ATE399171T1 - Camptothecinanaloge und deren zubereitungsmethoden - Google Patents

Camptothecinanaloge und deren zubereitungsmethoden

Info

Publication number
ATE399171T1
ATE399171T1 AT00921919T AT00921919T ATE399171T1 AT E399171 T1 ATE399171 T1 AT E399171T1 AT 00921919 T AT00921919 T AT 00921919T AT 00921919 T AT00921919 T AT 00921919T AT E399171 T1 ATE399171 T1 AT E399171T1
Authority
AT
Austria
Prior art keywords
preparation methods
camptothecin analogs
camptothecin
analogs
enantiomerically
Prior art date
Application number
AT00921919T
Other languages
German (de)
English (en)
Inventor
Dennis Curran
David Bom
Thomas Burke
Original Assignee
Univ Pittsburgh
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh, Univ Kentucky Res Found filed Critical Univ Pittsburgh
Application granted granted Critical
Publication of ATE399171T1 publication Critical patent/ATE399171T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
AT00921919T 1999-04-09 2000-04-07 Camptothecinanaloge und deren zubereitungsmethoden ATE399171T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/290,019 US6207832B1 (en) 1999-04-09 1999-04-09 Camptothecin analogs and methods of preparation thereof

Publications (1)

Publication Number Publication Date
ATE399171T1 true ATE399171T1 (de) 2008-07-15

Family

ID=23114196

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00921919T ATE399171T1 (de) 1999-04-09 2000-04-07 Camptothecinanaloge und deren zubereitungsmethoden

Country Status (13)

Country Link
US (7) US6207832B1 (https=)
EP (1) EP1173180B1 (https=)
JP (1) JP4866505B2 (https=)
KR (1) KR100717900B1 (https=)
CN (2) CN1319975C (https=)
AT (1) ATE399171T1 (https=)
AU (1) AU781302B2 (https=)
CA (1) CA2369270C (https=)
DE (1) DE60039291D1 (https=)
ES (1) ES2308977T3 (https=)
HK (1) HK1046374B (https=)
NZ (1) NZ514635A (https=)
WO (1) WO2000061146A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6629995B1 (en) * 2000-03-31 2003-10-07 Super Gen, Inc. Camptothecin conjugates
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) * 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) * 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
AU2003207369A1 (en) * 2002-02-18 2003-09-04 Dr. Reddy's Laboratories Limited A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride
WO2003099825A1 (en) * 2002-05-22 2003-12-04 University Of Pittsburgh Synthesis of polycyclic quinolines
AU2003243397A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Homo-camptothecin derivatives
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
EP1580216B1 (en) * 2002-10-31 2014-05-14 Nippon Kayaku Kabushiki Kaisha High-molecular weight derivatives of camptothecins
US7064206B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Highly lipophilic camptothecin intermediates and prodrugs and methods of preparation thereof
US7064202B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Camptothecin intermediates and prodrugs and methods of preparation thereof
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
JP4820758B2 (ja) * 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
EP1861111A4 (en) * 2005-03-02 2012-02-29 New Century Pharmaceuticals METHOD AND COMPOSITION FOR INCREASING THE SAFETY AND EFFECTIVENESS OF ALBUMIN-BINDING ACTIVE SUBSTANCES
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
JP5249016B2 (ja) 2006-03-28 2013-07-31 日本化薬株式会社 タキサン類の高分子結合体
KR20090009241A (ko) 2006-05-18 2009-01-22 니폰 가야꾸 가부시끼가이샤 포도필로톡신류의 고분자 결합체
ES2584840T3 (es) * 2006-10-03 2016-09-29 Nippon Kayaku Kabushiki Kaisha Compuesto de un derivado de resorcinol con un polímero
WO2008056596A1 (fr) 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
US8703878B2 (en) * 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
WO2009116509A1 (ja) * 2008-03-18 2009-09-24 日本化薬株式会社 生理活性物質の高分子結合体
WO2009136572A1 (ja) 2008-05-08 2009-11-12 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
EP2431403B1 (en) 2009-05-15 2016-09-28 Nipponkayaku Kabushikikaisha Polymer conjugate of bioactive substance having hydroxy group
EP2641605B1 (en) 2010-11-17 2018-03-07 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolism antagonist
KR101849142B1 (ko) 2011-09-11 2018-04-16 니폰 가야꾸 가부시끼가이샤 블록 공중합체의 제조방법
CN118414339A (zh) * 2021-12-16 2024-07-30 迈威(上海)生物科技股份有限公司 一种喜树碱类化合物及其偶联物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428166A (en) * 1992-06-18 1995-06-27 North Carolina State University Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs
US5405963A (en) 1993-06-10 1995-04-11 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
US6150343A (en) 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6136978A (en) 1993-06-30 2000-10-24 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6211371B1 (en) * 1993-06-30 2001-04-03 University Of Pittsburgh Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
US5744605A (en) * 1993-06-30 1998-04-28 University Of Pittsburgh Intermediates in the synthesis of (+) camptothecin and related compounds and synthesis thereof
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
US5935967A (en) 1995-06-05 1999-08-10 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of highly lipophilic camptothecin derivatives
FR2768431B1 (fr) 1997-08-29 2000-03-24 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation
BR9608639A (pt) 1995-06-21 1999-06-29 Sod Conseils Rech Applic Análogo de camptotecina composto processo de preparação dos compostos produtoos industriaia medicamentos composições farmacêuticas e utilização de produtos
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
FR2757514B1 (fr) 1996-12-20 1999-02-12 Sod Conseils Rech Applic Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
IL127800A (en) 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them
UA57757C2 (uk) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
ATE329903T1 (de) 1997-02-14 2006-07-15 Bionumerik Pharmaceuticals Inc Hochgradig lipophile camptothecin-derivate
CA2310112A1 (en) * 1997-08-04 1999-02-11 Abb Power T & D Company Inc. Method and apparatus for manufacturing a variable insulated helically wound electrical coil
US6057303A (en) 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6250342B1 (en) * 1999-09-02 2001-06-26 David Lonardelli Cv joint boot clamp tightening tool

Also Published As

Publication number Publication date
ES2308977T3 (es) 2008-12-16
HK1046374B (zh) 2007-08-24
CN1367694A (zh) 2002-09-04
US7982041B2 (en) 2011-07-19
US20090198061A1 (en) 2009-08-06
US6410731B2 (en) 2002-06-25
US7220860B2 (en) 2007-05-22
CA2369270C (en) 2011-08-16
AU781302B2 (en) 2005-05-12
US6809103B2 (en) 2004-10-26
US20120136153A1 (en) 2012-05-31
US20050014775A1 (en) 2005-01-20
JP2002541201A (ja) 2002-12-03
JP4866505B2 (ja) 2012-02-01
DE60039291D1 (de) 2008-08-07
EP1173180A1 (en) 2002-01-23
US20010003779A1 (en) 2001-06-14
NZ514635A (en) 2004-02-27
CN1319975C (zh) 2007-06-06
US6207832B1 (en) 2001-03-27
CN101058579A (zh) 2007-10-24
AU4217700A (en) 2000-11-14
EP1173180B1 (en) 2008-06-25
EP1173180A4 (en) 2004-12-01
US7538220B2 (en) 2009-05-26
US20080027224A1 (en) 2008-01-31
WO2000061146A1 (en) 2000-10-19
CA2369270A1 (en) 2000-10-19
WO2000061146A9 (en) 2002-01-03
US20030088101A1 (en) 2003-05-08
KR100717900B1 (ko) 2007-05-14
HK1046374A1 (en) 2003-01-10
KR20010113784A (ko) 2001-12-28

Similar Documents

Publication Publication Date Title
ATE399171T1 (de) Camptothecinanaloge und deren zubereitungsmethoden
NO2020007I1 (no) Sitagliptin, eventuelt i form av et farmasøytisk akseptabelt salt
EP1463515A4 (en) ISOFLAVONAL COMPOSITION FOR ORAL ADMINISTRATION
AP2002002637A0 (en) Novel piperazine
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
EG25822A (en) Quinolinyl-pyrrolopyrazoles
BG103945A (bg) Производни на 4"-заместен-9-деоксо-9а-аза-9а- хомоеритромицин а
NO2014012I1 (no) Oklacitinib, evt. i form av et farmasøytisk akseptabelt salt så som maleat
NO20053106D0 (no) Oral, analgesisk doseringsform med forlenget frigivelse.
NO2013017I2 (no) (a)dekstrometorfan eller et farmasøytisk akseptabelt salt derav, for eksempel dekstrometorfanhydrobromid og (b) quinidin eller etfarmasøytisk akseptabelt salt derav, for eksempel quinidinsulfat
EA200501901A1 (ru) Таблетка с основой, позволяющая осуществлять пролонгированное высвобождение триметазидина после введения оральным путём
UA90518C2 (ru) Фармацевтическая композиция в форме таблетки, которая имеет улучшеное всасывание при трансбукальном введение, которая содержит наркотический активный ингредиент и амин
YU17301A (sh) KRISTALNI OBLICI EtO2C-CH2-(R)-Cgl-Aze-Pab-OH
EP1274443A4 (en) MICELLES
MY140164A (en) Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
GEP20043162B (en) Derivatives of Isosorbid Mononitrate, Utilization as Vasodilator Agents with Reduced Tolerance
SE9802208D0 (sv) Novel compounds
IT1302682B1 (it) Composizioni farmaceutiche orali contenenti buprenorfina
NO20013060D0 (no) Kontrollert frigjörende farmasöytisk preparat med tilidinmesylat som virkestoff
ES2185153T3 (es) Uso de mefloquina(+) para el tratamiento de la malaria.
PT2112154E (pt) Ésteres na posição 20 de camptotecinas
GEP20043227B (en) 5HT1 Antagonists for Antidepressant Therapy
EE05241B1 (et) Distamtsiini a-halogenoakrlolderivaadi kasutamine
SE9802209D0 (sv) Novel compounds
MY133169A (en) Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1173180

Country of ref document: EP

EEFA Change of the company name