ATE473210T1 - Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1 - Google Patents

Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1

Info

Publication number
ATE473210T1
ATE473210T1 AT07761107T AT07761107T ATE473210T1 AT E473210 T1 ATE473210 T1 AT E473210T1 AT 07761107 T AT07761107 T AT 07761107T AT 07761107 T AT07761107 T AT 07761107T AT E473210 T1 ATE473210 T1 AT E473210T1
Authority
AT
Austria
Prior art keywords
compounds
hydroxysteroiddehydrogenase
inhibitors
beta
formula
Prior art date
Application number
AT07761107T
Other languages
German (de)
English (en)
Inventor
John Gordon Allen
Alexei Pavlovych Krasutsky
Owen Brendan Wallace
Yanping Xu
Jeremy Schulenburg York
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE473210T1 publication Critical patent/ATE473210T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT07761107T 2006-04-24 2007-04-23 Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1 ATE473210T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74546706P 2006-04-24 2006-04-24
PCT/US2007/067200 WO2007127693A1 (en) 2006-04-24 2007-04-23 Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
ATE473210T1 true ATE473210T1 (de) 2010-07-15

Family

ID=38512591

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07761107T ATE473210T1 (de) 2006-04-24 2007-04-23 Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1

Country Status (16)

Country Link
US (1) US7816349B2 (https=)
EP (1) EP2029529B1 (https=)
JP (1) JP5189078B2 (https=)
CN (1) CN101432263B (https=)
AT (1) ATE473210T1 (https=)
AU (1) AU2007244960B2 (https=)
BR (1) BRPI0710262A2 (https=)
CA (1) CA2649650C (https=)
DE (1) DE602007007614D1 (https=)
DK (1) DK2029529T3 (https=)
EA (1) EA016959B1 (https=)
ES (1) ES2346925T3 (https=)
MX (1) MX2008013644A (https=)
PL (1) PL2029529T3 (https=)
PT (1) PT2029529E (https=)
WO (1) WO2007127693A1 (https=)

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AU2007240450B2 (en) 2006-04-21 2011-12-22 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA014718B1 (ru) * 2006-04-21 2011-02-28 Эли Лилли Энд Компани Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1
JP5161869B2 (ja) * 2006-04-21 2013-03-13 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体
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JP5269765B2 (ja) * 2006-04-24 2013-08-21 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
JP5101602B2 (ja) * 2006-04-25 2012-12-19 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
CN101432265B (zh) 2006-04-25 2011-12-14 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
DK2021337T3 (da) 2006-04-25 2010-03-29 Lilly Co Eli Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1
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JP5161869B2 (ja) 2006-04-21 2013-03-13 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体
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JP5101602B2 (ja) 2006-04-25 2012-12-19 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
DK2049513T3 (da) 2006-04-28 2012-02-27 Lilly Co Eli Piperidinylsubstituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1
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Also Published As

Publication number Publication date
EP2029529A1 (en) 2009-03-04
CN101432263B (zh) 2012-03-07
CA2649650C (en) 2014-01-14
MX2008013644A (es) 2009-03-06
PL2029529T3 (pl) 2010-11-30
EP2029529B1 (en) 2010-07-07
EA016959B1 (ru) 2012-08-30
EA200870471A1 (ru) 2009-06-30
CN101432263A (zh) 2009-05-13
DE602007007614D1 (de) 2010-08-19
US20090069326A1 (en) 2009-03-12
BRPI0710262A2 (pt) 2011-08-09
ES2346925T3 (es) 2010-10-21
AU2007244960B2 (en) 2012-03-01
DK2029529T3 (da) 2010-09-20
JP2009534470A (ja) 2009-09-24
JP5189078B2 (ja) 2013-04-24
WO2007127693A1 (en) 2007-11-08
US7816349B2 (en) 2010-10-19
PT2029529E (pt) 2010-09-02
CA2649650A1 (en) 2007-11-08
AU2007244960A1 (en) 2007-11-08

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