DE602006019082D1 - Verfahren und vorrichtung zur chromatographischen reinigung - Google Patents

Verfahren und vorrichtung zur chromatographischen reinigung

Info

Publication number
DE602006019082D1
DE602006019082D1 DE602006019082T DE602006019082T DE602006019082D1 DE 602006019082 D1 DE602006019082 D1 DE 602006019082D1 DE 602006019082 T DE602006019082 T DE 602006019082T DE 602006019082 T DE602006019082 T DE 602006019082T DE 602006019082 D1 DE602006019082 D1 DE 602006019082D1
Authority
DE
Germany
Prior art keywords
section
outlet
inlet
intermediate product
impurities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006019082T
Other languages
English (en)
Inventor
Lars Aumann
Massimo Morbidelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Publication of DE602006019082D1 publication Critical patent/DE602006019082D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1828—Simulated moving beds characterized by process features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DE602006019082T 2005-04-29 2006-04-27 Verfahren und vorrichtung zur chromatographischen reinigung Active DE602006019082D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05405327 2005-04-29
EP05405421A EP1716900A1 (de) 2005-04-29 2005-07-01 Verfahren und Vorrichtung zur chromatographischen Reinigung
PCT/CH2006/000232 WO2006116886A1 (en) 2005-04-29 2006-04-27 Method and device for chromatographic purification

Publications (1)

Publication Number Publication Date
DE602006019082D1 true DE602006019082D1 (de) 2011-02-03

Family

ID=36602964

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006019082T Active DE602006019082D1 (de) 2005-04-29 2006-04-27 Verfahren und vorrichtung zur chromatographischen reinigung

Country Status (8)

Country Link
US (2) US7837881B2 (de)
EP (2) EP1716900A1 (de)
JP (1) JP5133872B2 (de)
CN (1) CN101166564B (de)
AT (1) ATE492804T1 (de)
DE (1) DE602006019082D1 (de)
DK (1) DK1877769T3 (de)
WO (1) WO2006116886A1 (de)

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US7799273B2 (en) 2004-05-06 2010-09-21 Smp Logic Systems Llc Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
FR2889665B1 (fr) * 2005-08-12 2007-11-09 Pic Solution Soc Par Actions S Procede et installation pour la regulation du taux de modificateur dans une chromatographie ou extraction supercritique avec recyclage
US9012212B2 (en) 2007-04-17 2015-04-21 Xendo Holding B.V. Method and device for continuous membrane adsorption
US7901581B2 (en) 2007-06-15 2011-03-08 Ge Healthcare Bio-Sciences Ab Chromatography method
FR2929533B1 (fr) 2008-04-03 2010-04-30 Novasep Procede de separation multicolonnes a gradient.
US8440086B2 (en) * 2009-01-06 2013-05-14 Chromacon Ag Multifraction purification processes and devices for such processes
EP2446257B1 (de) 2009-06-26 2020-06-03 GE Healthcare Bio-Sciences AB Verfahren in einem chromatographiesystem
US9527010B2 (en) * 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
KR102027596B1 (ko) * 2010-12-06 2019-10-01 타폰 바이오시스템즈, 인코포레이티드 생물학적 산물을 위한 연속 처리 방법
EP2500073A1 (de) 2011-03-17 2012-09-19 ChromaCon AG Verfahren zur Identifizierung und Reinigung von mehrfach spezifischen Polypeptiden
WO2013083482A1 (en) 2011-12-05 2013-06-13 Chromacon Ag Chromatographic method for the separation of fatty acid mixtures
CN102728102B (zh) * 2012-07-18 2014-06-18 成都欧林生物科技股份有限公司 一种大型凝胶层析柱纯化有机大分子物质的工艺
DK2772289T3 (en) 2013-03-01 2015-08-10 Chromacon Ag Chromatographic method for the enrichment and isolation
US10099156B2 (en) 2013-04-08 2018-10-16 Chromacon Ag Chromatographic purification method
US10948483B2 (en) 2013-04-08 2021-03-16 Chromacon Ag Method for control, monitoring and/or optimization of a chromatographic process
US10226719B2 (en) 2014-09-30 2019-03-12 Exxonmobil Chemical Patents Inc. Adsorptive separation of multi-component fluid mixtures
JP6639527B2 (ja) * 2015-02-11 2020-02-05 フナン、ディメーター、インストゥルメンツ、カンパニー、リミテッドＨｕｎａｎ Ｄｅｍｅｔｅｒ Ｉｎｓｔｒｕｍｅｎｔｓ Ｃｏ．， Ｌｔｄ． 二次元液体クロマトグラフィー
EP3037513A1 (de) * 2015-05-13 2016-06-29 Bayer Technology Services GmbH Verfahren zur kontinuierlichen elution eines produktes von chromatographiesäulen
GB201710130D0 (en) * 2017-06-26 2017-08-09 Ge Healthcare Bioprocess R & D Ab A Method of seperation
US11460454B2 (en) 2017-11-16 2022-10-04 Chromacon Ag Method for monitoring, evaluating, and controlling a cyclic chromatographic purification process
JP7173671B2 (ja) * 2018-10-09 2022-11-16 シー テクノロジーズ、インコーポレーテッド クロマトグラフィーのための質量制御システム
US11839835B2 (en) 2018-11-16 2023-12-12 Organo Corporation Simulated moving-bed type chromatographic separation method and simulated moving-bed type chromatographic separation system
GB201902743D0 (en) * 2019-02-28 2019-04-17 Ge Healthcare Bio Sciences Ab Improvements in and relating to optimizing the operation of a chromatography system
EP4314803A1 (de) * 2021-03-25 2024-02-07 Waters Technologies Corporation Automatisierte flüssigkeitschromatographie mit halbpräpariertem gradientenrecycling
WO2023052126A1 (en) * 2021-09-28 2023-04-06 Chromacon Ag Purification method and uses thereof
WO2023165947A1 (en) 2022-03-03 2023-09-07 Chromacon Ag Chromatographic purification method and uses thereof

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Publication number Priority date Publication date Assignee Title
US4031155A (en) 1975-09-29 1977-06-21 Exxon Research And Engineering Company Dual desorbent composition and temperature separation processes
US4234520A (en) * 1979-04-16 1980-11-18 Uop Inc. Process for the separation of isomers of chloronitrobenzene
JP2834225B2 (ja) * 1989-10-20 1998-12-09 オルガノ株式会社 擬似移動層式クロマト分離装置
JPH07106281B2 (ja) * 1991-01-16 1995-11-15 綜研化学株式会社 多成分混合物の分離精製方法及び装置
JP2965747B2 (ja) * 1991-06-24 1999-10-18 オルガノ株式会社 多成分系の分離方法および装置
JPH07106282B2 (ja) * 1992-09-28 1995-11-15 綜研化学株式会社 多成分混合物の分離精製方法及び装置
JP3256349B2 (ja) * 1993-09-01 2002-02-12 オルガノ株式会社 擬似移動層による分離方法及び装置
JP3694908B2 (ja) * 1993-12-27 2005-09-14 日本錬水株式会社 擬似移動床を用いた３成分分離方法
US5795398A (en) * 1994-09-30 1998-08-18 Cultor Ltd. Fractionation method of sucrose-containing solutions
US5560827A (en) * 1995-02-02 1996-10-01 Tennessee Valley Authority Exclusion chromatographic separation of ionic from nonionic solutes
JP3554808B2 (ja) * 1996-12-11 2004-08-18 株式会社 日立インダストリイズ 擬似移動床方式のクロマト分離法
JP3453516B2 (ja) * 1998-05-29 2003-10-06 オルガノ株式会社 クロマト分離方法
JP4627841B2 (ja) * 2000-06-08 2011-02-09 国立大学法人 香川大学 プシコースの分離方法
WO2002040129A2 (en) * 2000-11-15 2002-05-23 Purdue Research Foundation Systems and processes for performing separations using a simulated moving bed apparatus
US7141172B2 (en) * 2001-09-27 2006-11-28 Purdue Research Foundation Versatile simulated moving bed systems
US7108789B2 (en) * 2002-07-29 2006-09-19 Calgon Carbon Corporation High performance continuous reaction/separation process using a continuous liquid-solid contactor
DE10235385B4 (de) 2002-08-02 2006-10-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur chromatographischen Trennung von Komponenten
JP2004077329A (ja) * 2002-08-20 2004-03-11 Japan Organo Co Ltd クロマト分離装置
EP1545574B8 (de) * 2002-09-13 2014-09-24 Biogen Idec Inc. Verfahren zur reinigung von polypeptiden durch simulierte chromatographie im fliessbett
FR2846252B1 (fr) 2002-10-29 2005-07-01 Novasep Procede et dispositif de chromatographie integrant une etape de concentration

Also Published As

Publication number Publication date
JP2008539395A (ja) 2008-11-13
CN101166564A (zh) 2008-04-23
US20110042310A1 (en) 2011-02-24
US7837881B2 (en) 2010-11-23
EP1716900A1 (de) 2006-11-02
CN101166564B (zh) 2010-12-08
US20090050567A1 (en) 2009-02-26
EP1877769A1 (de) 2008-01-16
JP5133872B2 (ja) 2013-01-30
EP1877769B1 (de) 2010-12-22
WO2006116886A1 (en) 2006-11-09
ATE492804T1 (de) 2011-01-15
US8496836B2 (en) 2013-07-30
DK1877769T3 (da) 2011-03-28

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