ATE395137T1 - Individuell addressierbarer mikro- elektromagnetischer einheitsmatrix-chip - Google Patents

Individuell addressierbarer mikro- elektromagnetischer einheitsmatrix-chip

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Publication number
ATE395137T1
ATE395137T1 AT99973783T AT99973783T ATE395137T1 AT E395137 T1 ATE395137 T1 AT E395137T1 AT 99973783 T AT99973783 T AT 99973783T AT 99973783 T AT99973783 T AT 99973783T AT E395137 T1 ATE395137 T1 AT E395137T1
Authority
AT
Austria
Prior art keywords
electromagnetic
micro
chips
individually addressable
biomolecules
Prior art date
Application number
AT99973783T
Other languages
English (en)
Inventor
Xiaoshan Zhu
Yuxiang Zhou
Litian Liu
Ken Chen
Depu Chen
Jia Wang
Zewen Liu
Zhimin Tan
Junquan Xu
Xuezhong He
Wenzhang Xie
Zhiming Li
Xiumei Liu
Original Assignee
Aviva Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aviva Biosciences Corp filed Critical Aviva Biosciences Corp
Application granted granted Critical
Publication of ATE395137T1 publication Critical patent/ATE395137T1/de

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
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    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/0061—The surface being organic
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
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    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/0627—Sensor or part of a sensor is integrated
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Control Of El Displays (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Led Device Packages (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
AT99973783T 1999-03-15 1999-09-17 Individuell addressierbarer mikro- elektromagnetischer einheitsmatrix-chip ATE395137T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN99104113 1999-03-15
CN99120320.8A CN1185492C (zh) 1999-03-15 1999-09-16 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用

Publications (1)

Publication Number Publication Date
ATE395137T1 true ATE395137T1 (de) 2008-05-15

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Application Number Title Priority Date Filing Date
AT99973783T ATE395137T1 (de) 1999-03-15 1999-09-17 Individuell addressierbarer mikro- elektromagnetischer einheitsmatrix-chip

Country Status (10)

Country Link
US (2) US6355491B1 (de)
EP (1) EP1207959B1 (de)
JP (1) JP2003521674A (de)
CN (1) CN1185492C (de)
AT (1) ATE395137T1 (de)
AU (1) AU6045799A (de)
CA (1) CA2367698C (de)
DE (1) DE69938742D1 (de)
IL (1) IL145459A (de)
WO (1) WO2000054882A1 (de)

Families Citing this family (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE366418T1 (de) 1996-04-25 2007-07-15 Bioarray Solutions Ltd Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen
US20030104481A1 (en) * 1997-09-30 2003-06-05 Symyx Technologies Potential masking systems and methods for combinatorial library synthesis
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
DE59801410D1 (de) * 1997-12-17 2001-10-11 Ecole Polytech Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6587408B1 (en) * 1998-10-01 2003-07-01 Massachusetts Institute Of Technology High-density mechanical memory and turing machine
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
CN1185492C (zh) * 1999-03-15 2005-01-19 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
CN1181337C (zh) * 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US20010031467A1 (en) * 1999-12-10 2001-10-18 Johannes Dapprich Method for selectively isolating a nucleic acid
WO2001055701A1 (en) * 2000-01-31 2001-08-02 Board Of Regents, The University Of Texas System System and method for the analysis of bodily fluids
CA2399027C (en) * 2000-01-31 2010-06-22 Joel S. Rossier Method for fabricating micro-structures with various surface properties in multilayer body by plasma etching
AU2001247478A1 (en) 2000-03-16 2001-09-24 Sri International Microlaboratory devices and methods
US7682837B2 (en) * 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
DE60117556T2 (de) * 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
CN1137999C (zh) * 2000-07-04 2004-02-11 清华大学 集成式微阵列装置
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
AU2001282785A1 (en) * 2000-08-23 2002-03-04 Imego Ab A sample collecting arrangement and a method
US20020048821A1 (en) 2000-08-24 2002-04-25 David Storek Sample preparing arrangement and a method relating to such an arrangement
US7998746B2 (en) * 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
US6613285B1 (en) * 2000-09-25 2003-09-02 General Electric Company Reactor plate and method
ATE349011T1 (de) * 2000-10-03 2007-01-15 Minerva Biotechnologies Corp Magnetisches in situ dilutionsverfahren
ATE537264T1 (de) * 2000-10-03 2011-12-15 Mirari Biosciences Inc Verfahren und zusammensetzungen für die gerichtete mikrowellenchemiie
US20040209303A1 (en) 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
CA2424312A1 (en) * 2000-10-10 2002-04-18 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations
AU2001297014A1 (en) * 2000-10-10 2002-04-22 Aviva Biosciences Corporation An integrated biochip system for sample preparation and analysis
DE60138130D1 (de) * 2000-11-01 2009-05-07 Minerva Biotechnologies Corp Proteomanalyse verfahren zum drogen vergleich
US6623984B1 (en) * 2000-11-01 2003-09-23 The Cleveland Clinic Foundation MEMS-based integrated magnetic particle identification system
US20020123112A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for increasing detection sensitivity in optical dielectric sorting systems
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US20020121443A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for the combined electrical and optical identification, characterization and/or sorting of particles
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
FR2817266B1 (fr) * 2000-11-29 2004-01-16 Commissariat Energie Atomique Micro reseau statique de sondes biologiques ou chimiques, immobilisees sur un support par attraction magnetique
WO2002052045A1 (en) * 2000-12-26 2002-07-04 Aviva Biosciences Active and biocompatible platforms prepared by polymerization of surface coating films
US7015047B2 (en) 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US7811768B2 (en) 2001-01-26 2010-10-12 Aviva Biosciences Corporation Microdevice containing photorecognizable coding patterns and methods of using and producing the same
WO2002061392A2 (en) * 2001-01-31 2002-08-08 Board Of Regents, The University Of Texas System Method and apparatus for the confinement of materials in a micromachined chemical sensor array
US7407746B2 (en) 2001-02-08 2008-08-05 Ngk Insulators, Ltd. Biochip and method for producing the same
CN100409010C (zh) * 2001-02-23 2008-08-06 清华大学 微加工制作的二维光学编码器及应用
CN100458427C (zh) * 2001-02-28 2009-02-04 清华大学 生物芯片及检测生物样品的方法
CN1152055C (zh) 2001-03-20 2004-06-02 清华大学 磁性微球的表面包覆和基团功能化修饰方法及所得微球及其应用
AU2002307218A1 (en) 2001-03-24 2002-10-08 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
WO2002083918A2 (en) * 2001-04-10 2002-10-24 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
US20030124516A1 (en) * 2001-04-27 2003-07-03 Genoptix, Inc. Method of using optical interrogation to determine a biological property of a cell or population of cells
US20040023310A1 (en) * 2001-04-27 2004-02-05 Genoptix, Inc Quantitative determination of protein kinase C activation using optophoretic analysis
US20030194755A1 (en) * 2001-04-27 2003-10-16 Genoptix, Inc. Early detection of apoptotic events and apoptosis using optophoretic analysis
US20040009540A1 (en) * 2001-04-27 2004-01-15 Genoptix, Inc Detection and evaluation of cancer cells using optophoretic analysis
WO2002091028A2 (en) * 2001-05-03 2002-11-14 Colorado School Of Mines Devices employing colloidal-sized particles
US20020166760A1 (en) * 2001-05-11 2002-11-14 Prentiss Mara G. Micromagentic systems and methods for microfluidics
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003006676A2 (en) 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
AU2002365115A1 (en) * 2001-07-20 2003-09-02 North Carolina State University Light addressable electrochemical detection of duplex structures
US7169578B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7285412B2 (en) 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169577B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US10539561B1 (en) * 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
US20140008210A1 (en) 2012-07-06 2014-01-09 Aviva Biosciences Corporation Methods and compositions for separating or enriching cells
US7166443B2 (en) 2001-10-11 2007-01-23 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US6949355B2 (en) 2001-10-11 2005-09-27 Aviva Biosciences Methods, compositions, and automated systems for separating rare cells from fluid samples
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US20040002073A1 (en) 2001-10-15 2004-01-01 Li Alice Xiang Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US7427497B2 (en) * 2001-11-01 2008-09-23 Rensselaer Polytechnic Institute In vitro metabolic engineering on microscale devices
KR100442836B1 (ko) 2001-11-10 2004-08-02 삼성전자주식회사 생화학 유체를 온도가 다른 폐쇄된 챔버 구간을 따라 회전이동시키는 폐쇄 유체 회로 시스템
SE0103859D0 (sv) * 2001-11-20 2001-11-20 Sven Oscarsson Novel artificial structures with magnetic functionality
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
DE60227707D1 (de) * 2002-01-14 2008-08-28 Freni Brembo Spa Scheibe für eine scheibenbremse
US20040219695A1 (en) * 2002-01-19 2004-11-04 Fox John Stewart High sensitivity detection of and manipulation of biomolecules and cells with magnetic particles
US7214427B2 (en) 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US20040033546A1 (en) 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
AU2003228711C1 (en) 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US20030211461A1 (en) * 2002-05-01 2003-11-13 Genoptix, Inc Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
EP1501924A4 (de) * 2002-05-04 2006-05-24 Aviva Biosciences Corp Vorrichtung mit strukturen nachweisendem ionentransport und verwendungsverfahren
US6922128B2 (en) * 2002-06-18 2005-07-26 Nokia Corporation Method for forming a spiral inductor
JP2004037338A (ja) * 2002-07-05 2004-02-05 Yokogawa Electric Corp 磁気ビーズを用いて生体高分子を基板へ固定する方法およびその方法を用いた生体高分子測定装置
WO2004009840A1 (en) * 2002-07-24 2004-01-29 Board Of Regents, The University Of Texas System Capture and detection of microbes by membrane methods
WO2004029221A2 (en) 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20040121474A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis
US20040121307A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Early detection of cellular differentiation using optophoresis
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
WO2004074913A2 (en) * 2003-02-19 2004-09-02 Bioarray Solutions Ltd. A dynamically configurable electrode formed of pixels
EP1604184A4 (de) * 2003-02-27 2010-10-27 Stephen A Lesko Standardisierte bewertung von therapeutischer wirksamkeit auf basis zellulärer biomarker
EP1462173A1 (de) * 2003-03-28 2004-09-29 Interuniversitair Micro-Elektronica Centrum (IMEC) Verfahren zu kontrolliertem Transport von magenetischen Partikeln und zugehörige Vorrichtung
DE10321809A1 (de) * 2003-05-14 2005-03-17 Micronas Holding Gmbh Verfahren zum Drucken von Biomolekülen
CA2529285A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
TWI230760B (en) * 2003-07-29 2005-04-11 Univ Tsinghua Electrowetting electrode design with electromagnetic field for actuation of the magnetic-beads biochemical detection system
CN1289904C (zh) * 2003-08-01 2006-12-13 博奥生物有限公司 一种微阵列反应装置及其应用
EP1668355A4 (de) * 2003-08-28 2011-11-09 Celula Inc Verfahren und vorrichtung zur sortierung von zellen unter verwendung eines optischen schalters in einem mikrofluidischen kanalnetzwerk
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
PT1664722E (pt) 2003-09-22 2011-12-28 Bioarray Solutions Ltd Polielectrólito imobilizado à superfície com grupos funcionais múltiplos capazes de se ligarem covalentemente às biomoléculas
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
US7563569B2 (en) 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
US20100000881A1 (en) * 2003-10-30 2010-01-07 North Carolina State University Electrochemical detection of nucleic acid hybridization
US7651868B2 (en) * 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
WO2005072855A1 (en) 2004-01-28 2005-08-11 Drexel University Magnetic fluid manipulators and methods for their use
US8017367B2 (en) * 2004-01-29 2011-09-13 Narvalus S.R.L. Biochip electroporator and its use in multi-site, single-cell electroporation
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US20060257941A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
US8105849B2 (en) * 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
DE102004009985A1 (de) * 2004-03-01 2005-09-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Magnetische Manipulation von biologischen Proben
US7253029B2 (en) * 2004-03-10 2007-08-07 M/A-Com, Inc. Non-magnetic, hermetically-sealed micro device package
US7187286B2 (en) 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
US7491307B2 (en) * 2004-05-04 2009-02-17 Palo Alto Research Center Incorporated Portable bioagent concentrator
US7534336B2 (en) * 2004-05-04 2009-05-19 Palo Alto Research Center Incorporated Continuous flow particle concentrator
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US20060014155A1 (en) * 2004-07-16 2006-01-19 Wisconsin Alumni Research Foundation Methods for the production of sensor arrays using electrically addressable electrodes
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060088971A1 (en) * 2004-10-27 2006-04-27 Crawford Ankur M Integrated inductor and method of fabrication
US7147108B2 (en) * 2004-10-29 2006-12-12 Hewlett-Packard Development Company, Lp. Method and apparatus for the separation and collection of particles
US7811438B2 (en) 2004-12-08 2010-10-12 Palo Alto Research Center Incorporated Bio-enrichment device to enhance sample collection and detection
EP1674128A1 (de) * 2004-12-22 2006-06-28 Steinbeis-Transferzentrum für Herz-Kreislaufforschung Magnetische Polmatrix zur Verwendung für Gewebeherstellung und die Behandlung von Krankheiten
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
DE102005029808A1 (de) * 2005-06-27 2007-01-04 Siemens Ag Trägermaterial, Verfahren zu seiner Herstellung und Verwendung
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP4844045B2 (ja) * 2005-08-18 2011-12-21 Ｔｄｋ株式会社 電子部品及びその製造方法
US7681738B2 (en) * 2005-09-12 2010-03-23 Palo Alto Research Center Incorporated Traveling wave arrays, separation methods, and purification cells
US20070231794A1 (en) * 2005-09-21 2007-10-04 Combimatrix Corporation Process to detect binding events on an electrode microarray using enzymes
US20080260583A1 (en) * 2005-09-23 2008-10-23 Koninklijke Philips Electronics, N.V. Micro-Fluidic Device Based Upon Active Matrix Principles
DE102005051012B3 (de) * 2005-10-25 2007-04-19 Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. Vorrichtung zur Handhabung von biologischen Zellen bzw. Proben
US8158832B2 (en) 2005-11-09 2012-04-17 The Trustees Of Columbia University In The City Of New York Photochemical methods and photoactive compounds for modifying surfaces
WO2007092713A2 (en) * 2006-02-02 2007-08-16 Trustees Of The University Of Pennsylvania Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease
US20090220968A1 (en) * 2006-03-10 2009-09-03 President And Fellows Of Harvard College Methods and Apparatus for Near Field Irradiation
KR100723425B1 (ko) * 2006-04-13 2007-05-30 삼성전자주식회사 기판상에 생체분자 액적을 프린팅하는 장치 및 방법
AT503573B1 (de) * 2006-04-13 2007-11-15 Arc Seibersdorf Res Gmbh Vorrichtung zur steigerung der reaktions-, insbesondere der anbindungseffizienz zwischen molekülen bzw. molekülteilen
EP2024757A1 (de) * 2006-05-10 2009-02-18 Koninklijke Philips Electronics N.V. System und verfahren zur betätigung von magnetoresistiven sensoren
BRPI0712571B1 (pt) * 2006-06-02 2017-03-28 Luminex Corp sistemas e métodos para a realização de medições de um ou mais materiais
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
EP2064375B1 (de) * 2006-06-06 2012-11-21 Société de Commercialisation des Produits de la Recherche Appliquée - SOCPRA- Sciences et Génie s.e.c. Assayträger, umfassend einen peg-träger, wobei der träger aus einer peg-lösung unter trübungspunktbedingungen (theta-lösungsmittel) gebunden wird
GB2439119B (en) 2006-06-12 2011-04-20 Tandberg Television Asa Motion estimator
US20070292889A1 (en) * 2006-06-16 2007-12-20 The Regents Of The University Of California Immunoassay magnetic trapping device
US7851028B2 (en) * 2006-06-30 2010-12-14 The Invention Science Fund I, Llc Method of combing an elongated molecule
US7618771B2 (en) * 2006-06-30 2009-11-17 Searete Llc Method of combing a nucleic acid
US7858305B2 (en) * 2006-06-30 2010-12-28 The Invention Science Fund I, Llc Method of combing a nucleic acid
WO2008007291A2 (en) * 2006-07-11 2008-01-17 Koninklijke Philips Electronics N. V. Magnetic sensor device
EP2041299A4 (de) * 2006-07-14 2010-01-13 Aviva Biosciences Corp Verfahren und zusammensetzungen für den nachweis seltener zellen aus einer biologischen probe
US8658573B2 (en) * 2006-09-11 2014-02-25 The Trustees Of Columbia University In The City Of New York Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies
CN101523215B (zh) 2006-10-12 2014-07-30 皇家飞利浦电子股份有限公司 磁性和/或电子标签辅助检测系统和方法
ATE472372T1 (de) * 2006-10-26 2010-07-15 Imec Handhabung von magnetischen oder magnetisierbaren objekten unter verwendung von kombinierter magnetophorese und dielektrophorese
US9862624B2 (en) * 2007-11-07 2018-01-09 Palo Alto Research Center Incorporated Device and method for dynamic processing in water purification
US10052571B2 (en) * 2007-11-07 2018-08-21 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
US8276760B2 (en) * 2006-11-30 2012-10-02 Palo Alto Research Center Incorporated Serpentine structures for continuous flow particle separations
US9433880B2 (en) * 2006-11-30 2016-09-06 Palo Alto Research Center Incorporated Particle separation and concentration system
US9486812B2 (en) * 2006-11-30 2016-11-08 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation
US8931644B2 (en) * 2006-11-30 2015-01-13 Palo Alto Research Center Incorporated Method and apparatus for splitting fluid flow in a membraneless particle separation system
CN101589307A (zh) * 2007-01-24 2009-11-25 阿瑞欧米克斯公司 微型器件的分类
TWI388831B (zh) * 2007-01-30 2013-03-11 Academia Sinica 溶液中基因微陣列分析
DE602008001555D1 (de) * 2007-02-01 2010-07-29 Koninkl Philips Electronics Nv Magnetsensorvorrichtung und verfahren zur erfassung magnetischer teilchen
EP1970705A1 (de) * 2007-03-15 2008-09-17 Koninklijke Philips Electronics N.V. Analytnachweis anhand von Kügelchen
EP1974816A1 (de) * 2007-03-23 2008-10-01 Koninklijke Philips Electronics N.V. Integrierte Mikrofluidikvorrichtung mit integrierter Schaltung
EP1974815A1 (de) * 2007-03-23 2008-10-01 Koninklijke Philips Electronics N.V. Integrierte Mikrofluidikvorrichtung mit Abtast- und Steuerschaltungen
JP2008303412A (ja) * 2007-06-06 2008-12-18 Toyama Prefecture めっきによる検査・解析医療用磁気デバイスの製造方法
WO2009005680A1 (en) * 2007-06-29 2009-01-08 President And Fellows Of Harvard College Methods and apparatus for manipulation of fluidic species
WO2009006409A2 (en) * 2007-06-29 2009-01-08 President And Fellows Of Harvard College Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids
US20100300978A1 (en) * 2007-09-19 2010-12-02 Agency For Science, Technology And Research Device, system and method for washing and isolating magnetic particles in a continous fluid flow
WO2009047714A1 (en) * 2007-10-11 2009-04-16 Koninklijke Philips Electronics N. V. Magnetic manipulation device for magnetic beads
CN101158697B (zh) * 2007-11-29 2012-04-25 中国科学院理化技术研究所 可同时测试多种样品的磁传感器生物芯片样品舟
JP5401724B2 (ja) * 2007-12-03 2014-01-29 多摩川精機株式会社 被覆磁性微粒子を用いたバイオセンシング方法及び該方法に用いるバイオセンシング装置
US9656271B2 (en) * 2007-12-04 2017-05-23 Headway Technologies, Inc. Guided transport of magnetically labeled biological molecules and cells
RU2489704C2 (ru) * 2007-12-20 2013-08-10 Конинклейке Филипс Электроникс Н.В. Микроэлектронное сенсорное устройство сенсора для детектирования целевых частиц
EP2240778B1 (de) * 2008-01-07 2014-07-23 Luminex Corporation Isolierung und identifizierung von zellen aus einer komplexen probenmatrix
WO2009098623A1 (en) 2008-02-06 2009-08-13 Koninklijke Philips Electronics N.V. Magnetic bead actuation using feedback for ftir biosensor
US8157155B2 (en) * 2008-04-03 2012-04-17 Caterpillar Inc. Automated assembly and welding of structures
EP2108938A1 (de) * 2008-04-09 2009-10-14 Koninklijke Philips Electronics N.V. Träger für optische Detektion bei kleinen Probenvolumen
WO2009129236A2 (en) * 2008-04-14 2009-10-22 Integrated Nano-Technologies Llc Method for manipulating samples with magnetic nucleation nanoparticles
JP2012507703A (ja) * 2008-10-31 2012-03-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マルチチャンバー・カートリッジを有するバイオセンサー
EP2349917A2 (de) * 2008-11-03 2011-08-03 Yeda Research And Development Company Ltd. Magnetisches musterbildungsverfahren und -system
DE102009004086A1 (de) 2009-01-05 2010-07-22 Gottfried Wilhelm Leibniz Universität Hannover Elektromagnetisches Mikrosystem zur Manipulation magnetischer Mikro- oder Nanoperlen
KR101067695B1 (ko) * 2010-03-25 2011-09-27 충남대학교산학협력단 연자성 미세 구조물을 이용한 분자 이송 시스템
US9803236B2 (en) 2010-08-06 2017-10-31 Tsinghua University Microarray-based assay integrated with particles for analyzing molecular interactions
US9322804B2 (en) 2010-11-29 2016-04-26 President And Fellows Of Harvard College Quality control of diamagnetic materials using magnetic levitation
TW201319565A (zh) * 2011-08-22 2013-05-16 zheng-chun Peng 電磁式分子鑷夾陣列及其方法
EP2653868A1 (de) * 2012-04-18 2013-10-23 NovioSense B.V. Verfahren zur Herstellung eines Biosensors
EP2664914A1 (de) * 2012-05-16 2013-11-20 Koninklijke Philips N.V. Magnetisch unterstützte Verarbeitung eines Mediums
WO2014004577A1 (en) * 2012-06-25 2014-01-03 The General Hospital Corporation Sorting particles using high gradient magnetic fields
CN103760355B (zh) 2013-12-05 2015-09-16 博奥生物集团有限公司 微阵列芯片检测中核苷酸序列的颗粒标记方法
US10928404B2 (en) 2014-02-26 2021-02-23 The Brigham And Women's Hospital, Inc. System and method for cell levitation and monitoring
GB2524541A (en) * 2014-03-26 2015-09-30 Ibm Microfluidic chip with conic bead trapping cavities and fabrication thereof
KR101593545B1 (ko) * 2014-05-29 2016-02-26 서울대학교 산학협력단 재사용이 가능한 화학적 또는 생물학적 센서 및 그 사용방법
TWI671894B (zh) * 2014-06-26 2019-09-11 日商新力股份有限公司 電路基板、攝像元件及電子機器
US9773711B2 (en) 2014-12-01 2017-09-26 Industrial Technology Research Institute Picking-up and placing process for electronic devices and electronic module
US9607907B2 (en) 2014-12-01 2017-03-28 Industrial Technology Research Institute Electric-programmable magnetic module and picking-up and placement process for electronic devices
US10478827B2 (en) 2015-03-04 2019-11-19 Mcmaster University Devices for manipulating magnetic particles, and methods of fabricating the devices and the use thereof
US10162016B2 (en) * 2016-03-08 2018-12-25 Texas Instruments Incorporated Reduction of magnetic sensor component variation due to magnetic materials through the application of magnetic field
TWI605536B (zh) 2017-04-12 2017-11-11 財團法人工業技術研究院 磁性轉移模組及轉移電子元件的方法
US11673134B2 (en) * 2017-06-06 2023-06-13 Northwestern University Trans-interfacial magnetic separation
US11112416B2 (en) 2018-01-30 2021-09-07 Life Technologies Corporation Instruments, devices and consumables for use in a workflow of a smart molecular analysis system
US11162143B2 (en) 2018-10-21 2021-11-02 The University Of Kansas Methods for generating therapeutic delivery platforms
CN111292631B (zh) * 2018-11-21 2022-03-25 成都辰显光电有限公司 微发光二极管显示面板及其制备方法
WO2020147013A1 (zh) 2019-01-15 2020-07-23 京东方科技集团股份有限公司 检测芯片及其制备方法、检测系统
CN112020551B (zh) 2019-03-29 2022-11-25 京东方科技集团股份有限公司 检测芯片及其使用方法、反应系统
US11090574B2 (en) 2019-06-07 2021-08-17 Universal City Studios Llc Electromagnetic animated figure control system
CN110702753B (zh) * 2019-10-29 2020-09-08 华中科技大学 桥接式微纳结构传感单元的阵列传感器的制备方法及产品
US11542541B2 (en) 2019-11-26 2023-01-03 Bio-Rad Laboratories, Inc. Method and system for sampling material from cells
CN114826333A (zh) * 2020-01-07 2022-07-29 中兴通讯股份有限公司 一种电磁单元的调控方法、装置、设备和存储介质
CN111349558B (zh) * 2020-02-05 2023-06-06 重庆工商大学 一种点阵状磁感应强度可控细胞引导装置
CN111303451B (zh) * 2020-02-20 2021-08-17 北京大学 导电水凝胶的制备方法及其细胞阻抗传感检测方法
CN111389473B (zh) * 2020-03-25 2021-05-04 武汉大学 一种垂直沟道可调谐高通量声流控分选芯片及其制备方法
EP3910052A1 (de) 2020-05-13 2021-11-17 PreOmics GmbH Magnetische spaltung von verbindungen
CN111806589B (zh) * 2020-07-31 2023-12-22 苏州荣坤智能机器科技有限公司 一种基于电磁吸附的爬壁机器人足垫
US11951476B2 (en) 2020-11-19 2024-04-09 Rutgers, The State University Of New Jersey Electronic-sensing and magnetic-modulation (ESMM) biosensor for phagocytosis quantification in pathogenic infections and methods of use thereof
CN112592818A (zh) * 2020-12-18 2021-04-02 覃日华 一种基因分型芯片的自动化检测设备
CN113460955B (zh) * 2021-06-30 2024-03-08 上海交通大学 一种快速微机电磁通门芯片制造方法
TWI797820B (zh) * 2021-11-08 2023-04-01 財團法人工業技術研究院 Pcr快速檢測裝置及其方法
CN114653268B (zh) * 2022-03-21 2023-03-24 哈尔滨工业大学 一种微珠振动式气动微流控样品处理模块
CN116121063B (zh) * 2022-12-30 2023-08-04 山东大学 一种实现磁场调控与温度监测的生物芯片及其制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160645A (en) 1977-07-14 1979-07-10 Syva Company Catalyst mediated competitive protein binding assay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4894443A (en) 1984-02-08 1990-01-16 Cetus Corporation Toxin conjugates
DE3513168A1 (de) 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
US5238810A (en) 1986-09-22 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus thereof
EP0287665B1 (de) 1986-09-22 1996-07-31 Nippon Telegraph And Telephone Corporation Lasermagnetisches immuntestverfahren und vorrichtung dazu
US5122227A (en) 1986-10-31 1992-06-16 Texas Instruments Incorporated Method of making a monolithic integrated magnetic circuit
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5779976A (en) 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
MY105486A (en) * 1989-12-15 1994-10-31 Tdk Corp A multilayer hybrid circuit.
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
JP2943579B2 (ja) 1992-10-20 1999-08-30 三菱電機株式会社 磁気構造体並びにこれを用いた磁気ヘッドおよび磁気記録ヘッド
CA2153387A1 (en) 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
US5439586A (en) 1993-09-15 1995-08-08 The Terry Fox Laboratory Of The British Columbia Cancer Agnecy Magnetic filter with ordered wire array
US5612474A (en) 1994-06-30 1997-03-18 Eli Lilly And Company Acid labile immunoconjugate intermediates
US5655665A (en) 1994-12-09 1997-08-12 Georgia Tech Research Corporation Fully integrated micromachined magnetic particle manipulator and separator
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
KR970053126A (ko) 1995-12-30 1997-07-29 김광호 물반점 방지를 위한 반도체 장치의 세정 방법 및 장치
US5858666A (en) * 1996-08-29 1999-01-12 Biotechnology Research And Development Corporation Apparatus and method of detection employing an AC frequency sensor array
AU4662097A (en) * 1996-10-01 1998-04-24 Symyx Technologies, Inc. Potential masking systems and methods for combinitorial library synthesis
US5874554A (en) 1996-12-13 1999-02-23 Incyte Pharmaceuticals, Inc. Methods and solvent vehicles for reagent delivery in oligonucleotide synthesis using automated pulse jetting devices
US6187164B1 (en) * 1997-09-30 2001-02-13 Symyx Technologies, Inc. Method for creating and testing a combinatorial array employing individually addressable electrodes
EP1141690A4 (de) 1998-12-01 2002-08-07 Cyrano Sciences Inc Auf in linien gebrachten partikeln basieter sensor
CN1185492C (zh) * 1999-03-15 2005-01-19 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
CA2424312A1 (en) 2000-10-10 2002-04-18 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations

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US6806050B2 (en) 2004-10-19
DE69938742D1 (de) 2008-06-26
US6355491B1 (en) 2002-03-12
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AU6045799A (en) 2000-10-04
CA2367698C (en) 2005-06-28
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WO2000054882A1 (en) 2000-09-21
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