AU764180B2 - Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction - Google Patents

Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction Download PDF

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Publication number
AU764180B2
AU764180B2 AU53241/99A AU5324199A AU764180B2 AU 764180 B2 AU764180 B2 AU 764180B2 AU 53241/99 A AU53241/99 A AU 53241/99A AU 5324199 A AU5324199 A AU 5324199A AU 764180 B2 AU764180 B2 AU 764180B2
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seq
nucleic acid
polypeptide
receptor
gpcr
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AU5324199A (en
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Jon Elliot Adler
Juergen Lindemeier
Charles S. Zuker
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University of California
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University of California Berkeley
University of California San Diego UCSD
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU53241/99A 1998-07-28 1999-07-27 Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction Expired AU764180B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9546498P 1998-07-28 1998-07-28
US60/095464 1998-07-28
US11274798P 1998-12-17 1998-12-17
US60/112747 1998-12-17
PCT/US1999/017104 WO2000006593A1 (en) 1998-07-28 1999-07-27 Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2003254732A Division AU2003254732A1 (en) 1998-07-28 2003-10-15 Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction

Publications (2)

Publication Number Publication Date
AU5324199A AU5324199A (en) 2000-02-21
AU764180B2 true AU764180B2 (en) 2003-08-14

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AU53241/99A Expired AU764180B2 (en) 1998-07-28 1999-07-27 Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
AU2003254732A Abandoned AU2003254732A1 (en) 1998-07-28 2003-10-15 Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction

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AU2003254732A Abandoned AU2003254732A1 (en) 1998-07-28 2003-10-15 Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction

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US (8) US6383778B1 (enExample)
EP (1) EP1100811B1 (enExample)
JP (2) JP4657450B2 (enExample)
KR (1) KR100643622B1 (enExample)
CN (1) CN1178952C (enExample)
AT (2) ATE474852T1 (enExample)
AU (2) AU764180B2 (enExample)
BR (1) BR9912437A (enExample)
CA (1) CA2335376C (enExample)
DE (2) DE69942622D1 (enExample)
DK (1) DK1100811T3 (enExample)
ES (1) ES2289817T3 (enExample)
IL (3) IL140980A0 (enExample)
NO (1) NO20010320L (enExample)
WO (1) WO2000006593A1 (enExample)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6702949B2 (en) 1997-10-24 2004-03-09 Microdiffusion, Inc. Diffuser/emulsifier for aquaculture applications
US7654728B2 (en) * 1997-10-24 2010-02-02 Revalesio Corporation System and method for therapeutic application of dissolved oxygen
US20110075507A1 (en) * 1997-10-24 2011-03-31 Revalesio Corporation Diffuser/emulsifier
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
US6383778B1 (en) 1998-07-28 2002-05-07 The Regents Of The University Of California Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
US6875574B1 (en) * 1999-01-27 2005-04-05 The Regents Of The University Of California Assays for sensory modulators using a sensory cell specific G-protein alpha subunit
GB9923146D0 (en) * 1999-09-30 1999-12-01 Imperial College Detector array
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
CA2402940A1 (en) * 2000-03-14 2001-09-20 Tularik Inc. G-protein coupled receptors
AU2001251258B2 (en) * 2000-04-07 2008-06-05 Senomyx, Inc. T2r taste receptors and genes encoding same
US7678539B2 (en) * 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
US6977155B2 (en) * 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
DE60142592D1 (de) * 2000-09-22 2010-08-26 Chemcom Sa G-Protein Rezeptoren für Geruchs- und Pheromonmoleküle
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US6955887B2 (en) * 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US20080244761A1 (en) * 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7309577B2 (en) * 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US20040219632A1 (en) * 2001-04-20 2004-11-04 Robert Margolskee T1r3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
CN101891821A (zh) * 2001-06-26 2010-11-24 塞诺米克斯公司 T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
CN100489102C (zh) * 2001-06-26 2009-05-20 塞诺米克斯公司 T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途
AU2002320294B2 (en) 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
US7052857B2 (en) 2001-07-06 2006-05-30 Senomyx, Inc. Expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and use thereof in cell based assays to identify GPCR modulators
CA2452337A1 (en) 2001-07-10 2003-01-23 Senomyx, Inc. Use of specific t2r taste receptors to identify compounds that block bitter taste
AU2002326436A1 (en) * 2001-07-19 2003-03-03 Icogen Corporation Methods for identification of activators of g protein-coulpled receptors and nucleic acids encoding those receptors
EP1523308A4 (en) 2001-07-20 2007-01-10 Us Gov Health & Human Serv PHENYL THIOCARBAMIDE (PTC) TREATMENT RECEPTOR
WO2003025137A2 (en) * 2001-09-18 2003-03-27 Irm, Llc Sweet taste receptors
AU2003272551A1 (en) * 2002-09-17 2004-04-08 Perkinelmer Life Sciences, Inc. Real-time detection of nucleic acid reactions
CA2534027A1 (en) 2003-06-19 2005-01-27 Dennis Drayna Variants of human taste receptor genes
ES2625342T3 (es) 2003-06-27 2017-07-19 Monell Chemical Senses Center Receptores gustativos de la familia T1R del gato doméstico
US7517968B2 (en) * 2003-07-07 2009-04-14 Syracuse University Rapid and inexpensive method for the purification of proteorhodopsin
CA2535045A1 (en) * 2003-08-06 2005-02-17 Senomyx, Inc. T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
AR052477A1 (es) * 2005-02-04 2007-03-21 Senomyx Inc Moleculas que comprenden restos organicos conectados como modificadores del sabor para composiciones comestibles
SG159528A1 (en) 2005-02-04 2010-03-30 Senomyx Inc Compounds comprising linked hetero aryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
US8796441B2 (en) * 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
AR055329A1 (es) * 2005-06-15 2007-08-15 Senomyx Inc Amidas bis-aromaticas y sus usos como modificadores de sabor dulce, saborizantes, y realzadores de sabor
EP1937718B1 (en) 2005-10-20 2017-12-06 Senomyx, Inc. Chimeric human sweet-umami and umami-sweet taste receptors
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
WO2007121604A2 (en) * 2006-04-20 2007-11-01 Givaudan Sa Method relating to sweetness enhancement
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
EP2010009B1 (en) 2006-04-21 2017-06-14 Senomyx, Inc. Processes for preparing solid flavorant compositions
US9019300B2 (en) * 2006-08-04 2015-04-28 Apple Inc. Framework for graphics animation and compositing operations
US7777877B2 (en) * 2006-10-20 2010-08-17 California Institute Of Technology High efficiency coupling optics for pumping and detection of fluorescence
US8445546B2 (en) 2006-10-25 2013-05-21 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
US7832920B2 (en) * 2006-10-25 2010-11-16 Revalesio Corporation Mixing device for creating an output mixture by mixing a first material and a second material
JP5491185B2 (ja) * 2006-10-25 2014-05-14 リバルシオ コーポレイション 傷のケアおよび処置の方法
JP5595041B2 (ja) 2006-10-25 2014-09-24 リバルシオ コーポレイション 酸素富化溶液を用いる、眼および他のヒト組織の治療処置の方法
US8609148B2 (en) * 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CN101828111B (zh) 2007-08-21 2014-07-23 塞诺米克斯公司 人t2r苦味受体及其用途
US10125359B2 (en) * 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
US20100009008A1 (en) * 2007-10-25 2010-01-14 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20090227018A1 (en) * 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US9745567B2 (en) * 2008-04-28 2017-08-29 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US20100303918A1 (en) * 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100015235A1 (en) * 2008-04-28 2010-01-21 Revalesio Corporation Compositions and methods for treating multiple sclerosis
CA2703672A1 (en) * 2007-10-25 2009-04-30 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20100303917A1 (en) * 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US20100029764A1 (en) * 2007-10-25 2010-02-04 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
JP5901291B2 (ja) * 2008-05-01 2016-04-06 リバルシオ コーポレイション 消化器障害を治療するための組成物および方法
CN102256607B (zh) * 2008-10-22 2014-11-05 利发利希奥公司 用于治疗基质金属蛋白酶9(mmp9)介导的病症的组合物和方法
US20100098659A1 (en) * 2008-10-22 2010-04-22 Revalesio Corporation Compositions and methods for treating matrix metalloproteinase 9 (mmp9)-mediated conditions
US8815292B2 (en) * 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
CN101763735B (zh) * 2010-02-01 2015-02-25 王茜 可具有负系统损失时间的动态信号控制系统的控制方法
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
EP3153521B1 (en) 2010-03-26 2019-09-04 Trustees of Dartmouth College Vista regulatory t cell mediator protein, vista binding agents and use thereof
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
MX2012012971A (es) 2010-05-07 2013-02-07 Revalesio Corp Composiciones y metodos para mejorar el rendimiento fisiologico y el tiempo de recuperacion.
CA2803391C (en) 2010-06-22 2021-11-09 Neogenix Oncology, Inc. Npc1 antibodies that bind a muc5ac epitope
EA201300228A1 (ru) 2010-08-12 2013-06-28 Ревалезио Корпорейшн Композиции и способы лечения таупатии
CA3182320A1 (en) 2010-09-23 2012-03-29 Precision Biologics, Inc. Colon and pancreas cancer peptidomimetics
CA2837184C (en) 2011-05-25 2021-09-21 Innate Pharma, S.A. Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders
EP2742350B1 (en) 2011-08-08 2019-10-30 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
CN104619722B (zh) 2012-06-22 2022-10-04 达特茅斯大学理事会 新型vista-ig构建体和vista-ig用于治疗自身免疫性、过敏性和炎性疾病的用途
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
EP2892558B1 (en) 2012-09-07 2019-04-10 The Trustees Of Dartmouth College Vista modulators for diagnosis and treatment of cancer
ES2667333T3 (es) 2012-12-28 2018-05-10 Precision Biologics, Inc. Anticuerpos monoclonales humanizados y métodos de uso para el diagnóstico y el tratamiento del cáncer de colon y páncreas
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
KR20160097294A (ko) 2013-12-09 2016-08-17 뉴욕 유니버시티 항-포도상구균 제제의 식세포 전달을 위한 조성물 및 방법
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
SI3712174T1 (sl) 2013-12-24 2022-06-30 Janssen Pharmaceutica Nv Protitelesa in delci proti VISTA
JP6755640B2 (ja) 2014-03-28 2020-09-16 味の素株式会社 甘味受容体キメラタンパク質及びその利用
JP6997619B2 (ja) 2014-06-11 2022-01-17 キャシー・エイ・グリーン 液性免疫の抑制または増進のための、vistaアゴニスト及びvistaアンタゴニストの使用
AU2015357463B2 (en) 2014-12-05 2021-10-07 Immunext, Inc. Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
WO2016207717A1 (en) 2015-06-24 2016-12-29 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
CN109069626A (zh) 2016-02-12 2018-12-21 詹森药业有限公司 抗-vista(b7h5)抗体
EP3442579A4 (en) 2016-04-15 2019-12-18 Immunext Inc. ANTI-HUMAN-VISTA ANTIBODIES AND USE THEREOF
WO2019006246A1 (en) * 2017-06-30 2019-01-03 The Rockefeller University N-ACYL AMIDES DERIVED FROM THE HUMAN MICROBIOTE FOR THE TREATMENT OF A HUMAN DISEASE
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146501A (en) 1975-12-12 1979-03-27 Henkin Robert I Process for isolating and purifying taste bud receptors for screening and evaluating tastants
US5688662A (en) * 1992-04-09 1997-11-18 Linguagen Corporation Gustducin polynucleotides, vectors, host cells and recombinant methods
US6383778B1 (en) * 1998-07-28 2002-05-07 The Regents Of The University Of California Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
US20010037364A1 (en) 2000-05-10 2001-11-01 Michalek Nancy R. Management of enterprise communications
AU2002320294B2 (en) 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors

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EP1100811A1 (en) 2001-05-23
CA2335376A1 (en) 2000-02-10
WO2000006593A1 (en) 2000-02-10
US20120142029A1 (en) 2012-06-07
CA2335376C (en) 2013-07-02
EP1100811A4 (en) 2002-07-31
US20030022288A1 (en) 2003-01-30
US20020119526A1 (en) 2002-08-29
US20080249293A1 (en) 2008-10-09
DK1100811T3 (da) 2007-11-05
US20110105741A1 (en) 2011-05-05
BR9912437A (pt) 2001-09-25
NO20010320D0 (no) 2001-01-19
CN1178952C (zh) 2004-12-08
HK1101639A1 (en) 2007-10-18
CN1318068A (zh) 2001-10-17
AU2003254732A1 (en) 2003-11-20
US10031129B2 (en) 2018-07-24
JP4657450B2 (ja) 2011-03-23
KR100643622B1 (ko) 2006-11-10
JP5371567B2 (ja) 2013-12-18
AU5324199A (en) 2000-02-21
JP2002521050A (ja) 2002-07-16
ATE474852T1 (de) 2010-08-15
DE69936453D1 (de) 2007-08-16
DE69936453T2 (de) 2008-03-06
US20140065643A1 (en) 2014-03-06
JP2009201525A (ja) 2009-09-10
US20190018001A1 (en) 2019-01-17
US8071743B2 (en) 2011-12-06
US7863433B2 (en) 2011-01-04
KR20010085307A (ko) 2001-09-07
US6383778B1 (en) 2002-05-07
US8568990B2 (en) 2013-10-29
US7270967B2 (en) 2007-09-18
ES2289817T3 (es) 2008-02-01
EP1100811B1 (en) 2007-07-04
US7282557B2 (en) 2007-10-16
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ATE366256T1 (de) 2007-07-15
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