DE60201145D1 - Verfahren zur Reinigung von 5'-geschützten Thymidinen - Google Patents

Verfahren zur Reinigung von 5'-geschützten Thymidinen

Info

Publication number
DE60201145D1
DE60201145D1 DE60201145T DE60201145T DE60201145D1 DE 60201145 D1 DE60201145 D1 DE 60201145D1 DE 60201145 T DE60201145 T DE 60201145T DE 60201145 T DE60201145 T DE 60201145T DE 60201145 D1 DE60201145 D1 DE 60201145D1
Authority
DE
Germany
Prior art keywords
protected
thymidines
purification
prior
art
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60201145T
Other languages
English (en)
Other versions
DE60201145T2 (de
Inventor
Hironori Komatsu
Toshiyuki Kouno
Katsutoshi Tsuchiya
Hiroharu Tanikawa
Hiroki Ishibashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Publication of DE60201145D1 publication Critical patent/DE60201145D1/de
Application granted granted Critical
Publication of DE60201145T2 publication Critical patent/DE60201145T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Studio Circuits (AREA)
DE60201145T 2001-05-15 2002-05-14 Verfahren zur Reinigung von 5'-geschützten Thymidinen Expired - Lifetime DE60201145T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001144278 2001-05-15
JP2001144278 2001-05-15

Publications (2)

Publication Number Publication Date
DE60201145D1 true DE60201145D1 (de) 2004-10-14
DE60201145T2 DE60201145T2 (de) 2005-09-22

Family

ID=18990254

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60201145T Expired - Lifetime DE60201145T2 (de) 2001-05-15 2002-05-14 Verfahren zur Reinigung von 5'-geschützten Thymidinen

Country Status (8)

Country Link
US (1) US6875860B2 (de)
EP (1) EP1258489B1 (de)
KR (1) KR100474629B1 (de)
CN (1) CN1195771C (de)
AT (1) ATE275574T1 (de)
BR (1) BR0201842A (de)
CA (1) CA2386285A1 (de)
DE (1) DE60201145T2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0090789A1 (de) * 1982-03-26 1983-10-05 Monsanto Company Chemische DNA-Synthese
JPS60152495A (ja) 1984-01-18 1985-08-10 Nippon Zeon Co Ltd 保護化ヌクレオシドの製造法
US5672697A (en) 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5719273A (en) * 1993-06-14 1998-02-17 Nexstar Pharmaceuticals, Inc. Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide
DK0644196T3 (da) * 1993-09-17 1998-07-27 Novartis Ag TTTr som beskyttelsesgruppe i nucleotidsyntesen
US5734041A (en) 1995-10-20 1998-03-31 Mcgill University Preparation of chiral phosphorothioate oligomers
US6414137B1 (en) * 1998-12-23 2002-07-02 Alliedsignal Inc. Selective solvent extraction for the purification of protected nucleosides
JP4420360B2 (ja) 1999-01-14 2010-02-24 ヤマサ醤油株式会社 ５’−ｏ−トリチルヌクレオシド類の製造法
WO2000075154A2 (en) * 1999-06-04 2000-12-14 Alliedsignal Inc. Protected nucleosides

Also Published As

Publication number Publication date
US6875860B2 (en) 2005-04-05
EP1258489A1 (de) 2002-11-20
CA2386285A1 (en) 2002-11-15
KR100474629B1 (ko) 2005-03-08
BR0201842A (pt) 2003-04-29
CN1385437A (zh) 2002-12-18
US20030004331A1 (en) 2003-01-02
EP1258489B1 (de) 2004-09-08
ATE275574T1 (de) 2004-09-15
DE60201145T2 (de) 2005-09-22
KR20030022675A (ko) 2003-03-17
CN1195771C (zh) 2005-04-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition