ATE412759T1 - Loxp sequenz-varianten und deren verwendung - Google Patents
Loxp sequenz-varianten und deren verwendungInfo
- Publication number
- ATE412759T1 ATE412759T1 AT98953027T AT98953027T ATE412759T1 AT E412759 T1 ATE412759 T1 AT E412759T1 AT 98953027 T AT98953027 T AT 98953027T AT 98953027 T AT98953027 T AT 98953027T AT E412759 T1 ATE412759 T1 AT E412759T1
- Authority
- AT
- Austria
- Prior art keywords
- bases
- loxp site
- wild
- image
- specific recombination
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33128997 | 1997-11-13 | ||
| JP27315098A JP4206154B2 (ja) | 1997-11-13 | 1998-09-28 | 変異型ｌｏｘＰ配列とその応用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE412759T1 true ATE412759T1 (de) | 2008-11-15 |
Family
ID=26550537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98953027T ATE412759T1 (de) | 1997-11-13 | 1998-11-12 | Loxp sequenz-varianten und deren verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6465254B1 (https=) |
| EP (1) | EP1035208B1 (https=) |
| JP (1) | JP4206154B2 (https=) |
| KR (1) | KR100639088B1 (https=) |
| CN (1) | CN1173039C (https=) |
| AT (1) | ATE412759T1 (https=) |
| AU (1) | AU741415B2 (https=) |
| CA (1) | CA2309386C (https=) |
| DE (1) | DE69840173D1 (https=) |
| DK (1) | DK1035208T3 (https=) |
| NZ (1) | NZ504307A (https=) |
| WO (1) | WO1999025851A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6964861B1 (en) | 1998-11-13 | 2005-11-15 | Invitrogen Corporation | Enhanced in vitro recombinational cloning of using ribosomal proteins |
| DK0937098T3 (da) | 1995-06-07 | 2002-12-02 | Invitrogen Corp | Rekombinatorisk kloning under anvendelse af gensplejsede rekombinationssites |
| US6143557A (en) | 1995-06-07 | 2000-11-07 | Life Technologies, Inc. | Recombination cloning using engineered recombination sites |
| US6720140B1 (en) | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| US5851808A (en) | 1997-02-28 | 1998-12-22 | Baylor College Of Medicine | Rapid subcloning using site-specific recombination |
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| EP1025217B1 (en) | 1997-10-24 | 2006-10-04 | Invitrogen Corporation | Recombinational cloning using nucleic acids having recombination sites |
| JP4153607B2 (ja) | 1998-11-18 | 2008-09-24 | 大日本住友製薬株式会社 | 新規な組換えアデノウイルス |
| EP2119788A1 (en) | 1999-03-02 | 2009-11-18 | Life Technologies Corporation | Compositions and methods for use in recombinational cloning of nucleic acids |
| AU6529900A (en) * | 1999-08-09 | 2001-03-05 | Monsanto Technology Llc | Novel cloning methods and vectors |
| EP2210948A3 (en) | 1999-12-10 | 2010-10-06 | Life Technologies Corporation | Use of multiple recombination sites with unique specificity in recombinational cloning |
| JP2001321174A (ja) * | 2000-05-11 | 2001-11-20 | Japan Science & Technology Corp | アンチセンス型ジーントラップベクター |
| US7244560B2 (en) | 2000-05-21 | 2007-07-17 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| EP1322152A2 (en) * | 2000-10-03 | 2003-07-02 | ADEREGEM (Association pour le Développement de la Recherche en Génétique Moléculaire | Transgenic mouse for targeted recombination mediated by modified cre-er |
| FR2814642B1 (fr) * | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| WO2002083889A2 (en) * | 2001-04-10 | 2002-10-24 | Imperial College Innovations Limited | Methods for the production of minicircles |
| EP1427816A4 (en) * | 2001-09-18 | 2004-12-01 | Clontech Lab Inc | METHOD FOR THE PRODUCTION OF ADENOVIRUS VECTORS, BASED ON A SPECIFIC RECOMBINASE |
| EP1457559B1 (en) | 2001-11-22 | 2008-01-16 | Keio University | Artificial antibody library with super-repertory |
| US6818420B2 (en) | 2002-02-27 | 2004-11-16 | Biosource International, Inc. | Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same |
| CA2484360A1 (en) | 2002-05-02 | 2003-11-13 | The University Of North Carolina At Chapel Hill | In vitro mutagenesis, phenotyping, and gene mapping |
| WO2004020605A2 (en) | 2002-08-29 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Circular nucleic acid vectors, and methods for making and using the same |
| WO2004078939A2 (en) * | 2003-03-03 | 2004-09-16 | University Of Massachusetts | REGULATION OF Mdm2 FUNCTION |
| WO2005042781A2 (en) | 2003-10-31 | 2005-05-12 | Agencourt Personal Genomics Corporation | Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof |
| US8304189B2 (en) | 2003-12-01 | 2012-11-06 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
| WO2005081632A2 (en) * | 2004-02-26 | 2005-09-09 | State Of Israel, Ministry Of Agriculture, Agricultural Research Organization | Enzymes, cells and methods for site specific recombination at asymmetric sites |
| JP2006333742A (ja) * | 2005-05-31 | 2006-12-14 | Chemicals Evaluation & Research Institute | 細胞及び細胞へのｄｎａ導入方法 |
| BRPI0612862A2 (pt) | 2005-07-18 | 2010-11-30 | Pioneer Hi Bred Int | polinucleotìdeo isolado, método para obtenção de uma célula transformada, método para obtenção de uma planta transformada, método de produção de recombinação de dna de sìtio especìfico, biblioteca isolada, método de geração de biblioteca de moléculas e método para selecionar sìtio de recombinação frt modificado |
| JP2009524406A (ja) * | 2005-10-13 | 2009-07-02 | ビーシー キャンサー エージェンシー | 合成生物学および代謝工学のためのモジュラー型ゲノム |
| US20070143881A1 (en) * | 2005-12-16 | 2007-06-21 | Pioneer Hi-Bred International, Inc. | Methods and Compositions for Improving the Efficiency of Site-Specific Polynucleotide Exchange |
| US7993913B2 (en) | 2006-05-09 | 2011-08-09 | The Curators Of The University Of Missouri | Plant artificial chromosome platforms via telomere truncation |
| WO2007137114A2 (en) | 2006-05-17 | 2007-11-29 | Pioneer Hi-Bred International, Inc. | Artificial plant minichromosomes |
| CN101849010A (zh) | 2007-06-29 | 2010-09-29 | 先锋高级育种国际公司 | 用于改变单子叶植物细胞的基因组的方法 |
| EP2067858A1 (en) | 2007-12-07 | 2009-06-10 | Universidad de Sevilla | Animal models for neurodegenerative diseases |
| WO2012044847A1 (en) | 2010-10-01 | 2012-04-05 | Life Technologies Corporation | Nucleic acid adaptors and uses thereof |
| EP2235217B1 (en) | 2008-01-09 | 2016-04-20 | Life Technologies Corporation | Method of making a paired tag library for nucleic acid sequencing |
| ES2337973B8 (es) | 2008-05-16 | 2011-07-21 | Proyecto De Biomedicina Cima, S.L. | Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad. |
| US8704041B2 (en) | 2009-12-30 | 2014-04-22 | Pioneer Hi Bred International Inc | Methods and compositions for targeted polynucleotide modification |
| MX2013010911A (es) | 2011-03-23 | 2015-03-03 | Pioneer Hi Bred Int | Metodos para producir un locus de rasgo transgenico complejo. |
| KR102068107B1 (ko) | 2011-04-27 | 2020-01-20 | 아미리스 인코퍼레이티드 | 게놈 변형 방법 |
| BR112013033176A2 (pt) | 2011-06-21 | 2018-06-12 | E I Du Pont De Nemouras And Company | método para produzir uma modificação direcionada em um gene de fertilidade masculina, planta, molécula de ácido nucleio isolada, construto de expressão |
| EP2825651B1 (en) * | 2012-03-12 | 2018-04-25 | DSM IP Assets B.V. | Recombination system |
| CN103361342B (zh) * | 2012-03-30 | 2019-01-25 | 上海杰隆生物工程股份有限公司 | 一种转基因定位整合的方法及其应用 |
| US20140173781A1 (en) | 2012-12-13 | 2014-06-19 | Pioneer Hi-Bred International, Inc. | Methods and compositions for producing and selecting transgenic wheat plants |
| ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
| MX2016007797A (es) | 2013-12-19 | 2016-09-07 | Amyris Inc | Metodos para integracion genomica. |
| JP2018501814A (ja) | 2014-11-11 | 2018-01-25 | クララ フーズ カンパニー | 卵白タンパク質産生のための方法および組成物 |
| CN105316362B (zh) * | 2015-08-19 | 2020-03-17 | 暨南大学 | 一种Dual-RMCE介导的TCR基因置换系统及其方法 |
| CN108513584A (zh) | 2015-08-28 | 2018-09-07 | 先锋国际良种公司 | 苍白杆菌介导的植物转化 |
| EP4219731A3 (en) | 2016-05-18 | 2023-08-09 | Amyris, Inc. | Compositions and methods for genomic integration of nucleic acids into exogenous landing pads |
| BR112022000545A2 (pt) | 2019-07-11 | 2022-04-05 | Clara Foods Co | Composições de proteína e produtos de consumo destas |
| US12096784B2 (en) | 2019-07-11 | 2024-09-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
| WO2023015822A1 (zh) * | 2021-08-13 | 2023-02-16 | 上海鑫湾生物科技有限公司 | 缺氧触发的人工转录因子、转录控制系统及其应用 |
| WO2023127871A1 (ja) | 2021-12-27 | 2023-07-06 | 株式会社レプリテック | 温度感受性のマイナス鎖ｒｎａウイルスまたはウイルスベクターおよびそのｒｎａゲノム |
| CN117165627A (zh) * | 2022-05-27 | 2023-12-05 | 上海科技大学 | 基于Cre-LoxP和CRISPR的核酸构建体及其应用 |
| JPWO2024195811A1 (https=) | 2023-03-22 | 2024-09-26 | ||
| CN118147146B (zh) * | 2024-03-25 | 2024-09-17 | 中国科学院水生生物研究所 | 突变型LoxP元件、其表达载体和在鱼类基因工程育种中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6228646B1 (en) * | 1996-03-07 | 2001-05-08 | The Regents Of The University Of California | Helper-free, totally defective adenovirus for gene therapy |
| EP0941310A1 (en) * | 1996-10-11 | 1999-09-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Methods for the generation of primordial germ cells and transgenic animal species |
-
1998
- 1998-09-28 JP JP27315098A patent/JP4206154B2/ja not_active Expired - Lifetime
- 1998-11-12 DE DE69840173T patent/DE69840173D1/de not_active Expired - Lifetime
- 1998-11-12 CA CA2309386A patent/CA2309386C/en not_active Expired - Fee Related
- 1998-11-12 EP EP98953027A patent/EP1035208B1/en not_active Expired - Lifetime
- 1998-11-12 WO PCT/JP1998/005094 patent/WO1999025851A1/ja not_active Ceased
- 1998-11-12 CN CNB988127237A patent/CN1173039C/zh not_active Expired - Lifetime
- 1998-11-12 DK DK98953027T patent/DK1035208T3/da active
- 1998-11-12 AU AU10526/99A patent/AU741415B2/en not_active Ceased
- 1998-11-12 US US09/554,271 patent/US6465254B1/en not_active Expired - Lifetime
- 1998-11-12 NZ NZ504307A patent/NZ504307A/en not_active IP Right Cessation
- 1998-11-12 KR KR1020007005138A patent/KR100639088B1/ko not_active Expired - Fee Related
- 1998-11-12 AT AT98953027T patent/ATE412759T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6465254B1 (en) | 2002-10-15 |
| KR20010032020A (ko) | 2001-04-16 |
| JPH11196880A (ja) | 1999-07-27 |
| CA2309386A1 (en) | 1999-05-27 |
| CN1283233A (zh) | 2001-02-07 |
| EP1035208A4 (en) | 2002-01-30 |
| KR100639088B1 (ko) | 2006-10-27 |
| CA2309386C (en) | 2010-07-13 |
| NZ504307A (en) | 2001-07-27 |
| DK1035208T3 (da) | 2009-02-23 |
| JP4206154B2 (ja) | 2009-01-07 |
| WO1999025851A1 (en) | 1999-05-27 |
| DE69840173D1 (de) | 2008-12-11 |
| EP1035208A1 (en) | 2000-09-13 |
| CN1173039C (zh) | 2004-10-27 |
| AU1052699A (en) | 1999-06-07 |
| EP1035208B1 (en) | 2008-10-29 |
| AU741415B2 (en) | 2001-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |