PE20020876A1 - Proteinas de fusion para la secrecion de una proteina de interes en sobrenadantes bacterianos - Google Patents
Proteinas de fusion para la secrecion de una proteina de interes en sobrenadantes bacterianosInfo
- Publication number
- PE20020876A1 PE20020876A1 PE2002000081A PE2002000081A PE20020876A1 PE 20020876 A1 PE20020876 A1 PE 20020876A1 PE 2002000081 A PE2002000081 A PE 2002000081A PE 2002000081 A PE2002000081 A PE 2002000081A PE 20020876 A1 PE20020876 A1 PE 20020876A1
- Authority
- PE
- Peru
- Prior art keywords
- protein
- interest
- bacterial
- supernadants
- secretion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A ADN QUE CODIFICA UNA PROTEINA DE FUSION -F-Asm-Rn-Y-, F ES ADN QUE CODIFICA UNA SECUENCIA DE AMINOACIDOS QUE PERMITE LA SECRECION DE UNA PROTEINA Y TAL COMO LEPIRUDINA, SER-HIRUDINA, ALA-HIRUDINA, EN UN MEDIO DE FERMENTACION; As ES UN ENLACE O ADN QUE CODIFICA UN AMINOACIDO CODIFICABLE POR EL CODIGO GENETICO; m ES 0-10; R ES UN ENLACE O UN CODON DE ARGININA; n ES 0-1; Y ES ADN QUE CODIFICA UNA PROTEINA DE INTERES CORRECTAMENTE PLEGADA ES PARTE DE UNA PROTEINA DE FUSION EN EL MEDIO DE FERMENTACION, TAL COMO PROINSULINA, INSULINA. TAMBIEN SE REFIERE A ADN, EN EL CUAL EL CASSETE DE EXPRESION P-S-F-Asm-Rn-Y-T; P ES UN PROMOTOR, S ES ADN QUE CODIFICA UNA SECUENCIA QUE PERMITE RENDIMIENTOS OPTIMOS, oprF DE PSEUDOMONAS FLUORESCENCES O CODIFICA LA PROTEINA EXTERIOR DE S TYPHIMURIUM, PROTEINA PRECURSORA DE LA FOSFATASA ALCALINA DE E COLI, SECUENCIA SENAL ECCOMPC DERIVADA DEL GEN OMPc DE E COLI, ENTRE OTROS; T ES ADN SIN TRADUCIR QUE MEJORA LA EXPRESION. TAMBIEN SE REFIERE A UN PLASMIDO, UNA CELULA CON EL ADN MENCIONADO TAL COMO E. COLI, B-SUBTILIS, STREPTOMYCES. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PRODUCCION FERMENTATIVA DE UNA PROTEINA DE FUSION. HIRUDINA ES EXPORTADA COMO PARTE DE UNA PROTEINA DE FUSION CON POLIPEPTIDOS COMO DERIVADOS DE PROINSULINA PRESENTE EN UNA CORRECTA ESTRUCTURA TRIDIMENSIONAL OBTENIENDO UNA PRODUCCION MAS RENTABLE POR LOS SISTEMA DE HOSPEDANTE BACTERIANO/VECTOR, OBTENIENDO UN PROCEDIMIENTO DE PURIFICACION DE PROTEINAS MAS SIMPLE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108212A DE10108212A1 (de) | 2001-02-20 | 2001-02-20 | Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020876A1 true PE20020876A1 (es) | 2002-11-05 |
Family
ID=7674913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000081A PE20020876A1 (es) | 2001-02-20 | 2002-02-06 | Proteinas de fusion para la secrecion de una proteina de interes en sobrenadantes bacterianos |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1364029B1 (es) |
| JP (1) | JP4243104B2 (es) |
| KR (1) | KR100858009B1 (es) |
| CN (1) | CN100500853C (es) |
| AT (1) | ATE314480T1 (es) |
| AU (1) | AU2002231784B2 (es) |
| BR (1) | BRPI0207394B8 (es) |
| CA (1) | CA2438886C (es) |
| DE (2) | DE10108212A1 (es) |
| DK (1) | DK1364029T3 (es) |
| ES (1) | ES2254658T3 (es) |
| HK (1) | HK1065335A1 (es) |
| IL (1) | IL157414A0 (es) |
| MX (1) | MXPA03007114A (es) |
| NO (1) | NO331271B1 (es) |
| NZ (1) | NZ527643A (es) |
| PE (1) | PE20020876A1 (es) |
| WO (1) | WO2002068660A1 (es) |
| ZA (1) | ZA200305869B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| CA2546157C (en) | 2003-11-21 | 2014-07-22 | Dow Global Technolgies Inc. | Improved expression systems with sec-system secretion |
| KR101183720B1 (ko) | 2004-01-16 | 2012-09-17 | 다우 글로벌 테크놀로지스 엘엘씨 | 슈도모나스 플루오레센스에서의 포유류 단백질의 발현 |
| JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
| DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102006031962A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| DE102006050332A1 (de) | 2006-10-25 | 2008-04-30 | Wacker Chemie Ag | DNS-Konstrukt und Verfahren zur fermentativen Herstellung von Fusionsproteinen |
| EP2468869B1 (en) | 2007-01-31 | 2015-03-18 | Pfenex Inc. | Bacterial leader sequences for increased expression |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| AU2008245696B2 (en) | 2007-04-27 | 2013-11-07 | Pelican Technology Holdings, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| DE102008025008A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| BRPI0907119A2 (pt) | 2008-01-09 | 2015-07-14 | Sanofi Aventis Deutschland | Derivados de insulina tendo um perfil de ação de tempo extremamente retardado |
| DE102008025007A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| KR20100111682A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
| EP2344524B1 (en) | 2008-10-02 | 2019-12-04 | Unitargeting Research As | Kit for the optimisation of protein synthesis/secretion |
| KR101820024B1 (ko) | 2008-10-17 | 2018-01-18 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 ｇｌｐ－1 효능제의 병용물 |
| ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
| HUE037735T2 (hu) | 2009-11-13 | 2018-09-28 | Sanofi Aventis Deutschland | DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény |
| BR112013004756B1 (pt) | 2010-08-30 | 2020-04-28 | Sanofi Aventis Deutschland | uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| CN105473154A (zh) | 2013-03-12 | 2016-04-06 | 通用医疗公司 | 修饰的缪勒抑制物质(mis)蛋白及其用于疾病治疗的用途 |
| AU2014362307A1 (en) | 2013-12-11 | 2016-06-30 | The General Hospital Corporation | Use of mullerian inhibiting substance (MIS) proteins for contraception and ovarian reserve preservation |
| JP6970615B2 (ja) | 2014-12-12 | 2021-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン／リキシセナチド固定比処方 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341414C (fr) * | 1984-03-27 | 2002-12-31 | Paul Tolstoshev | Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine |
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| ES2129749T3 (es) * | 1990-11-08 | 1999-06-16 | Japan Energy Corp | Vector de secrecion, microorganismos transformados que contienen el indicado vector y produccion de un producto a partir de dicho microorganismo. |
| WO1995009125A1 (en) * | 1992-09-28 | 1995-04-06 | Pehr Harold T | Kicker latch for container closures |
| DE10033195A1 (de) * | 2000-07-07 | 2002-03-21 | Aventis Pharma Gmbh | Bifunktionale Fusionsproteine aus Hirudin und TAP |
-
2001
- 2001-02-20 DE DE10108212A patent/DE10108212A1/de not_active Withdrawn
-
2002
- 2002-02-06 PE PE2002000081A patent/PE20020876A1/es not_active Application Discontinuation
- 2002-02-08 BR BRPI0207394A patent/BRPI0207394B8/pt not_active IP Right Cessation
- 2002-02-08 CA CA2438886A patent/CA2438886C/en not_active Expired - Lifetime
- 2002-02-08 IL IL15741402A patent/IL157414A0/xx active IP Right Grant
- 2002-02-08 ES ES02711847T patent/ES2254658T3/es not_active Expired - Lifetime
- 2002-02-08 DE DE60208343T patent/DE60208343T2/de not_active Expired - Lifetime
- 2002-02-08 CN CNB028068505A patent/CN100500853C/zh not_active Expired - Lifetime
- 2002-02-08 NZ NZ527643A patent/NZ527643A/en not_active IP Right Cessation
- 2002-02-08 WO PCT/EP2002/001307 patent/WO2002068660A1/en active IP Right Grant
- 2002-02-08 MX MXPA03007114A patent/MXPA03007114A/es active IP Right Grant
- 2002-02-08 EP EP02711847A patent/EP1364029B1/en not_active Expired - Lifetime
- 2002-02-08 AT AT02711847T patent/ATE314480T1/de active
- 2002-02-08 KR KR1020037010943A patent/KR100858009B1/ko active IP Right Grant
- 2002-02-08 AU AU2002231784A patent/AU2002231784B2/en not_active Expired
- 2002-02-08 DK DK02711847T patent/DK1364029T3/da active
- 2002-02-08 JP JP2002568754A patent/JP4243104B2/ja not_active Expired - Lifetime
-
2003
- 2003-07-30 ZA ZA200305869A patent/ZA200305869B/en unknown
- 2003-08-19 NO NO20033673A patent/NO331271B1/no not_active IP Right Cessation
-
2004
- 2004-10-20 HK HK04108196.1A patent/HK1065335A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004518444A (ja) | 2004-06-24 |
| KR100858009B1 (ko) | 2008-09-11 |
| CA2438886C (en) | 2013-07-23 |
| EP1364029B1 (en) | 2005-12-28 |
| ZA200305869B (en) | 2004-06-25 |
| NO20033673D0 (no) | 2003-08-19 |
| MXPA03007114A (es) | 2003-11-18 |
| ATE314480T1 (de) | 2006-01-15 |
| DE10108212A1 (de) | 2002-08-22 |
| CA2438886A1 (en) | 2002-09-06 |
| NZ527643A (en) | 2005-07-29 |
| DE60208343T2 (de) | 2006-06-22 |
| ES2254658T3 (es) | 2006-06-16 |
| EP1364029A1 (en) | 2003-11-26 |
| IL157414A0 (en) | 2004-03-28 |
| WO2002068660A1 (en) | 2002-09-06 |
| NO331271B1 (no) | 2011-11-14 |
| KR20030074842A (ko) | 2003-09-19 |
| AU2002231784B2 (en) | 2006-10-26 |
| NO20033673L (no) | 2003-10-17 |
| BRPI0207394B1 (pt) | 2015-06-16 |
| DE60208343D1 (de) | 2006-02-02 |
| CN100500853C (zh) | 2009-06-17 |
| CN1529757A (zh) | 2004-09-15 |
| JP4243104B2 (ja) | 2009-03-25 |
| HK1065335A1 (en) | 2005-02-18 |
| DK1364029T3 (da) | 2006-05-08 |
| BRPI0207394B8 (pt) | 2021-05-25 |
| BR0207394A (pt) | 2004-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |