DE69623122T2 - Methode zur expression in und isolation von biologisch aktiven molekülen aus urin - Google Patents

Methode zur expression in und isolation von biologisch aktiven molekülen aus urin

Info

Publication number
DE69623122T2
DE69623122T2 DE69623122T DE69623122T DE69623122T2 DE 69623122 T2 DE69623122 T2 DE 69623122T2 DE 69623122 T DE69623122 T DE 69623122T DE 69623122 T DE69623122 T DE 69623122T DE 69623122 T2 DE69623122 T2 DE 69623122T2
Authority
DE
Germany
Prior art keywords
expression
urine
isolation
biologically active
active molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69623122T
Other languages
English (en)
Other versions
DE69623122D1 (de
Inventor
Tung-Tien Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU filed Critical New York University NYU
Publication of DE69623122D1 publication Critical patent/DE69623122D1/de
Application granted granted Critical
Publication of DE69623122T2 publication Critical patent/DE69623122T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69623122T 1995-06-05 1996-05-31 Methode zur expression in und isolation von biologisch aktiven molekülen aus urin Expired - Fee Related DE69623122T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/464,961 US5824543A (en) 1995-06-05 1995-06-05 Method for expression and isolation of biologically active molecules in urine using a mouse uroplakin-II promoter
PCT/US1996/008233 WO1996039494A1 (en) 1995-06-05 1996-05-31 Method for expression and isolation of biologically active molecules in urine

Publications (2)

Publication Number Publication Date
DE69623122D1 DE69623122D1 (de) 2002-09-26
DE69623122T2 true DE69623122T2 (de) 2002-12-12

Family

ID=23845974

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69623122T Expired - Fee Related DE69623122T2 (de) 1995-06-05 1996-05-31 Methode zur expression in und isolation von biologisch aktiven molekülen aus urin

Country Status (7)

Country Link
US (2) US5824543A (de)
EP (1) EP0837931B1 (de)
AT (1) ATE222601T1 (de)
AU (1) AU5961596A (de)
CA (1) CA2221453A1 (de)
DE (1) DE69623122T2 (de)
WO (1) WO1996039494A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179611B2 (en) * 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
US20020184655A1 (en) * 1997-12-01 2002-12-05 Henryk Lubon Methods for the degradation and detoxification of organic material using urine produced by transgenic animals and related transgenic animals and proteins
US7157615B2 (en) 1998-03-17 2007-01-02 Nexia Biotechnologies, Inc. Production of biofilaments in transgenic animals
WO2000015772A2 (en) * 1998-09-16 2000-03-23 Nexia Biotechnologies, Inc. Recombinant protein production in urine
US6888047B1 (en) 1998-11-13 2005-05-03 New York University Transgenic animals as urinary bioreactors for the production of polypeptide in the urine, recombinant DNA construct for kidney-specific expression, and method of using same
DE60037397T2 (de) * 1999-01-06 2008-06-05 Merrimack Pharmaceuticals, Inc., Cambridge Expression von ausgeschiedenem, menschlichem alpha-fetoprotein in transgenen tieren
US6692736B2 (en) * 2000-03-24 2004-02-17 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
US7048920B2 (en) * 2000-03-24 2006-05-23 Cell Genesys, Inc. Recombinant oncolytic adenovirus for human melanoma
AU4594401A (en) * 2000-03-24 2001-10-08 Calydon Inc Human urothelial cell specific uroplakin transcriptional regulatory sequences, vectors comprising uroplakin-specific transcriptional regulatory sequences, and methods of use thereof
KR100552634B1 (ko) * 2002-11-04 2006-02-20 조아제약주식회사 돼지의 유로플라킨 ⅱ 유전자의 프로모터 및 이를 이용한유용단백질의 생산 방법
WO2004042062A1 (en) * 2002-11-04 2004-05-21 Cho-A Pharm Co., Ltd. Porcine uroplakin ii promoter and the production method of useful proteins using said promoter
US20070061899A1 (en) * 2005-04-13 2007-03-15 The Trustees Of Columbia University In The City Of New York Transgenic mammal with constitutive, tissue-specific cytokine expression and use as a cancer model
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
WO1994005782A1 (en) * 1992-09-10 1994-03-17 Trustees Of Tufts College In vivo production of transgenic organ by introducing the transgene via lumen

Also Published As

Publication number Publication date
AU5961596A (en) 1996-12-24
DE69623122D1 (de) 2002-09-26
US5824543A (en) 1998-10-20
WO1996039494A1 (en) 1996-12-12
EP0837931A1 (de) 1998-04-29
EP0837931B1 (de) 2002-08-21
ATE222601T1 (de) 2002-09-15
EP0837931A4 (de) 1999-06-02
US6001646A (en) 1999-12-14
CA2221453A1 (en) 1996-12-12

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee