ATE381941T1 - Stabilisierte zusammensetzung zum enzymatischen entfernen von wundgrind - Google Patents

Stabilisierte zusammensetzung zum enzymatischen entfernen von wundgrind

Info

Publication number
ATE381941T1
ATE381941T1 AT01962345T AT01962345T ATE381941T1 AT E381941 T1 ATE381941 T1 AT E381941T1 AT 01962345 T AT01962345 T AT 01962345T AT 01962345 T AT01962345 T AT 01962345T AT E381941 T1 ATE381941 T1 AT E381941T1
Authority
AT
Austria
Prior art keywords
stabilized composition
enzymatic wound
enzymatic
grind removal
grind
Prior art date
Application number
AT01962345T
Other languages
English (en)
Inventor
David Hobson
David Jones
Katarzyna Koster
Pilar Duque
Original Assignee
Healthpoint Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Healthpoint Ltd filed Critical Healthpoint Ltd
Application granted granted Critical
Publication of ATE381941T1 publication Critical patent/ATE381941T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Enzymes And Modification Thereof (AREA)
AT01962345T 2000-12-27 2001-08-06 Stabilisierte zusammensetzung zum enzymatischen entfernen von wundgrind ATE381941T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/749,217 US6548556B2 (en) 2000-12-27 2000-12-27 Stable enzymatic wound debrider

Publications (1)

Publication Number Publication Date
ATE381941T1 true ATE381941T1 (de) 2008-01-15

Family

ID=25012779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01962345T ATE381941T1 (de) 2000-12-27 2001-08-06 Stabilisierte zusammensetzung zum enzymatischen entfernen von wundgrind

Country Status (14)

Country Link
US (1) US6548556B2 (de)
EP (1) EP1345620B1 (de)
JP (1) JP4071628B2 (de)
CN (1) CN1230200C (de)
AT (1) ATE381941T1 (de)
AU (1) AU2001283537B2 (de)
CA (1) CA2433080C (de)
DE (1) DE60132113T2 (de)
DK (1) DK1345620T3 (de)
ES (1) ES2296788T3 (de)
HK (1) HK1056834A1 (de)
MX (1) MXPA03005851A (de)
PT (1) PT1345620E (de)
WO (1) WO2002051436A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20030099693A1 (en) * 2001-11-02 2003-05-29 Auffret Anthony David Wafer
US20030198631A1 (en) * 2002-04-18 2003-10-23 Healthpoint, Ltd. Thermolysin enzymatic wound debrider
US7785584B2 (en) * 2003-08-13 2010-08-31 Healthpoint, Ltd. Ointment wound spray
EP1673112A1 (de) * 2003-10-10 2006-06-28 Coloplast A/S Wundverband enthaltend proteolytische enzyme
US20050079147A1 (en) * 2003-10-14 2005-04-14 Bernard Delaey Wound healing compositions and uses
US20060182705A1 (en) * 2005-02-11 2006-08-17 Cruse Maria K Composition for reduction and prevention of wrinkles on the skin
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
FR2892949B1 (fr) * 2005-11-08 2008-05-16 Maco Pharma Sa Unite de filtration des leucocytes a adhesion des plaquettes reduites
EP1971365A4 (de) * 2005-12-20 2010-01-13 Swiss American Products Inc Proteasezusammensetzungen zur behandlung von geschädigtem gewebe
GB0606921D0 (en) * 2006-04-06 2006-05-17 Insense Ltd Skin dressing
WO2008063229A2 (en) * 2006-05-12 2008-05-29 Livingston James A Enzymatic debridement therapy for abnormal cell proliferation
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US11016104B2 (en) 2008-07-01 2021-05-25 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
NZ593831A (en) 2009-01-06 2013-09-27 Curelon Llc Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces
NZ593823A (en) 2009-01-06 2013-09-27 Curelon Llc Compositions and methods for the treatment or the prevention of infections by e. coli
EP2226382A1 (de) 2009-03-03 2010-09-08 B.R.A.I.N. Biotechnology Research and Information Network AG Protease zur Wundbehandlung und Hautpflege
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
WO2011050135A1 (en) 2009-10-21 2011-04-28 Curemark Llc Methods and compositions for the prevention and treatment of influenza
WO2011071986A1 (en) * 2009-12-08 2011-06-16 Healthpoint, Ltd. Enzymatic wound debriding compositions with enhanced enzymatic activity
JP5833643B2 (ja) 2010-06-08 2015-12-16 バックマン・ラボラトリーズ・インターナショナル・インコーポレーテッドBuckman Laboratories International Incorporated パルプ及び紙の製造による汚泥を分解する方法
GB2503852B (en) 2011-04-21 2018-12-12 Curemark Llc Compounds for the treatment of neuropsychiatric disorders
AU2012253379A1 (en) * 2011-05-12 2013-11-21 Healthpoint, Ltd. Wound debridement compositions containing seaprose and methods of wound treatment using same
EP2809341B1 (de) * 2012-02-02 2020-12-30 Galenagen, LLC Enzymzusammensetzungen und anwendung davon zur wundheilung
AU2013259360B2 (en) 2012-05-11 2017-07-13 Smith & Nephew, Inc. Use of Seaprose to remove bacterial biofilm
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
AU2013344659B2 (en) 2012-11-14 2017-10-05 Smith & Nephew, Inc. Stable thermolysin hydrogel
KR20150127280A (ko) 2013-03-15 2015-11-16 스미스 앤드 네퓨, 인크. 활성제의 전달을 위한 용해가능한 겔-형성 필름
CA2931564C (en) 2013-11-25 2022-08-30 Dermal Devices Inc. Composition, system and method for treating skin
US9592280B2 (en) 2014-10-10 2017-03-14 Rochal Industries Llc Compositions and kits for enzymatic debridement and methods of using the same
US20160101166A1 (en) 2014-10-10 2016-04-14 Rochal Industries, Llp Compositions and kits for treating pruritus and methods of using the same
US10238719B2 (en) 2014-10-10 2019-03-26 Rochal Industries, Llc Compositions and kits for enzymatic debridement and methods of using the same
WO2016094675A1 (en) 2014-12-12 2016-06-16 Smith & Nephew, Inc. Use of clostridium histolyticum protease mixture in promoting wound healing
CN105255825B (zh) * 2015-11-16 2019-07-19 广州赛莱拉干细胞科技股份有限公司 一种跟腱来源肌腱干细胞原代分离消化液及分离方法
NZ745240A (en) 2016-01-31 2022-12-23 Mediwound Ltd Debriding composition for treating wounds
WO2017183018A1 (en) 2016-04-18 2017-10-26 Mediwound Ltd Methods of debridement of chronic wounds
EP3490588A1 (de) 2016-07-27 2019-06-05 Smith&Nephew, Inc. Verwendung von thermolysin zur verringerung oder eliminierung von bakteriellen biofilmen von oberflächen
WO2018140707A1 (en) 2017-01-30 2018-08-02 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce eliminate bacterial biofilms from surfaces
CN106902075A (zh) * 2017-02-23 2017-06-30 任君刚 一种基于无水技术的水敏感粘附性软膏及其制备方法
CN110180019A (zh) * 2019-07-11 2019-08-30 周玉芳 一种提高皮肤修复功能的复合酶及其制备方法
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2917433A (en) 1956-04-02 1959-12-15 Rystan Company Stable aqueous papain topical compositions
US2995493A (en) 1957-04-17 1961-08-08 Johnson & Johnson Ficus enzyme and hydrophilic carrier composition
US3019171A (en) 1957-11-25 1962-01-30 Ethicon Inc Activated enzyme compositions
US3003917A (en) 1959-01-14 1961-10-10 Nat Drug Co Wound healing composition
US3409719A (en) 1967-05-23 1968-11-05 Baxter Laboratories Inc Debridement agent
US3860702A (en) 1972-07-11 1975-01-14 Schuyler Dev Corp Anti-inflammatory compositions
US3983209A (en) 1975-01-28 1976-09-28 Alza Corporation Method for treating burns
GB1594389A (en) 1977-06-03 1981-07-30 Max Planck Gesellschaft Dressing material for wounds
US4250167A (en) 1978-09-19 1981-02-10 Davis Elgan A Methods for reducing calcium deposits
SE8302268L (sv) 1983-04-22 1984-10-23 Lars G I Hellgren Ny kombination av proteolytiska och lipolytiska enzymer lemplig som tvettkomposition
AU573730B2 (en) 1982-10-25 1988-06-23 Antarctic Pharma Ab Enzyme composition from euphausiaceae (antarctic krill) as cleaning agent
US4668228A (en) * 1985-03-12 1987-05-26 Johnson & Johnson Products, Inc. Debriding tape
GB8724728D0 (en) 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
US5206026A (en) 1988-05-24 1993-04-27 Sharik Clyde L Instantaneous delivery film
US5296222A (en) 1989-02-23 1994-03-22 University Of Utah Percutaneous drug delivery system
US5130131A (en) 1989-08-18 1992-07-14 University Of Florida Methods for the control of fungi and bacteria
EP0498532A1 (de) 1991-01-10 1992-08-12 E.R. SQUIBB & SONS, INC. Proteolytische Enzyme enthaltende Puderzusammensetzung zur Entfernung von nekrotischem Gewebe
EP0648113A4 (de) 1992-04-23 1996-12-04 Berlex Lab Bioadhaesive feste mineraloelemulsion.
US6030612A (en) 1994-11-22 2000-02-29 Phairson Medical Inc. Antimicrobial uses of multifunctional enzyme
IL105699A0 (en) 1992-06-26 1993-09-22 Genzyme Corp Hydrophilic creams for delivery of therapeutic agents
AU1939895A (en) 1994-03-01 1995-09-18 E.R. Squibb & Sons, Inc. Enzymatic debridement compositions and methods
US5387517A (en) 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
US5505958A (en) 1994-10-31 1996-04-09 Algos Pharmaceutical Corporation Transdermal drug delivery device and method for its manufacture
US5494896A (en) 1995-03-31 1996-02-27 Xoma Corporation Method of treating conditions associated with burn injuries
US5747005A (en) * 1995-08-02 1998-05-05 Barels; Ronald R. Oil-based, anti-plaque dentifrice composition
EP0866683A4 (de) 1995-09-14 1999-01-07 Sorenson Pharmaceutical Inc Mittel und verfahren zur behandlung erkrankter nägel
US6017531A (en) 1997-06-02 2000-01-25 W. R. Grace & Co. Hydrophilic composition containing protease produced by Vibrio
JP2002514960A (ja) 1997-06-18 2002-05-21 コヘージョン テクノロジーズ,インコーポレイテッド トロンビンおよびミクロフィブリルコラーゲンを含む組成物、ならびにその調製および使用の方法

Also Published As

Publication number Publication date
JP2004520321A (ja) 2004-07-08
WO2002051436A3 (en) 2002-10-03
ES2296788T3 (es) 2008-05-01
CN1494431A (zh) 2004-05-05
DK1345620T3 (da) 2008-05-13
JP4071628B2 (ja) 2008-04-02
HK1056834A1 (en) 2004-03-05
WO2002051436A2 (en) 2002-07-04
US6548556B2 (en) 2003-04-15
CN1230200C (zh) 2005-12-07
PT1345620E (pt) 2008-01-10
EP1345620B1 (de) 2007-12-26
EP1345620A2 (de) 2003-09-24
AU2001283537B2 (en) 2005-04-14
CA2433080A1 (en) 2002-07-04
CA2433080C (en) 2004-07-06
MXPA03005851A (es) 2004-05-04
DE60132113D1 (de) 2008-02-07
US20020114798A1 (en) 2002-08-22
DE60132113T2 (de) 2008-12-18

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