ATE376054T1 - Diacylglyzerin o-acyltransferase - Google Patents

Diacylglyzerin o-acyltransferase

Info

Publication number
ATE376054T1
ATE376054T1 AT98942283T AT98942283T ATE376054T1 AT E376054 T1 ATE376054 T1 AT E376054T1 AT 98942283 T AT98942283 T AT 98942283T AT 98942283 T AT98942283 T AT 98942283T AT E376054 T1 ATE376054 T1 AT E376054T1
Authority
AT
Austria
Prior art keywords
nucleic acid
well
acid compositions
applications
diacylglycerin
Prior art date
Application number
AT98942283T
Other languages
English (en)
Inventor
Robert Farese
Sylvaine Cases
Steven Smith
Sandra K Erickson
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE376054T1 publication Critical patent/ATE376054T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT98942283T 1998-06-24 1998-08-28 Diacylglyzerin o-acyltransferase ATE376054T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/103,754 US6344548B1 (en) 1998-06-24 1998-06-24 Diacylglycerol o-acyltransferase

Publications (1)

Publication Number Publication Date
ATE376054T1 true ATE376054T1 (de) 2007-11-15

Family

ID=22296862

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942283T ATE376054T1 (de) 1998-06-24 1998-08-28 Diacylglyzerin o-acyltransferase

Country Status (7)

Country Link
US (1) US6344548B1 (de)
EP (1) EP1088088B8 (de)
AT (1) ATE376054T1 (de)
AU (1) AU758438B2 (de)
CA (1) CA2330549C (de)
DE (1) DE69838592T2 (de)
WO (1) WO1999067403A1 (de)

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ES2202805T3 (es) 1997-02-10 2004-04-01 National Research Council Of Canada Gen de la piruvato deshidrogenasa quinasa de plantas.
US6166176A (en) * 1998-03-17 2000-12-26 Immvarx, Inc. Cancer marker protein and peptides thereof
US7135617B2 (en) * 1998-07-02 2006-11-14 Calgene Llc Diacylglycerol acyl transferase proteins
CA2703147C (en) 1998-12-02 2014-07-29 Karlene H. Butler Plant diacylglycerol acyltransferases
AU2166400A (en) * 1998-12-04 2000-06-19 Calgene Llc Diacylglycerol acyl transferase proteins
US7015373B1 (en) * 1998-12-17 2006-03-21 National Research Council Of Canada Diacylglycerol acyltransferase gene from plants
CA2355845C (en) * 1998-12-17 2008-08-05 National Research Council Of Canada Diacylglycerol acyltransferase gene from plants
US6995301B1 (en) 1999-05-04 2006-02-07 Cargill, Incorporated Plant acyltransferases
CA2372632C (en) * 1999-05-04 2011-02-15 Basil S. Shorrosh Plant acyltransferases
US6552250B1 (en) 2000-06-14 2003-04-22 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Diacylglycerol O-acyltransferase
US6444427B1 (en) * 2000-07-11 2002-09-03 The Regents Of The University Of California Polymorphisms in a diacylglycerol acyltransferase gene, and methods of use thereof
EP1330552B1 (de) * 2000-10-31 2007-01-24 Michel Alphonse Julien Georges Marker-unterstützte auswahl von rindvieh für verbesserte milchproduktion unter verwendung des diacylglycerin-acyltransferase-gens dgat1
US7045326B2 (en) 2001-02-23 2006-05-16 The Regents Of The University Of California Mono- and diacylglycerol acyltransferases and methods of use thereof
US20020119138A1 (en) 2001-02-26 2002-08-29 Sylvaine Cases Diacylglycerol o-acyltransferase 2alpha (DGAT2alpha)
WO2003053363A2 (en) * 2001-12-19 2003-07-03 Millennium Pharmaceuticals, Inc. Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor
MXPA05001239A (es) * 2002-07-31 2005-06-08 Monsanto Technology Llc Secuencias de acidos nucleicos de diacilglicerol aciltransferasa y productos asociados.
US20040185559A1 (en) 2003-03-21 2004-09-23 Isis Pharmaceuticals Inc. Modulation of diacylglycerol acyltransferase 1 expression
AR044152A1 (es) * 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
US7825235B2 (en) * 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
AU2005209115A1 (en) * 2004-01-30 2005-08-11 Japan Tobacco Inc. Anorectic compounds
EP1789564B1 (de) * 2004-09-13 2012-01-04 Monsanto Technology LLC Promotormoleküle zur verwendung in pflanzen
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
US7273746B2 (en) * 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
KR20070088656A (ko) * 2004-12-22 2007-08-29 얀센 파마슈티카 엔.브이. 디아실글리세롤 아실트랜스퍼라제 분석
CA2693630C (en) 2006-07-14 2021-08-31 Commonwealth Scientific And Industrial Research Organisation Altering the fatty acid composition of rice
EP2057177B1 (de) 2006-08-04 2012-11-21 Isis Pharmaceuticals, Inc. Zusammensetzungen und ihre verwendung in bezug auf diacylglycerol-acyltransferase 1
US8143473B2 (en) * 2007-05-24 2012-03-27 E. I. Du Pont De Nemours And Company DGAT genes from Yarrowia lipolytica for increased seed storage lipid production and altered fatty acid profiles in soybean
US20110190165A1 (en) * 2008-05-16 2011-08-04 Randall Weselake High throughput methods of identifying neutral lipid synthases
CA2722458C (en) 2008-05-23 2018-03-27 E. I. Du Pont De Nemours And Company Dgat genes from yarrowia lipolytica combined with plastidic phosphoglucomutase down regulation for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
EP2620502A3 (de) 2008-05-23 2013-09-25 E. I. du Pont de Nemours and Company DGAT-Gene aus ölhaltigen Organismen für erhöhte Samenfettproduktion sowie veränderte Fettsäureprofile bei Ölsamenpflanzen
CA2990650C (en) 2008-05-23 2021-02-09 Pioneer Hi-Bred International, Inc. Novel dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
CA2768737A1 (en) * 2008-07-21 2010-01-28 Commonwealth Scientific And Industrial Research Organisation Improved vegetable oils and uses therefor
ES2603530T3 (es) 2008-07-21 2017-02-28 Commonwealth Scientific And Industrial Research Organisation Aceite de semilla de algodón mejorado y usos
AR078829A1 (es) 2009-10-30 2011-12-07 Du Pont Plantas y semillas con niveles alterados de compuesto de almacenamiento, construcciones relacionadas y metodos relacionados con genes que codifican proteinas similares a las aldolasas bacterianas de la clase ii del acido 2,4- dihidroxi-hept-2-eno-1,7-dioico
WO2011062748A1 (en) 2009-11-23 2011-05-26 E.I. Du Pont De Nemours And Company Sucrose transporter genes for increasing plant seed lipids
KR20130073884A (ko) 2010-03-30 2013-07-03 노파르티스 아게 Ｄｇａｔ1 억제제의 용도
AU2011274301B2 (en) 2010-06-28 2015-06-11 Nuseed Global Innovation Ltd Methods of producing lipids
EP2794888B1 (de) 2011-12-22 2017-02-22 E. I. du Pont de Nemours and Company Verwendung des sojabohnensucrosesynthasepromotors zur erhöhung des pflanzensamenlipidgehalts
US8809026B2 (en) 2011-12-27 2014-08-19 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
US8735111B2 (en) 2011-12-27 2014-05-27 Commonwealth Scientific And Industrial Research Organisation Processes for producing hydrocarbon products
US11639507B2 (en) 2011-12-27 2023-05-02 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
NZ631696A (en) 2012-04-25 2017-02-24 Grains Res & Dev Corp High oleic acid oils
BR112015009455A2 (pt) 2012-10-30 2017-11-14 Agresearch Ltd polinucleotídeo isolado, uso de uma célula, célula de planta, planta, parte de planta, propágulo ou progênie, proteína dgat1 de planta modificada, seu método de produção, matéria-prima animal ou de biocombustível e método para produzir lipídeo
AU2013340444B2 (en) 2012-10-30 2019-08-29 Agresearch Limited Novel acyltransferase polynucleotides, polypeptides, and methods of use
CA2889985C (en) 2012-10-30 2022-09-06 Agresearch Limited Improved acyltransferase polynucleotides, polypeptides, and methods of use
CN109576241A (zh) 2012-12-21 2019-04-05 新西兰植物和食品研究院有限公司 基因表达的调控
WO2015164457A1 (en) 2014-04-22 2015-10-29 E. I. Du Pont De Nemours And Company Plastidic carbonic anhydrase genes for oil augmentation in seeds with increased dgat expression
ES2969618T3 (es) 2014-07-07 2024-05-21 Nuseed Global Innovation Ltd Procesos para producir productos industriales de lípidos vegetales
SG10202006563PA (en) 2015-07-10 2020-08-28 Ionis Pharmaceuticals Inc Modulators of diacyglycerol acyltransferase 2 (dgat2)
US11859193B2 (en) 2016-09-02 2024-01-02 Nuseed Global Innovation Ltd. Plants with modified traits
MX2020009604A (es) 2018-03-16 2023-01-25 Anji Pharmaceuticals Inc Composiciones y metodos para tratar el estre?imiento grave.
WO2023085931A1 (en) 2021-11-11 2023-05-19 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatic organoids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3225997A (en) 1996-05-30 1998-01-05 Trustees Of Columbia University In The City Of New York, The Dna encoding acylcoenzyme a: cholesterol acyltransferase and uses thereof

Also Published As

Publication number Publication date
AU758438B2 (en) 2003-03-20
CA2330549A1 (en) 1999-12-29
EP1088088B1 (de) 2007-10-17
AU9037698A (en) 2000-01-10
DE69838592D1 (de) 2007-11-29
CA2330549C (en) 2010-04-20
US6344548B1 (en) 2002-02-05
EP1088088A1 (de) 2001-04-04
WO1999067403A1 (en) 1999-12-29
EP1088088B8 (de) 2007-11-21
EP1088088A4 (de) 2004-05-06
DE69838592T2 (de) 2008-07-24

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