ATE421336T1 - Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung - Google Patents
Medizinische zusammensetzungen mit cholesterin erniedrigender wirkungInfo
- Publication number
- ATE421336T1 ATE421336T1 AT98933883T AT98933883T ATE421336T1 AT E421336 T1 ATE421336 T1 AT E421336T1 AT 98933883 T AT98933883 T AT 98933883T AT 98933883 T AT98933883 T AT 98933883T AT E421336 T1 ATE421336 T1 AT E421336T1
- Authority
- AT
- Austria
- Prior art keywords
- effect
- ppar
- cholesterol
- delta
- activating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19823297 | 1997-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE421336T1 true ATE421336T1 (de) | 2009-02-15 |
Family
ID=16387713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98933883T ATE421336T1 (de) | 1997-07-24 | 1998-07-22 | Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung |
Country Status (9)
Country | Link |
---|---|
US (1) | US6300364B1 (de) |
EP (1) | EP1023907B1 (de) |
JP (1) | JP4427825B2 (de) |
AT (1) | ATE421336T1 (de) |
AU (1) | AU8355998A (de) |
CA (1) | CA2295930C (de) |
DE (1) | DE69840510D1 (de) |
ES (1) | ES2320181T3 (de) |
WO (1) | WO1999004815A1 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0103714A3 (en) | 1998-05-11 | 2003-05-28 | Takeda Pharmaceutical | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity, medicaments containing them and their use |
GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
GB9917405D0 (en) * | 1999-07-23 | 1999-09-22 | Univ Dundee | Methods of treatment and drug screening methods |
TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
AU1303301A (en) * | 1999-11-10 | 2001-06-06 | Takeda Chemical Industries Ltd. | Body weight gain inhibitors |
AU2001277723A1 (en) | 2000-08-11 | 2002-02-25 | Nippon Chemiphar Co., Ltd. | Ppardelta activators |
GB0024361D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
GB0024362D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
WO2002070011A2 (en) * | 2001-02-02 | 2002-09-12 | Smithkline Beecham Corporation | Treatment of ppar mediated diseases |
EP1375484A4 (de) | 2001-03-28 | 2009-08-05 | Eisai R&D Man Co Ltd | Carbonsäuren |
WO2002081428A1 (fr) | 2001-03-30 | 2002-10-17 | Eisai Co., Ltd. | Compose de benzene et sel de ce compose |
TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
US20040077689A1 (en) * | 2001-04-25 | 2004-04-22 | Yasuo Sugiyama | Abc expression promoters |
JPWO2002098840A1 (ja) | 2001-06-04 | 2004-09-16 | エーザイ株式会社 | カルボン酸誘導体及びその塩もしくはそのエステルからなる医薬 |
US20040242459A1 (en) * | 2001-06-11 | 2004-12-02 | Forrest Michael J | Method for treating inflammatory diseases by administering a ppar-delta agonist |
KR100912852B1 (ko) | 2001-07-17 | 2009-08-18 | 데이진 가부시키가이샤 | PPAR δ활성화 작용을 측정하는 것을 특징으로 하는물질의 선택방법 및 약제 |
JP4870464B2 (ja) * | 2001-07-17 | 2012-02-08 | 帝人株式会社 | PPARδ活性化作用を測定することを特徴とする物質の選択方法及び薬剤 |
CA2457054C (en) * | 2001-08-10 | 2011-10-11 | Nippon Chemiphar Co., Ltd. | Activator of peroxisome proliferator-activated receptor .delta. |
WO2003016265A1 (fr) | 2001-08-17 | 2003-02-27 | Eisai Co., Ltd. | Compose cyclique et agoniste du recepteur ppar |
JP4269052B2 (ja) | 2001-09-14 | 2009-05-27 | アムジエン・インコーポレーテツド | 連結ビアリール化合物 |
CA2463569C (en) * | 2001-10-12 | 2012-05-15 | Nippon Chemiphar Co., Ltd. | Activator for peroxisome proliferator-activated receptor .delta. |
US7091245B2 (en) | 2002-09-05 | 2006-08-15 | Novo Novdisk A/S | Compounds, their preparation and use |
US7129268B2 (en) | 2002-10-28 | 2006-10-31 | Novo Nordisk A/S | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives |
BR0315683A (pt) | 2002-10-28 | 2005-08-30 | Novo Nordisk As | Composto, uso do mesmo, composição farmacêutica, e, método para o tratamento e/ou prevenção de condições mediadas por receptores nucleares e para o tratamento e/ou prevenção do diabete do tipo i, diabete do tipo ii, tolerância à glicose prejudicada, resistência à insulina ou obesidade |
US20050080115A1 (en) | 2002-10-28 | 2005-04-14 | Lone Jeppesen | Novel compounds, their preparation and use |
CN1708479A (zh) | 2002-10-28 | 2005-12-14 | 诺沃挪第克公司 | 可用于治疗ppar所介导的疾病的新颖化合物 |
WO2004093910A1 (ja) * | 2003-04-22 | 2004-11-04 | Astellas Pharma Inc. | PPARδアゴニストによる脳神経変性疾患治療剤 |
US7301050B2 (en) | 2003-09-19 | 2007-11-27 | Janssen Pharmaceutical N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US8053598B2 (en) | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
EP1751120A4 (de) | 2004-05-25 | 2010-05-05 | Metabolex Inc | Substituierte triazole als ppar-modulatoren und herstellungsverfahren dafür |
US8111617B2 (en) * | 2004-08-13 | 2012-02-07 | Broadcom Corporation | Multiple independent pathway communications |
MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
JP2008538351A (ja) | 2005-03-21 | 2008-10-23 | メタボレックス インコーポレーティッド | 癌を含むPPARγ反応性疾患の処置または予防における浮腫を回避するための方法 |
ATE529404T1 (de) | 2005-06-30 | 2011-11-15 | High Point Pharmaceuticals Llc | Phenoxyessigsäuren als ppar-delta-aktivatoren |
AU2006282403B2 (en) * | 2005-08-26 | 2011-07-07 | Institute Of Medicinal Molecular Design, Inc. | Derivative having PPAR agonistic activity |
JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
CN103224477A (zh) | 2005-12-22 | 2013-07-31 | 高点制药有限责任公司 | 作为PPAR-δ活化剂的苯氧基乙酸 |
JP2009529512A (ja) | 2006-03-09 | 2009-08-20 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 新規な化合物、それらの製造法、及び使用法 |
CN102643248A (zh) * | 2006-04-18 | 2012-08-22 | 日本化学医药株式会社 | 过氧化物酶体增殖剂激活受体δ的激活剂 |
UY30288A1 (es) | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
AU2007292874B2 (en) | 2006-09-08 | 2013-11-21 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced liver disease |
US9308198B2 (en) | 2006-09-08 | 2016-04-12 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
EP2155769B1 (de) | 2007-05-04 | 2012-06-27 | Katholieke Universiteit Leuven KU Leuven Research & Development | Schutz gegen gewebedegeneration |
MX2010011252A (es) * | 2008-04-15 | 2010-11-30 | Nippon Chemiphar Co | Activador para el receptor activado por el proliferador de peroxisoma. |
KR20120099378A (ko) * | 2009-08-14 | 2012-09-10 | 닛뽕 케미파 가부시키가이샤 | 염증 또는 에너지 대사/생산 관련 질환의 치료 또는 예방을 위한 ppar 델타 리간드의 용도 |
WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
EP3043789B1 (de) | 2013-09-09 | 2020-07-08 | vTv Therapeutics LLC | Verwendung von ppar-delta-agonisten zur behandlung von muskelatrophie |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA858493B (en) | 1984-11-12 | 1986-07-30 | Yamanouchi Pharma Co Ltd | Heterocyclic compounds and process of producing them |
JPS61268657A (ja) | 1985-05-23 | 1986-11-28 | Takeda Chem Ind Ltd | フエニル酢酸誘導体およびその製造法 |
JPH0788426B2 (ja) | 1986-07-30 | 1995-09-27 | 住友ベークライト株式会社 | 耐熱性樹脂の製造方法 |
JPH02215717A (ja) | 1989-02-14 | 1990-08-28 | Yamanouchi Pharmaceut Co Ltd | 血清脂質低下剤 |
CZ281130B6 (cs) | 1993-06-18 | 1996-06-12 | Galena, A.S. | Deriváty 4-alkyloxy-3-propyl-2-hydroxyacetofenonu |
WO1996001317A2 (en) | 1994-07-01 | 1996-01-18 | The Salk Institute For Biological Studies | Mammalian peroxisome proliferator-activated receptors and uses thereof |
GB2292885A (en) | 1994-09-08 | 1996-03-13 | Merck & Co Inc | Method of treating hyperlipidemia |
AU725998B2 (en) | 1995-09-18 | 2000-10-26 | Eisai R&D Management Co., Ltd. | Treating NIDDM with RXR agonists |
EP0788353A1 (de) * | 1995-09-18 | 1997-08-13 | Ligand Pharmaceuticals, Inc. | Ppar gamma antagonisten zur behandlung der fettleibigkeit |
EP1011651B1 (de) | 1996-02-02 | 2005-04-27 | Merck & Co., Inc. | Verfahren zur behandlung von diabetes und verwandter krankheitszustände. |
US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
-
1998
- 1998-07-22 ES ES98933883T patent/ES2320181T3/es not_active Expired - Lifetime
- 1998-07-22 AU AU83559/98A patent/AU8355998A/en not_active Abandoned
- 1998-07-22 DE DE69840510T patent/DE69840510D1/de not_active Expired - Lifetime
- 1998-07-22 JP JP50965799A patent/JP4427825B2/ja not_active Expired - Fee Related
- 1998-07-22 US US09/463,334 patent/US6300364B1/en not_active Expired - Lifetime
- 1998-07-22 EP EP98933883A patent/EP1023907B1/de not_active Revoked
- 1998-07-22 WO PCT/JP1998/003266 patent/WO1999004815A1/ja active Application Filing
- 1998-07-22 CA CA2295930A patent/CA2295930C/en not_active Expired - Fee Related
- 1998-07-22 AT AT98933883T patent/ATE421336T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU8355998A (en) | 1999-02-16 |
CA2295930C (en) | 2010-12-14 |
EP1023907A4 (de) | 2001-02-21 |
WO1999004815A1 (fr) | 1999-02-04 |
EP1023907B1 (de) | 2009-01-21 |
EP1023907A1 (de) | 2000-08-02 |
CA2295930A1 (en) | 1999-02-04 |
US6300364B1 (en) | 2001-10-09 |
DE69840510D1 (de) | 2009-03-12 |
ES2320181T3 (es) | 2009-05-19 |
JP4427825B2 (ja) | 2010-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |