ATE381340T1 - Erhöhte löslichkeit von flavanolignan- zubereitungen - Google Patents

Erhöhte löslichkeit von flavanolignan- zubereitungen

Info

Publication number
ATE381340T1
ATE381340T1 AT02757502T AT02757502T ATE381340T1 AT E381340 T1 ATE381340 T1 AT E381340T1 AT 02757502 T AT02757502 T AT 02757502T AT 02757502 T AT02757502 T AT 02757502T AT E381340 T1 ATE381340 T1 AT E381340T1
Authority
AT
Austria
Prior art keywords
flavanolignan
increased solubility
compositions
approaches
preparation
Prior art date
Application number
AT02757502T
Other languages
English (en)
Inventor
Kvetoslava Benesova
Ladislav Cvak
Milan Stuchlik
Original Assignee
Ivax Pharmaceuticals Sro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Pharmaceuticals Sro filed Critical Ivax Pharmaceuticals Sro
Application granted granted Critical
Publication of ATE381340T1 publication Critical patent/ATE381340T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02757502T 2001-08-30 2002-08-30 Erhöhte löslichkeit von flavanolignan- zubereitungen ATE381340T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20013153A CZ292832B6 (cs) 2001-08-30 2001-08-30 Způsob přípravy silymarinu se zvýšenou rozpustností

Publications (1)

Publication Number Publication Date
ATE381340T1 true ATE381340T1 (de) 2008-01-15

Family

ID=5473538

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02757502T ATE381340T1 (de) 2001-08-30 2002-08-30 Erhöhte löslichkeit von flavanolignan- zubereitungen

Country Status (15)

Country Link
US (1) US7384919B2 (de)
EP (1) EP1420802B1 (de)
JP (1) JP2005519863A (de)
KR (1) KR20040074052A (de)
CN (1) CN1582159A (de)
AT (1) ATE381340T1 (de)
AU (1) AU2002323517B2 (de)
CA (1) CA2458963A1 (de)
CZ (1) CZ292832B6 (de)
DE (1) DE60224202T2 (de)
MX (1) MXPA04001700A (de)
NO (1) NO20041300L (de)
NZ (1) NZ531429A (de)
TW (1) TWI238065B (de)
WO (1) WO2003020291A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005026755A1 (de) * 2005-06-09 2006-12-14 Basf Ag Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung
EP2211611B1 (de) * 2007-10-17 2014-12-10 Todd F. Ovokaitys Verfahren zum modifizieren des festen aggregatszustands einer verbindung und hiermit hergestellte co-amorphe zusammensetzungen
DE102008039271A1 (de) * 2007-12-23 2009-06-25 Euromed Sa Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
CZ300846B6 (cs) * 2008-06-26 2009-08-26 Agra Group, A. S. Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
EP2430017B1 (de) * 2009-05-14 2016-06-29 Madaus GmbH Ein Verfahren zur Herstellung von AMORPHEm SILIBININ
JP5698663B2 (ja) * 2009-05-19 2015-04-08 サントリーホールディングス株式会社 フロフラン型リグナン４位グルコース転移酵素、及びそれをコードするポリヌクレオチド
CN102228430B (zh) * 2011-06-14 2015-12-09 中国中医科学院中药研究所 水飞蓟宾磷脂复合物的纳米混悬剂及其制备方法
US8877259B2 (en) 2012-02-09 2014-11-04 Mary Kay Inc. Cosmetic formulation
ITMI20121317A1 (it) * 2012-07-27 2014-01-28 Indena Spa Composizioni per il trattamento della fatica oncologica
JP2015113332A (ja) * 2013-12-16 2015-06-22 花王株式会社 生薬粉体
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
JP6348024B2 (ja) * 2014-09-03 2018-06-27 株式会社ファンケル 水分散性の良いシリマリン含有組成物
KR101598752B1 (ko) * 2015-01-28 2016-02-29 순천향대학교 산학협력단 표면적 및/또는 다공성이 조절된 당알콜을 담체로 이용한 리포솜 조성물 및 그의 제조방법
ES2706008B8 (es) * 2017-09-22 2021-07-12 Euromed S A Procedimiento para la preparacion de una composicion a partir del cardo mariano y composicion obtenida

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554662A (en) * 1976-05-05 1979-10-24 Inverni Della Beffa Spa Polyhydroxyphenylchromanones
IT1215291B (it) * 1985-07-17 1990-01-31 Inverni Della Beffa Spa Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
US4767508A (en) * 1986-02-27 1988-08-30 Nippon Mining Co., Ltd. Strike plating solution useful in applying primer plating to electronic parts
IT1222012B (it) * 1987-07-10 1990-08-31 Indena Spa Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
IT1241673B (it) * 1989-10-09 1994-01-27 Istituto Biochimico Italiano Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
US5196448A (en) * 1991-01-22 1993-03-23 Stiefel Laboratories, Inc. Antiinflammatory compositions and method of use
DE19501266A1 (de) 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
CZ287657B6 (cs) 1996-06-12 2001-01-17 Mikrobiologický Ústav Av Čr Glykosidy silybininu a způsob jejich výroby
DE19744459A1 (de) 1997-10-08 1999-04-15 Schwabe Willmar Gmbh & Co Flavonolignan-Zubereitungen, insbesondere Silymarin-Zubereitungen

Also Published As

Publication number Publication date
CZ292832B6 (cs) 2003-12-17
US7384919B2 (en) 2008-06-10
WO2003020291A1 (en) 2003-03-13
AU2002323517B2 (en) 2009-12-10
DE60224202T2 (de) 2008-12-04
JP2005519863A (ja) 2005-07-07
TWI238065B (en) 2005-08-21
EP1420802A1 (de) 2004-05-26
US20050101546A1 (en) 2005-05-12
NO20041300L (no) 2004-03-29
CZ20013153A3 (cs) 2003-04-16
MXPA04001700A (es) 2005-04-11
EP1420802A4 (de) 2005-02-09
DE60224202D1 (de) 2008-01-31
EP1420802B1 (de) 2007-12-19
CN1582159A (zh) 2005-02-16
KR20040074052A (ko) 2004-08-21
NZ531429A (en) 2005-11-25
CA2458963A1 (en) 2003-03-13

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