ATE471384T1 - Herstellung von dicarbonsäure durch verbesserte yarrowia lipolytica-mutantenstämme - Google Patents
Herstellung von dicarbonsäure durch verbesserte yarrowia lipolytica-mutantenstämmeInfo
- Publication number
- ATE471384T1 ATE471384T1 AT05826569T AT05826569T ATE471384T1 AT E471384 T1 ATE471384 T1 AT E471384T1 AT 05826569 T AT05826569 T AT 05826569T AT 05826569 T AT05826569 T AT 05826569T AT E471384 T1 ATE471384 T1 AT E471384T1
- Authority
- AT
- Austria
- Prior art keywords
- yarrowia lipolytica
- dicarbononic
- acid
- production
- improved
- Prior art date
Links
- 241000235015 Yarrowia lipolytica Species 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101100084403 Homo sapiens PRODH gene Proteins 0.000 abstract 1
- 101150059359 POX2 gene Proteins 0.000 abstract 1
- 101150053659 POX4 gene Proteins 0.000 abstract 1
- 101150004239 POX5 gene Proteins 0.000 abstract 1
- 102100028772 Proline dehydrogenase 1, mitochondrial Human genes 0.000 abstract 1
- 101100313649 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) POT1 gene Proteins 0.000 abstract 1
- 101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 abstract 1
- 101100029251 Zea mays PER2 gene Proteins 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 238000002703 mutagenesis Methods 0.000 abstract 1
- 231100000350 mutagenesis Toxicity 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0413468A FR2879215B1 (fr) | 2004-12-15 | 2004-12-15 | Production d'acides dicarboxyliques par des souches mutantes ameliorees de yarrowia lipolytica |
| PCT/FR2005/003140 WO2006064131A1 (fr) | 2004-12-15 | 2005-12-13 | Production d’acides dicarboxyliques par des souches mutantes ameliorees de yarrowia lipolytica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE471384T1 true ATE471384T1 (de) | 2010-07-15 |
Family
ID=34954795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05826569T ATE471384T1 (de) | 2004-12-15 | 2005-12-13 | Herstellung von dicarbonsäure durch verbesserte yarrowia lipolytica-mutantenstämme |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100041115A1 (https=) |
| EP (1) | EP1828392B1 (https=) |
| JP (3) | JP2008523794A (https=) |
| CN (1) | CN101228282B (https=) |
| AT (1) | ATE471384T1 (https=) |
| BR (1) | BRPI0519928A2 (https=) |
| CA (1) | CA2590795C (https=) |
| DE (1) | DE602005021913D1 (https=) |
| DK (1) | DK1828392T3 (https=) |
| ES (1) | ES2346773T3 (https=) |
| FR (1) | FR2879215B1 (https=) |
| PL (1) | PL1828392T3 (https=) |
| WO (1) | WO2006064131A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2927089B1 (fr) | 2008-02-05 | 2011-03-25 | Inst Nat De La Rech Agronomique Inra | Procede d'integration ciblee de multicopies d'un gene d'interet dans une souche de yarrowia |
| US8597931B2 (en) | 2008-07-11 | 2013-12-03 | Institut National De La Recherche Agronomique (Inra) | Mutant yeast strains capable of accumulating a large quantity of lipids |
| FR2957074B1 (fr) | 2010-03-05 | 2012-04-27 | Organisation Nationale Interprofessionnelle Des Graines Et Fruits Oleagineux O N I D O L | Procede de preparation d'acides carboxyliques par coupure oxydante d'un diol vicinal |
| FR2962133B1 (fr) | 2010-07-01 | 2014-09-12 | Agronomique Inst Nat Rech | Optimisation de la synthese et de l'accumulation de lipides |
| WO2013006733A2 (en) | 2011-07-06 | 2013-01-10 | Verdezyne, Inc. | Biological methods for preparing a fatty dicarboxylic acid |
| SG10201705057QA (en) | 2012-12-19 | 2017-07-28 | Verdezyne Inc | Biological methods for preparing a fatty dicarboxylic acid |
| HUE052914T2 (hu) | 2012-12-19 | 2021-05-28 | Corvay Bioproducts Gmbh | Biológiai eljárások zsírdikarbonsav elõállítására |
| FR3002774A1 (fr) | 2013-03-04 | 2014-09-05 | Agronomique Inst Nat Rech | Levures mutantes ayant une production accrue de lipides et d'acide citrique |
| FR3005317B1 (fr) | 2013-05-02 | 2016-03-18 | Agronomique Inst Nat Rech | Levures mutantes capables de produire un acide gras inhabituel |
| DE102014220186B4 (de) * | 2013-12-12 | 2017-06-22 | Technische Universität Dresden | Hefestämme und Verfahren zur Produktion von Omega-Hydroxyfettsäuren und Dicarbonsäuren |
| EP3155094A1 (en) | 2014-06-11 | 2017-04-19 | Institut National De La Recherche Agronomique (INRA) | Improved lipid accumulation in yarrowia lipolytica strains by overexpression of hexokinase and new strains thereof |
| US10174350B2 (en) | 2014-07-18 | 2019-01-08 | Industrial Technology Research Institute | Genetically modified microorganism for producing medium-chain lauric acid and/or dodecanedioic acid and method of using thereof |
| US9695404B2 (en) | 2014-07-18 | 2017-07-04 | Industrial Technology Research Institute | Genetically modified microorganism for producing long-chain dicarboxylic acid and method of using thereof |
| US9932665B2 (en) | 2015-01-22 | 2018-04-03 | United Technologies Corporation | Corrosion resistant coating application method |
| CA2979423A1 (fr) | 2015-03-27 | 2016-10-06 | Fonds De Developpement Des Filieres Des Oleagineux Et Des Proteagineux Fidop | Microorganismes et leur utilisation pour la production de diacides |
| EP3085788A1 (en) | 2015-04-23 | 2016-10-26 | Institut National De La Recherche Agronomique | Mutant yeast strain capable of degrading cellobiose |
| EP3106520A1 (en) | 2015-06-17 | 2016-12-21 | Institut National De La Recherche Agronomique | Mutant yarrowia strain capable of degrading galactose |
| EP3325607A1 (en) * | 2015-07-22 | 2018-05-30 | E. I. du Pont de Nemours and Company | High level production of long-chain dicarboxylic acids with microbes |
| KR101903553B1 (ko) * | 2015-10-27 | 2018-10-04 | 한국생명공학연구원 | 중쇄 아미노카르복시산의 생산 방법 |
| US20190136278A1 (en) | 2016-05-10 | 2019-05-09 | Institut National De La Recherche Agronomique | Mutant yeast strains with enhanced production of erythritol or erythrulose |
| EP3348647A1 (en) | 2017-01-13 | 2018-07-18 | Institut National De La Recherche Agronomique | Mutant yeast strain capable of producing medium chain fatty acids |
| EP3360956A1 (en) | 2017-02-10 | 2018-08-15 | Institut National De La Recherche Agronomique | Mutant yeast strain capable of degrading cellulose |
| CN107083338A (zh) * | 2017-05-15 | 2017-08-22 | 天津大学 | 重组菌株及其构建方法与在产菜油甾醇中的应用 |
| CA3069697A1 (en) | 2017-07-13 | 2019-01-17 | Radici Chimica S.P.A. | Biological methods for modifying cellular carbon flux |
| CN110684676B (zh) * | 2018-07-06 | 2023-08-08 | 上海凯赛生物技术股份有限公司 | 一种低含量羟基酸杂质的长链二元酸及其生产方法 |
| US11136596B2 (en) * | 2018-07-06 | 2021-10-05 | Cibt America Inc. | Long-chain dibasic acid with low content of hydroxyl acid impurity and production method thereof |
| CN111117982B (zh) * | 2019-12-25 | 2023-05-12 | 武汉新华扬生物股份有限公司 | 一种拟除虫菊酯降解酶、其编码基因、重组菌株和应用 |
| US20230089404A1 (en) | 2021-09-18 | 2023-03-23 | Indian Oil Corporation Limited | Bioassisted Process For Selective Conversion Of Alkane Rich Refinery Stream |
| CN114958900B (zh) * | 2022-05-16 | 2024-04-19 | 华中科技大学 | 一种解脂耶氏酵母高效无标记基因整合载体及其应用 |
| WO2026008448A1 (en) | 2024-07-01 | 2026-01-08 | Universiteit Gent | Modified yeast strains to produce long chain dicarboxylic acids |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3540834A1 (de) | 1985-11-18 | 1987-05-21 | Henkel Kgaa | Verfahren zur herstellung von dicarbonsaeuren |
| US5254466A (en) | 1989-11-06 | 1993-10-19 | Henkel Research Corporation | Site-specific modification of the candida tropicals genome |
| WO1991014781A1 (en) * | 1990-03-19 | 1991-10-03 | Henkel Research Corporation | METHOD FOR INCREASING THE OMEGA-HYDROXYLASE ACTIVITY IN $i(CANDIDA TROPICALIS) |
| US6673613B2 (en) * | 2000-07-26 | 2004-01-06 | Cognis Corporation | Use of CYP52A2A promoter to increase gene expression in yeast |
| WO2003100013A2 (en) * | 2002-05-23 | 2003-12-04 | Cognis Corporation | NON-REVERTIBLE β-OXIDATION BLOCKED CANDIDA TROPICALIS |
-
2004
- 2004-12-15 FR FR0413468A patent/FR2879215B1/fr not_active Expired - Fee Related
-
2005
- 2005-12-13 BR BRPI0519928-0A patent/BRPI0519928A2/pt not_active IP Right Cessation
- 2005-12-13 DE DE602005021913T patent/DE602005021913D1/de not_active Expired - Lifetime
- 2005-12-13 CA CA2590795A patent/CA2590795C/fr not_active Expired - Fee Related
- 2005-12-13 JP JP2007546115A patent/JP2008523794A/ja active Pending
- 2005-12-13 EP EP05826569A patent/EP1828392B1/fr not_active Expired - Lifetime
- 2005-12-13 PL PL05826569T patent/PL1828392T3/pl unknown
- 2005-12-13 US US11/721,726 patent/US20100041115A1/en not_active Abandoned
- 2005-12-13 CN CN2005800483222A patent/CN101228282B/zh not_active Expired - Fee Related
- 2005-12-13 ES ES05826569T patent/ES2346773T3/es not_active Expired - Lifetime
- 2005-12-13 AT AT05826569T patent/ATE471384T1/de active
- 2005-12-13 WO PCT/FR2005/003140 patent/WO2006064131A1/fr not_active Ceased
- 2005-12-13 DK DK05826569.5T patent/DK1828392T3/da active
-
2012
- 2012-03-06 JP JP2012049322A patent/JP5462303B2/ja not_active Expired - Fee Related
- 2012-03-06 JP JP2012049326A patent/JP5615859B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101228282B (zh) | 2013-09-18 |
| JP5462303B2 (ja) | 2014-04-02 |
| WO2006064131A8 (fr) | 2007-08-02 |
| EP1828392A1 (fr) | 2007-09-05 |
| EP1828392B1 (fr) | 2010-06-16 |
| FR2879215A1 (fr) | 2006-06-16 |
| JP2008523794A (ja) | 2008-07-10 |
| JP2012130352A (ja) | 2012-07-12 |
| CA2590795C (fr) | 2014-09-02 |
| ES2346773T3 (es) | 2010-10-20 |
| DE602005021913D1 (de) | 2010-07-29 |
| WO2006064131A1 (fr) | 2006-06-22 |
| CA2590795A1 (fr) | 2006-06-22 |
| BRPI0519928A2 (pt) | 2009-04-07 |
| JP2012105680A (ja) | 2012-06-07 |
| FR2879215B1 (fr) | 2010-08-20 |
| PL1828392T3 (pl) | 2011-04-29 |
| JP5615859B2 (ja) | 2014-10-29 |
| DK1828392T3 (da) | 2010-09-27 |
| CN101228282A (zh) | 2008-07-23 |
| US20100041115A1 (en) | 2010-02-18 |
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| UEP | Publication of translation of european patent specification |
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