ATE422494T1 - Substituierte pyridine und pyridazine mit angiogenesis hemmender wirkung - Google Patents

Substituierte pyridine und pyridazine mit angiogenesis hemmender wirkung

Info

Publication number
ATE422494T1
ATE422494T1 AT00978215T AT00978215T ATE422494T1 AT E422494 T1 ATE422494 T1 AT E422494T1 AT 00978215 T AT00978215 T AT 00978215T AT 00978215 T AT00978215 T AT 00978215T AT E422494 T1 ATE422494 T1 AT E422494T1
Authority
AT
Austria
Prior art keywords
pyridazines
inhibiting effect
substituted pyridines
angiogenesis inhibiting
angiogenesis
Prior art date
Application number
AT00978215T
Other languages
German (de)
English (en)
Inventor
Jacques Dumas
Teddy JOE
Harold Kluender
Wendy Lee
Dhanapalan Nagarathnam
Robert Sibley
Ning Su
Stephen Boyer
Julie Dixon
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Application granted granted Critical
Publication of ATE422494T1 publication Critical patent/ATE422494T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
AT00978215T 1999-09-28 2000-09-26 Substituierte pyridine und pyridazine mit angiogenesis hemmender wirkung ATE422494T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40760099A 1999-09-28 1999-09-28

Publications (1)

Publication Number Publication Date
ATE422494T1 true ATE422494T1 (de) 2009-02-15

Family

ID=23612752

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00978215T ATE422494T1 (de) 1999-09-28 2000-09-26 Substituierte pyridine und pyridazine mit angiogenesis hemmender wirkung

Country Status (35)

Country Link
EP (1) EP1228063B1 (https=)
JP (1) JP4919567B2 (https=)
KR (3) KR100895571B1 (https=)
CN (3) CN100422172C (https=)
AR (3) AR025752A1 (https=)
AT (1) ATE422494T1 (https=)
AU (1) AU782820B2 (https=)
BG (1) BG65860B1 (https=)
BR (1) BRPI0014382B8 (https=)
CA (1) CA2385817C (https=)
CO (1) CO5200835A1 (https=)
CZ (1) CZ304767B6 (https=)
DE (1) DE60041548D1 (https=)
DO (1) DOP2000000070A (https=)
EE (1) EE05258B1 (https=)
ES (1) ES2320525T3 (https=)
GT (1) GT200000158A (https=)
HR (1) HRP20020308A2 (https=)
HU (1) HU230223B1 (https=)
IL (3) IL148880A0 (https=)
MA (1) MA25563A1 (https=)
MX (1) MXPA02003156A (https=)
MY (3) MY143580A (https=)
NO (1) NO20021520L (https=)
NZ (1) NZ518589A (https=)
PA (1) PA8503201A1 (https=)
PE (1) PE20010607A1 (https=)
PL (1) PL205957B1 (https=)
RS (1) RS50369B (https=)
RU (1) RU2260008C2 (https=)
SK (1) SK287417B6 (https=)
TW (1) TW593315B (https=)
UA (1) UA75053C2 (https=)
WO (1) WO2001023375A2 (https=)
ZA (1) ZA200202760B (https=)

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JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
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WO2008026748A1 (en) 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
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US8952035B2 (en) 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
MY162940A (en) 2009-08-19 2017-07-31 Eisai R&D Man Co Ltd Quinoline derivative-containing pharmaceutical composition
CN102958523B (zh) 2010-06-25 2014-11-19 卫材R&D管理有限公司 使用具有激酶抑制作用的组合的抗肿瘤剂
CN103402519B (zh) 2011-04-18 2015-11-25 卫材R&D管理有限公司 肿瘤治疗剂
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
KR20150098605A (ko) 2012-12-21 2015-08-28 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 비정질 형태 및 그의 제조방법
NZ714049A (en) 2013-05-14 2020-05-29 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN103396361B (zh) * 2013-07-24 2016-05-04 中国人民解放军第二军医大学 3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
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KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
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FR1516777A (fr) * 1966-08-02 1968-02-05 Innothera Lab Sa Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
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CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
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PT1254138E (pt) * 2000-02-09 2005-09-30 Novartis Ag Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf

Also Published As

Publication number Publication date
CN100422173C (zh) 2008-10-01
CZ304767B6 (cs) 2014-10-08
SK287417B6 (sk) 2010-09-07
BG106637A (bg) 2003-02-28
CN100374435C (zh) 2008-03-12
DE60041548D1 (de) 2009-03-26
BR0014382B1 (pt) 2014-04-01
MY143580A (en) 2011-05-31
CA2385817A1 (en) 2001-04-05
CN1769283A (zh) 2006-05-10
CN100422172C (zh) 2008-10-01
IL193367A (en) 2011-03-31
IL193367A0 (en) 2009-02-11
HK1091819A1 (zh) 2007-01-26
PL366342A1 (en) 2005-01-24
NZ518589A (en) 2005-03-24
ZA200202760B (en) 2003-10-29
MA25563A1 (fr) 2002-10-01
KR100895571B1 (ko) 2009-04-29
HU230223B1 (en) 2015-10-28
WO2001023375A2 (en) 2001-04-05
KR100895572B1 (ko) 2009-04-29
TW593315B (en) 2004-06-21
BRPI0014382B8 (pt) 2021-05-25
UA75053C2 (en) 2006-03-15
AR082231A2 (es) 2012-11-21
IL193368A (en) 2011-05-31
CZ20021444A3 (cs) 2002-08-14
RS50369B (sr) 2009-11-10
JP4919567B2 (ja) 2012-04-18
HRP20020308A2 (en) 2004-06-30
HUP0202704A2 (hu) 2002-12-28
IL193368A0 (en) 2009-02-11
MY135058A (en) 2008-01-31
NO20021520D0 (no) 2002-03-26
CN1420879A (zh) 2003-05-28
JP2003526632A (ja) 2003-09-09
CO5200835A1 (es) 2002-09-27
IL148880A0 (en) 2002-09-12
NO20021520L (no) 2002-05-23
BR0014382A (pt) 2003-06-24
YU22902A (sh) 2004-12-31
PA8503201A1 (es) 2002-08-26
KR20080086547A (ko) 2008-09-25
KR20080091505A (ko) 2008-10-13
RU2260008C2 (ru) 2005-09-10
EE200200161A (et) 2003-08-15
AR025752A1 (es) 2002-12-11
PL205957B1 (pl) 2010-06-30
WO2001023375A3 (en) 2002-05-02
AU782820B2 (en) 2005-09-01
ES2320525T3 (es) 2009-05-25
PE20010607A1 (es) 2001-07-12
EP1228063B1 (en) 2009-02-11
CA2385817C (en) 2010-05-04
KR100890473B1 (ko) 2009-03-26
AR082232A2 (es) 2012-11-21
AU1569601A (en) 2001-04-30
MY143377A (en) 2011-05-13
DOP2000000070A (es) 2002-02-28
EP1228063A2 (en) 2002-08-07
CN1769282A (zh) 2006-05-10
SK5912002A3 (en) 2003-01-09
HRP20020308B1 (https=) 2013-01-31
KR20020038775A (ko) 2002-05-23
HUP0202704A3 (en) 2003-12-29
MXPA02003156A (es) 2002-09-30
EE05258B1 (et) 2010-02-15
BG65860B1 (bg) 2010-03-31
HK1091818A1 (zh) 2007-01-26
GT200000158A (es) 2002-03-16

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