DE3677848D1 - Chromosomale dna-sequenz, expressionsvektor fuer menschlichen gewebeplasminogen aktivierenden faktor mit diesem transfektierte, gezuechtete zellen, sowie verfahren zur herstellung des genannten aktivierungsfaktors. - Google Patents

Chromosomale dna-sequenz, expressionsvektor fuer menschlichen gewebeplasminogen aktivierenden faktor mit diesem transfektierte, gezuechtete zellen, sowie verfahren zur herstellung des genannten aktivierungsfaktors.

Info

Publication number
DE3677848D1
DE3677848D1 DE8686109385T DE3677848T DE3677848D1 DE 3677848 D1 DE3677848 D1 DE 3677848D1 DE 8686109385 T DE8686109385 T DE 8686109385T DE 3677848 T DE3677848 T DE 3677848T DE 3677848 D1 DE3677848 D1 DE 3677848D1
Authority
DE
Germany
Prior art keywords
factor
transfected
producing
expression vector
dna sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686109385T
Other languages
English (en)
Inventor
Tetsu Kakutani
Keiji Matsumoto
Hitoshi Yahara
Hiroyuki Maruyama
Hajime Kawaharada
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60152810A external-priority patent/JPS6214783A/ja
Priority claimed from JP61020469A external-priority patent/JPS62179390A/ja
Priority claimed from JP61097481A external-priority patent/JPS62253383A/ja
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Application granted granted Critical
Publication of DE3677848D1 publication Critical patent/DE3677848D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8686109385T 1985-07-10 1986-07-09 Chromosomale dna-sequenz, expressionsvektor fuer menschlichen gewebeplasminogen aktivierenden faktor mit diesem transfektierte, gezuechtete zellen, sowie verfahren zur herstellung des genannten aktivierungsfaktors. Expired - Fee Related DE3677848D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP60152810A JPS6214783A (ja) 1985-07-10 1985-07-10 ヒト組織プラスミノ−ゲン活性化因子
JP61020469A JPS62179390A (ja) 1986-01-31 1986-01-31 ヒト組織プラスミノ−ゲン活性化因子遺伝子
JP61097481A JPS62253383A (ja) 1986-04-26 1986-04-26 ヒト組織プラスミノゲン活性化因子の製造法

Publications (1)

Publication Number Publication Date
DE3677848D1 true DE3677848D1 (de) 1991-04-11

Family

ID=27283055

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686109385T Expired - Fee Related DE3677848D1 (de) 1985-07-10 1986-07-09 Chromosomale dna-sequenz, expressionsvektor fuer menschlichen gewebeplasminogen aktivierenden faktor mit diesem transfektierte, gezuechtete zellen, sowie verfahren zur herstellung des genannten aktivierungsfaktors.

Country Status (4)

Country Link
EP (1) EP0211260B1 (de)
AU (1) AU593264B2 (de)
CA (1) CA1295959C (de)
DE (1) DE3677848D1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3676604D1 (de) * 1985-03-22 1991-02-07 Chiron Corp Expression von epa in saeugetierzellen.
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
WO1987001389A1 (en) * 1985-09-06 1987-03-12 Codon Methods for the recovery of tissue plasminogen activator
JP2581668B2 (ja) * 1985-11-27 1997-02-12 三井東圧化学株式会社 ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator
PT86162B (pt) * 1986-11-21 1990-11-20 Smithkline Beecham Corp Expressao de proteina recombinante
CA1341345C (en) * 1987-05-08 2002-03-05 Hanne Ranch Johansen Expression of foreign genes in drosophila cells
US5681713A (en) * 1987-05-08 1997-10-28 Smithkline Beecham Corporation Expression of heterologous proteins in Drosophila cells
WO1989000605A1 (en) * 1987-07-16 1989-01-26 Codon Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79202B (de) * 1982-05-05 1984-10-22 Genentech Inc
SU1662352A3 (ru) 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
AU572108B2 (en) * 1983-01-19 1988-05-05 Genentech Inc. Human tpa production using vectors coding for dhfr protein

Also Published As

Publication number Publication date
CA1295959C (en) 1992-02-18
AU593264B2 (en) 1990-02-08
EP0211260A1 (de) 1987-02-25
AU6000886A (en) 1987-01-15
EP0211260B1 (de) 1991-03-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee