ITMI20021803A1 - Proteine di fusione aventi aumentata attivita' in vivo di eritropoietina. - Google Patents

Proteine di fusione aventi aumentata attivita' in vivo di eritropoietina.

Info

Publication number
ITMI20021803A1
ITMI20021803A1 IT001803A ITMI20021803A ITMI20021803A1 IT MI20021803 A1 ITMI20021803 A1 IT MI20021803A1 IT 001803 A IT001803 A IT 001803A IT MI20021803 A ITMI20021803 A IT MI20021803A IT MI20021803 A1 ITMI20021803 A1 IT MI20021803A1
Authority
IT
Italy
Prior art keywords
erythropoietin
increased
fusion proteins
vivo activity
carboxy terminal
Prior art date
Application number
IT001803A
Other languages
English (en)
Inventor
Bo-Sup Chung
Ki-Wan Kim
Dong-Eok Lee
Myung-Suk Oh
Ji-Sook Park
Original Assignee
Cheil Jedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cheil Jedang Corp filed Critical Cheil Jedang Corp
Publication of ITMI20021803A1 publication Critical patent/ITMI20021803A1/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/524Thrombopoietin, i.e. C-MPL ligand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/505Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT001803A 2001-11-29 2002-08-08 Proteine di fusione aventi aumentata attivita' in vivo di eritropoietina. ITMI20021803A1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2001-0074975A KR100467750B1 (ko) 2001-11-29 2001-11-29 생체내 에리스로포이에틴 활성이 증진된 융합단백질

Publications (1)

Publication Number Publication Date
ITMI20021803A1 true ITMI20021803A1 (it) 2003-05-30

Family

ID=36821313

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001803A ITMI20021803A1 (it) 2001-11-29 2002-08-08 Proteine di fusione aventi aumentata attivita' in vivo di eritropoietina.

Country Status (23)

Country Link
US (1) US7098318B2 (it)
EP (1) EP1319712B1 (it)
JP (1) JP3860097B2 (it)
KR (1) KR100467750B1 (it)
CN (1) CN100390201C (it)
AR (1) AR036384A1 (it)
AT (1) ATE460483T1 (it)
AU (1) AU2002300359B2 (it)
BR (1) BRPI0203394B1 (it)
CA (1) CA2394572C (it)
DE (2) DE10235248B4 (it)
ES (1) ES2339426T3 (it)
FR (1) FR2832716B1 (it)
GB (1) GB2382580B (it)
IT (1) ITMI20021803A1 (it)
MX (1) MXPA02008131A (it)
MY (1) MY122935A (it)
NZ (1) NZ520442A (it)
RU (1) RU2225220C1 (it)
SG (1) SG117416A1 (it)
TW (1) TWI237056B (it)
WO (1) WO2003046013A1 (it)
ZA (1) ZA200206172B (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
CN1897959A (zh) * 2003-09-29 2007-01-17 沃伦药品公司 用于治疗和预防脓毒病和粘连形成的组织保护细胞因子
US7625564B2 (en) 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US7553941B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
BRPI0814465B1 (pt) 2007-07-26 2021-11-23 Novagen Holding Corporation Proteína de fusão, dímero, método para produzir uma proteína de fusão, linhagem de célula, usos de uma proteína de fusão e de uma composição farmacêutica e composição farmacêutica
CN101863982A (zh) * 2009-04-17 2010-10-20 哈药集团生物工程有限公司 一种用于升高血小板的融合蛋白及其制备方法
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
CN103864913A (zh) * 2012-12-18 2014-06-18 联亚生技开发股份有限公司 重组蛋白
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
US10960058B2 (en) 2015-06-19 2021-03-30 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
CN118085104A (zh) 2016-07-11 2024-05-28 Opko生物科学有限公司 长效凝血因子及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3045539B2 (ja) * 1989-02-21 2000-05-29 ワシントン ユニバーシティ 改変型生殖ホルモン
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
ZA946122B (en) * 1993-08-17 1995-03-20 Amgen Inc Erythropoietin analogs
GB2285446B (en) * 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
ITFI940106A1 (it) * 1994-05-27 1995-11-27 Menarini Ricerche Sud Spa Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica
JPH11500308A (ja) * 1995-02-03 1999-01-12 ジー.ディー.サール アンド カンパニー 新規c−MPLリガンド
US6242570B1 (en) * 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
AU8182298A (en) * 1997-07-10 1999-02-08 Beth Israel Deaconess Medical Center Recombinant erythropoietin / immunoglobulin fusion proteins
EP1012184B1 (en) * 1997-07-14 2007-10-10 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US6342220B1 (en) * 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
WO1999057147A1 (fr) * 1998-04-30 1999-11-11 Kirin Brewery Company, Limited Mutants de la thrombopoietine humaine
US7754855B1 (en) * 1999-07-13 2010-07-13 Bolder Biotechnology, Inc. Immunoglobulin fusion proteins
JP2003514552A (ja) * 1999-11-12 2003-04-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 改善された性質を有するエリトロポエチンの形態

Also Published As

Publication number Publication date
GB0218252D0 (en) 2002-09-11
ATE460483T1 (de) 2010-03-15
KR100467750B1 (ko) 2005-01-24
BR0203394A (pt) 2004-05-11
CN100390201C (zh) 2008-05-28
KR20030044272A (ko) 2003-06-09
CA2394572A1 (en) 2003-05-29
ES2339426T3 (es) 2010-05-20
NZ520442A (en) 2003-10-31
JP3860097B2 (ja) 2006-12-20
FR2832716B1 (fr) 2004-12-03
ZA200206172B (en) 2003-04-03
RU2002123438A (ru) 2004-03-27
EP1319712A3 (en) 2003-11-12
MXPA02008131A (es) 2004-12-13
TWI237056B (en) 2005-08-01
CA2394572C (en) 2007-08-14
MY122935A (en) 2006-05-31
DE60235603D1 (de) 2010-04-22
GB2382580B (en) 2003-10-08
DE10235248B4 (de) 2004-12-23
RU2225220C1 (ru) 2004-03-10
BRPI0203394B1 (pt) 2015-12-01
EP1319712B1 (en) 2010-03-10
US7098318B2 (en) 2006-08-29
US20030124115A1 (en) 2003-07-03
WO2003046013A1 (en) 2003-06-05
GB2382580A (en) 2003-06-04
JP2003169671A (ja) 2003-06-17
CN1421461A (zh) 2003-06-04
SG117416A1 (en) 2005-12-29
EP1319712A2 (en) 2003-06-18
DE10235248A1 (de) 2003-06-12
AU2002300359B2 (en) 2004-12-23
AR036384A1 (es) 2004-09-01
FR2832716A1 (fr) 2003-05-30

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