WO2003068712A3 - Procede de preparation de biopuces a adn et leurs applications - Google Patents

Procede de preparation de biopuces a adn et leurs applications Download PDF

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Publication number
WO2003068712A3
WO2003068712A3 PCT/FR2003/000464 FR0300464W WO03068712A3 WO 2003068712 A3 WO2003068712 A3 WO 2003068712A3 FR 0300464 W FR0300464 W FR 0300464W WO 03068712 A3 WO03068712 A3 WO 03068712A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
biochips
production
detection
relates
Prior art date
Application number
PCT/FR2003/000464
Other languages
English (en)
Other versions
WO2003068712A2 (fr
Inventor
Pierre Nassoy
Marie-Claude Potier
M Luc Talini
Nathalie Gibelin
Jean Rossier
Original Assignee
Centre Nat Rech Scient
Inst Curie
Pierre Nassoy
Marie-Claude Potier
M Luc Talini
Nathalie Gibelin
Jean Rossier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Inst Curie, Pierre Nassoy, Marie-Claude Potier, M Luc Talini, Nathalie Gibelin, Jean Rossier filed Critical Centre Nat Rech Scient
Priority to CA002475696A priority Critical patent/CA2475696A1/fr
Priority to US10/504,163 priority patent/US20050100905A1/en
Priority to AU2003226885A priority patent/AU2003226885A1/en
Priority to JP2003567847A priority patent/JP2005517902A/ja
Priority to EP03739533A priority patent/EP1474368A2/fr
Publication of WO2003068712A2 publication Critical patent/WO2003068712A2/fr
Publication of WO2003068712A3 publication Critical patent/WO2003068712A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention est relative à un procédé de préparation d'une biopuce activée pour la fixation covalente de sondes oligonucléotidiques sur un support solide par l'intermédiaire d'un composé espaceur de type NHS-PEG-VS, ainsi que les biopuces susceptibles d'être obtenues par un tel procédé. L'invention comprend également des méthodes de détection d'acides nucléiques dans un échantillon ou des méthodes de criblage de composés capables de se fixer spécifiquement sur des sondes oligonucléotidiques dans lesquelles sont mises en oeuvre les biopuces selon l'invention. La présente invention a aussi pour objet des kits de détection, d'analyse quantitative ou qualitative d'acides nucléiques dans un échantillon, comprenant de telles biopuces ainsi que l'utilisation de ces dernières comme matrice d'affinité pour la purification d'acide nucléique, pour le séquençage d'acide nucléique, pour l'analyse qualitative ou quantitative de l'expression de gènes ou encore pour l'étude et la détection de polymorphisme génétique.
PCT/FR2003/000464 2002-02-13 2003-02-13 Procede de preparation de biopuces a adn et leurs applications WO2003068712A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002475696A CA2475696A1 (fr) 2002-02-13 2003-02-13 Nouveau procede de preparation de biopuces a adn et leurs applications
US10/504,163 US20050100905A1 (en) 2002-02-13 2003-02-13 Novel method for production of dna biochips and applications thereof
AU2003226885A AU2003226885A1 (en) 2002-02-13 2003-02-13 Novel method for production of dna biochips and applications thereof
JP2003567847A JP2005517902A (ja) 2002-02-13 2003-02-13 Ｄｎａバイオチップ作製法およびその適用法
EP03739533A EP1474368A2 (fr) 2002-02-13 2003-02-13 Procede de preparation de biopuces a adn et leurs applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0201791A FR2835829B1 (fr) 2002-02-13 2002-02-13 Nouveau procede de preparation de biopuces a adn ou a proteines et leurs applications
FR02/01791 2002-02-13

Publications (2)

Publication Number Publication Date
WO2003068712A2 WO2003068712A2 (fr) 2003-08-21
WO2003068712A3 true WO2003068712A3 (fr) 2004-03-25

Family

ID=27620174

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/000464 WO2003068712A2 (fr) 2002-02-13 2003-02-13 Procede de preparation de biopuces a adn et leurs applications

Country Status (7)

Country Link
US (1) US20050100905A1 (fr)
EP (1) EP1474368A2 (fr)
JP (1) JP2005517902A (fr)
AU (1) AU2003226885A1 (fr)
CA (1) CA2475696A1 (fr)
FR (1) FR2835829B1 (fr)
WO (1) WO2003068712A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101151979B1 (ko) 2003-11-14 2012-06-01 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Ｎ-술포닐디카르복스이미드 함유 테더링 화합물

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943388B2 (en) 2003-11-14 2011-05-17 3M Innovative Properties Company Acoustic sensors and methods
WO2005066092A2 (fr) * 2003-12-30 2005-07-21 3M Innovative Properties Company Capteurs acoustiques and procedes
US7423155B2 (en) * 2003-11-14 2008-09-09 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US7342082B2 (en) 2004-12-17 2008-03-11 3M Innovative Properties Company Soluble polymers as amine capture agents and methods
US7402678B2 (en) 2004-12-17 2008-07-22 3M Innovative Properties Company Multifunctional amine capture agents
US7544756B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544754B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544755B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
WO2008039998A2 (fr) * 2006-09-28 2008-04-03 President And Fellows Of Harvard College Procédés de séquençage d'adn
WO2010151714A2 (fr) * 2009-06-24 2010-12-29 Life Technologies Corporation Réseaux moléculaires
MX2014007125A (es) * 2011-12-13 2015-04-16 Immunogen Inc Uso de n-hidroxisuccinimida para mejorar la estabilidad de conjugados.
AU2013330344B2 (en) 2012-09-17 2018-07-05 W. R. Grace & Co.-Conn. Chromatography media and devices
ES2730737T3 (es) 2012-09-17 2019-11-12 Grace W R & Co Material de soporte de partículas funcionalizado y métodos de fabricación y uso del mismo
ES2887110T3 (es) 2014-01-16 2021-12-21 Grace W R & Co Medios para cromatografía de afinidad y dispositivos para cromatografía
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 官能化担体材料並びに官能化担体材料を作製及び使用する方法
EP3302784B1 (fr) 2015-06-05 2021-10-06 W.R. Grace & Co.-Conn. Agents de clarification adsorbants pour le biotraitement et procédés de production et d'utilisation desdits agents
EP3907293A4 (fr) * 2018-12-12 2022-04-06 BGI Shenzhen Biopuce, procédé de fabrication et application correspondants
CA3193411A1 (fr) * 2020-09-22 2022-03-31 Tohid DIDAR Interface de biodetection a surface impregnee de lubrifiant, procedes de preparation et utilisations associees

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WO1995034326A1 (fr) * 1994-06-14 1995-12-21 Tadahiko Kohno Reactifs de couplage de derives de polyethyleneglycol et composes formes avec ces derniers
WO1997041897A1 (fr) * 1996-05-09 1997-11-13 Virion Systems, Inc. Vaccins a base de conjugues proteine/polysaccharide prepares a l'aide de vinylsulfones homobifonctionnelles et heterobifonctionnelles
EP1106603A2 (fr) * 1999-12-06 2001-06-13 Fuji Photo Film Co., Ltd. Puce d'ADN et support réactif solide
WO2002042426A2 (fr) * 2000-11-10 2002-05-30 University Of Utah Research Foundation Systeme de transporteur pour apport specifique de genes au niveau de la paroi arterielle

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ATE272224T1 (de) * 1997-11-17 2004-08-15 Max Planck Gesellschaft Konfokales spektroskopiesystem und -verfahren
JPH11242189A (ja) * 1997-12-25 1999-09-07 Olympus Optical Co Ltd 像形成法、像形成装置

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1995034326A1 (fr) * 1994-06-14 1995-12-21 Tadahiko Kohno Reactifs de couplage de derives de polyethyleneglycol et composes formes avec ces derniers
WO1997041897A1 (fr) * 1996-05-09 1997-11-13 Virion Systems, Inc. Vaccins a base de conjugues proteine/polysaccharide prepares a l'aide de vinylsulfones homobifonctionnelles et heterobifonctionnelles
EP1106603A2 (fr) * 1999-12-06 2001-06-13 Fuji Photo Film Co., Ltd. Puce d'ADN et support réactif solide
WO2002042426A2 (fr) * 2000-11-10 2002-05-30 University Of Utah Research Foundation Systeme de transporteur pour apport specifique de genes au niveau de la paroi arterielle

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Title
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LUNDBERG, BO B. ET AL: "Conjugation of an anti-B-cell lymphoma monoclonal antibody, LL2, to long-circulating drug-carrier lipid emulsions", JOURNAL OF PHARMACY AND PHARMACOLOGY (1999), 51(10), 1099-1105, XP008010201 *
NAH J-W ET AL: "Artery wall binding peptide-poly(ethylene glycol)-grafted-poly(l-lysi ne)-based gene delivery to artery wall cells", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 78, no. 1-3, 17 January 2002 (2002-01-17), pages 273 - 284, XP004329825, ISSN: 0168-3659 *
PERRET, EMILIE ET AL: "Versatile decoration of glass surfaces to probe individual protein-protein interactions and cellular adhesion", LANGMUIR (2002), 18(3), 846-854, 10 January 2002 (2002-01-10), XP002220430 *
WANG, TONG ET AL: "Protein stretching III: force-extension curves of tethered bovine carbonic anhydrase B to the silicon substrate under native, intermediate and denaturing conditions", JAPANESE JOURNAL OF APPLIED PHYSICS, PART 1: REGULAR PAPERS, SHORT NOTES & REVIEW PAPERS (1999), 38(6B), 3912-3917, XP001092793 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101151979B1 (ko) 2003-11-14 2012-06-01 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Ｎ-술포닐디카르복스이미드 함유 테더링 화합물

Also Published As

Publication number Publication date
WO2003068712A2 (fr) 2003-08-21
US20050100905A1 (en) 2005-05-12
EP1474368A2 (fr) 2004-11-10
FR2835829B1 (fr) 2007-09-14
AU2003226885A1 (en) 2003-09-04
FR2835829A1 (fr) 2003-08-15
JP2005517902A (ja) 2005-06-16
CA2475696A1 (fr) 2003-08-21

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