ATE492804T1 - Verfahren und vorrichtung zur chromatographischen reinigung - Google Patents

Verfahren und vorrichtung zur chromatographischen reinigung

Info

Publication number
ATE492804T1
ATE492804T1 AT06721934T AT06721934T ATE492804T1 AT E492804 T1 ATE492804 T1 AT E492804T1 AT 06721934 T AT06721934 T AT 06721934T AT 06721934 T AT06721934 T AT 06721934T AT E492804 T1 ATE492804 T1 AT E492804T1
Authority
AT
Austria
Prior art keywords
section
outlet
inlet
intermediate product
impurities
Prior art date
Application number
AT06721934T
Other languages
English (en)
Inventor
Lars Aumann
Massimo Morbidelli
Original Assignee
Eidgenoess Tech Hochschule
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoess Tech Hochschule filed Critical Eidgenoess Tech Hochschule
Application granted granted Critical
Publication of ATE492804T1 publication Critical patent/ATE492804T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1828—Simulated moving beds characterized by process features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
AT06721934T 2005-04-29 2006-04-27 Verfahren und vorrichtung zur chromatographischen reinigung ATE492804T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05405327 2005-04-29
EP05405421A EP1716900A1 (de) 2005-04-29 2005-07-01 Verfahren und Vorrichtung zur chromatographischen Reinigung
PCT/CH2006/000232 WO2006116886A1 (en) 2005-04-29 2006-04-27 Method and device for chromatographic purification

Publications (1)

Publication Number Publication Date
ATE492804T1 true ATE492804T1 (de) 2011-01-15

Family

ID=36602964

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06721934T ATE492804T1 (de) 2005-04-29 2006-04-27 Verfahren und vorrichtung zur chromatographischen reinigung

Country Status (8)

Country Link
US (2) US7837881B2 (de)
EP (2) EP1716900A1 (de)
JP (1) JP5133872B2 (de)
CN (1) CN101166564B (de)
AT (1) ATE492804T1 (de)
DE (1) DE602006019082D1 (de)
DK (1) DK1877769T3 (de)
WO (1) WO2006116886A1 (de)

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US7799273B2 (en) 2004-05-06 2010-09-21 Smp Logic Systems Llc Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
FR2889665B1 (fr) 2005-08-12 2007-11-09 Pic Solution Soc Par Actions S Procede et installation pour la regulation du taux de modificateur dans une chromatographie ou extraction supercritique avec recyclage
DK2155347T3 (da) 2007-04-17 2013-10-21 Xendo Holding B V Fremgangsmåde og apparat til kontinuerlig membranadsorption
CN101687119B (zh) * 2007-06-15 2013-06-12 通用电气健康护理生物科学股份公司 色谱方法
FR2929533B1 (fr) * 2008-04-03 2010-04-30 Novasep Procede de separation multicolonnes a gradient.
WO2010079060A1 (en) * 2009-01-06 2010-07-15 Chromacon Ag Multifraction purification processes and devices for such processes
CN102472731B (zh) 2009-06-26 2016-01-13 通用电气健康护理生物科学股份公司 色谱系统中的方法
US9527010B2 (en) * 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
CN103562145B (zh) * 2010-12-06 2016-09-21 颇尔公司 生物制品的连续加工方法
EP2500073A1 (de) 2011-03-17 2012-09-19 ChromaCon AG Verfahren zur Identifizierung und Reinigung von mehrfach spezifischen Polypeptiden
WO2013083482A1 (en) 2011-12-05 2013-06-13 Chromacon Ag Chromatographic method for the separation of fatty acid mixtures
CN102728102B (zh) * 2012-07-18 2014-06-18 成都欧林生物科技股份有限公司 一种大型凝胶层析柱纯化有机大分子物质的工艺
EP2772289B1 (de) 2013-03-01 2015-05-06 ChromaCon AG Chromatographieverfahren zur Anreicherung und Isolierung
US10099156B2 (en) 2013-04-08 2018-10-16 Chromacon Ag Chromatographic purification method
US10948483B2 (en) 2013-04-08 2021-03-16 Chromacon Ag Method for control, monitoring and/or optimization of a chromatographic process
US10226719B2 (en) 2014-09-30 2019-03-12 Exxonmobil Chemical Patents Inc. Adsorptive separation of multi-component fluid mixtures
WO2016127330A1 (zh) * 2015-02-11 2016-08-18 王峰 一种二维液相色谱仪
EP3037513A1 (de) * 2015-05-13 2016-06-29 Bayer Technology Services GmbH Verfahren zur kontinuierlichen elution eines produktes von chromatographiesäulen
GB201710130D0 (en) * 2017-06-26 2017-08-09 Ge Healthcare Bioprocess R & D Ab A Method of seperation
CN111356512B (zh) * 2017-11-16 2022-08-09 克罗麦肯公司 用于监测、评估和控制循环色谱纯化工艺的方法
EP3863763A4 (de) * 2018-10-09 2022-10-19 C Technologies, Inc. Massensteuerungssystem für die chromatographie
ES2943844T3 (es) 2018-11-16 2023-06-16 Organo Corp Método de separación cromatográfica usando una técnica de tipo lecho móvil simulado y sistema de separación cromatográfica usando una técnica de tipo lecho móvil simulado
GB201902743D0 (en) * 2019-02-28 2019-04-17 Ge Healthcare Bio Sciences Ab Improvements in and relating to optimizing the operation of a chromatography system
US20220308020A1 (en) * 2021-03-25 2022-09-29 Waters Technologies Corporation Automated semi-preparative gradient recycling liquid chromatography
KR20240065316A (ko) * 2021-09-28 2024-05-14 크로마콘 아게 정제 방법 및 그의 사용
WO2023165947A1 (en) 2022-03-03 2023-09-07 Chromacon Ag Chromatographic purification method and uses thereof

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US4234520A (en) * 1979-04-16 1980-11-18 Uop Inc. Process for the separation of isomers of chloronitrobenzene
JP2834225B2 (ja) * 1989-10-20 1998-12-09 オルガノ株式会社 擬似移動層式クロマト分離装置
JPH07106281B2 (ja) * 1991-01-16 1995-11-15 綜研化学株式会社 多成分混合物の分離精製方法及び装置
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JP3453516B2 (ja) * 1998-05-29 2003-10-06 オルガノ株式会社 クロマト分離方法
JP4627841B2 (ja) * 2000-06-08 2011-02-09 国立大学法人 香川大学 プシコースの分離方法
US6740243B2 (en) * 2000-11-15 2004-05-25 Purdue Research Foundation Systems and processes for performing separations using a simulated moving bed apparatus
WO2003026772A2 (en) * 2001-09-27 2003-04-03 Purdue Research Foundation Versatile simulated moving bed systems
US7108789B2 (en) * 2002-07-29 2006-09-19 Calgon Carbon Corporation High performance continuous reaction/separation process using a continuous liquid-solid contactor
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JP2004077329A (ja) * 2002-08-20 2004-03-11 Japan Organo Co Ltd クロマト分離装置
AU2003272368C1 (en) * 2002-09-13 2009-07-23 Biogen Idec Inc. Method of purifying polypeptides by simulated moving bed chromatography
FR2846252B1 (fr) 2002-10-29 2005-07-01 Novasep Procede et dispositif de chromatographie integrant une etape de concentration

Also Published As

Publication number Publication date
EP1716900A1 (de) 2006-11-02
US7837881B2 (en) 2010-11-23
US20090050567A1 (en) 2009-02-26
EP1877769A1 (de) 2008-01-16
US8496836B2 (en) 2013-07-30
DK1877769T3 (da) 2011-03-28
JP5133872B2 (ja) 2013-01-30
US20110042310A1 (en) 2011-02-24
DE602006019082D1 (de) 2011-02-03
CN101166564A (zh) 2008-04-23
CN101166564B (zh) 2010-12-08
JP2008539395A (ja) 2008-11-13
WO2006116886A1 (en) 2006-11-09
EP1877769B1 (de) 2010-12-22

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