WO2000045179A3 - Screening for modulators of g-protein subunit beta 3 - Google Patents

Screening for modulators of g-protein subunit beta 3 Download PDF

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Publication number
WO2000045179A3
WO2000045179A3 PCT/US2000/002218 US0002218W WO0045179A3 WO 2000045179 A3 WO2000045179 A3 WO 2000045179A3 US 0002218 W US0002218 W US 0002218W WO 0045179 A3 WO0045179 A3 WO 0045179A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
screening
protein subunit
subunit beta
sensory
Prior art date
Application number
PCT/US2000/002218
Other languages
French (fr)
Other versions
WO2000045179A2 (en
Inventor
Charles S Zuker
Jon Elliot Adler
Juergen Lindemeier
Original Assignee
Univ California
Charles S Zuker
Jon Elliot Adler
Juergen Lindemeier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Charles S Zuker, Jon Elliot Adler, Juergen Lindemeier filed Critical Univ California
Priority to AU29760/00A priority Critical patent/AU2976000A/en
Publication of WO2000045179A2 publication Critical patent/WO2000045179A2/en
Publication of WO2000045179A3 publication Critical patent/WO2000045179A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells

Abstract

The invention identifies nucleic acid and amino acid sequences of sensory specific G-protein beta subunits that are specifically expressed in sensory cells, antibodies to such subunits, methods of detecting such nucleic acids and proteins, and methods of screening for modulators of sensory cell specific beta subunits.
PCT/US2000/002218 1999-01-27 2000-01-26 Screening for modulators of g-protein subunit beta 3 WO2000045179A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29760/00A AU2976000A (en) 1999-01-27 2000-01-26 Assays for sensory modulators using a sensory cell specific g-pr otein beta subunit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11740499P 1999-01-27 1999-01-27
US60/117,404 1999-01-27

Publications (2)

Publication Number Publication Date
WO2000045179A2 WO2000045179A2 (en) 2000-08-03
WO2000045179A3 true WO2000045179A3 (en) 2000-12-07

Family

ID=22372740

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002218 WO2000045179A2 (en) 1999-01-27 2000-01-26 Screening for modulators of g-protein subunit beta 3

Country Status (2)

Country Link
AU (1) AU2976000A (en)
WO (1) WO2000045179A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7364867B2 (en) 2000-04-17 2008-04-29 The Mount Sinai School Of Medicine Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US20020164645A1 (en) * 2000-12-29 2002-11-07 The Regents Of The University Of California Assays for taste receptor cell specific ion channel
CA2536360C (en) 2003-08-28 2013-08-06 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
AT500800B1 (en) 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh PROCESS FOR DETERMINING PROBNP
US20090221691A1 (en) 2005-03-07 2009-09-03 University Of Rochester Compositions and methods for inhibiting g protein signaling
US7407769B2 (en) 2005-07-06 2008-08-05 The Regents Of The University Of California Method of identifying activity modulators of a polycystin-2L1 taste receptor polypeptide
US7601883B2 (en) 2005-07-06 2009-10-13 The Regents Of The University Of California Mammalian sour/acid taste and CSF receptor genes, polypeptides and assays
AU2011285694B2 (en) 2010-08-04 2014-12-18 Idexx Laboratories, Inc. Detection of degradation products of canine NT-proBNP
AU2012262154B2 (en) 2011-05-31 2016-08-04 Idexx Laboratories, Inc. Detection of degradation products of feline NT-proBNP

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001810A1 (en) * 1990-07-19 1992-02-06 Lerner Michael R Methods of identifying compounds that act as agonists or antagonists for proteins involved in signal transduction
WO1993021337A1 (en) * 1992-04-09 1993-10-28 Margolskee Robert F Gustducin materials and methods
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
WO1997048820A1 (en) * 1996-06-21 1997-12-24 Aurora Biosciences Corporation Promiscuous g-protein compositions and their use
CA2219958A1 (en) * 1998-01-07 1999-07-07 Ekkehard Leberer The g-protein .beta.subunit interaction domain of ste20p/pak family of protein kinases and uses thereof in bioassays
WO2000006592A1 (en) * 1998-07-28 2000-02-10 The Regents Of The University Of California Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001810A1 (en) * 1990-07-19 1992-02-06 Lerner Michael R Methods of identifying compounds that act as agonists or antagonists for proteins involved in signal transduction
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
WO1993021337A1 (en) * 1992-04-09 1993-10-28 Margolskee Robert F Gustducin materials and methods
WO1997048820A1 (en) * 1996-06-21 1997-12-24 Aurora Biosciences Corporation Promiscuous g-protein compositions and their use
CA2219958A1 (en) * 1998-01-07 1999-07-07 Ekkehard Leberer The g-protein .beta.subunit interaction domain of ste20p/pak family of protein kinases and uses thereof in bioassays
WO2000006592A1 (en) * 1998-07-28 2000-02-10 The Regents Of The University Of California Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KINNAMON, S.C. AND MARGOLSKEE, R.F.: "Mechanisms of taste transduction", CURRENT OPINION IN NEUROBIOLOGY, vol. 6, no. 4, August 1996 (1996-08-01), pages 506 - 513, XP000925139 *
KURIHARA, K. ET AL.: "Receptor Mechanisms of Bitter Substances", PHYSIOLOGY AND BEHAVIOR, vol. 56, no. 6, 1994, pages 1125 - 1132, XP000925135 *
RAY, K. AND ROBISHAW, J.D.: "Cloning and sequencing of a rat heart cDNA encoding a G-protein beta subunit related to the human retinal beta3 subunit", GENE, vol. 149, 1994, pages 337 - 340, XP000915421 *

Also Published As

Publication number Publication date
WO2000045179A2 (en) 2000-08-03
AU2976000A (en) 2000-08-18

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