WO1999004815A1 - Compositions medicinales hypocholesterolemiantes - Google Patents
Compositions medicinales hypocholesterolemiantes Download PDFInfo
- Publication number
- WO1999004815A1 WO1999004815A1 PCT/JP1998/003266 JP9803266W WO9904815A1 WO 1999004815 A1 WO1999004815 A1 WO 1999004815A1 JP 9803266 W JP9803266 W JP 9803266W WO 9904815 A1 WO9904815 A1 WO 9904815A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cholesterol
- ppar
- artificial sequence
- activating
- lowering
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2295930A CA2295930C (en) | 1997-07-24 | 1998-07-22 | Pharmaceutical compositions having cholesterol-lowering effect |
JP50965799A JP4427825B2 (ja) | 1997-07-24 | 1998-07-22 | コレステロール低下作用を有する医薬組成物 |
EP98933883A EP1023907B1 (en) | 1997-07-24 | 1998-07-22 | Medicinal compositions with cholesterol-lowering effect |
US09/463,334 US6300364B1 (en) | 1997-07-24 | 1998-07-22 | Medicinal compositions with cholesterol-lowering effect |
DE69840510T DE69840510D1 (de) | 1997-07-24 | 1998-07-22 | Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung |
AU83559/98A AU8355998A (en) | 1997-07-24 | 1998-07-22 | Medicinal compositions with cholesterol-lowering effect |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19823297 | 1997-07-24 | ||
JP9/198232 | 1997-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999004815A1 true WO1999004815A1 (fr) | 1999-02-04 |
Family
ID=16387713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1998/003266 WO1999004815A1 (fr) | 1997-07-24 | 1998-07-22 | Compositions medicinales hypocholesterolemiantes |
Country Status (9)
Country | Link |
---|---|
US (1) | US6300364B1 (ja) |
EP (1) | EP1023907B1 (ja) |
JP (1) | JP4427825B2 (ja) |
AT (1) | ATE421336T1 (ja) |
AU (1) | AU8355998A (ja) |
CA (1) | CA2295930C (ja) |
DE (1) | DE69840510D1 (ja) |
ES (1) | ES2320181T3 (ja) |
WO (1) | WO1999004815A1 (ja) |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001000603A1 (en) * | 1999-06-25 | 2001-01-04 | Glaxo Group Limited | Thiazole and oxazole derivatives and their pharmaceutical use |
US6251926B1 (en) | 1998-05-11 | 2001-06-26 | Takeda Chemical Industries, Ltd. | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity |
WO2002014291A1 (en) | 2000-08-11 | 2002-02-21 | Nippon Chemiphar Co.,Ltd. | PPARδ ACTIVATORS |
WO2002087580A1 (fr) * | 2001-04-25 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Promoteurs d'expression d'abc |
WO2003008967A1 (fr) | 2001-07-17 | 2003-01-30 | Teijin Limited | Procede d'analyse d'une substance reposant sur l'analyse de l'effet d'activation de ppar$g(d) et medicament associe |
JP2003505058A (ja) * | 1999-07-23 | 2003-02-12 | ザ、ユニバーシティー、オブ、ダンディー | 治療法および薬剤スクリーニング法 |
WO2004037776A2 (en) | 2002-10-28 | 2004-05-06 | Novo Nordisk A/S | Novel compounds and their use as prar-modulators |
WO2004037775A1 (en) | 2002-10-28 | 2004-05-06 | Novo Nordisk A/S | Novel compounds useful in treating ppar mediated diseases |
WO2004093910A1 (ja) * | 2003-04-22 | 2004-11-04 | Astellas Pharma Inc. | PPARδアゴニストによる脳神経変性疾患治療剤 |
US6869975B2 (en) | 2001-09-14 | 2005-03-22 | Tularik Inc. | Linked biaryl compounds |
US6884821B1 (en) | 1999-10-01 | 2005-04-26 | Eisai Co., Ltd. | Carboxylic acid derivatives and drugs containing the same |
JP2006188538A (ja) * | 2001-07-17 | 2006-07-20 | Teijin Ltd | PPARδ活性化作用を測定することを特徴とする物質の選択方法及び薬剤 |
US7091245B2 (en) | 2002-09-05 | 2006-08-15 | Novo Novdisk A/S | Compounds, their preparation and use |
US7129268B2 (en) | 2002-10-28 | 2006-10-31 | Novo Nordisk A/S | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives |
WO2007003581A1 (en) | 2005-06-30 | 2007-01-11 | Novo Nordisk A/S | Phenoxy acetic acids as ppar delta activators |
US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
US7253178B2 (en) | 2001-03-28 | 2007-08-07 | Eisai Co., Ltd. | Carboxylic acids |
US7323480B2 (en) | 2004-05-25 | 2008-01-29 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
EP1911462A2 (en) | 2001-01-26 | 2008-04-16 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
JP2008513373A (ja) * | 2004-09-15 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 4−((フェノキシアルキル)チオ)−フェノキシ酢酸および類似物 |
JP2008513374A (ja) * | 2004-09-15 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 4−((フェノキシアルキル)チオ)−フェノキシ酢酸および類似物 |
US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
WO2008134828A2 (en) | 2007-05-04 | 2008-11-13 | Katholieke Universiteit Leuven | Tissue degeneration protection |
US7544835B2 (en) | 2001-04-20 | 2009-06-09 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative and salt thereof |
US7687664B2 (en) | 2001-06-04 | 2010-03-30 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it |
US7709528B2 (en) | 2002-10-28 | 2010-05-04 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7943613B2 (en) | 2005-12-22 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7943612B2 (en) | 2006-03-09 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds that modulate PPAR activity, their preparation and use |
US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US8053598B2 (en) | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US8288438B2 (en) | 2005-03-21 | 2012-10-16 | Metabolex, Inc. | Methods for avoiding edema in the treatment or prevention of PPARγ-responsive diseases, including cancer |
US8633184B2 (en) | 2006-04-18 | 2014-01-21 | Janssen Pharmaceutica N.V. | Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol |
US8669288B2 (en) | 2005-09-14 | 2014-03-11 | Janssen Pharmaceutica N.V. | Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives |
US9724322B2 (en) | 2003-09-19 | 2017-08-08 | Janssen Pharmaceutica N.V. | 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
US10456406B2 (en) | 2013-09-09 | 2019-10-29 | Vtv Therapeutics Llc | Use of a PPAR-δ agonist for reducing loss of muscle strength, muscle mass, or type I muscle fibers in an immobilized limb |
US11931365B2 (en) | 2022-01-25 | 2024-03-19 | Reneo Pharmaceuticals, Inc. | Use of PPAR-delta agonists in the treatment of disease |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1423566A (zh) * | 1999-11-10 | 2003-06-11 | 武田药品工业株式会社 | 体重增加抑制剂 |
GB0024362D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
GB0024361D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
WO2002070011A2 (en) * | 2001-02-02 | 2002-09-12 | Smithkline Beecham Corporation | Treatment of ppar mediated diseases |
US20040242459A1 (en) * | 2001-06-11 | 2004-12-02 | Forrest Michael J | Method for treating inflammatory diseases by administering a ppar-delta agonist |
CN1330641C (zh) * | 2001-08-10 | 2007-08-08 | 日本化学医药株式会社 | 过氧化物酶体增殖剂响应受体δ活化剂 |
DE60232739D1 (de) * | 2001-10-12 | 2009-08-06 | Nippon Chemiphar Co | Aktivator des peroxisomproliferator-aktivierten rezeptors delta |
US8111617B2 (en) * | 2004-08-13 | 2012-02-07 | Broadcom Corporation | Multiple independent pathway communications |
US8097610B2 (en) * | 2005-08-26 | 2012-01-17 | Shionogi & Co., Ltd. | Derivative having PPAR agonistic activity |
AU2007239283B2 (en) * | 2006-04-18 | 2013-02-07 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor delta |
WO2008030604A2 (en) | 2006-09-08 | 2008-03-13 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
AU2007292874B2 (en) | 2006-09-08 | 2013-11-21 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced liver disease |
LT2277874T (lt) * | 2008-04-15 | 2018-10-10 | Nippon Chemiphar Co., Ltd. | Peroksisomų proliferatoriaus aktyvuotų receptorių aktyvatorius |
CA2770494A1 (en) * | 2009-08-14 | 2011-02-17 | Ronald Barbaras | Use of ppar delta ligands for the treatment or prevention of inflammation or energy metabolism/production related diseases |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS61268657A (ja) * | 1985-05-23 | 1986-11-28 | Takeda Chem Ind Ltd | フエニル酢酸誘導体およびその製造法 |
JPS62174057A (ja) * | 1984-11-12 | 1987-07-30 | Yamanouchi Pharmaceut Co Ltd | ヘテロ環化合物及びその製造法 |
JPS6335626A (ja) | 1986-07-30 | 1988-02-16 | Sumitomo Bakelite Co Ltd | 耐熱性樹脂の製造方法 |
JPH02215717A (ja) | 1989-02-14 | 1990-08-28 | Yamanouchi Pharmaceut Co Ltd | 血清脂質低下剤 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CZ281130B6 (cs) | 1993-06-18 | 1996-06-12 | Galena, A.S. | Deriváty 4-alkyloxy-3-propyl-2-hydroxyacetofenonu |
WO1996001317A2 (en) | 1994-07-01 | 1996-01-18 | The Salk Institute For Biological Studies | Mammalian peroxisome proliferator-activated receptors and uses thereof |
GB2292885A (en) | 1994-09-08 | 1996-03-13 | Merck & Co Inc | Method of treating hyperlipidemia |
WO1997010813A1 (en) | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
BR9610624A (pt) | 1995-09-18 | 1999-03-16 | Ligand Pharm Inc | Tratamento de dmndi com agonistas de de rxr |
JP2000504021A (ja) | 1996-02-02 | 2000-04-04 | メルク エンド カンパニー インコーポレーテッド | 糖尿病及び関連疾患状態を治療する方法 |
US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
-
1998
- 1998-07-22 DE DE69840510T patent/DE69840510D1/de not_active Expired - Lifetime
- 1998-07-22 US US09/463,334 patent/US6300364B1/en not_active Expired - Lifetime
- 1998-07-22 AT AT98933883T patent/ATE421336T1/de not_active IP Right Cessation
- 1998-07-22 CA CA2295930A patent/CA2295930C/en not_active Expired - Fee Related
- 1998-07-22 EP EP98933883A patent/EP1023907B1/en not_active Revoked
- 1998-07-22 AU AU83559/98A patent/AU8355998A/en not_active Abandoned
- 1998-07-22 JP JP50965799A patent/JP4427825B2/ja not_active Expired - Fee Related
- 1998-07-22 WO PCT/JP1998/003266 patent/WO1999004815A1/ja active Application Filing
- 1998-07-22 ES ES98933883T patent/ES2320181T3/es not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS62174057A (ja) * | 1984-11-12 | 1987-07-30 | Yamanouchi Pharmaceut Co Ltd | ヘテロ環化合物及びその製造法 |
JPS61268657A (ja) * | 1985-05-23 | 1986-11-28 | Takeda Chem Ind Ltd | フエニル酢酸誘導体およびその製造法 |
JPS6335626A (ja) | 1986-07-30 | 1988-02-16 | Sumitomo Bakelite Co Ltd | 耐熱性樹脂の製造方法 |
JPH02215717A (ja) | 1989-02-14 | 1990-08-28 | Yamanouchi Pharmaceut Co Ltd | 血清脂質低下剤 |
Non-Patent Citations (23)
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FORMAN B. M., ET AL.: "HYPOLIPIDEMIC DRUGS, POLYUNSATURATED FATTY ACIDS, AND EICOSANOIDS ARE LIGANDS FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA AND DELTA.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 94., 1 April 1997 (1997-04-01), US, pages 4312 - 4317., XP002912922, ISSN: 0027-8424, DOI: 10.1073/pnas.94.9.4312 * |
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Cited By (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251926B1 (en) | 1998-05-11 | 2001-06-26 | Takeda Chemical Industries, Ltd. | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity |
US6924300B2 (en) | 1998-05-11 | 2005-08-02 | Takeda Chemical Industries, Ltd. | Oxyiminoalkanoic acid derivatives |
US6495581B1 (en) | 1998-05-11 | 2002-12-17 | Takeda Chemical Industries, Ltd. | Oxyiminoalkanoic acid derivatives |
US6710063B1 (en) | 1999-06-25 | 2004-03-23 | Smithkline Beecham Corporation | Activators of PPAR delta |
US6723740B2 (en) | 1999-06-25 | 2004-04-20 | Smithkline Beecham Corporation | Activator of PPAR delta |
WO2001000603A1 (en) * | 1999-06-25 | 2001-01-04 | Glaxo Group Limited | Thiazole and oxazole derivatives and their pharmaceutical use |
JP2003505058A (ja) * | 1999-07-23 | 2003-02-12 | ザ、ユニバーシティー、オブ、ダンディー | 治療法および薬剤スクリーニング法 |
US6884821B1 (en) | 1999-10-01 | 2005-04-26 | Eisai Co., Ltd. | Carboxylic acid derivatives and drugs containing the same |
WO2002014291A1 (en) | 2000-08-11 | 2002-02-21 | Nippon Chemiphar Co.,Ltd. | PPARδ ACTIVATORS |
EP1911462A2 (en) | 2001-01-26 | 2008-04-16 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
US7253178B2 (en) | 2001-03-28 | 2007-08-07 | Eisai Co., Ltd. | Carboxylic acids |
US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
US7544835B2 (en) | 2001-04-20 | 2009-06-09 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative and salt thereof |
WO2002087580A1 (fr) * | 2001-04-25 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Promoteurs d'expression d'abc |
US7687664B2 (en) | 2001-06-04 | 2010-03-30 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it |
JP2006188538A (ja) * | 2001-07-17 | 2006-07-20 | Teijin Ltd | PPARδ活性化作用を測定することを特徴とする物質の選択方法及び薬剤 |
KR101106518B1 (ko) * | 2001-07-17 | 2012-01-20 | 데이진 가부시키가이샤 | PPAR δ활성화 작용을 측정하는 것을 특징으로 하는 물질의 선택방법 및 약제 |
WO2003008967A1 (fr) | 2001-07-17 | 2003-01-30 | Teijin Limited | Procede d'analyse d'une substance reposant sur l'analyse de l'effet d'activation de ppar$g(d) et medicament associe |
CN100419425C (zh) * | 2001-07-17 | 2008-09-17 | 帝人株式会社 | 通过测定PPARδ激活作用筛选物质的方法和药剂 |
US7396642B2 (en) | 2001-07-17 | 2008-07-08 | Teijin Limited | Methods of screening for a compound that enhances thermogenesis |
US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
US6869975B2 (en) | 2001-09-14 | 2005-03-22 | Tularik Inc. | Linked biaryl compounds |
US7645779B2 (en) | 2001-09-14 | 2010-01-12 | Amgen Inc. | Linked biaryl compounds |
US7091245B2 (en) | 2002-09-05 | 2006-08-15 | Novo Novdisk A/S | Compounds, their preparation and use |
WO2004037775A1 (en) | 2002-10-28 | 2004-05-06 | Novo Nordisk A/S | Novel compounds useful in treating ppar mediated diseases |
US7709528B2 (en) | 2002-10-28 | 2010-05-04 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7129268B2 (en) | 2002-10-28 | 2006-10-31 | Novo Nordisk A/S | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives |
WO2004037776A2 (en) | 2002-10-28 | 2004-05-06 | Novo Nordisk A/S | Novel compounds and their use as prar-modulators |
WO2004093910A1 (ja) * | 2003-04-22 | 2004-11-04 | Astellas Pharma Inc. | PPARδアゴニストによる脳神経変性疾患治療剤 |
US9724322B2 (en) | 2003-09-19 | 2017-08-08 | Janssen Pharmaceutica N.V. | 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
US8053598B2 (en) | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7323480B2 (en) | 2004-05-25 | 2008-01-29 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
US8242173B2 (en) | 2004-09-15 | 2012-08-14 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
JP2008513374A (ja) * | 2004-09-15 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 4−((フェノキシアルキル)チオ)−フェノキシ酢酸および類似物 |
JP2008513373A (ja) * | 2004-09-15 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 4−((フェノキシアルキル)チオ)−フェノキシ酢酸および類似物 |
US8288438B2 (en) | 2005-03-21 | 2012-10-16 | Metabolex, Inc. | Methods for avoiding edema in the treatment or prevention of PPARγ-responsive diseases, including cancer |
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Also Published As
Publication number | Publication date |
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AU8355998A (en) | 1999-02-16 |
CA2295930A1 (en) | 1999-02-04 |
ATE421336T1 (de) | 2009-02-15 |
US6300364B1 (en) | 2001-10-09 |
EP1023907A1 (en) | 2000-08-02 |
JP4427825B2 (ja) | 2010-03-10 |
EP1023907A4 (en) | 2001-02-21 |
ES2320181T3 (es) | 2009-05-19 |
EP1023907B1 (en) | 2009-01-21 |
CA2295930C (en) | 2010-12-14 |
DE69840510D1 (de) | 2009-03-12 |
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