ATE460483T1 - Fusionsprotein mit gesteigerter in vivo erythropoietin-aktivität - Google Patents

Fusionsprotein mit gesteigerter in vivo erythropoietin-aktivität

Info

Publication number
ATE460483T1
ATE460483T1 AT02016953T AT02016953T ATE460483T1 AT E460483 T1 ATE460483 T1 AT E460483T1 AT 02016953 T AT02016953 T AT 02016953T AT 02016953 T AT02016953 T AT 02016953T AT E460483 T1 ATE460483 T1 AT E460483T1
Authority
AT
Austria
Prior art keywords
increased
fusion protein
erythropoietin activity
vivo
vivo erythropoietin
Prior art date
Application number
AT02016953T
Other languages
English (en)
Inventor
Dong-Eok Lee
Myung-Suk Oh
Bo-Sup Chung
Ji-Sook Park
Ki-Wan Kim
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Application granted granted Critical
Publication of ATE460483T1 publication Critical patent/ATE460483T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
AT02016953T 2001-11-29 2002-08-01 Fusionsprotein mit gesteigerter in vivo erythropoietin-aktivität ATE460483T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2001-0074975A KR100467750B1 (ko) 2001-11-29 2001-11-29 생체내 에리스로포이에틴 활성이 증진된 융합단백질

Publications (1)

Publication Number Publication Date
ATE460483T1 true ATE460483T1 (de) 2010-03-15

Family

ID=36821313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02016953T ATE460483T1 (de) 2001-11-29 2002-08-01 Fusionsprotein mit gesteigerter in vivo erythropoietin-aktivität

Country Status (23)

Country Link
US (1) US7098318B2 (de)
EP (1) EP1319712B1 (de)
JP (1) JP3860097B2 (de)
KR (1) KR100467750B1 (de)
CN (1) CN100390201C (de)
AR (1) AR036384A1 (de)
AT (1) ATE460483T1 (de)
AU (1) AU2002300359B2 (de)
BR (1) BRPI0203394B1 (de)
CA (1) CA2394572C (de)
DE (2) DE10235248B4 (de)
ES (1) ES2339426T3 (de)
FR (1) FR2832716B1 (de)
GB (1) GB2382580B (de)
IT (1) ITMI20021803A1 (de)
MX (1) MXPA02008131A (de)
MY (1) MY122935A (de)
NZ (1) NZ520442A (de)
RU (1) RU2225220C1 (de)
SG (1) SG117416A1 (de)
TW (1) TWI237056B (de)
WO (1) WO2003046013A1 (de)
ZA (1) ZA200206172B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
AU2004277954A1 (en) * 2003-09-29 2005-04-14 The Kenneth S Warren Institute, Inc. Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions
US7625564B2 (en) 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US7553940B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting EPO polypeptides and derivatives thereof and methods thereof
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
CA2720628A1 (en) 2007-07-26 2009-01-29 Novagen Holding Corporation Fusion proteins having mutated immunoglobulin hinge region
CN101863982A (zh) * 2009-04-17 2010-10-20 哈药集团生物工程有限公司 一种用于升高血小板的融合蛋白及其制备方法
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
CN103864913A (zh) * 2012-12-18 2014-06-18 联亚生技开发股份有限公司 重组蛋白
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
WO2016203482A2 (en) 2015-06-19 2016-12-22 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
ES2963725T3 (es) 2016-07-11 2024-04-01 Opko Biologics Ltd Factor VII de coagulación de acción prolongada y métodos para producir el mismo

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69029799T2 (de) * 1989-02-21 1997-05-28 Univ Washington Modifizierte formen von fortpflanzungshormonen
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
CN1057534C (zh) * 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
GB2285446B (en) * 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
ITFI940106A1 (it) * 1994-05-27 1995-11-27 Menarini Ricerche Sud Spa Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica
US6254870B1 (en) * 1995-02-03 2001-07-03 G. D. Searle & Co. Thrombopoietin: IL-3 fusion protein
US6242570B1 (en) * 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
AU8182298A (en) * 1997-07-10 1999-02-08 Beth Israel Deaconess Medical Center Recombinant erythropoietin / immunoglobulin fusion proteins
WO1999003887A1 (en) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US6342220B1 (en) * 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
WO1999057147A1 (fr) * 1998-04-30 1999-11-11 Kirin Brewery Company, Limited Mutants de la thrombopoietine humaine
ES2317843T3 (es) * 1999-07-13 2009-05-01 Bolder Biotechnology, Inc. Proteinas de fusion de eritropoyetina-inmunoglobulina.
WO2001036489A2 (en) * 1999-11-12 2001-05-25 Merck Patent Gmbh Erythropoietin forms with improved properties

Also Published As

Publication number Publication date
SG117416A1 (en) 2005-12-29
GB2382580A (en) 2003-06-04
CN100390201C (zh) 2008-05-28
RU2225220C1 (ru) 2004-03-10
EP1319712B1 (de) 2010-03-10
MXPA02008131A (es) 2004-12-13
RU2002123438A (ru) 2004-03-27
JP2003169671A (ja) 2003-06-17
BR0203394A (pt) 2004-05-11
ITMI20021803A1 (it) 2003-05-30
AR036384A1 (es) 2004-09-01
ZA200206172B (en) 2003-04-03
EP1319712A3 (de) 2003-11-12
NZ520442A (en) 2003-10-31
MY122935A (en) 2006-05-31
US20030124115A1 (en) 2003-07-03
FR2832716B1 (fr) 2004-12-03
DE60235603D1 (de) 2010-04-22
EP1319712A2 (de) 2003-06-18
FR2832716A1 (fr) 2003-05-30
KR100467750B1 (ko) 2005-01-24
GB2382580B (en) 2003-10-08
CA2394572A1 (en) 2003-05-29
CN1421461A (zh) 2003-06-04
TWI237056B (en) 2005-08-01
CA2394572C (en) 2007-08-14
DE10235248B4 (de) 2004-12-23
GB0218252D0 (en) 2002-09-11
DE10235248A1 (de) 2003-06-12
ES2339426T3 (es) 2010-05-20
US7098318B2 (en) 2006-08-29
JP3860097B2 (ja) 2006-12-20
WO2003046013A1 (en) 2003-06-05
KR20030044272A (ko) 2003-06-09
AU2002300359B2 (en) 2004-12-23
BRPI0203394B1 (pt) 2015-12-01

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