20040086892A1/en not_active Abandoned
- 2003-11-05 EP EP03781775A patent/EP1558764B1/de not_active Expired - Lifetime
- 2003-11-05 CA CA2505254A patent/CA2505254C/en not_active Expired - Fee Related
- 2003-11-05 AT AT03781775T patent/ATE494389T1/de not_active IP Right Cessation
- 2003-11-05 JP JP2005507099A patent/JP4505414B2/ja not_active Expired - Fee Related
- 2003-11-05 AU AU2003287533A patent/AU2003287533A1/en not_active Abandoned
- 2003-11-05 DE DE60335649T patent/DE60335649D1/de not_active Expired - Lifetime
- 2003-11-05 WO PCT/US2003/035378 patent/WO2004044549A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CA2505254A1 (en) | 2004-05-27 |
| EP1558764A4 (de) | 2006-05-24 |
| WO2004044549A2 (en) | 2004-05-27 |
| DE60335649D1 (de) | 2011-02-17 |
| WO2004044549A3 (en) | 2004-10-21 |
| CA2505254C (en) | 2012-10-30 |
| JP4505414B2 (ja) | 2010-07-21 |
| EP1558764A2 (de) | 2005-08-03 |
| AU2003287533A1 (en) | 2004-06-03 |
| US20040086892A1 (en) | 2004-05-06 |
| EP1558764B1 (de) | 2011-01-05 |
| JP2006507014A (ja) | 2006-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE494389T1 (de) | Universeller tag-assay | |
| Sapsford et al. | Sensors for detecting biological agents | |
| WO2005010199A3 (en) | Invasive cleavage reaction with electrochemical readout | |
| Pianowski et al. | Imaging of mRNA in live cells using nucleic acid-templated reduction of azidorhodamine probes | |
| Stains et al. | Site-specific detection of DNA methylation utilizing mCpG-SEER | |
| US20040072158A1 (en) | Electrochemical detection of nucleic acid sequences | |
| US7455975B2 (en) | Electrochemical detection of nucleic acid sequences | |
| US10041111B2 (en) | Method for detecting and quantifying biomaterials by using activity of nucleic acid polymerase regulated by target material | |
| ATE534748T1 (de) | Direkter snp-nachweis mit nichtamplifizierter dna | |
| ATE431433T1 (de) | Ligation und amplifikationsreaktionen zur bestimmung von zielmolekülen | |
| CA2306907A1 (en) | Dna base mismatch detection using flow cytometry | |
| DE60133111D1 (de) | Verfahren zur erkennung und zum assay von nukleinsäuresequenzen | |
| DE60023539D1 (de) | Immunologischer nachweis von rna:dna hybriden auf mikroarrays | |
| WO2002083839A3 (en) | P450 single nucleotide polymorphism biochip analysis | |
| CN103614489B (zh) | 一种登革热病毒的恒温扩增检测试剂盒及检测方法 | |
| US20220170071A1 (en) | System | |
| Zhang et al. | Sensitive detection of transcription factors in cell nuclear extracts by using a molecular beacons based amplification strategy | |
| Verhaegen et al. | Quantitative polymerase chain reaction based on a dual-analyte chemiluminescence hybridization assay for target DNA and internal standard | |
| Lee et al. | Development of an electrochemical detection system for measuring DNA methylation levels using methyl CpG-binding protein and glucose dehydrogenase-fused zinc finger protein | |
| Aoki et al. | 384-Channel electrochemical sensor array chips based on hybridization-triggered switching for simultaneous oligonucleotide detection | |
| Walker et al. | Detection of Mycobacterium tuberculosis DNA with thermophilic strand displacement amplification and fluorescence polarization | |
| ATE429513T1 (de) | Nachweissystem | |
| Ma et al. | Real-time monitoring of restriction endonuclease activity using molecular beacon | |
| Chiu et al. | Hybridization assays using an expressible DNA fragment encoding firefly luciferase as a label | |
| EP1668158B1 (de) | Rna-nachweis und quantifizierung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |