ATE474852T1 - Nukleinsäuren, die für einen an ein g-protein gekoppelten, an der sensorischen transduktion beteiligten rezeptor kodieren - Google Patents
Nukleinsäuren, die für einen an ein g-protein gekoppelten, an der sensorischen transduktion beteiligten rezeptor kodierenInfo
- Publication number
- ATE474852T1 ATE474852T1 AT07008610T AT07008610T ATE474852T1 AT E474852 T1 ATE474852 T1 AT E474852T1 AT 07008610 T AT07008610 T AT 07008610T AT 07008610 T AT07008610 T AT 07008610T AT E474852 T1 ATE474852 T1 AT E474852T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- code
- protein involved
- receptor coupled
- sensory transduction
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 230000015155 detection of stimulus involved in sensory perception Effects 0.000 title 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 2
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 230000001953 sensory effect Effects 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9546498P | 1998-07-28 | 1998-07-28 | |
| US11274798P | 1998-12-17 | 1998-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE474852T1 true ATE474852T1 (de) | 2010-08-15 |
Family
ID=26790259
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07008610T ATE474852T1 (de) | 1998-07-28 | 1999-07-27 | Nukleinsäuren, die für einen an ein g-protein gekoppelten, an der sensorischen transduktion beteiligten rezeptor kodieren |
| AT99938846T ATE366256T1 (de) | 1998-07-28 | 1999-07-27 | Für einen g-protein gekoppelten rezeptor, der an der empfindungstransduktion beteiligt ist, kodierende nukleinsäuren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99938846T ATE366256T1 (de) | 1998-07-28 | 1999-07-27 | Für einen g-protein gekoppelten rezeptor, der an der empfindungstransduktion beteiligt ist, kodierende nukleinsäuren |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US6383778B1 (enExample) |
| EP (1) | EP1100811B1 (enExample) |
| JP (2) | JP4657450B2 (enExample) |
| KR (1) | KR100643622B1 (enExample) |
| CN (1) | CN1178952C (enExample) |
| AT (2) | ATE474852T1 (enExample) |
| AU (2) | AU764180B2 (enExample) |
| BR (1) | BR9912437A (enExample) |
| CA (1) | CA2335376C (enExample) |
| DE (2) | DE69942622D1 (enExample) |
| DK (1) | DK1100811T3 (enExample) |
| ES (1) | ES2289817T3 (enExample) |
| IL (3) | IL140980A0 (enExample) |
| NO (1) | NO20010320L (enExample) |
| WO (1) | WO2000006593A1 (enExample) |
Families Citing this family (99)
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|---|---|---|---|---|
| US20110075507A1 (en) * | 1997-10-24 | 2011-03-31 | Revalesio Corporation | Diffuser/emulsifier |
| US7654728B2 (en) * | 1997-10-24 | 2010-02-02 | Revalesio Corporation | System and method for therapeutic application of dissolved oxygen |
| US6702949B2 (en) | 1997-10-24 | 2004-03-09 | Microdiffusion, Inc. | Diffuser/emulsifier for aquaculture applications |
| US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| AU764180B2 (en) | 1998-07-28 | 2003-08-14 | Regents Of The University Of California, The | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction |
| US6875574B1 (en) * | 1999-01-27 | 2005-04-05 | The Regents Of The University Of California | Assays for sensory modulators using a sensory cell specific G-protein alpha subunit |
| GB9923146D0 (en) * | 1999-09-30 | 1999-12-01 | Imperial College | Detector array |
| TW201006846A (en) * | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| EP1263787B1 (en) * | 2000-03-14 | 2005-09-28 | Tularik, Inc. | G-protein coupled receptor |
| AU2001251258B2 (en) | 2000-04-07 | 2008-06-05 | Senomyx, Inc. | T2r taste receptors and genes encoding same |
| US7678539B2 (en) * | 2000-08-10 | 2010-03-16 | Corning Incorporated | Arrays of biological membranes and methods and use thereof |
| US6977155B2 (en) * | 2000-08-10 | 2005-12-20 | Corning Incorporated | Arrays of biological membranes and methods and use thereof |
| DK1612222T3 (da) * | 2000-09-22 | 2010-11-01 | Chemcom Sa | Olfaktoriske og feromon G-proteinkoblede receptorer |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US7368285B2 (en) * | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US20080244761A1 (en) * | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US6955887B2 (en) * | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
| US7309577B2 (en) * | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
| US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
| US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US7883856B2 (en) | 2001-04-05 | 2011-02-08 | Senomyx Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| WO2002086079A2 (en) * | 2001-04-20 | 2002-10-31 | Mount Sinai School Of Medicine | T1r3 a novel taste receptor |
| US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
| EP2327985B2 (en) | 2001-06-26 | 2019-08-21 | Senomyx, Inc. | T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| JP5001512B2 (ja) * | 2001-06-26 | 2012-08-15 | セノミックス インコーポレイテッド | T1rヘテロオリゴマー味覚受容体及び前記受容体を発現する細胞系並びに味覚化合物の特定のためのその使用 |
| AU2002320294B2 (en) | 2001-07-03 | 2009-01-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mammalian sweet and amino acid heterodimeric taste receptors |
| AU2002329196B2 (en) | 2001-07-06 | 2008-08-07 | Senomyx, Inc. | Human olfactory nucleotide-gated ion channels |
| EP1502112A4 (en) | 2001-07-10 | 2008-07-23 | Senomyx Inc | USE OF SPECIFIC T2R TASTE RECIPES TO IDENTIFY CONNECTIONS WHICH BLOCK A BITTER TASTE |
| US20040175712A1 (en) * | 2001-07-19 | 2004-09-09 | Hagen Frederick S | Method for the identification of activators of g protein-coupled receptors and nucleic acids encoding those receptors |
| EP1523308A4 (en) * | 2001-07-20 | 2007-01-10 | Us Gov Health & Human Serv | PHENYL THIOCARBAMIDE (PTC) TREATMENT RECEPTOR |
| WO2003025137A2 (en) * | 2001-09-18 | 2003-03-27 | Irm, Llc | Sweet taste receptors |
| WO2004027384A2 (en) * | 2002-09-17 | 2004-04-01 | Perkinelmer Life Sciences, Inc. | Real-time detection of nucleic acid reactions |
| WO2005007891A2 (en) * | 2003-06-19 | 2005-01-27 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Variants of human taste receptor genes |
| AU2004256023B2 (en) | 2003-06-27 | 2008-03-13 | Monell Chemical Senses Center | Taste receptors of the T1R family from domestic cat |
| US7517968B2 (en) * | 2003-07-07 | 2009-04-14 | Syracuse University | Rapid and inexpensive method for the purification of proteorhodopsin |
| NZ619746A (en) | 2003-08-06 | 2014-05-30 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
| US20050106571A1 (en) | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
| US20060045953A1 (en) * | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
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| US7777877B2 (en) * | 2006-10-20 | 2010-08-17 | California Institute Of Technology | High efficiency coupling optics for pumping and detection of fluorescence |
| US8445546B2 (en) | 2006-10-25 | 2013-05-21 | Revalesio Corporation | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures |
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| US8784897B2 (en) | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
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| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
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| US20100009008A1 (en) * | 2007-10-25 | 2010-01-14 | Revalesio Corporation | Bacteriostatic or bacteriocidal compositions and methods |
| US9523090B2 (en) | 2007-10-25 | 2016-12-20 | Revalesio Corporation | Compositions and methods for treating inflammation |
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| US10125359B2 (en) * | 2007-10-25 | 2018-11-13 | Revalesio Corporation | Compositions and methods for treating inflammation |
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| US20100015235A1 (en) * | 2008-04-28 | 2010-01-21 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
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| US20100098659A1 (en) * | 2008-10-22 | 2010-04-22 | Revalesio Corporation | Compositions and methods for treating matrix metalloproteinase 9 (mmp9)-mediated conditions |
| US8815292B2 (en) | 2009-04-27 | 2014-08-26 | Revalesio Corporation | Compositions and methods for treating insulin resistance and diabetes mellitus |
| CN101763735B (zh) * | 2010-02-01 | 2015-02-25 | 王茜 | 可具有负系统损失时间的动态信号控制系统的控制方法 |
| CA2794483C (en) | 2010-03-26 | 2020-07-07 | Trustees Of Dartmouth College | Vista regulatory t cell mediator protein, vista binding agents and use thereof |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
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| EP3327035A1 (en) | 2010-06-22 | 2018-05-30 | Precision Biologics Inc. | Colon and pancreas cancer specific antigens and antibodies |
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| WO2013022948A1 (en) | 2011-08-08 | 2013-02-14 | The Coca-Cola Company | Cell lines comprising endogenous taste receptors and their uses |
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| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| EP2892558B1 (en) | 2012-09-07 | 2019-04-10 | The Trustees Of Dartmouth College | Vista modulators for diagnosis and treatment of cancer |
| WO2014106176A1 (en) | 2012-12-28 | 2014-07-03 | Precision Biologics, Inc. | Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer |
| US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
| EP3080161B1 (en) | 2013-12-09 | 2021-03-24 | New York University | Compositions and methods for phagocyte delivery of anti-staphylococcal agents |
| CN119775416A (zh) | 2013-12-24 | 2025-04-08 | 杨森制药公司 | 抗vista抗体及片段 |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| JP6755640B2 (ja) | 2014-03-28 | 2020-09-16 | 味の素株式会社 | 甘味受容体キメラタンパク質及びその利用 |
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Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146501A (en) | 1975-12-12 | 1979-03-27 | Henkin Robert I | Process for isolating and purifying taste bud receptors for screening and evaluating tastants |
| US5688662A (en) * | 1992-04-09 | 1997-11-18 | Linguagen Corporation | Gustducin polynucleotides, vectors, host cells and recombinant methods |
| AU764180B2 (en) * | 1998-07-28 | 2003-08-14 | Regents Of The University Of California, The | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction |
| TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| US20010037364A1 (en) | 2000-05-10 | 2001-11-01 | Michalek Nancy R. | Management of enterprise communications |
| AU2002320294B2 (en) | 2001-07-03 | 2009-01-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mammalian sweet and amino acid heterodimeric taste receptors |
-
1999
- 1999-07-27 AU AU53241/99A patent/AU764180B2/en not_active Expired
- 1999-07-27 AT AT07008610T patent/ATE474852T1/de not_active IP Right Cessation
- 1999-07-27 IL IL14098099A patent/IL140980A0/xx active IP Right Grant
- 1999-07-27 JP JP2000562390A patent/JP4657450B2/ja not_active Expired - Lifetime
- 1999-07-27 CN CNB998105317A patent/CN1178952C/zh not_active Expired - Lifetime
- 1999-07-27 ES ES99938846T patent/ES2289817T3/es not_active Expired - Lifetime
- 1999-07-27 DK DK99938846T patent/DK1100811T3/da active
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2001
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2002
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2003
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2007
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2009
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2010
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2011
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