ATE411293T1 - Kondensierte azabicyclische verbindungen, die den vanilloidrezeptorsubtyp 1 (vr1)- rezeptor inhibieren - Google Patents
Kondensierte azabicyclische verbindungen, die den vanilloidrezeptorsubtyp 1 (vr1)- rezeptor inhibierenInfo
- Publication number
- ATE411293T1 ATE411293T1 AT04780017T AT04780017T ATE411293T1 AT E411293 T1 ATE411293 T1 AT E411293T1 AT 04780017 T AT04780017 T AT 04780017T AT 04780017 T AT04780017 T AT 04780017T AT E411293 T1 ATE411293 T1 AT E411293T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- receptor
- condensed
- inhibit
- azabicyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/364,210 US7074805B2 (en) | 2002-02-20 | 2003-02-11 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US10/634,678 US6933311B2 (en) | 2003-02-11 | 2003-08-05 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE411293T1 true ATE411293T1 (de) | 2008-10-15 |
Family
ID=32824388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04780017T ATE411293T1 (de) | 2003-02-11 | 2004-08-04 | Kondensierte azabicyclische verbindungen, die den vanilloidrezeptorsubtyp 1 (vr1)- rezeptor inhibieren |
Country Status (14)
Country | Link |
---|---|
US (1) | US6933311B2 (de) |
EP (1) | EP1660455B1 (de) |
JP (1) | JP2007501246A (de) |
KR (1) | KR20070026291A (de) |
CN (1) | CN1863777A (de) |
AT (1) | ATE411293T1 (de) |
AU (1) | AU2004265306A1 (de) |
BR (1) | BRPI0413305A (de) |
CA (1) | CA2534542A1 (de) |
DE (1) | DE602004017196D1 (de) |
ES (1) | ES2315704T3 (de) |
MX (1) | MXPA06001396A (de) |
WO (1) | WO2005016890A1 (de) |
ZA (1) | ZA200601022B (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
CA2476936A1 (en) * | 2002-02-20 | 2003-08-28 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7015233B2 (en) * | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
GB0322016D0 (en) * | 2003-09-19 | 2003-10-22 | Merck Sharp & Dohme | New compounds |
US20070004679A1 (en) * | 2004-05-17 | 2007-01-04 | Nathalie Schlienger | Androgen receptor modulators and methods of treating disease using the same |
US7268232B2 (en) * | 2004-05-17 | 2007-09-11 | Acadia Pharmaceuticals Inc. | Androgen receptor modulators and method of treating disease using the same |
US20060035939A1 (en) * | 2004-07-14 | 2006-02-16 | Japan Tobacco Inc. | 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity |
RU2392278C2 (ru) * | 2004-07-15 | 2010-06-20 | Джапан Тобакко Инк. | Конденсированное производное бензамида и ингибитор активности подтипа 1 рецептора ваниллоида (vr1) |
MX2007008334A (es) * | 2005-01-10 | 2007-09-11 | Acadia Pharm Inc | Derivados aminofenilo como moduladores de receptor de androgeno selectivos. |
US20060173037A1 (en) * | 2005-01-10 | 2006-08-03 | Nathalie Schlienger | Aminophenyl derivatives as selective androgen receptor modulators |
US7297700B2 (en) * | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
DE102005023943A1 (de) | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln |
JP2009511465A (ja) | 2005-10-07 | 2009-03-19 | グレンマーク・ファーマシューティカルズ・エスエー | 置換ベンゾ縮合誘導体およびバニロイド受容体リガンドとしてのその使用 |
WO2007073405A1 (en) * | 2005-12-21 | 2007-06-28 | Decode Genetics Ehf | N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation |
US7906508B2 (en) * | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
CA2643983A1 (en) * | 2006-02-21 | 2007-08-30 | Amgen, Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
EP1996574A1 (de) * | 2006-03-08 | 2008-12-03 | Amgen Inc. | Chinolin- und isochinolinderivate als phosphodiesterase-10-inhibitoren |
CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
WO2007120083A1 (en) * | 2006-04-13 | 2007-10-25 | Astrazeneca Ab | The use of carboxamide derivatives in the manufacture of a medicament for the treatment of inflammatory, allergic and dermatological conditions |
CA2647256A1 (en) * | 2006-04-18 | 2007-10-25 | Abbott Laboratories | Antagonists of the vanilloid receptor subtype 1 (vr1) and uses thereof |
TW200824687A (en) * | 2006-08-25 | 2008-06-16 | Abbott Lab | Compounds that inhibit TRPV1 and uses thereof |
US20080153845A1 (en) * | 2006-10-27 | 2008-06-26 | Redpoint Bio Corporation | Trpv1 antagonists and uses thereof |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
JP2010513557A (ja) * | 2006-12-20 | 2010-04-30 | アボット・ラボラトリーズ | 疼痛治療のためのtrpv1バニロイド受容体アンタゴニストとしてのn−(5,6,7,8−テトラヒドロナフタレン−1−イル)尿素誘導体および関連化合物 |
KR20100016593A (ko) * | 2007-04-16 | 2010-02-12 | 그뤼넨탈 게엠베하 | 신규한 바닐로이드 수용체 리간드 및 약제의 제조를 위한 이의 용도 |
DE102007018151A1 (de) | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
DE102007018149A1 (de) | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
WO2009081222A1 (en) | 2007-12-21 | 2009-07-02 | Glenmark Pharmaceuticals, S.A. | Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands |
EP2323989A4 (de) * | 2008-03-20 | 2011-06-22 | Abbott Lab | Verfahren zur herstellung von auf das zentrale nervensystem wirkenden mitteln, bei denen es sich um trpv1-antagonisten handelt |
CN101983197B (zh) | 2008-04-18 | 2015-04-22 | 大熊制药株式会社 | 新型苯并噁嗪苯并咪唑衍生物、含有该衍生物的药物组合物及其用途 |
CA2761639C (en) * | 2009-05-29 | 2016-06-07 | Raqualia Pharma Inc. | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
EP2377850A1 (de) * | 2010-03-30 | 2011-10-19 | Pharmeste S.r.l. | TRPV1-Vanilloidrezeptorantagonisten mit einem bizyklischen Teil |
MX2012012204A (es) | 2010-04-22 | 2012-12-05 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
KR101293384B1 (ko) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
US8802711B2 (en) * | 2011-03-25 | 2014-08-12 | Abbvie Inc. | TRPV1 antagonists |
FR3016031B1 (fr) | 2013-12-26 | 2016-02-05 | Grdf | Teledistribution d'une mise a jour logicielle a des terminaux de tele-releve |
ES2957761T3 (es) | 2014-04-15 | 2024-01-25 | Vertex Pharma | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
CR20180443A (es) | 2016-03-17 | 2018-11-21 | Hoffmann La Roche | Derivado de morfolina |
CN105906564B (zh) * | 2016-05-05 | 2018-11-30 | 海南省药物研究所 | 化合物、制备方法及其用途 |
CA3056970A1 (en) | 2017-03-21 | 2018-09-27 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
EP3781565A1 (de) | 2018-04-18 | 2021-02-24 | Bayer Pharma Aktiengesellschaft | 2-methyl-aza-chinazoline |
DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1344579A (fr) | 1961-11-23 | 1963-11-29 | Sandoz Sa | Nouveaux dérivés de l'indole et leur préparation |
US3647910A (en) * | 1970-03-20 | 1972-03-07 | Standard Oil Co Ohio | Dehydrogenation of hydrocarbons employing a catalyst of iron oxide-containing activated carbon |
US3711610A (en) * | 1971-06-01 | 1973-01-16 | Sterling Drug Inc | Anticoccidiosis method and compositions involving indazolylphenylureas and indazolylphenylthioureas |
US3814711A (en) | 1971-07-26 | 1974-06-04 | Mallinckrodt Chemical Works | 10-acetamido-s-triazolo-(3,4-a)-isoquinolines |
NL7902993A (nl) | 1978-04-24 | 1979-10-26 | Rhone Poulenc Ind | Nieuwe isochinolinederivaten, de bereiding ervan en farmaceutische preparaten, die de nieuwe isochinoline- derivaten bevatten. |
JPS5587771A (en) * | 1978-12-27 | 1980-07-02 | Teikoku Hormone Mfg Co Ltd | 1-phenylisoquinoline derivative |
EP0189473B1 (de) * | 1984-08-15 | 1992-05-27 | Schering Aktiengesellschaft | Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPS62116559A (ja) * | 1985-11-18 | 1987-05-28 | Sagami Chem Res Center | 4−アシルメチリデン−4,5,6,7−テトラヒドロインド−ル誘導体及びその製造方法 |
MX22406A (es) | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
EP0518961A1 (de) | 1990-03-07 | 1992-12-23 | Aventis Pharma S.A. | Glycinamidderivate, ihre herstellung und diese enthaltende arzneimittel |
US5362878A (en) * | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
US5444038A (en) * | 1992-03-09 | 1995-08-22 | Zeneca Limited | Arylindazoles and their use as herbicides |
GB9307833D0 (en) * | 1993-04-15 | 1993-06-02 | Glaxo Inc | Modulators of cholecystokinin and gastrin |
PL328094A1 (en) * | 1996-01-16 | 1999-01-04 | Bristol Myers Squibb Co | Conformingly restricted aromatic inhibitors triglycerides carrying chromosome protein and method of obtaining such inhibitors |
US5760246A (en) * | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
EP1154989B1 (de) * | 1999-02-22 | 2005-12-14 | Pacific Corporation | Vanilloid-analoge die resiniferatoxin-pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung |
EP1177188B1 (de) * | 1999-05-12 | 2005-10-12 | Ortho-McNeil Pharmaceutical, Inc. | Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen |
YU54202A (sh) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
NZ521192A (en) * | 2000-03-09 | 2005-01-28 | Ono Pharmaceutical Co | Indole derivatives, process for preparation of the same and use thereof |
MXPA03000458A (es) * | 2000-07-20 | 2004-06-02 | Neurogen Corp | Ligandos receptores de capsaicina. |
US7199147B2 (en) * | 2001-06-12 | 2007-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Rho kinase inhibitors |
JP2005501873A (ja) * | 2001-07-31 | 2005-01-20 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | アミン誘導体 |
TWI283665B (en) * | 2001-09-13 | 2007-07-11 | Smithkline Beecham Plc | Novel urea compound, pharmaceutical composition containing the same and its use |
GB0130550D0 (en) * | 2001-12-20 | 2002-02-06 | Smithkline Beecham Plc | Novel compounds |
CA2476936A1 (en) * | 2002-02-20 | 2003-08-28 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
-
2003
- 2003-08-05 US US10/634,678 patent/US6933311B2/en not_active Expired - Lifetime
-
2004
- 2004-08-04 CN CNA2004800288846A patent/CN1863777A/zh active Pending
- 2004-08-04 KR KR1020067002563A patent/KR20070026291A/ko not_active Application Discontinuation
- 2004-08-04 EP EP04780017A patent/EP1660455B1/de not_active Expired - Lifetime
- 2004-08-04 AU AU2004265306A patent/AU2004265306A1/en not_active Abandoned
- 2004-08-04 DE DE602004017196T patent/DE602004017196D1/de not_active Expired - Lifetime
- 2004-08-04 BR BRPI0413305-6A patent/BRPI0413305A/pt not_active IP Right Cessation
- 2004-08-04 AT AT04780017T patent/ATE411293T1/de not_active IP Right Cessation
- 2004-08-04 CA CA002534542A patent/CA2534542A1/en not_active Abandoned
- 2004-08-04 WO PCT/US2004/025109 patent/WO2005016890A1/en active Application Filing
- 2004-08-04 ES ES04780017T patent/ES2315704T3/es not_active Expired - Lifetime
- 2004-08-04 JP JP2006522680A patent/JP2007501246A/ja not_active Ceased
- 2004-08-04 MX MXPA06001396A patent/MXPA06001396A/es not_active Application Discontinuation
-
2006
- 2006-02-03 ZA ZA200601022A patent/ZA200601022B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20040157849A1 (en) | 2004-08-12 |
ZA200601022B (en) | 2007-05-30 |
BRPI0413305A (pt) | 2006-10-10 |
EP1660455A1 (de) | 2006-05-31 |
MXPA06001396A (es) | 2007-02-13 |
CA2534542A1 (en) | 2005-02-24 |
KR20070026291A (ko) | 2007-03-08 |
AU2004265306A1 (en) | 2005-02-24 |
EP1660455B1 (de) | 2008-10-15 |
CN1863777A (zh) | 2006-11-15 |
DE602004017196D1 (de) | 2008-11-27 |
US6933311B2 (en) | 2005-08-23 |
JP2007501246A (ja) | 2007-01-25 |
ES2315704T3 (es) | 2009-04-01 |
WO2005016890A1 (en) | 2005-02-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE411293T1 (de) | Kondensierte azabicyclische verbindungen, die den vanilloidrezeptorsubtyp 1 (vr1)- rezeptor inhibieren | |
ATE420644T1 (de) | Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1) | |
MY144307A (en) | Antagonists of the vanilloid receptor subtype 1 (vr1) and uses thereof | |
DK1501507T3 (da) | Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet | |
WO2006062981A3 (en) | Antagonists to the vanilloid receptor subtype 1 (vr1) and uses thereof | |
ATE469892T1 (de) | Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung | |
GB0504828D0 (en) | Therapeutic agents | |
MX2007007100A (es) | Benzisotiazol-1,1-dioxido que actua como antagonistas para el subtipo 1 del receptor de vanilloida (vr1) y usos de los mismos. | |
WO2005013894A3 (en) | Benzodiazepine cgrp receptor antagonists | |
WO2004013120A8 (en) | Novel benzodioxoles | |
EA200501333A1 (ru) | 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ | |
GB9929552D0 (en) | Compounds | |
DE602004030334D1 (de) | Synthese von 5-substituierten 7-azaindolen und 7-azaindolinen | |
BR0213140A (pt) | Fungicidas de pirazol-pirimidina | |
WO2005040121A3 (en) | Amides that inhibit vanilloid receptor subtype 1 (vr1) receptor | |
WO2005000807A3 (en) | Benzodiazepine cgrp receptor antagonists | |
GB0030305D0 (en) | Compounds | |
DE60126978D1 (de) | Inhibitoren von serin proteasen | |
SE9904108D0 (sv) | Nya föreningar | |
MXPA03010586A (es) | N-[(1s)-1,2,3,4-tertrahidro-1-naftalenil benzamidas trisubtituidas, las cuales inhiben receptores que contienen p2x2/3. | |
TR200201128T2 (tr) | PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri. | |
DE60215637D1 (de) | Tri- und tetraaza-acenaphthylen-derivate als crf-rezeptor-antagonisten | |
DE60100811D1 (de) | Crf rezeptor-antagonisten und darauf bezogene methoden | |
MXPA04004980A (es) | Antagonistas del receptor ccr-3. | |
DE60227113D1 (de) | Kondensierte camptothecine als antitumormittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |