ATE395412T1 - Kontrolle der selbsterneuerung embryonaler stammzellen, deren differenzierung und kulturmedium dafür - Google Patents

Kontrolle der selbsterneuerung embryonaler stammzellen, deren differenzierung und kulturmedium dafür

Info

Publication number
ATE395412T1
ATE395412T1 AT03725376T AT03725376T ATE395412T1 AT E395412 T1 ATE395412 T1 AT E395412T1 AT 03725376 T AT03725376 T AT 03725376T AT 03725376 T AT03725376 T AT 03725376T AT E395412 T1 ATE395412 T1 AT E395412T1
Authority
AT
Austria
Prior art keywords
renewal
self
differentiation
control
stem cells
Prior art date
Application number
AT03725376T
Other languages
English (en)
Inventor
Austin Smith
Qi-Long Ying
Original Assignee
Univ Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Edinburgh filed Critical Univ Edinburgh
Application granted granted Critical
Publication of ATE395412T1 publication Critical patent/ATE395412T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03725376T 2002-05-08 2003-05-08 Kontrolle der selbsterneuerung embryonaler stammzellen, deren differenzierung und kulturmedium dafür ATE395412T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0210539.3A GB0210539D0 (en) 2002-05-08 2002-05-08 Control of es cell self renewal and lineage specification, and medium therefor

Publications (1)

Publication Number Publication Date
ATE395412T1 true ATE395412T1 (de) 2008-05-15

Family

ID=9936286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03725376T ATE395412T1 (de) 2002-05-08 2003-05-08 Kontrolle der selbsterneuerung embryonaler stammzellen, deren differenzierung und kulturmedium dafür

Country Status (15)

Country Link
US (2) US20050221478A1 (de)
EP (1) EP1504086B1 (de)
JP (2) JP4185489B2 (de)
CN (1) CN1659273A (de)
AT (1) ATE395412T1 (de)
AU (1) AU2003227912B8 (de)
CA (1) CA2484701A1 (de)
DE (1) DE60320977D1 (de)
DK (1) DK1504086T3 (de)
ES (1) ES2305460T3 (de)
GB (1) GB0210539D0 (de)
IL (1) IL165062A (de)
NZ (1) NZ536580A (de)
RU (1) RU2342427C2 (de)
WO (1) WO2003095628A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210539D0 (en) * 2002-05-08 2002-06-19 Univ Edinburgh Control of es cell self renewal and lineage specification, and medium therefor
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
AU2015200780B2 (en) * 2003-12-23 2017-03-02 Viacyte, Inc. Definitive endoderm
WO2005080598A1 (ja) 2004-02-19 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. 体細胞核初期化物質のスクリーニング方法
EP3354723B1 (de) 2005-08-29 2023-12-13 Technion Research & Development Foundation Ltd. Medien zur züchtung von stammzellen
GB0615327D0 (en) 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
WO2007113505A2 (en) 2006-03-30 2007-10-11 The University Court Of The University Of Edinburgh Culture medium containing kinase inhibitors. and uses thereof
EP2733203B1 (de) 2006-08-02 2018-10-10 Technion Research & Development Foundation Ltd. Verfahren zur Expansion embryonaler Stammzellen in einer Suspensionskultur
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
KR101617243B1 (ko) 2007-07-31 2016-05-02 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
KR101679082B1 (ko) 2008-03-17 2016-11-23 더 스크립스 리서치 인스티튜트 유도 만능 줄기 세포 생성을 위한 화학적 및 유전적 조합 접근법
PL2310492T3 (pl) 2008-06-30 2015-12-31 Janssen Biotech Inc Różnocowanie pluripotencjalnych komórek macierzystych
CN102317442B (zh) * 2008-12-17 2014-08-13 斯克里普斯研究所 干细胞的产生和保持
US20120122212A1 (en) * 2009-03-06 2012-05-17 Marica Grskovic Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells
CN113621576A (zh) 2009-10-16 2021-11-09 斯克里普斯研究所 多能细胞的诱导
EP2551343B1 (de) * 2010-03-23 2018-05-02 Olympus Corporation Verfahren zur überwachung des differenzierungsstatus einer stammzelle
JP5909482B2 (ja) 2010-03-31 2016-04-26 ザ スクリプス リサーチ インスティテュート 細胞の再プログラム
EP4438734A2 (de) 2010-06-14 2024-10-02 The Scripps Research Institute Neuprogrammierung von zellen in ein neues fett
JP6182456B2 (ja) 2010-12-22 2017-08-23 フェイト セラピューティクス，インコーポレイテッド 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強
SG11201405052RA (en) * 2012-03-07 2014-10-30 Janssen Biotech Inc Defined media for expansion and maintenance of pluripotent stem cells
KR20240091064A (ko) 2014-03-04 2024-06-21 페이트 세러퓨틱스, 인코포레이티드 개선된 재프로그래밍 방법 및 세포 배양 플랫폼
CN117737124A (zh) 2015-10-16 2024-03-22 菲特治疗公司 用于诱导和维护基态多能性的平台
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
CN108359638B (zh) * 2018-04-04 2020-02-14 浙江霍德生物工程有限公司 功能大脑皮层细胞的诱导分化方法
CN111574593B (zh) * 2020-05-28 2022-05-24 澳门大学 一种基于毒液的肽及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2898064B2 (ja) * 1989-08-03 1999-05-31 忠三 岸本 ヒトｇｐ１３０蛋白質
RU2164240C2 (ru) * 1990-12-17 2001-03-20 Риджентс оф дзе Юниверсити оф Мичиган Способ культивирования, фибробласт, способ отделения клеток
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
JP2001517927A (ja) * 1996-02-28 2001-10-09 バンダービルト ユニバーシティ 胚幹細胞を作製する組成物および方法
DE19632532A1 (de) * 1996-08-13 1998-02-19 Boehringer Ingelheim Int Verfahren zur Herstellung von Säugetieren mit definierten genetischen Eigenschaften
US6750376B1 (en) * 1997-02-05 2004-06-15 Utah State University Methods for producing apomictic plants
AU4346401A (en) * 2000-03-09 2001-09-17 Cryo Cell Int Human cord blood as a source of neural tissue for repair of the brain and spinalcord
AU2001293586A1 (en) * 2000-09-29 2002-04-08 Vincent Tropepe Primitive neural stem cells and method for differentiation of stem cells to neural cells
EP2292734A1 (de) * 2001-12-07 2011-03-09 Geron Corporation Hämatopoietische Zellen aus menschlichen Embryostammzellen
GB0210539D0 (en) * 2002-05-08 2002-06-19 Univ Edinburgh Control of es cell self renewal and lineage specification, and medium therefor

Also Published As

Publication number Publication date
DE60320977D1 (de) 2008-06-26
WO2003095628A3 (en) 2004-03-18
AU2003227912B2 (en) 2006-11-16
IL165062A0 (en) 2005-12-18
EP1504086A2 (de) 2005-02-09
GB0210539D0 (en) 2002-06-19
RU2342427C2 (ru) 2008-12-27
EP1504086B1 (de) 2008-05-14
AU2003227912B8 (en) 2009-07-02
RU2004135816A (ru) 2005-06-27
US20050221478A1 (en) 2005-10-06
DK1504086T3 (da) 2008-08-25
AU2003227912A1 (en) 2003-11-11
JP4185489B2 (ja) 2008-11-26
CA2484701A1 (en) 2003-11-20
ES2305460T3 (es) 2008-11-01
CN1659273A (zh) 2005-08-24
JP2005524411A (ja) 2005-08-18
NZ536580A (en) 2006-03-31
US20080145936A1 (en) 2008-06-19
WO2003095628A2 (en) 2003-11-20
IL165062A (en) 2010-12-30
JP2008228742A (ja) 2008-10-02

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