DE69635899D1 - Polypeptid, das die differenzierung unterdrueckt - Google Patents

Polypeptid, das die differenzierung unterdrueckt

Info

Publication number
DE69635899D1
DE69635899D1 DE69635899T DE69635899T DE69635899D1 DE 69635899 D1 DE69635899 D1 DE 69635899D1 DE 69635899 T DE69635899 T DE 69635899T DE 69635899 T DE69635899 T DE 69635899T DE 69635899 D1 DE69635899 D1 DE 69635899D1
Authority
DE
Germany
Prior art keywords
polypeptide
differentiation
suppressing differentiation
supression
efficacious
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69635899T
Other languages
English (en)
Other versions
DE69635899T2 (de
Inventor
Seiji Sakano
Akira Itoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of DE69635899D1 publication Critical patent/DE69635899D1/de
Publication of DE69635899T2 publication Critical patent/DE69635899T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69635899T 1995-11-17 1996-11-15 Polypeptid, das die differenzierung unterdrueckt Expired - Lifetime DE69635899T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP29961195 1995-11-17
JP29961195 1995-11-17
JP31181195 1995-11-30
JP31181195 1995-11-30
PCT/JP1996/003356 WO1997019172A1 (fr) 1995-11-17 1996-11-15 Polypeptide suppresseur et de differenciation

Publications (2)

Publication Number Publication Date
DE69635899D1 true DE69635899D1 (de) 2006-05-04
DE69635899T2 DE69635899T2 (de) 2006-11-23

Family

ID=26561997

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69635899T Expired - Lifetime DE69635899T2 (de) 1995-11-17 1996-11-15 Polypeptid, das die differenzierung unterdrueckt

Country Status (7)

Country Link
US (5) US6337387B1 (de)
EP (1) EP0861894B1 (de)
JP (1) JP4283891B2 (de)
AT (1) ATE319827T1 (de)
AU (1) AU716889B2 (de)
DE (1) DE69635899T2 (de)
WO (1) WO1997019172A1 (de)

Families Citing this family (99)

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US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
WO2000053753A2 (en) * 1999-03-08 2000-09-14 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
PT861261E (pt) 1995-06-28 2009-12-16 Imp Cancer Res Tech Sequências nucleotídicas e proteicas de genes delta de vertebrado e métodos nelas baseados
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
JP4283891B2 (ja) 1995-11-17 2009-06-24 旭化成株式会社 分化抑制ポリペプチド
US6716974B1 (en) * 1996-05-31 2004-04-06 Maine Medical Center Research Institute Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
AU720930B2 (en) 1996-07-16 2000-06-15 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
DE69733695T2 (de) * 1996-11-07 2006-05-18 Lorantis Ltd. Notch-liganden zur verwendung in der immuntherapie
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
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JP4171528B2 (ja) 1997-05-14 2008-10-22 旭化成株式会社 新規な分化抑制剤
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US6136952A (en) * 1997-06-25 2000-10-24 University Of Washington Human jagged polypeptide, encoding nucleic acids and methods of use
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
EP1518930B1 (de) * 1998-10-13 2007-05-30 Genentech, Inc. Verfahren und Zusammenstzung zur Hemmung des Wachtums von neoplastischen Zellen
JP3695642B2 (ja) * 1998-12-01 2005-09-14 ジェネンテック・インコーポレーテッド 血管形成及び心臓血管新生の促進又は阻害
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US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
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US8148147B2 (en) 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
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US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
IL101728A (en) 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US5624899A (en) 1994-07-20 1997-04-29 Genentech Inc. Method for using Htk ligand
WO1996011212A1 (fr) 1994-10-07 1996-04-18 Asahi Kasei Kogyo Kabushiki Kaisha Nouveau ligand de tyrosine kinase de type recepteur
PT861261E (pt) * 1995-06-28 2009-12-16 Imp Cancer Res Tech Sequências nucleotídicas e proteicas de genes delta de vertebrado e métodos nelas baseados
JP4283891B2 (ja) * 1995-11-17 2009-06-24 旭化成株式会社 分化抑制ポリペプチド

Also Published As

Publication number Publication date
US6337387B1 (en) 2002-01-08
US7179622B2 (en) 2007-02-20
US7141379B2 (en) 2006-11-28
US20020128197A1 (en) 2002-09-12
US20050130271A1 (en) 2005-06-16
AU7587696A (en) 1997-06-11
DE69635899T2 (de) 2006-11-23
AU716889B2 (en) 2000-03-09
EP0861894B1 (de) 2006-03-08
EP0861894A4 (de) 2002-08-07
ATE319827T1 (de) 2006-03-15
US7253265B2 (en) 2007-08-07
EP0861894A1 (de) 1998-09-02
JP4283891B2 (ja) 2009-06-24
US20050130268A1 (en) 2005-06-16
WO1997019172A1 (fr) 1997-05-29
US20050164348A1 (en) 2005-07-28
US7198918B2 (en) 2007-04-03

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