JP4657450B2 - 感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸 - Google Patents

感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸 Download PDF

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Publication number
JP4657450B2
JP4657450B2 JP2000562390A JP2000562390A JP4657450B2 JP 4657450 B2 JP4657450 B2 JP 4657450B2 JP 2000562390 A JP2000562390 A JP 2000562390A JP 2000562390 A JP2000562390 A JP 2000562390A JP 4657450 B2 JP4657450 B2 JP 4657450B2
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gpcr
receptor
nucleic acid
protein
amino acid
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JP2002521050A (ja
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チャールズ エス． ザッカー，
ジョン エリオット アドラー，
ユエルゲン リンデマイエル，
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University of California
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University of California
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2000562390A 1998-07-28 1999-07-27 感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸 Expired - Lifetime JP4657450B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9546498P 1998-07-28 1998-07-28
US60/095,464 1998-07-28
US11274798P 1998-12-17 1998-12-17
US60/112,747 1998-12-17
PCT/US1999/017104 WO2000006593A1 (en) 1998-07-28 1999-07-27 Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction

Related Child Applications (1)

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JP2009144772A Division JP5371567B2 (ja) 1998-07-28 2009-06-17 感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸

Publications (2)

Publication Number Publication Date
JP2002521050A JP2002521050A (ja) 2002-07-16
JP4657450B2 true JP4657450B2 (ja) 2011-03-23

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JP2000562390A Expired - Lifetime JP4657450B2 (ja) 1998-07-28 1999-07-27 感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸
JP2009144772A Expired - Lifetime JP5371567B2 (ja) 1998-07-28 2009-06-17 感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸

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JP2009144772A Expired - Lifetime JP5371567B2 (ja) 1998-07-28 2009-06-17 感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸

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US (8) US6383778B1 (enExample)
EP (1) EP1100811B1 (enExample)
JP (2) JP4657450B2 (enExample)
KR (1) KR100643622B1 (enExample)
CN (1) CN1178952C (enExample)
AT (2) ATE366256T1 (enExample)
AU (2) AU764180B2 (enExample)
BR (1) BR9912437A (enExample)
CA (1) CA2335376C (enExample)
DE (2) DE69942622D1 (enExample)
DK (1) DK1100811T3 (enExample)
ES (1) ES2289817T3 (enExample)
IL (3) IL140980A0 (enExample)
NO (1) NO20010320L (enExample)
WO (1) WO2000006593A1 (enExample)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7654728B2 (en) * 1997-10-24 2010-02-02 Revalesio Corporation System and method for therapeutic application of dissolved oxygen
US20110075507A1 (en) * 1997-10-24 2011-03-31 Revalesio Corporation Diffuser/emulsifier
US6702949B2 (en) 1997-10-24 2004-03-09 Microdiffusion, Inc. Diffuser/emulsifier for aquaculture applications
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
AU764180B2 (en) 1998-07-28 2003-08-14 Regents Of The University Of California, The Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
US6875574B1 (en) * 1999-01-27 2005-04-05 The Regents Of The University Of California Assays for sensory modulators using a sensory cell specific G-protein alpha subunit
GB9923146D0 (en) * 1999-09-30 1999-12-01 Imperial College Detector array
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
EP1263787B1 (en) * 2000-03-14 2005-09-28 Tularik, Inc. G-protein coupled receptor
AU2001251258B2 (en) 2000-04-07 2008-06-05 Senomyx, Inc. T2r taste receptors and genes encoding same
US6977155B2 (en) * 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
US7678539B2 (en) * 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
DK1612222T3 (da) * 2000-09-22 2010-11-01 Chemcom Sa Olfaktoriske og feromon G-proteinkoblede receptorer
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US6955887B2 (en) * 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US20080244761A1 (en) * 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7338771B2 (en) 2001-07-10 2008-03-04 Alexey Pronin Use of specific T2R taste receptors to identify compounds that block bitter taste
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
CA2445197A1 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
IL159243A0 (en) * 2001-06-26 2004-06-01 Senomyx Inc Tir hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
WO2003001876A2 (en) * 2001-06-26 2003-01-09 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
CA2452716C (en) * 2001-07-03 2012-06-26 The Regents Of The University Of California Mammalian sweet and amino acid heterodimeric taste receptors
US7052857B2 (en) 2001-07-06 2006-05-30 Senomyx, Inc. Expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and use thereof in cell based assays to identify GPCR modulators
AU2002326436A1 (en) * 2001-07-19 2003-03-03 Icogen Corporation Methods for identification of activators of g protein-coulpled receptors and nucleic acids encoding those receptors
WO2003008627A2 (en) 2001-07-20 2003-01-30 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phenylthiocarbamide (ptc) taste receptor
AU2002336571A1 (en) 2001-09-18 2003-04-01 Irm, Llc Sweet taste receptors
JP2005538735A (ja) * 2002-09-17 2005-12-22 パーキネルマー ラス インコーポレイテッド 核酸反応のリアルタイム検出法
EP1644528A2 (en) * 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Variants of human taste receptor genes
ES2625342T3 (es) 2003-06-27 2017-07-19 Monell Chemical Senses Center Receptores gustativos de la familia T1R del gato doméstico
US7517968B2 (en) * 2003-07-07 2009-04-14 Syracuse University Rapid and inexpensive method for the purification of proteorhodopsin
SG145745A1 (en) * 2003-08-06 2008-09-29 Senomyx Inc Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
AU2006210513C1 (en) * 2005-02-04 2012-10-25 Senomyx, Inc. Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
JP2008530017A (ja) * 2005-02-04 2008-08-07 セノミックス インコーポレイテッド 食料用組成物のための風味調整剤として連結された有機部分を含む分子
US8796441B2 (en) * 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
TW200715993A (en) * 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
EP1937718B1 (en) 2005-10-20 2017-12-06 Senomyx, Inc. Chimeric human sweet-umami and umami-sweet taste receptors
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
WO2007121604A2 (en) * 2006-04-20 2007-11-01 Givaudan Sa Method relating to sweetness enhancement
EP2010009B1 (en) 2006-04-21 2017-06-14 Senomyx, Inc. Processes for preparing solid flavorant compositions
US9019300B2 (en) * 2006-08-04 2015-04-28 Apple Inc. Framework for graphics animation and compositing operations
US7777877B2 (en) * 2006-10-20 2010-08-17 California Institute Of Technology High efficiency coupling optics for pumping and detection of fluorescence
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US8609148B2 (en) * 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
US8445546B2 (en) 2006-10-25 2013-05-21 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
EP2097107B1 (en) 2006-10-25 2016-05-04 Revalesio Corporation Therapeutic treatment of eyes using an oxygen-enriched solution
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
WO2008115290A2 (en) * 2006-10-25 2008-09-25 Revalesio Corporation Methods of wound care and treatment
EP3170401B1 (en) 2006-10-25 2019-06-05 Revalesio Corporation Ionic aqueous fluid composition containing oxygen microbubbles
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
HUE025137T2 (en) 2007-08-21 2016-01-28 Senomyx Inc Compositions are bitter taste blocking (blocking) compounds
US9745567B2 (en) * 2008-04-28 2017-08-29 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US20100009008A1 (en) * 2007-10-25 2010-01-14 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20100029764A1 (en) * 2007-10-25 2010-02-04 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20090227018A1 (en) * 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
WO2009055614A1 (en) * 2007-10-25 2009-04-30 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20100015235A1 (en) * 2008-04-28 2010-01-21 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US20100303918A1 (en) * 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100303917A1 (en) * 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US10125359B2 (en) * 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
CA2723215A1 (en) * 2008-05-01 2009-11-05 Revalesio Corporation Compositions and methods for treating digestive disorders
BRPI0920201A2 (pt) * 2008-10-22 2019-09-10 Revalesio Corp composicoes e metodos para tratar condicoes mediadas por linfopoetina do estroma timico(tslp)
US20100098659A1 (en) * 2008-10-22 2010-04-22 Revalesio Corporation Compositions and methods for treating matrix metalloproteinase 9 (mmp9)-mediated conditions
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
CN101763735B (zh) * 2010-02-01 2015-02-25 王茜 可具有负系统损失时间的动态信号控制系统的控制方法
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
CN107098958B (zh) 2010-03-26 2021-11-05 达特茅斯大学理事会 Vista调节性t细胞介体蛋白、vista结合剂及其用途
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
MX2012012971A (es) 2010-05-07 2013-02-07 Revalesio Corp Composiciones y metodos para mejorar el rendimiento fisiologico y el tiempo de recuperacion.
EP2585476A4 (en) 2010-06-22 2014-01-22 Neogenix Oncology Inc ANTIGENS AND ANTIBODIES SPECIFIC TO COLON AND PANCREATIC CANCER
MX2013001636A (es) 2010-08-12 2013-05-01 Revalesio Corp Composiciones y metodos para el tratamiento de taupatias
CA2812556C (en) 2010-09-23 2023-02-14 Xue-Ping Wang Colon and pancreas cancer peptidomimetics
EP2714741B1 (en) 2011-05-25 2019-10-30 Innate Pharma, S.A. Anti-kir antibodies for the treatment of inflammatory disorders
EP2742350B1 (en) 2011-08-08 2019-10-30 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
FI3421486T3 (fi) 2012-06-22 2023-12-15 Dartmouth College Uusia vista-ig-rakenteita ja vista-ig:n käyttö autoimmuuni-, allergia- ja tulehdushäiriöiden hoitamiseksi
JP6368308B2 (ja) 2012-09-07 2018-08-01 トラスティーズ・オブ・ダートマス・カレッジ 癌の診断および治療のためのｖｉｓｔａ調節剤
AU2013370171B2 (en) 2012-12-28 2018-09-13 Precision Biologics, Inc. Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
MX2016007533A (es) 2013-12-09 2016-12-14 Univ New York Composiciones y metodos para el suministro fagocitico de agentes anti-estafilococicos.
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
SG10201912797XA (en) 2013-12-24 2020-02-27 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
JP6755640B2 (ja) * 2014-03-28 2020-09-16 味の素株式会社 甘味受容体キメラタンパク質及びその利用
CN107073109B (zh) 2014-06-11 2021-08-06 凯西·A·格林 Vista激动剂和拮抗剂抑制或增强体液免疫的用途
CA2969730A1 (en) 2014-12-05 2016-06-09 Immunext, Inc. Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
MX388164B (es) 2015-06-24 2025-03-19 Janssen Pharmaceutica Nv Anticuerpos y fragmentos anti-vista
US10899836B2 (en) 2016-02-12 2021-01-26 Janssen Pharmaceutica Nv Method of identifying anti-VISTA antibodies
NZ746658A (en) 2016-04-15 2025-09-26 Immunext Inc Anti-human vista antibodies and use thereof
WO2019006246A1 (en) * 2017-06-30 2019-01-03 The Rockefeller University N-ACYL AMIDES DERIVED FROM THE HUMAN MICROBIOTE FOR THE TREATMENT OF A HUMAN DISEASE
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146501A (en) * 1975-12-12 1979-03-27 Henkin Robert I Process for isolating and purifying taste bud receptors for screening and evaluating tastants
US5688662A (en) * 1992-04-09 1997-11-18 Linguagen Corporation Gustducin polynucleotides, vectors, host cells and recombinant methods
AU764180B2 (en) * 1998-07-28 2003-08-14 Regents Of The University Of California, The Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
US20010037364A1 (en) 2000-05-10 2001-11-01 Michalek Nancy R. Management of enterprise communications
CA2452716C (en) 2001-07-03 2012-06-26 The Regents Of The University Of California Mammalian sweet and amino acid heterodimeric taste receptors

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DE69936453D1 (de) 2007-08-16
AU2003254732A1 (en) 2003-11-20
KR100643622B1 (ko) 2006-11-10
EP1100811B1 (en) 2007-07-04
JP2002521050A (ja) 2002-07-16
DK1100811T3 (da) 2007-11-05
US20030022288A1 (en) 2003-01-30
US20140065643A1 (en) 2014-03-06
JP2009201525A (ja) 2009-09-10
HK1101639A1 (en) 2007-10-18
US20080249293A1 (en) 2008-10-09
JP5371567B2 (ja) 2013-12-18
CN1318068A (zh) 2001-10-17
IL184795A0 (en) 2007-12-03
US7270967B2 (en) 2007-09-18
WO2000006593A1 (en) 2000-02-10
ATE366256T1 (de) 2007-07-15
EP1100811A4 (en) 2002-07-31
US8071743B2 (en) 2011-12-06
US20120142029A1 (en) 2012-06-07
ATE474852T1 (de) 2010-08-15
DE69936453T2 (de) 2008-03-06
NO20010320L (no) 2001-03-28
KR20010085307A (ko) 2001-09-07
US10031129B2 (en) 2018-07-24
NO20010320D0 (no) 2001-01-19
DE69942622D1 (de) 2010-09-02
US20190018001A1 (en) 2019-01-17
IL140980A (en) 2007-10-31
AU5324199A (en) 2000-02-21
IL140980A0 (en) 2002-02-10
AU764180B2 (en) 2003-08-14
EP1100811A1 (en) 2001-05-23
BR9912437A (pt) 2001-09-25
ES2289817T3 (es) 2008-02-01
US7282557B2 (en) 2007-10-16
US20020119526A1 (en) 2002-08-29
US7863433B2 (en) 2011-01-04
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US20110105741A1 (en) 2011-05-05
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