ATE444717T1 - Lasermikroporator - Google Patents
LasermikroporatorInfo
- Publication number
- ATE444717T1 ATE444717T1 AT06743320T AT06743320T ATE444717T1 AT E444717 T1 ATE444717 T1 AT E444717T1 AT 06743320 T AT06743320 T AT 06743320T AT 06743320 T AT06743320 T AT 06743320T AT E444717 T1 ATE444717 T1 AT E444717T1
- Authority
- AT
- Austria
- Prior art keywords
- laser
- biological membrane
- laser beam
- direct
- poration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/208—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser with multiple treatment beams not sharing a common path, e.g. non-axial or parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Electromagnetism (AREA)
- Animal Behavior & Ethology (AREA)
- Otolaryngology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Lasers (AREA)
- Lubricants (AREA)
- Gyroscopes (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2005/051704 WO2006111201A1 (en) | 2005-04-18 | 2005-04-18 | Laser microporator |
PCT/EP2006/061639 WO2006111526A1 (en) | 2005-04-18 | 2006-04-18 | Laser microporator |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE444717T1 true ATE444717T1 (de) | 2009-10-15 |
Family
ID=35447691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06743320T ATE444717T1 (de) | 2005-04-18 | 2006-04-18 | Lasermikroporator |
Country Status (7)
Country | Link |
---|---|
US (1) | US9283037B2 (de) |
EP (3) | EP1874213B1 (de) |
JP (1) | JP5063586B2 (de) |
AT (1) | ATE444717T1 (de) |
DE (1) | DE602006009640D1 (de) |
ES (1) | ES2334705T3 (de) |
WO (2) | WO2006111201A1 (de) |
Families Citing this family (56)
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WO2005122694A2 (en) * | 2004-06-21 | 2005-12-29 | Alex Rapoport | Thermal energy applicator |
US7717905B2 (en) * | 2004-11-01 | 2010-05-18 | Technolas Perfect Vision Gmbh | Time-resolved scanning patterns for intrastromal surgery |
WO2006111201A1 (en) | 2005-04-18 | 2006-10-26 | Pantec Biosolutions Ag | Laser microporator |
US8048089B2 (en) | 2005-12-30 | 2011-11-01 | Edge Systems Corporation | Apparatus and methods for treating the skin |
WO2007126999A2 (en) | 2006-04-12 | 2007-11-08 | Lumenis Ltd. | System and method for microablation of tissue |
US9078680B2 (en) | 2006-04-12 | 2015-07-14 | Lumenis Ltd. | System and method for microablation of tissue |
US20100004582A1 (en) | 2006-10-25 | 2010-01-07 | Pantec Biosolutions Ag | Wide-Area Parasystemic Treatment of Skin Related Conditions |
US10588694B1 (en) | 2007-01-19 | 2020-03-17 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for biomedical applications |
WO2008089344A2 (en) * | 2007-01-19 | 2008-07-24 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for biomedical applications |
JP2008230124A (ja) * | 2007-03-22 | 2008-10-02 | Toppan Forms Co Ltd | カードの製造方法及びカード |
JP5028124B2 (ja) * | 2007-03-29 | 2012-09-19 | 株式会社ニデック | 眼科用レーザ治療装置 |
WO2009052866A1 (en) * | 2007-10-25 | 2009-04-30 | Pantec Biosolutions Ag | Laser device and method for ablating biological tissue |
KR101836310B1 (ko) | 2008-01-04 | 2018-03-08 | 엣지 시스템즈 엘엘씨 | 피부 처리 장치 및 방법 |
GR1006838B (el) * | 2008-01-16 | 2010-07-05 | Παναγιωτης Εμμανουηλ Οικονομιδης | Συστημα διατασης δερματος για εφαρμογες λειζερ |
DE102008011811B3 (de) * | 2008-02-29 | 2009-10-15 | Anton Dr. Kasenbacher | Dentales Laserbearbeitungsgerät zur Bearbeitung von Zahnmaterial |
US10543123B2 (en) | 2008-04-28 | 2020-01-28 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for opthalmic surgery and opthalmic applications |
EP2133715A1 (de) | 2008-06-11 | 2009-12-16 | Pantec Biosolutions AG | Vorrichtung und Verfahren zum Ablenken einer elektromagnetischen Strahlung, insbesondere eines Laserstrahls |
WO2009150210A2 (en) * | 2008-06-11 | 2009-12-17 | Pantec Biosolutions Ag | Apparatus and method for the deflection of electromagnetic radiation, in particular of a laser beam |
JP5372527B2 (ja) * | 2009-01-07 | 2013-12-18 | 株式会社ニデック | 眼科用レーザ治療装置 |
DE102009005194B4 (de) * | 2009-01-20 | 2016-09-08 | Anton Kasenbacher | Laserbearbeitungsgerät zur Bearbeitung eines Materials |
EP2443707B1 (de) | 2009-06-15 | 2015-09-30 | Pantec Biosolutions AG | Monolithischer seitengepumpter festkörperlaser und seine anwendung |
WO2010145855A1 (en) | 2009-06-15 | 2010-12-23 | Pantec Biosolutions Ag | Monolithic, side pumped solid-state laser and method for operating the same |
IT1405000B1 (it) * | 2010-02-04 | 2013-12-16 | El En Spa | Dispositivo per il trattamento del canale vaginale e relativo apparecchio |
JPWO2011114984A1 (ja) * | 2010-03-15 | 2013-06-27 | ヤーマン株式会社 | レーザトリートメント装置 |
AU2011233613A1 (en) * | 2010-03-29 | 2012-10-18 | Follica, Inc. | Combination therapy |
JP5919258B2 (ja) * | 2010-04-22 | 2016-05-18 | プリサイス ライト サージカル インコーポレイテッド | フラッシュ蒸発手術システム |
WO2012010861A1 (en) * | 2010-07-22 | 2012-01-26 | Ambicare Health Limited | Disposable skin care device |
CN102397621B (zh) * | 2011-08-24 | 2014-07-30 | 南京理工大学 | 封闭式激光冲击波透皮给药装置 |
BR112014004915A2 (pt) * | 2011-09-02 | 2017-04-04 | Convergent Dental Inc | sistema de preparação dentário controlado por computador com base em laser |
WO2013190537A1 (en) * | 2012-06-18 | 2013-12-27 | Michael Tavger | Method and system for delivering solution into the pores of recipient human skin |
US9364684B2 (en) * | 2012-06-22 | 2016-06-14 | S & Y Enterprises Llc | Aesthetic treatment device and method |
US20150216598A1 (en) * | 2013-03-13 | 2015-08-06 | Cynosure, Inc. | Controlled photomechanical and photothermal tissue treatment in the picosecond regime |
EP2967633B1 (de) | 2013-03-15 | 2018-04-25 | Edge Systems LLC | Vorrichtungen zur hautbehandlung |
US10413359B2 (en) | 2013-07-18 | 2019-09-17 | International Business Machines Corporation | Laser-assisted transdermal delivery of nanoparticulates and hydrogels |
EP3033138A4 (de) * | 2013-08-12 | 2017-03-29 | Nanomedical Systems Inc. | Vorrichtung und verfahren zur verzögerten freisetzung von therapiemitteln mit niedriger wasserlöslichkeit in einem lösungsvermittler |
JP6165354B2 (ja) * | 2014-04-01 | 2017-07-19 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 皮膚を局所的に処置するための皮膚処置装置 |
US11178823B2 (en) | 2014-04-07 | 2021-11-23 | Premier Citrus Apz, Llc | Systems and methods for using light energy to facilitate penetration of substances in plants |
EP4324414A3 (de) | 2014-12-23 | 2024-05-01 | HydraFacial LLC | Vorrichtungen und verfahren zur hautbehandlung mit einem rollball oder einem dochtelement |
AU2015417085B2 (en) * | 2015-12-10 | 2019-07-18 | Premier Citrus Apz, Llc | Systems and methods for using light energy to facilitate penetration of substances in plants |
CN105727433A (zh) * | 2016-01-28 | 2016-07-06 | 中山大学 | 一种微孔药贴和采用激光冲击精确经皮给药系统以及给药方法 |
CA3061639A1 (en) * | 2017-05-08 | 2018-11-15 | Vulcur Medtech Aps | Laser device for treatment of wounds |
AU2018384825A1 (en) | 2017-12-14 | 2020-06-25 | Avava, Inc. | Electromagnetic radiation beam scanning system and method |
JP7205137B2 (ja) * | 2018-09-26 | 2023-01-17 | 株式会社ニデック | 眼科用レーザ治療装置 |
JP2020069118A (ja) * | 2018-10-31 | 2020-05-07 | キヤノン株式会社 | 加工装置及び加工方法 |
KR102305007B1 (ko) * | 2018-12-20 | 2021-09-24 | 제이에스케이바이오메드(주) | 멀티 인젝터가 구비된 바늘 없는 주사기 |
KR20220024048A (ko) * | 2019-05-14 | 2022-03-03 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 고속 및 고종횡비 레이저 절삭 재료 가공을 위한 방법 및 장치 |
WO2021155381A1 (en) * | 2020-01-31 | 2021-08-05 | Apollo Medical Optics, Ltd. | Illumination system with etendue-squeezing module and method thereof |
US11747586B2 (en) * | 2020-02-19 | 2023-09-05 | Elemental Scientific Lasers, Llc | Variable beam size via homogenizer movement |
US11235167B2 (en) | 2020-04-30 | 2022-02-01 | L'oreal | Systems and methods for administering light therapy while increasing pain threshold with distraction stimulus |
FR3111564B1 (fr) * | 2020-06-23 | 2023-07-21 | Oreal | Systemes et procedes d’administration de luminotherapie tout en augmentant le seuil de douleur avec un stimulus de distraction |
WO2021222346A1 (en) * | 2020-04-30 | 2021-11-04 | L'oreal | System for administering light therapy while increasing pain threshold with distraction stimulus |
DE102020215583A1 (de) | 2020-12-09 | 2022-06-09 | Carl Zeiss Meditec Ag | Vorrichtung zur Erzeugung eines gesteigerten Abflusses von Kammerwasser zur Senkung des Augeninnendruckes bei Glaukom |
CN112894148B (zh) * | 2021-01-17 | 2022-06-28 | 长春理工大学 | 用于制备多级微结构的加工设备及加工方法 |
USD1016615S1 (en) | 2021-09-10 | 2024-03-05 | Hydrafacial Llc | Container for a skin treatment device |
US20230104221A1 (en) * | 2021-10-06 | 2023-04-06 | Oren Aharon | Rejuvenating laser drilling apparatus |
CN114832228A (zh) * | 2022-07-04 | 2022-08-02 | 中国科学院长春光学精密机械与物理研究所 | 一种多波长激光促进透皮给药装置 |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE111711T1 (de) * | 1985-03-22 | 1994-10-15 | Massachusetts Inst Technology | Katheter für laserangiochirurgie. |
GB2184021A (en) * | 1985-12-13 | 1987-06-17 | Micra Ltd | Laser treatment apparatus for port wine stains |
US5817089A (en) * | 1991-10-29 | 1998-10-06 | Thermolase Corporation | Skin treatment process using laser |
US6315772B1 (en) * | 1993-09-24 | 2001-11-13 | Transmedica International, Inc. | Laser assisted pharmaceutical delivery and fluid removal |
US5643252A (en) * | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
US5360447A (en) * | 1993-02-03 | 1994-11-01 | Coherent, Inc. | Laser assisted hair transplant method |
US5628744A (en) | 1993-12-21 | 1997-05-13 | Laserscope | Treatment beam handpiece |
WO1995018984A1 (en) * | 1994-01-07 | 1995-07-13 | Coherent, Inc. | Apparatus for creating a square or rectangular laser beam with a uniform intensity profile |
JPH0833645A (ja) | 1994-07-21 | 1996-02-06 | Toshiba Corp | 医療用レーザ装置 |
US5554153A (en) | 1994-08-29 | 1996-09-10 | Cell Robotics, Inc. | Laser skin perforator |
US5947957A (en) | 1994-12-23 | 1999-09-07 | Jmar Technology Co. | Portable laser for blood sampling |
US5743902A (en) * | 1995-01-23 | 1998-04-28 | Coherent, Inc. | Hand-held laser scanner |
US5735844A (en) | 1995-02-01 | 1998-04-07 | The General Hospital Corporation | Hair removal using optical pulses |
WO1996028212A1 (en) * | 1995-03-09 | 1996-09-19 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US6475138B1 (en) * | 1995-07-12 | 2002-11-05 | Laser Industries Ltd. | Apparatus and method as preparation for performing a myringotomy in a child's ear without the need for anaesthesia |
EP0952850A2 (de) | 1996-12-31 | 1999-11-03 | Altea Technologies, Inc. | Mikroporation von gewebe zur bioaktive-mittel-abgabe |
US5938657A (en) | 1997-02-05 | 1999-08-17 | Sahar Technologies, Inc. | Apparatus for delivering energy within continuous outline |
US5980934A (en) | 1997-05-19 | 1999-11-09 | Motorola, Inc. | Transdermal delivery apparatus |
US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
US5947956A (en) | 1997-11-04 | 1999-09-07 | Karell; Manuel Leon | Laser apparatus for making holes and etchings |
US6165170A (en) * | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
WO1999051157A1 (en) | 1998-04-07 | 1999-10-14 | The General Hospital Corporation | Apparatus and methods for removing blood vessels |
US6569157B1 (en) * | 1998-05-18 | 2003-05-27 | Abbott Laboratories | Removal of stratum corneum by means of light |
US6597946B2 (en) | 1998-11-09 | 2003-07-22 | Transpharma Ltd. | Electronic card for transdermal drug delivery and analyte extraction |
US6148232A (en) | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
WO2000056240A1 (en) | 1999-03-19 | 2000-09-28 | Asah Medico A/S | An apparatus for tissue treatment |
WO2000069515A1 (en) | 1999-05-17 | 2000-11-23 | Marchitto Kevin S | Remote and local controlled delivery of pharmaceutical compounds using electromagnetic energy |
AU3953299A (en) | 1999-05-25 | 2000-12-12 | International Technologies (Laser) Ltd | Laser for skin treatment |
EP1645305A1 (de) | 1999-06-08 | 2006-04-12 | Altea Therapeutics Corporation | Vorrichtung zum Erzeugen von Mikroporen in biologischen Membranen mittels Dünnfilm-Gewebeschnittstelle und Herstellungsverfahren |
WO2000078242A1 (en) | 1999-06-18 | 2000-12-28 | Spectrx, Inc. | Light beam generation and focusing device |
US20030078499A1 (en) * | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
JP4774146B2 (ja) | 1999-12-23 | 2011-09-14 | パナソニック株式会社 | レーザを用いて波長より小さなピッチで穴を開けるための方法および装置 |
US20040005349A1 (en) | 2000-05-12 | 2004-01-08 | Joseph Neev | Opto-thermal material modification |
US6733493B2 (en) | 2000-11-16 | 2004-05-11 | Innotech Usa, Inc. | Laser skin perforator |
GB2369057A (en) | 2000-11-18 | 2002-05-22 | Lynton Lasers Ltd | Dermatological treatment apparatus |
CA2468998A1 (en) | 2001-12-05 | 2003-06-12 | Norwood Abbey Ltd | Attachment for laser emitting device |
US20040030325A1 (en) | 2001-12-05 | 2004-02-12 | Nicholas Cahir | Removable attachments for laser emitting devices |
US20050049582A1 (en) * | 2001-12-12 | 2005-03-03 | Debenedictis Leonard C. | Method and apparatus for fractional photo therapy of skin |
US10695577B2 (en) | 2001-12-21 | 2020-06-30 | Photothera, Inc. | Device and method for providing phototherapy to the heart |
GB0203276D0 (en) | 2002-02-12 | 2002-03-27 | Novartis Ag | Organic compounds |
JP4219650B2 (ja) | 2002-10-18 | 2009-02-04 | 株式会社トプコン | 眼科用手術装置 |
ITTO20021007A1 (it) | 2002-11-19 | 2004-05-20 | Franco Bartoli | Apparecchiatura laser ad eccimeri e metodo di pilotaggio |
JP2005046247A (ja) | 2003-07-31 | 2005-02-24 | Topcon Corp | レーザ手術装置 |
US7241291B2 (en) | 2004-06-02 | 2007-07-10 | Syneron Medical Ltd. | Method and system for skin treatment using light energy and skin deformation |
EP1874212A1 (de) | 2005-04-18 | 2008-01-09 | Pantec Biosolutions AG | Mikroporator zur poration einer biologischen membran und integriertes durchdringendes verabreichungssystem |
WO2006111201A1 (en) | 2005-04-18 | 2006-10-26 | Pantec Biosolutions Ag | Laser microporator |
WO2007039646A1 (en) | 2005-10-06 | 2007-04-12 | Pantec Biosolutions Ag | Transdermal delivery system for treating infertility |
-
2005
- 2005-04-18 WO PCT/EP2005/051704 patent/WO2006111201A1/en not_active Application Discontinuation
-
2006
- 2006-04-18 JP JP2008507066A patent/JP5063586B2/ja not_active Expired - Fee Related
- 2006-04-18 EP EP06743320A patent/EP1874213B1/de not_active Not-in-force
- 2006-04-18 EP EP10186255.5A patent/EP2275051B1/de not_active Not-in-force
- 2006-04-18 DE DE602006009640T patent/DE602006009640D1/de active Active
- 2006-04-18 AT AT06743320T patent/ATE444717T1/de not_active IP Right Cessation
- 2006-04-18 WO PCT/EP2006/061639 patent/WO2006111526A1/en active Search and Examination
- 2006-04-18 ES ES06743320T patent/ES2334705T3/es active Active
- 2006-04-18 EP EP09169806A patent/EP2191782A3/de not_active Withdrawn
- 2006-04-18 US US11/911,850 patent/US9283037B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2009506795A (ja) | 2009-02-19 |
DE602006009640D1 (de) | 2009-11-19 |
EP2275051A3 (de) | 2011-11-23 |
ES2334705T3 (es) | 2010-03-15 |
EP2275051B1 (de) | 2013-06-12 |
US9283037B2 (en) | 2016-03-15 |
WO2006111526A8 (en) | 2007-04-19 |
JP5063586B2 (ja) | 2012-10-31 |
EP1874213A1 (de) | 2008-01-09 |
EP2191782A3 (de) | 2011-08-31 |
EP1874213B1 (de) | 2009-10-07 |
EP2191782A2 (de) | 2010-06-02 |
WO2006111526A1 (en) | 2006-10-26 |
US20080208104A1 (en) | 2008-08-28 |
WO2006111201A1 (en) | 2006-10-26 |
EP2275051A2 (de) | 2011-01-19 |
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