ATE397177T1 - Vorrichtungen und verfahren zur programmierbaren mikrohandhabung von fluiden - Google Patents

Vorrichtungen und verfahren zur programmierbaren mikrohandhabung von fluiden

Info

Publication number
ATE397177T1
ATE397177T1 AT03790346T AT03790346T ATE397177T1 AT E397177 T1 ATE397177 T1 AT E397177T1 AT 03790346 T AT03790346 T AT 03790346T AT 03790346 T AT03790346 T AT 03790346T AT E397177 T1 ATE397177 T1 AT E397177T1
Authority
AT
Austria
Prior art keywords
directed
present
fluids
methods
devices
Prior art date
Application number
AT03790346T
Other languages
English (en)
Inventor
Piero Zucchelli
De Vyver Bart Van
Original Assignee
Spinx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spinx Inc filed Critical Spinx Inc
Application granted granted Critical
Publication of ATE397177T1 publication Critical patent/ATE397177T1/de

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/10—Mixers with shaking, oscillating, or vibrating mechanisms with a mixing receptacle rotating alternately in opposite directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/003—Valves for single use only
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F16K99/004—Operating means specially adapted for microvalves operated by temperature variations using radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/058—Microfluidics not provided for in B81B2201/051 - B81B2201/054
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
    • B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
    • B81C2201/019—Bonding or gluing multiple substrate layers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/2886—Laser cutting, e.g. tissue catapult
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/1624—Destructible or deformable element controlled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/1624—Destructible or deformable element controlled
    • Y10T137/1632—Destructible element
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Pathology (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Toxicology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micromachines (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Manipulator (AREA)
AT03790346T 2002-12-04 2003-12-04 Vorrichtungen und verfahren zur programmierbaren mikrohandhabung von fluiden ATE397177T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43079202P 2002-12-04 2002-12-04

Publications (1)

Publication Number Publication Date
ATE397177T1 true ATE397177T1 (de) 2008-06-15

Family

ID=32469532

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03790346T ATE397177T1 (de) 2002-12-04 2003-12-04 Vorrichtungen und verfahren zur programmierbaren mikrohandhabung von fluiden

Country Status (9)

Country Link
US (1) US7152616B2 (de)
EP (2) EP1567796B1 (de)
JP (1) JP2006508790A (de)
CN (3) CN101158695A (de)
AT (1) ATE397177T1 (de)
AU (1) AU2003293399A1 (de)
CA (1) CA2508475C (de)
DE (1) DE60321376D1 (de)
WO (1) WO2004050242A2 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7032608B2 (en) * 2004-09-01 2006-04-25 Harris Corporation Microfluidic check-valve embedded in LCP
US7608042B2 (en) 2004-09-29 2009-10-27 Intellidx, Inc. Blood monitoring system
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
WO2006044841A2 (en) * 2004-10-18 2006-04-27 Applera Corporation Fluid processing device including size-changing barrier
US7822276B2 (en) * 2005-02-17 2010-10-26 Iris International, Inc. Method and apparatus for analyzing body fluids
EP1853697A2 (de) * 2005-03-02 2007-11-14 The Regents Of The University Of California Strömungsschaltung auf einer multistrukturierten mikrofluidischen cd (compact disc) mittels corioliskraft
US7507575B2 (en) * 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
CN101291736B (zh) * 2005-06-03 2011-11-23 斯平克斯公司 用于流体的可编程微量操作的剂量计
US20070009382A1 (en) * 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7527763B2 (en) * 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US7390377B1 (en) * 2005-09-22 2008-06-24 Sandia Corporation Bonding thermoplastic polymers
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US7998433B2 (en) 2006-04-04 2011-08-16 Samsung Electronics Co., Ltd. Valve unit and apparatus having the same
US8092385B2 (en) 2006-05-23 2012-01-10 Intellidx, Inc. Fluid access interface
FR2901489A1 (fr) 2006-05-29 2007-11-30 Debiotech Sa Dispositif microfluidique avec materiau de volume variable
KR100763924B1 (ko) * 2006-08-16 2007-10-05 삼성전자주식회사 밸브 유닛, 이를 구비한 반응 장치 및, 채널에 밸브를형성하는 방법
US8464760B2 (en) * 2006-08-16 2013-06-18 Samsung Electronic Co., Ltd. Valve unit, reaction apparatus with the same, and method of forming valve in channel
KR100851980B1 (ko) * 2006-09-05 2008-08-12 삼성전자주식회사 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
EP1916524A1 (de) * 2006-09-27 2008-04-30 Roche Diagnostics GmbH Rotierbares Testelement
KR100846501B1 (ko) 2006-11-09 2008-07-17 삼성전자주식회사 밸브 유닛 및 이를 구비한 유체 처리 장치
KR100818290B1 (ko) * 2006-12-11 2008-03-31 삼성전자주식회사 성분 분리 장치 및 성분 분리 방법
US8307988B2 (en) * 2006-12-11 2012-11-13 Samsung Electronics Co., Ltd. Apparatus and method for separating components
US7857141B2 (en) * 2006-12-11 2010-12-28 Samsung Electronics Co., Ltd. Apparatus and method for separating components
KR20090105934A (ko) * 2006-12-22 2009-10-07 쓰리엠 이노베이티브 프로퍼티즈 컴파니 향상된 샘플 처리 장치, 시스템 및 방법
AU2007336774A1 (en) 2006-12-22 2008-07-03 3M Innovative Properties Company Thermal transfer methods and structures for microfluidic systems
CN101568754B (zh) * 2006-12-28 2011-05-25 株式会社富士金 带入口节流槽的微小流量控制装置的设计方法
KR101258434B1 (ko) * 2007-05-03 2013-05-02 삼성전자주식회사 미세유동 시스템 및,이의 제조방법
KR20080107212A (ko) * 2007-06-05 2008-12-10 삼성전자주식회사 유체 컨테이너를 구비한 미세유동 장치
KR101391736B1 (ko) 2007-08-07 2014-05-07 삼성전자주식회사 미세유동 밸브, 상기 미세유동 밸브의 제조 방법 및 상기미세유동 밸브를 포함하는 미세유동 장치
JP2009069011A (ja) * 2007-09-13 2009-04-02 Sony Corp 反応制御装置及び反応制御方法
CN101873885B (zh) * 2007-11-22 2013-07-31 三星电子株式会社 薄膜阀器件及其控制装置
WO2009112030A1 (en) * 2008-03-12 2009-09-17 Fluimedix Aps Controlled liquid handling
CN102046807B (zh) * 2008-04-24 2014-11-26 3M创新有限公司 利用小波变换分析核酸扩增曲线
WO2009150549A2 (en) * 2008-06-13 2009-12-17 Spinx, Inc. Microfluidic devices and methods for proteins crystallization and in situ x-ray diffraction
US9879360B2 (en) * 2008-06-20 2018-01-30 International Business Machines Corporation Microfluidic selection of library elements
JP2010071675A (ja) * 2008-09-16 2010-04-02 Yuichi Uchiumi 微小化学システム及び微小化学システム装置
US8151482B2 (en) * 2008-11-25 2012-04-10 William H Moss Two-stage static dryer for converting organic waste to solid fuel
US9057568B2 (en) * 2008-12-16 2015-06-16 California Institute Of Technology Temperature control devices and methods
GB2467298A (en) * 2009-01-23 2010-07-28 Univ Dublin City Multilayer microfluidic device
GB2468111A (en) * 2009-02-23 2010-08-25 Univ Dublin City Multilayer Fluidic Device
US8753290B2 (en) 2009-03-27 2014-06-17 Intellectual Inspiration, Llc Fluid transfer system and method
US20100282766A1 (en) * 2009-05-06 2010-11-11 Heiko Arndt Low-Dead Volume Microfluidic Component and Method
US8230744B2 (en) 2009-05-06 2012-07-31 Cequr Sa Low-dead volume microfluidic circuit and methods
WO2011026315A1 (en) * 2009-09-02 2011-03-10 The Hong Kong University Of Science And Technology Method of producing spatially variable pretilt angles across a liquid crystal cell
KR101532314B1 (ko) * 2009-10-27 2015-06-29 삼성전자주식회사 미세 유체 소자의 품질 관리 방법 및 품질 관리 장치
JP2013509578A (ja) 2009-10-30 2013-03-14 スピンクス インコーポレイテッド 異種アッセイの洗浄方法及び装置としてのサイフォン吸引
US8980550B2 (en) 2009-12-15 2015-03-17 California Institute Of Technology Methods for measuring samples using consumer electronic devices and systems
US20110244581A1 (en) * 2010-03-31 2011-10-06 Abbott Point Of Care, Inc. Biologic fluid analysis system with sample motion
JP2012098272A (ja) * 2010-08-23 2012-05-24 Nsk Ltd 標的物質濃度測定装置および標的物質濃度測定方法
CN101949377A (zh) * 2010-09-17 2011-01-19 大连理工大学 一种薄膜式仿生微流控液体驱动泵
WO2012069925A1 (en) 2010-11-23 2012-05-31 Andrew Alliance S.A Devices and methods for programmable manipulation of pipettes
US9233369B2 (en) 2010-12-23 2016-01-12 California Institute Of Technology Fluidic devices and fabrication methods for microfluidics
US8968585B2 (en) 2010-12-23 2015-03-03 California Institute Of Technology Methods of fabrication of cartridges for biological analysis
US8808516B2 (en) * 2011-03-04 2014-08-19 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for long-term intracellular access
US9856448B2 (en) 2011-03-04 2018-01-02 The Board Of Trustees Of The Leland Stanford Junior Univesity Devices and methods for long-term intracellular access
CA3043100C (en) 2011-03-08 2022-03-01 Universite Laval Fluidic centripetal device
US9266725B2 (en) 2011-04-27 2016-02-23 The Board Of Trustees Of The Leland Stanford Junior University Nanotube structures, methods of making nanotube structures, and methods of accessing intracellular space
AU2012255144B2 (en) 2011-05-18 2015-01-29 Diasorin Italia S.P.A. Systems and methods for volumetric metering on a sample processing device
CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的系统和方法
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
JP5974429B2 (ja) 2011-07-20 2016-08-23 ソニー株式会社 複合材料構造物及びその製造方法
EP2751540A4 (de) 2011-08-30 2015-05-20 Nat Res Council Canada Zentrifugal verstärktes erfassungsverfahren und vorrichtung dafür
US8883088B2 (en) 2011-12-23 2014-11-11 California Institute Of Technology Sample preparation devices and systems
US9090890B2 (en) 2011-12-23 2015-07-28 California Institute Of Technology Devices and methods for biological sample preparation
US9518291B2 (en) 2011-12-23 2016-12-13 California Institute Of Technology Devices and methods for biological sample-to-answer and analysis
US9090891B2 (en) 2011-12-23 2015-07-28 California Institute Of Technology Pen-shaped device for biological sample preparation and analysis
CN104685344B (zh) 2012-08-03 2017-07-28 加州理工学院 用于化学分析和生物化学分析的光学技术
KR101815031B1 (ko) * 2012-09-28 2018-01-08 고쿠리츠켄큐카이하츠호진 카가쿠기쥬츠신코키코 기능성 디바이스 및 기능성 디바이스의 제조 방법
WO2014071259A1 (en) * 2012-11-05 2014-05-08 California Institute Of Technology Methods of fabrication of cartridges for biological analysis
US9284520B2 (en) 2012-11-05 2016-03-15 California Institute Of Technology Instruments for biological sample preparation devices
JP6498125B2 (ja) * 2012-12-21 2019-04-10 マイクロニクス， インコーポレイテッド 流体回路および関連する製造方法
EP2972219B1 (de) * 2013-03-15 2022-01-19 Abbott Laboratories Automatisierter reagensmanager eines diagnostischen analysatorsystems
JP6098315B2 (ja) * 2013-04-15 2017-03-22 株式会社島津製作所 光または放射線測定用容器並びに測定システム
WO2015010071A1 (en) * 2013-07-19 2015-01-22 Saint-Gobain Performance Plastics Corporation Reciprocating fluid agitator
CN103394382A (zh) * 2013-08-07 2013-11-20 苏州扬清芯片科技有限公司 一种具有滤光特性的微流控芯片
CN103387683A (zh) * 2013-08-07 2013-11-13 苏州扬清芯片科技有限公司 一种感温性聚二甲基硅氧烷薄膜的制备方法
CN103399419A (zh) * 2013-08-07 2013-11-20 苏州扬清芯片科技有限公司 一种温控型滤光器件
CN103389171A (zh) * 2013-08-07 2013-11-13 苏州扬清芯片科技有限公司 一种具有感温特性的微流控芯片
AU2015225844B2 (en) 2014-03-07 2019-10-24 National Research Council Of Canada Centrifugal microfluidic chip control
JP6600861B2 (ja) * 2015-04-08 2019-11-06 株式会社パートナーファーム 固相反応チップ及びこれを用いた測定方法
CN114540192A (zh) * 2015-08-26 2022-05-27 仿真股份有限公司 灌注歧管组件
WO2017066485A1 (en) 2015-10-13 2017-04-20 Landers James P Devices and methods for extraction, separation and thermocycling
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
KR20190019129A (ko) 2016-06-09 2019-02-26 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 개선된 세포 트랜스펙션 및 생존율을 위한 나노스트로 웰 인서트 디바이스
KR102429636B1 (ko) * 2016-06-27 2022-08-05 조에티스 서비시즈 엘엘씨 수정된 도관을 갖는 장치
CN107583675B (zh) * 2016-07-06 2023-04-14 广州好芝生物科技有限公司 一种流控机构及含有该机构的系统
WO2018053020A1 (en) 2016-09-13 2018-03-22 The Board Of Trustees Of The Leland Stanford Junior University Methods of non-destructive nanostraw intracellular sampling for longitudinal cell monitoring
GB201622024D0 (en) * 2016-11-14 2017-02-08 Inventage Lab Inc Apparatus and method for large scale production of monodisperse, microsheric and biodegradable polymer-based drug delivery
RU170307U1 (ru) * 2016-12-05 2017-04-20 Общество с ограниченной ответственностью "Химпродукт" Устройство для приготовления раствора коагулянта путем циркуляции раствора с помощью насоса
WO2018112786A1 (zh) * 2016-12-21 2018-06-28 无锡源清天木生物科技有限公司 一种用于微流控制的液体流量控制装置和微流控制方法
CN107051598B (zh) * 2017-03-20 2019-12-06 上海交通大学 Pcr微流控芯片和其制备与使用方法以及pcr设备
SG11202001029WA (en) 2017-07-19 2020-03-30 Univ Leland Stanford Junior Apparatuses and methods using nanostraws to deliver biologically relevant cargo into non-adherent cells
CN107524919B (zh) * 2017-08-16 2019-09-17 朱伟明 管道流体流速增速方法及管道流体输送系统
CN108671971A (zh) * 2018-05-11 2018-10-19 北京科技大学 一种循环肿瘤细胞及团簇阴性分离的微流控装置和方法
WO2019240959A1 (en) * 2018-06-16 2019-12-19 Sandstone Diagnostics, Inc. Device and method of imaging fluidic samples
US11369958B2 (en) * 2018-08-24 2022-06-28 Zoetis Services Llc Microfluidic rotor device
JP2022504858A (ja) 2018-10-16 2022-01-13 クリプトス バイオテクノロジーズ，インコーポレイテッド 生化学反応容器の温度監視のための方法およびシステム
CN111330655A (zh) * 2018-12-18 2020-06-26 深圳先进技术研究院 用于脂质化合物检测的微流控芯片和脂质化合物的检测方法
CN111889027A (zh) * 2019-05-05 2020-11-06 微纳芯 (苏州)科技有限公司 一种滴落试剂制备小球的方法及设备
CN110705007B (zh) * 2019-08-16 2021-03-26 北京航空航天大学 一种等离子体涡旋发生器的效率评估方法
CN111024768B (zh) * 2019-11-25 2025-04-18 中国计量大学 一种微流控阻抗式生物在线检测装置
US11761888B2 (en) * 2020-01-09 2023-09-19 Government Of The United States Of America, As Represented By The Secretary Of Commerce Infrared thermal desorber and performing infrared thermal desorption
CN111378578A (zh) * 2020-03-23 2020-07-07 广州再生医学与健康广东省实验室 一种细胞培养用的气体限流器
CN112324929A (zh) * 2020-10-09 2021-02-05 东南大学 一种光圈式微流控流量调节器
CN112275336B (zh) * 2020-10-20 2021-11-19 大连理工大学 一种多通道集成微流控芯片及其高通量制备单分散凝胶微球的方法
CN113009167B (zh) * 2021-02-23 2022-06-24 山东美毅生物技术有限公司 一种可实现液体精准控制吸入排出的显微操作装置
WO2022191830A1 (en) * 2021-03-10 2022-09-15 Hewlett-Packard Development Company, L.P. Destructible microfluidic valves
US20230012094A1 (en) * 2021-07-07 2023-01-12 Siphox, Inc. Systems and methods for fluid sensing using passive flow
EP4124385A1 (de) * 2021-07-26 2023-02-01 Helaxy Inc. Anordnung und verfahren zur kombinierten reinigung und amplifikation von nukleinsäuren
CN113952993B (zh) * 2021-11-23 2022-09-20 中北大学 集成微混合器与Tesla阀的多级惯性微流控血样处理芯片
CN114370711B (zh) * 2021-12-29 2023-01-20 华北电力大学 一种相变材料层辅助的特斯拉阀型流道光伏光热组件
JP7832592B2 (ja) * 2022-04-18 2026-03-18 株式会社島津製作所 移動相送液システム及び移動相送液方法
CN115518698B (zh) * 2022-08-22 2025-03-14 深圳市卓润生物科技有限公司 微流控芯片
TWI832456B (zh) * 2022-09-29 2024-02-11 梭特科技股份有限公司 高親水性的測量方法
CN115899339B (zh) * 2023-03-10 2023-05-26 成都凯天电子股份有限公司 一种反拱型光纤爆破片
AU2024334367A1 (en) * 2023-09-01 2026-03-12 Flo Optics Ltd. Method and system for producing tinted optical coatings
WO2025083614A1 (en) * 2023-10-19 2025-04-24 Vital Biosciences Inc. Devices, systems, and methods for optical analysis of biological samples
CN119657246B (zh) * 2024-12-31 2025-11-04 中北大学 一种基于声学微流控的生物微粒自旋排列装置及方法
CN119746762B (zh) * 2025-01-14 2025-10-10 西北大学 一种基于激光辐照的哑铃形纳米材料可控制备装置及方法

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736432A (en) * 1971-03-22 1973-05-29 Varian Associates Bacterial colony counting method and apparatus
US4248346A (en) * 1979-01-29 1981-02-03 Fluoroware, Inc. Shipping container for semiconductor substrate wafers
US4276048A (en) * 1979-06-14 1981-06-30 Dynatech Ag Miniature reaction container and a method and apparatus for introducing micro volumes of liquid to such a container
US5278048A (en) * 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
US5160702A (en) 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
CA2028829A1 (en) 1989-03-07 1990-09-08 Minoru Takase Analyzer of liquid sample and analyzing method of liquid sample using said analyzer
JPH02269938A (ja) 1989-04-11 1990-11-05 Idemitsu Petrochem Co Ltd 分析装置
JP2754747B2 (ja) * 1989-06-19 1998-05-20 ソニー株式会社 基板収納容器
GB2249492B (en) 1989-12-13 1993-10-13 Imperial College Crystallisation of materials
US5858188A (en) * 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
DE59105165D1 (de) * 1990-11-01 1995-05-18 Ciba Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse.
DE59108006D1 (de) * 1991-01-28 1996-08-22 Ciba Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
WO1993007311A1 (en) 1991-10-09 1993-04-15 Schering Corporation Crystal forming device and automated crystallization system
US5583838A (en) * 1992-03-12 1996-12-10 Mitsubishi Denki Kabushiki Kaisha Recording apparatus having data recording rate phase-synchronized to recording time data recorded on a recording medium
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
CA2155186A1 (en) * 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US6309601B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
US6287517B1 (en) * 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
JP3403233B2 (ja) * 1994-01-20 2003-05-06 テルモ株式会社 バルーンカテーテル
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5789251A (en) * 1994-06-16 1998-08-04 Astle; Thomas W. Multi-well bioassay tray with evaporation protection and method of use
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US6327031B1 (en) 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
DE69533554T2 (de) 1994-11-10 2005-01-27 Orchid Biosciences, Inc. Flüssigkeitsverteilungssystem
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US6048734A (en) * 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
AU702403B2 (en) * 1995-12-05 1999-02-18 Gamera Bioscience Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6709869B2 (en) * 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
FR2744803B1 (fr) * 1996-02-12 1998-03-13 Bio Merieux Procede et dispositif de traitement d'une carte d'analyse
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
CN1329729C (zh) * 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US5882903A (en) * 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
US6447727B1 (en) * 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
CN1249816A (zh) 1997-02-28 2000-04-05 伯斯坦恩实验室股份有限公司 盘片中的实验室
US5911737A (en) * 1997-02-28 1999-06-15 The Regents Of The University Of California Microfabricated therapeutic actuators
WO1998049548A1 (en) * 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
DE19721104A1 (de) * 1997-05-20 1998-11-26 Sympatec Gmbh Verfahren und Vorrichtung zur Probenahme aus dispersen Stoffströmen
WO1998053311A2 (en) * 1997-05-23 1998-11-26 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US5851346A (en) * 1997-05-29 1998-12-22 Beckman Instruments, Inc. Apparatus for sealing containers
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5882465A (en) * 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US5959291A (en) * 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
AU1517999A (en) 1997-10-15 1999-05-03 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US5958694A (en) * 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6857449B1 (en) * 1998-01-20 2005-02-22 Caliper Life Sciences, Inc. Multi-layer microfluidic devices
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6756019B1 (en) * 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6100541A (en) * 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6131410A (en) * 1998-03-16 2000-10-17 The Regents Of The University Of California Vacuum fusion bonding of glass plates
US6123798A (en) * 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
GB9809943D0 (en) 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6306590B1 (en) * 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6039804A (en) * 1998-09-09 2000-03-21 Emerald Biostructures, Inc. Crystallization tray
US6231721B1 (en) * 1998-10-09 2001-05-15 Weyerhaeuser Company Compressible wood pulp product
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6086740A (en) * 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6062261A (en) * 1998-12-16 2000-05-16 Lockheed Martin Energy Research Corporation MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
DE19858443A1 (de) * 1998-12-17 2000-07-06 Inst Mikrotechnik Mainz Gmbh Verfahren zum Abgeben eines Fluids, fluidisches Bauteil sowie Vorrichtung zur Handhabung solcher Bauteile
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6334301B1 (en) * 1999-02-25 2002-01-01 Vacco Industries, Inc. Assembly of etched sheets forming a fluidic module
US6322683B1 (en) * 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7601270B1 (en) 1999-06-28 2009-10-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
SE9902474D0 (sv) * 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
US6340589B1 (en) * 1999-07-23 2002-01-22 Mj Research, Inc. Thin-well microplate and methods of making same
SE9903011D0 (sv) * 1999-08-26 1999-08-26 Aamic Ab Sätt att framställa en plastprodukt och ett härför utnyttjat plastproduktformande arrangemang
WO2001017797A1 (en) * 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
GB2355717A (en) * 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US6521451B2 (en) * 1999-12-09 2003-02-18 California Institute Of Technology Sealed culture chamber
US6884395B2 (en) * 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
EP1246698B1 (de) * 2000-01-06 2006-09-20 Caliper Life Sciences, Inc. Vorrichtungen und verfahren für hochdurchsatz-probenentnahme und analyse
EP1259324A2 (de) * 2000-02-18 2002-11-27 Aclara BioSciences, Inc. Mehrstellige reaktionsvorrichtung und zugehöriges verfahren
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
WO2001075415A2 (en) * 2000-03-31 2001-10-11 Micronics, Inc. Protein crystallization in microfluidic structures
US6368402B2 (en) * 2000-04-21 2002-04-09 Hauptman-Woodward Medical Research Institute, Inc. Method for growing crystals
WO2001087487A2 (en) 2000-05-15 2001-11-22 Tecan Trading Ag Bidirectional flow centrifugal microfluidic devices
EP1284819A2 (de) 2000-05-15 2003-02-26 Tecan Trading AG Mikrofluidische vorrichtungen und verfahren für hochdurchsatzscreening (hts)
JP2003533361A (ja) * 2000-05-15 2003-11-11 テカン・トレーディング・アクチェンゲゼルシャフト ミクロ流体構造での蒸着相似コーティングの使用
WO2002001081A2 (en) 2000-06-23 2002-01-03 Micronics, Inc. Valve for use in microfluidic structures
US7062418B2 (en) 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
US6885982B2 (en) * 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
US6615856B2 (en) * 2000-08-04 2003-09-09 Biomicro Systems, Inc. Remote valving for microfluidic flow control
USD463031S1 (en) * 2000-10-11 2002-09-17 Aclara Biosciences, Inc. Microvolume sample plate
DE20100345U1 (de) 2001-01-09 2002-05-23 EVOTEC BioSystems AG, 22525 Hamburg Probenträger
WO2002060754A1 (en) * 2001-01-29 2002-08-08 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
CA2440785A1 (en) 2001-04-10 2002-10-24 Bioprocessors Corporation Microfermentor device and cell based screening method
SE0104077D0 (sv) 2001-10-21 2001-12-05 Gyros Ab A method and instrumentation for micro dispensation of droplets
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications

Also Published As

Publication number Publication date
CA2508475C (en) 2011-08-30
EP1567796B1 (de) 2008-05-28
CN101158447A (zh) 2008-04-09
EP1567796A4 (de) 2006-06-28
CN101158447B (zh) 2012-12-26
AU2003293399A1 (en) 2004-06-23
EP2096341A1 (de) 2009-09-02
WO2004050242A3 (en) 2004-08-05
WO2004050242A2 (en) 2004-06-17
EP1567796A2 (de) 2005-08-31
HK1115181A1 (en) 2008-11-21
AU2003293399A8 (en) 2004-06-23
CA2508475A1 (en) 2004-06-17
CN100380034C (zh) 2008-04-09
JP2006508790A (ja) 2006-03-16
US20050109396A1 (en) 2005-05-26
US7152616B2 (en) 2006-12-26
CN1745264A (zh) 2006-03-08
CN101158695A (zh) 2008-04-09
DE60321376D1 (de) 2008-07-10

Similar Documents

Publication Publication Date Title
ATE397177T1 (de) Vorrichtungen und verfahren zur programmierbaren mikrohandhabung von fluiden
WO2007057788A3 (en) Dosimeter for programmable microscale manipulation of fluids
Yu et al. Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers
DE60012562D1 (de) Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
EP3779257A4 (de) Zur steuerung des durchflusses eines fluids fähiges, multifunktionales mikroventil, mikrofluidischer chip und verfahren
ATE357283T1 (de) Mehrstufige vorrichtung und verfahren zur trennung von fluiden
EP1623227A4 (de) Proteine, sensoren und verfahren zur charakterisierung von analyten damit
WO2004058406A3 (en) Microfluidics devices and methods for diluting samples and reagents
CN112672697B (zh) 用于创建细胞处理协议的系统和方法
WO2007111651A3 (en) Systems and methods of sample processing and fluid control in a fluidic system
DE602005000643D1 (de) Kühlmittelvolumenstromregelungsverfahren und Vorrichtung
DE60236427D1 (de) Verfahren und vorrichtung zum zugreifen auf abgezielten personalisierten sprach-/audio-web-inhalt durch drahtlose einrichtungen
DE50212473D1 (de) Verfahren zur eliminierung von potentiell toxischen und/oder schädlichen stoffen
DE10391476D2 (de) Verfahren und Vorrichtung zum Auftragen von Fluiden
DE60302575D1 (de) Verfahren zur entfernung von bohrklein aus bohrlöchern und bohrflüssigkeiten
ATE428481T1 (de) Filtervorrichtung
WO2001070381A3 (en) Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
DE60210773D1 (de) Verfahren und Gerät für Überwachung von Steuerventilen
WO2001087485A3 (en) Microfluidics devices and methods for high throughput screening
NO20052273L (no) Fremgangsmate og system for kontroll av fluidstromning
DE60302076D1 (de) Verbindungsvorrichtung mit variabler Kapazität und Verfahren zum Einstellen von Verbindungen variabler Kapazität
EP1930635A3 (de) Vorrichtungen und Verfahren zur programmierbaren Mikrohandhabung von Fluiden
EP4283855C0 (de) Phasenverschobener vollbrückenwandler, steuerungsverfahren und vorrichtung dafür und medium
IL169156A0 (en) Flow control method for clustering fluid and flow control device for clustering fluid
EP3597297C0 (de) Vorrichtung zum sammeln von flüssigen proben und zum gewinnen von partikeln, sowie mikrofluidischer chip

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1567796

Country of ref document: EP