ATE423199T1 - Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik - Google Patents

Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik

Info

Publication number
ATE423199T1
ATE423199T1 AT02743820T AT02743820T ATE423199T1 AT E423199 T1 ATE423199 T1 AT E423199T1 AT 02743820 T AT02743820 T AT 02743820T AT 02743820 T AT02743820 T AT 02743820T AT E423199 T1 ATE423199 T1 AT E423199T1
Authority
AT
Austria
Prior art keywords
human thrombin
prethrombin
human
producing human
thrombin
Prior art date
Application number
AT02743820T
Other languages
German (de)
English (en)
Inventor
Hiroshi Yonemura
Takayuki Imamura
Hiroshi Nakatake
Kenji Soejima
Chikateru Nozaki
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of ATE423199T1 publication Critical patent/ATE423199T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AT02743820T 2001-07-06 2002-07-04 Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik ATE423199T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001206919 2001-07-06

Publications (1)

Publication Number Publication Date
ATE423199T1 true ATE423199T1 (de) 2009-03-15

Family

ID=19042979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02743820T ATE423199T1 (de) 2001-07-06 2002-07-04 Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik

Country Status (9)

Country Link
US (1) US7635577B2 (zh)
EP (1) EP1405910B1 (zh)
JP (1) JP4227012B2 (zh)
KR (2) KR20040032147A (zh)
CN (1) CN100347297C (zh)
AT (1) ATE423199T1 (zh)
CA (1) CA2452768C (zh)
DE (1) DE60231210D1 (zh)
WO (1) WO2003004641A1 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040219140A1 (en) * 2001-02-22 2004-11-04 Reiner Class Compositions and methods for preventing platelet aggregation
JP4573775B2 (ja) 2003-07-29 2010-11-04 一般財団法人化学及血清療法研究所 組換えフィブリノゲン高産生細胞の作製方法及び高産生細胞
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
ATE465245T1 (de) 2003-10-24 2010-05-15 Chemo Sero Therapeut Res Inst Neue rekombinante tierzellen mit hoher proteinproduktion, verfahren zur konstruktion davon sowie verfahren zur massenproduktion von protein unter verwendung davon
JP2008504808A (ja) * 2004-05-24 2008-02-21 パナコス ファーマシューティカルズ インコーポレーティッド ウイルスキャプシドスペーサーペプチド１タンパク質のプロセシングの破壊によるｈｉｖ−１複製の阻害
CN101198696B (zh) 2005-04-13 2014-02-26 阿斯利康(瑞典)有限公司 包含产生需要γ-羧化的蛋白质用的载体的宿主细胞
CA2624072A1 (en) 2005-09-30 2007-04-12 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for producing recombinant human thrombin by cultured cell
EP1996186A4 (en) * 2006-03-06 2009-07-22 Humagene Inc PROCESS FOR THE PREPARATION OF RECOMBINANT HUMAN THROMBIN AND FIBRINOGEN
US8206967B2 (en) * 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
JP5437236B2 (ja) 2008-04-16 2014-03-12 一般財団法人化学及血清療法研究所 トロンビン固定化生体吸収性シート製剤の製造方法
EP2940133A4 (en) 2012-12-25 2016-07-06 Chemo Sero Therapeut Res Inst VACCINE AGAINST HPV AND / OR HEPATITIS B INFECTION CONTAINING CHIMERIC HPV / HBS PROTEIN AS AN ACTIVE INGREDIENT
JP6216647B2 (ja) 2013-03-15 2017-10-18 シスメックス株式会社 組換え型プロトロンビンの製造方法およびその利用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2824434B2 (ja) * 1989-11-28 1998-11-11 財団法人化学及血清療法研究所 新規発現ベクター
US5278144A (en) 1990-09-04 1994-01-11 Cor Therapeutics, Inc. Antithrombosis agents
US5583107A (en) 1990-09-04 1996-12-10 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
JP3168087B2 (ja) * 1993-01-11 2001-05-21 株式会社ヤスヰ 洗車方法及びその装置
AT404357B (de) 1995-06-13 1998-11-25 Immuno Ag Prothrombin-derivate
JP2002514433A (ja) 1998-05-14 2002-05-21 バッテル メモリアル インスティテュート トランスジェニック植物由来ヒト凝血因子
US6413737B1 (en) * 1999-07-09 2002-07-02 Cohesion Technologies, Inc. Ecarin prothrombin protease and methods
CN1298017A (zh) * 1999-11-29 2001-06-06 中国科学技术大学 一种快速活化凝血酶原的方法

Also Published As

Publication number Publication date
CA2452768A1 (en) 2003-01-16
WO2003004641A1 (fr) 2003-01-16
US20040197858A1 (en) 2004-10-07
KR20040032147A (ko) 2004-04-14
EP1405910B1 (en) 2009-02-18
KR20090087136A (ko) 2009-08-14
CA2452768C (en) 2011-06-07
KR100983878B1 (ko) 2010-09-27
US7635577B2 (en) 2009-12-22
DE60231210D1 (de) 2009-04-02
EP1405910A1 (en) 2004-04-07
JPWO2003004641A1 (ja) 2004-10-28
JP4227012B2 (ja) 2009-02-18
EP1405910A4 (en) 2005-02-02
CN100347297C (zh) 2007-11-07
CN1551917A (zh) 2004-12-01

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