AR036384A1 - Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada - Google Patents
Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentadaInfo
- Publication number
- AR036384A1 AR036384A1 ARP020103279A ARP020103279A AR036384A1 AR 036384 A1 AR036384 A1 AR 036384A1 AR P020103279 A ARP020103279 A AR P020103279A AR P020103279 A ARP020103279 A AR P020103279A AR 036384 A1 AR036384 A1 AR 036384A1
- Authority
- AR
- Argentina
- Prior art keywords
- increased
- fusion protein
- activity
- erythropoyetin
- vivid
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 102000003951 Erythropoietin Human genes 0.000 abstract 2
- 108090000394 Erythropoietin Proteins 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229940105423 erythropoietin Drugs 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 2
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 abstract 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 102000044890 human EPO Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Una proteína de fusión que tiene actividad de eritropoyetina in vivo aumentada en donde un fragmento de péptido del extremo carboxilo terminal de tromboyetina es fusionado con el extremo carboxilo terminal de la eritropoyetina humana. Esta proteína de fusión tiene una vida media in vivo muy aumentada debido al contenido aumentado de carbohidratos sin pérdidas de la actividad inherente de la eritropoyetina, y no provoca ninguna antigenicidad cuando se aplica al cuerpo humano.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2001-0074975A KR100467750B1 (ko) | 2001-11-29 | 2001-11-29 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036384A1 true AR036384A1 (es) | 2004-09-01 |
Family
ID=36821313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020103279A AR036384A1 (es) | 2001-11-29 | 2002-08-30 | Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada |
Country Status (23)
Country | Link |
---|---|
US (1) | US7098318B2 (es) |
EP (1) | EP1319712B1 (es) |
JP (1) | JP3860097B2 (es) |
KR (1) | KR100467750B1 (es) |
CN (1) | CN100390201C (es) |
AR (1) | AR036384A1 (es) |
AT (1) | ATE460483T1 (es) |
AU (1) | AU2002300359B2 (es) |
BR (1) | BRPI0203394B1 (es) |
CA (1) | CA2394572C (es) |
DE (2) | DE10235248B4 (es) |
ES (1) | ES2339426T3 (es) |
FR (1) | FR2832716B1 (es) |
GB (1) | GB2382580B (es) |
IT (1) | ITMI20021803A1 (es) |
MX (1) | MXPA02008131A (es) |
MY (1) | MY122935A (es) |
NZ (1) | NZ520442A (es) |
RU (1) | RU2225220C1 (es) |
SG (1) | SG117416A1 (es) |
TW (1) | TWI237056B (es) |
WO (1) | WO2003046013A1 (es) |
ZA (1) | ZA200206172B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7345019B1 (en) * | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
CN1897959A (zh) * | 2003-09-29 | 2007-01-17 | 沃伦药品公司 | 用于治疗和预防脓毒病和粘连形成的组织保护细胞因子 |
US7625564B2 (en) | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US7553940B2 (en) * | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting EPO polypeptides and derivatives thereof and methods thereof |
US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8067548B2 (en) | 2007-07-26 | 2011-11-29 | Novagen Holding Corporation | Fusion proteins having mutated immunoglobulin hinge region |
CN101863982A (zh) * | 2009-04-17 | 2010-10-20 | 哈药集团生物工程有限公司 | 一种用于升高血小板的融合蛋白及其制备方法 |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
CN103864913A (zh) * | 2012-12-18 | 2014-06-18 | 联亚生技开发股份有限公司 | 重组蛋白 |
US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2016203482A2 (en) | 2015-06-19 | 2016-12-22 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
BR112019000610A2 (pt) | 2016-07-11 | 2019-07-02 | Opko Biologics Ltd | fator vii de coagulação de longa ação e métodos de produção do mesmo |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2053864C (en) * | 1989-02-21 | 2001-11-20 | Irving Boime | Modified forms of reproductive hormones |
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5856298A (en) * | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
CN1057534C (zh) * | 1993-08-17 | 2000-10-18 | 柯瑞英-艾格公司 | 促红细胞生成素类似物 |
SG47030A1 (en) * | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
ITFI940106A1 (it) * | 1994-05-27 | 1995-11-27 | Menarini Ricerche Sud Spa | Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica |
WO1996023888A1 (en) * | 1995-02-03 | 1996-08-08 | G.D. Searle & Co. | NOVEL c-MPL LIGANDS |
AU8182298A (en) * | 1997-07-10 | 1999-02-08 | Beth Israel Deaconess Medical Center | Recombinant erythropoietin / immunoglobulin fusion proteins |
US6242570B1 (en) * | 1997-07-10 | 2001-06-05 | Beth Israel Deaconess Medical Center | Production and use of recombinant protein multimers with increased biological activity |
DE69838552T2 (de) * | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
US6342220B1 (en) * | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
AU3538799A (en) * | 1998-04-30 | 1999-11-23 | Kirin Brewery Company, Limited | Human thrombopoietin mutants |
JP4944324B2 (ja) * | 1999-07-13 | 2012-05-30 | ボルダー バイオテクノロジー, インコーポレイテッド | 免疫グロブリン融合タンパク質 |
CA2391080A1 (en) * | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
-
2001
- 2001-11-29 KR KR10-2001-0074975A patent/KR100467750B1/ko not_active IP Right Cessation
-
2002
- 2002-07-24 CA CA002394572A patent/CA2394572C/en not_active Expired - Fee Related
- 2002-07-26 WO PCT/KR2002/001420 patent/WO2003046013A1/en active Search and Examination
- 2002-07-26 TW TW091116686A patent/TWI237056B/zh not_active IP Right Cessation
- 2002-07-30 MY MYPI20022857A patent/MY122935A/en unknown
- 2002-07-30 NZ NZ520442A patent/NZ520442A/en not_active IP Right Cessation
- 2002-07-30 AU AU2002300359A patent/AU2002300359B2/en not_active Ceased
- 2002-08-01 EP EP02016953A patent/EP1319712B1/en not_active Expired - Lifetime
- 2002-08-01 DE DE10235248A patent/DE10235248B4/de not_active Expired - Fee Related
- 2002-08-01 ES ES02016953T patent/ES2339426T3/es not_active Expired - Lifetime
- 2002-08-01 DE DE60235603T patent/DE60235603D1/de not_active Expired - Lifetime
- 2002-08-01 SG SG200204673A patent/SG117416A1/en unknown
- 2002-08-01 AT AT02016953T patent/ATE460483T1/de active
- 2002-08-02 FR FR0209867A patent/FR2832716B1/fr not_active Expired - Lifetime
- 2002-08-02 ZA ZA200206172A patent/ZA200206172B/xx unknown
- 2002-08-06 GB GB0218252A patent/GB2382580B/en not_active Expired - Fee Related
- 2002-08-08 IT IT001803A patent/ITMI20021803A1/it unknown
- 2002-08-20 BR BRPI0203394A patent/BRPI0203394B1/pt not_active IP Right Cessation
- 2002-08-21 MX MXPA02008131A patent/MXPA02008131A/es active IP Right Grant
- 2002-08-23 CN CNB021301557A patent/CN100390201C/zh not_active Expired - Fee Related
- 2002-08-29 US US10/230,454 patent/US7098318B2/en active Active
- 2002-08-30 RU RU2002123438/15A patent/RU2225220C1/ru not_active IP Right Cessation
- 2002-08-30 JP JP2002253938A patent/JP3860097B2/ja not_active Expired - Fee Related
- 2002-08-30 AR ARP020103279A patent/AR036384A1/es not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR036384A1 (es) | Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada | |
ECSP064643A (es) | Proteinas de fusion de glp-1 | |
ATE473011T1 (de) | Modifizierte transferrin-fusionsproteine mit doppelten transferrin-amino- oder carboxy- terminalen domänen | |
ES2077666T3 (es) | Proteina de union a fibronectina y su preparacion. | |
HRP20050354B1 (es) | ||
ES2059547T3 (es) | Expresion y secrecion mejoradas de proteinas heterologas en levadura, empleando secuencia conductora de factor alfa truncado. | |
ATE551048T1 (de) | Proteinhydrolysate enthaltende kosmetische zusammensetzungen | |
DE60033431D1 (de) | Chimärische natriuretische peptide | |
BR9407377A (pt) | Toxina hibrida | |
BR0212256A (pt) | Proteìnas de fusão de transferrina modificadas | |
CR7584A (es) | Nuevas proteinas de fusion con trombomodulina dirigidas contra factores tisulares como anticoagulantes | |
PE20020876A1 (es) | Proteinas de fusion para la secrecion de una proteina de interes en sobrenadantes bacterianos | |
ATE320449T1 (de) | Fusionsprotein mit verbesserter in vivo erythropoietinwirkung | |
ATE411082T1 (de) | Neue verwendung von kurzkettigen carbonsäuren | |
ATE317441T1 (de) | Cathepsin-02-protease | |
DK1088084T3 (da) | Erythropoietin analog-humant serumalbumin fusionsprotein | |
MX353234B (es) | Variantes de polipeptidos con función efectora alterada. | |
EE9800306A (et) | Isoleeritud dimeerne fibroblastide aktivatsioonivalk alfa ja selle kasutusalad | |
ATE328101T1 (de) | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften | |
ATE433491T1 (de) | Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential | |
ATE471956T1 (de) | Verzweigte polyalkylenglykole | |
ES2091824T3 (es) | Proteina recombinante de fusion toxina anticuerpo. | |
AR025660A1 (es) | PRECURSOR DE HIRUDINA, PROCEDIMIENTO PAA LA PREPARACIoN DE LEU-HIRUDINA Y SU EMPLEO PARA LA PREPARACIoN DE LEU-HIRUDINA. | |
EA200000875A1 (ru) | Белки, взаимодействующие с каспазой-8 | |
ATE113965T1 (de) | Stabilisierte, starke grf-analoga. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed, e.g., due to non-payment of fee |