ATE422368T1 - Multikomponenten impfstoffe gegen staphylococcus aureus - Google Patents
Multikomponenten impfstoffe gegen staphylococcus aureusInfo
- Publication number
- ATE422368T1 ATE422368T1 AT99942533T AT99942533T ATE422368T1 AT E422368 T1 ATE422368 T1 AT E422368T1 AT 99942533 T AT99942533 T AT 99942533T AT 99942533 T AT99942533 T AT 99942533T AT E422368 T1 ATE422368 T1 AT E422368T1
- Authority
- AT
- Austria
- Prior art keywords
- proteins
- fragments
- fragment
- protein
- bacterial
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 241000191967 Staphylococcus aureus Species 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000014914 Carrier Proteins Human genes 0.000 abstract 3
- 108091008324 binding proteins Proteins 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 101710198480 Clumping factor A Proteins 0.000 abstract 1
- 101710198481 Clumping factor B Proteins 0.000 abstract 1
- 241001574013 Collogenes Species 0.000 abstract 1
- 206010041925 Staphylococcal infections Diseases 0.000 abstract 1
- 241000191940 Staphylococcus Species 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000029586 bacterial cell surface binding Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9843998P | 1998-08-31 | 1998-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE422368T1 true ATE422368T1 (de) | 2009-02-15 |
Family
ID=22269290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99942533T ATE422368T1 (de) | 1998-08-31 | 1999-08-31 | Multikomponenten impfstoffe gegen staphylococcus aureus |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1109577B1 (de) |
JP (2) | JP2002523473A (de) |
KR (1) | KR100644953B1 (de) |
CN (1) | CN1314450C (de) |
AT (1) | ATE422368T1 (de) |
AU (1) | AU771426B2 (de) |
BR (1) | BR9913340A (de) |
CA (2) | CA2777661C (de) |
DE (1) | DE69940404D1 (de) |
ES (1) | ES2322409T3 (de) |
IL (1) | IL141639A (de) |
MX (1) | MXPA01002119A (de) |
WO (1) | WO2000012131A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2341177A1 (en) * | 1998-08-31 | 2000-03-09 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
CN1283798C (zh) * | 1998-08-31 | 2006-11-08 | 都柏林伊丽莎白女皇神学院 | 凝固酶阴性葡萄球菌的多肽及多核苷酸 |
US6692739B1 (en) | 1998-08-31 | 2004-02-17 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
GB0014907D0 (en) * | 2000-06-20 | 2000-08-09 | Univ Sheffield | Antigenic polypeptides |
EP1334131B1 (de) * | 2000-10-20 | 2008-07-16 | Inhibitex, Inc. | Monoklonale antikörper gegen das map-protein und verfahren zu dessen anwendung bei der behandlung bzw. prävention von infektionen |
AU2003216487A1 (en) * | 2002-03-05 | 2003-09-22 | Inhibitex, Inc. | Monoclonal and polyclonal antibodies recognizing coagulase-negative staphylococcal proteins |
AU2004220590B2 (en) * | 2003-03-07 | 2010-02-18 | Inhibitex, Inc. | Polysaccharide - Staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
US20070053925A1 (en) * | 2003-04-16 | 2007-03-08 | Eric Brown | Staphylococcus aureus efb protein and c3 binding region which inhibit complement activation |
CA2526753A1 (en) * | 2003-05-29 | 2004-12-23 | Inhibitex, Inc. | Sdr proteins from staphylococcus capitis and their use in preventing and treating infections |
CA2580103C (en) * | 2004-09-22 | 2021-11-16 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
ATE517991T1 (de) * | 2004-12-28 | 2011-08-15 | Sekisui Medical Co Ltd | Monoklonaler antikörper gegen menschliches lösliches fibrin sowie immunologisches testverfahren unter verwendung des antikörpers |
GB0526038D0 (en) | 2005-12-21 | 2006-02-01 | Glaxosmithkline Biolog Sa | Immunogenic composition |
EP1998800A2 (de) * | 2006-01-18 | 2008-12-10 | University Of Chicago | Zusammensetzungen und verfahren in verbindung mit stayphylokokken-bakterienproteinen |
CN103169960A (zh) * | 2006-03-30 | 2013-06-26 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
MX2010000864A (es) * | 2007-07-23 | 2010-04-30 | Vaccine Res Internat Plc | Vacuna de celulas enteras estafilococcicas inactivadas. |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
CN105367656A (zh) | 2007-08-31 | 2016-03-02 | 芝加哥大学 | 与针对葡萄球菌性肺部疾病和病症进行免疫相关的方法和组合物 |
EA018068B1 (ru) | 2008-03-03 | 2013-05-30 | Айрм Ллк | Соединения и композиции в качестве модуляторов активности tlr |
WO2010014304A1 (en) | 2008-07-29 | 2010-02-04 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
SI3281947T1 (sl) | 2009-04-03 | 2020-07-31 | The University Of Chicago | Sestave in metode v zvezi z variantami proteina A (SPA) |
CN102762226A (zh) | 2009-06-10 | 2012-10-31 | 诺华有限公司 | 含苯并萘啶的疫苗 |
KR20140119165A (ko) | 2009-06-22 | 2014-10-08 | 와이어쓰 엘엘씨 | 황색포도상구균 혈청형 5 및 8 협막 다당류 접합체 면역원성 조성물 및 이의 제조 방법 |
US8568735B2 (en) | 2009-06-22 | 2013-10-29 | Wyeth Llc | Immunogenic compositions of Staphylococcus aureus antigens |
MX350234B (es) | 2009-07-15 | 2017-08-30 | Aimm Therapeutics Bv | Compuestos de enlace especificos de bacterias gram-positivas. |
JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
NZ598654A (en) | 2009-09-02 | 2014-05-30 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
SG10201501980SA (en) | 2009-12-15 | 2015-05-28 | Novartis Ag | Homogeneous suspension of immunopotentiating compounds and uses thereof |
CN102905703B (zh) | 2010-03-23 | 2016-09-28 | 诺华股份有限公司 | 作为tlr2激动剂用于治疗感染、炎症、呼吸疾病等的化合物(基于半胱氨酸的脂肽)和组合物 |
AU2011274367B2 (en) | 2010-07-02 | 2015-04-23 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
US20130259896A1 (en) * | 2010-12-22 | 2013-10-03 | Lakshmi Khandke | Stable Immunogenic Compositions of Staphylococcus Aureus Antigens |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
KR20150024315A (ko) * | 2012-05-07 | 2015-03-06 | 재단법인 목암생명공학연구소 | 포도상구균 감염 예방용 백신 조성물 |
US9827190B2 (en) | 2013-02-01 | 2017-11-28 | Glaxosmithkline Biologicals Sa | Intradermal delivery of immunological compositions comprising toll-like receptor 7 agonists |
AU2015359503B2 (en) * | 2014-12-10 | 2019-05-09 | Glaxosmithkline Biologicals Sa | Method of treatment |
CN107007832A (zh) * | 2016-01-28 | 2017-08-04 | 中创云牧科技咨询(北京)股份有限公司 | 一种ClfA-A靶位的金黄色葡萄球菌奶牛乳房炎疫苗的制备方法 |
AU2019218978A1 (en) | 2018-02-12 | 2020-09-03 | Inimmune Corporation | Toll-like receptor ligands |
KR102528412B1 (ko) * | 2020-09-08 | 2023-05-04 | 클립스비엔씨 주식회사 | 신규한 포도상구균 감염 질환의 예방 또는 치료용 조성물 |
IL302448A (en) | 2020-11-04 | 2023-06-01 | Eligo Bioscience | Phage-derived particles for in situ delivery of DNA cargo into the C. acnes population |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5189015A (en) * | 1984-05-30 | 1993-02-23 | Alfa-Laval Agri International Ab | Method for prophylactic treatment of the colonization of a Staphylococcus aureus bacterial strain by bacterial cell surface protein with fibronectin and fibrinogen binding ability |
SE454403B (sv) * | 1984-05-30 | 1988-05-02 | Alfa Laval Agri Int | Anvendning av ett cellyteprotein med fibronektin-, fibrinogen-, kollagen-, och/eller lamininbindande egenskaper vid framstellning av sarbehandlingsmedel |
US5730978A (en) * | 1989-09-01 | 1998-03-24 | Fred Hutchinson Cancer Research Center | Inhibition of lymphocyte adherence with α4β1-specific antibodies |
US5440014A (en) * | 1990-08-10 | 1995-08-08 | H+E,Uml/Oo/ K; Magnus | Fibronectin binding peptide |
US5851794A (en) * | 1990-10-22 | 1998-12-22 | Alfa Laval Ab | Collagen binding protein as well as its preparation |
US5648240A (en) * | 1994-05-24 | 1997-07-15 | Texas A&M University | MHC II analog from Staphylococcus aureus |
US6288214B1 (en) * | 1996-05-16 | 2001-09-11 | Texas A&M University Systems | Collagen binding protein compositions and methods of use |
SE9602496D0 (sv) * | 1996-06-20 | 1996-06-20 | Bengt Guss | Method and means for producing a fibrinogen binding protein and its use in biotechnology |
JP5124062B2 (ja) * | 1997-01-21 | 2013-01-23 | ザ・テキサス・エイ・アンド・エム・ユニバーシテイ・システム | フィブロネクチン結合タンパク質組成物および使用法 |
CA2310217A1 (en) * | 1997-11-26 | 1999-06-03 | Inhibitex, Inc. | Extracellular matrix-binding proteins from staphylococcus aureus |
-
1999
- 1999-08-31 WO PCT/US1999/019727 patent/WO2000012131A1/en active IP Right Grant
- 1999-08-31 CA CA2777661A patent/CA2777661C/en not_active Expired - Lifetime
- 1999-08-31 EP EP99942533A patent/EP1109577B1/de not_active Expired - Lifetime
- 1999-08-31 ES ES99942533T patent/ES2322409T3/es not_active Expired - Lifetime
- 1999-08-31 AT AT99942533T patent/ATE422368T1/de not_active IP Right Cessation
- 1999-08-31 CA CA2340304A patent/CA2340304C/en not_active Expired - Lifetime
- 1999-08-31 CN CNB998104884A patent/CN1314450C/zh not_active Expired - Lifetime
- 1999-08-31 JP JP2000567242A patent/JP2002523473A/ja active Pending
- 1999-08-31 DE DE69940404T patent/DE69940404D1/de not_active Expired - Lifetime
- 1999-08-31 AU AU55889/99A patent/AU771426B2/en not_active Expired
- 1999-08-31 KR KR1020017002672A patent/KR100644953B1/ko not_active IP Right Cessation
- 1999-08-31 BR BR9913340-7A patent/BR9913340A/pt not_active Application Discontinuation
- 1999-08-31 MX MXPA01002119A patent/MXPA01002119A/es active IP Right Grant
- 1999-08-31 IL IL14163999A patent/IL141639A/xx not_active IP Right Cessation
-
2011
- 2011-04-14 JP JP2011089946A patent/JP5460642B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2002523473A (ja) | 2002-07-30 |
CA2340304A1 (en) | 2000-03-09 |
BR9913340A (pt) | 2001-11-06 |
DE69940404D1 (de) | 2009-03-26 |
CA2777661A1 (en) | 2000-03-09 |
EP1109577A1 (de) | 2001-06-27 |
IL141639A0 (en) | 2002-03-10 |
JP2011168607A (ja) | 2011-09-01 |
EP1109577B1 (de) | 2009-02-11 |
CA2340304C (en) | 2012-12-04 |
EP1109577A4 (de) | 2002-03-13 |
AU5588999A (en) | 2000-03-21 |
CA2777661C (en) | 2014-10-21 |
CN1314450C (zh) | 2007-05-09 |
KR20010085745A (ko) | 2001-09-07 |
WO2000012131A1 (en) | 2000-03-09 |
JP5460642B2 (ja) | 2014-04-02 |
ES2322409T3 (es) | 2009-06-19 |
AU771426B2 (en) | 2004-03-18 |
MXPA01002119A (es) | 2003-03-27 |
IL141639A (en) | 2005-12-18 |
KR100644953B1 (ko) | 2006-11-10 |
CN1317976A (zh) | 2001-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |