ATE362536T1 - Gdp-dissoziation stimulierendes protein, gehirnspezifisches nucleosomfügungsprotein, skelettmuskel-spezifisches ubiquitin- conjugationsenzym, zellproliferationsprotein, phosphatidylinositolkinase, nel verwandte proteine - Google Patents
Gdp-dissoziation stimulierendes protein, gehirnspezifisches nucleosomfügungsprotein, skelettmuskel-spezifisches ubiquitin- conjugationsenzym, zellproliferationsprotein, phosphatidylinositolkinase, nel verwandte proteineInfo
- Publication number
- ATE362536T1 ATE362536T1 AT02026841T AT02026841T ATE362536T1 AT E362536 T1 ATE362536 T1 AT E362536T1 AT 02026841 T AT02026841 T AT 02026841T AT 02026841 T AT02026841 T AT 02026841T AT E362536 T1 ATE362536 T1 AT E362536T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- specific
- phosphatidylinositolkinase
- nel
- brain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6341096 | 1996-03-19 | ||
JP06916397A JP3646191B2 (ja) | 1996-03-19 | 1997-03-05 | ヒト遺伝子 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE362536T1 true ATE362536T1 (de) | 2007-06-15 |
Family
ID=26404531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02026841T ATE362536T1 (de) | 1996-03-19 | 1997-03-19 | Gdp-dissoziation stimulierendes protein, gehirnspezifisches nucleosomfügungsprotein, skelettmuskel-spezifisches ubiquitin- conjugationsenzym, zellproliferationsprotein, phosphatidylinositolkinase, nel verwandte proteine |
Country Status (8)
Country | Link |
---|---|
US (7) | US5831058A (de) |
EP (6) | EP1860189A1 (de) |
JP (1) | JP3646191B2 (de) |
AT (1) | ATE362536T1 (de) |
CA (2) | CA2641565C (de) |
DE (1) | DE69737740T2 (de) |
DK (1) | DK1295944T3 (de) |
ES (1) | ES2284770T3 (de) |
Families Citing this family (89)
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US6410506B1 (en) * | 1995-05-19 | 2002-06-25 | Human Genome Sciences, Inc. | Transforming growth factor α HII |
US20030170864A1 (en) * | 2000-05-30 | 2003-09-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
AU5706198A (en) * | 1996-12-18 | 1998-07-15 | Genetics Institute Inc. | Secreted proteins and polynucleotides encoding them |
US5976837A (en) * | 1997-03-14 | 1999-11-02 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
US5863779A (en) * | 1997-08-21 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | UBC7-like ubiquitin-conjugating enzyme |
AU3045099A (en) * | 1998-03-27 | 1999-10-18 | University Of Leeds, The | Ubiquitin conjugating enzyme |
US6171790B1 (en) | 1998-05-01 | 2001-01-09 | Incyte Pharmaceuticals, Inc. | Human protease associated proteins |
JP2000109433A (ja) * | 1998-08-05 | 2000-04-18 | Otsuka Pharmaceut Co Ltd | 神経変性疾患治療剤 |
AU777006B2 (en) * | 1998-12-16 | 2004-09-30 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
AU4649600A (en) * | 1999-04-22 | 2000-11-10 | Joel F. Habener | Bridge-1, a transcription factor |
US7544486B2 (en) * | 2003-02-07 | 2009-06-09 | The Regents Of The University Of California | Nell peptide expression systems and bone formation activity of nell peptide |
US7884066B2 (en) * | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
AU2001240820A1 (en) * | 2000-03-15 | 2001-09-24 | Oxford Glycosciences (Uk) Ltd. | Proteins, genes and their use for diagnosis and treatment of vascular dementia |
US6689877B2 (en) * | 2000-11-06 | 2004-02-10 | The Board Of Regents Of The University Of Nebraska | Methods and compositions for the treatment of human immunodeficiency virus infection |
US20030039968A1 (en) * | 2001-07-10 | 2003-02-27 | Applera Corporation | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
US20040049024A1 (en) * | 2001-12-07 | 2004-03-11 | Geoff Clark | Compositions and methods related to the minn1 tumor suppressor gene and protein |
AU2003299314A1 (en) * | 2002-12-16 | 2004-07-09 | Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung | Fwd, pp2c1, adk3, cg3860, cdk4, cg7134, eip75b involved in the regulation of energy homeostasis |
US7691607B2 (en) | 2004-02-09 | 2010-04-06 | The Regents Of The University Of California | Expression system of NELL peptide |
MXPA06014065A (es) | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
JP4948413B2 (ja) | 2004-09-23 | 2012-06-06 | ジェネンテック, インコーポレイテッド | システイン操作抗体および結合体 |
EP1817059A2 (de) | 2004-12-01 | 2007-08-15 | Genentech, Inc. | Konjugate von 1,8-bis-naphthalimiden mit einem antikörper |
CN101835803B (zh) * | 2007-10-19 | 2016-05-25 | 健泰科生物技术公司 | 半胱氨酸改造的抗tenb2抗体和抗体药物偶联物 |
CA2739608A1 (en) | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
JP2013504585A (ja) | 2009-09-09 | 2013-02-07 | セントローズ, エルエルシー | 細胞外標的化薬物複合体 |
US20130028917A1 (en) | 2010-04-15 | 2013-01-31 | Spirogen Developments Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
RU2626537C2 (ru) | 2010-06-08 | 2017-07-28 | Дженентек, Инк. | Полученные с помощью генной инженерии антитела с цистеиновыми заменами и их конъюгаты |
US20120121615A1 (en) | 2010-11-17 | 2012-05-17 | Flygare John A | Alaninyl maytansinol antibody conjugates |
MX2013013054A (es) | 2011-05-12 | 2014-02-20 | Genentech Inc | Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura. |
EA026827B1 (ru) | 2011-10-14 | 2017-05-31 | Медимьюн Лимитед | Пирролбензодиазепины и их конъюгаты |
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SI2766048T1 (sl) | 2012-10-12 | 2015-03-31 | Spirogen Sarl | Pirolobenzodiazepini in njihovi konjugati |
PT2906253T (pt) | 2012-10-12 | 2018-11-05 | Medimmune Ltd | Conjugados de anticorpo anti-psma de pirrolobenzodiazepina |
WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
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CN105246894A (zh) | 2012-12-21 | 2016-01-13 | 斯皮罗根有限公司 | 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
CA2894961C (en) | 2012-12-21 | 2020-09-15 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP2968585B1 (de) | 2013-03-13 | 2018-07-18 | Medimmune Limited | Pyrrolobenzodiazepine und konjugate davon |
EA027910B1 (ru) | 2013-03-13 | 2017-09-29 | Медимьюн Лимитед | Пирролобензодиазепины и их конъюгаты |
EP2968594B1 (de) | 2013-03-13 | 2019-04-24 | Medimmune Limited | Pyrrolobenzodiazepine und konjugate davon |
CA2918139A1 (en) | 2013-08-12 | 2015-02-19 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
WO2015052532A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
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KR20160092024A (ko) | 2013-12-16 | 2016-08-03 | 제넨테크, 인크. | 1-(클로로메틸)-2,3-디히드로-1H-벤조[e]인돌 이량체 항체-약물 접합체 화합물, 및 사용 및 치료 방법 |
KR102354207B1 (ko) | 2013-12-16 | 2022-01-20 | 제넨테크, 인크. | 펩티드모방체 화합물 및 그의 항체-약물 접합체 |
EA201691023A1 (ru) | 2013-12-16 | 2016-10-31 | Дженентек, Инк. | Пептидомиметические соединения и их конъюгаты антитела с лекарственным средством |
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MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
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MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
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JP6943872B2 (ja) | 2016-03-25 | 2021-10-06 | ジェネンテック, インコーポレイテッド | 多重全抗体及び抗体複合体化薬物定量化アッセイ |
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ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
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GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
US11160872B2 (en) | 2017-02-08 | 2021-11-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
CN110582505B (zh) | 2017-04-18 | 2021-04-02 | 免疫医疗有限公司 | 吡咯并苯并二氮杂*缀合物 |
EP3612234B1 (de) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Kombinationstherapie mit anti-axl-antikörper-arzneimittel-konjugat |
US11318211B2 (en) | 2017-06-14 | 2022-05-03 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-CD19 ADC |
SI3668874T1 (sl) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pirolobenzodiazepinski konjugati |
BR112020004307A2 (pt) | 2017-09-20 | 2020-11-10 | Ph Pharma Co., Ltd. | análogos de tailanestatina |
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GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
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AU2019365238A1 (en) | 2018-10-24 | 2021-05-13 | F. Hoffmann-La Roche Ag | Conjugated chemical inducers of degradation and methods of use |
JP2022513198A (ja) | 2018-12-10 | 2022-02-07 | ジェネンテック, インコーポレイテッド | Fc含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
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Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05268957A (ja) | 1992-03-27 | 1993-10-19 | Bio Material Kenkyusho:Kk | ラット多機能プロテアーゼ構成因子およびそのdna |
JP3125235B2 (ja) | 1992-04-22 | 2001-01-15 | 株式会社バイオマテリアル研究所 | ヒト26sプロテアソーム |
JPH05317059A (ja) | 1992-05-22 | 1993-12-03 | Bio Material Kenkyusho:Kk | ラットプロテアソームのコンポーネントおよび そのdna |
US5470577A (en) * | 1993-07-07 | 1995-11-28 | Trustees Of Boston University | Stimulation of tanning by DNA fragments or single-stranded DNA |
WO1996036709A1 (en) * | 1995-05-19 | 1996-11-21 | Human Genome Sciences, Inc. | Transforming growth factor alpha hii |
US5863779A (en) * | 1997-08-21 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | UBC7-like ubiquitin-conjugating enzyme |
US7544486B2 (en) * | 2003-02-07 | 2009-06-09 | The Regents Of The University Of California | Nell peptide expression systems and bone formation activity of nell peptide |
-
1997
- 1997-03-05 JP JP06916397A patent/JP3646191B2/ja not_active Expired - Fee Related
- 1997-03-19 ES ES02026841T patent/ES2284770T3/es not_active Expired - Lifetime
- 1997-03-19 EP EP07014998A patent/EP1860189A1/de not_active Withdrawn
- 1997-03-19 US US08/820,170 patent/US5831058A/en not_active Expired - Lifetime
- 1997-03-19 EP EP02026841A patent/EP1295944B1/de not_active Expired - Lifetime
- 1997-03-19 EP EP10182760A patent/EP2272960A1/de not_active Withdrawn
- 1997-03-19 DE DE69737740T patent/DE69737740T2/de not_active Expired - Lifetime
- 1997-03-19 EP EP97104842A patent/EP0796913A3/de not_active Ceased
- 1997-03-19 CA CA2641565A patent/CA2641565C/en not_active Expired - Fee Related
- 1997-03-19 AT AT02026841T patent/ATE362536T1/de active
- 1997-03-19 CA CA002200371A patent/CA2200371C/en not_active Expired - Fee Related
- 1997-03-19 DK DK02026841T patent/DK1295944T3/da active
- 1997-03-19 EP EP04004141A patent/EP1439230A3/de not_active Withdrawn
- 1997-03-19 EP EP10185775A patent/EP2361982A1/de not_active Withdrawn
-
2004
- 2004-02-20 US US10/781,841 patent/US20060134634A1/en not_active Abandoned
-
2006
- 2006-11-07 US US11/593,525 patent/US7674889B2/en not_active Expired - Fee Related
-
2007
- 2007-07-06 US US11/774,330 patent/US7592438B2/en not_active Expired - Fee Related
-
2009
- 2009-07-27 US US12/510,074 patent/US7858754B2/en not_active Expired - Fee Related
-
2010
- 2010-01-19 US US12/689,917 patent/US8048995B2/en not_active Expired - Fee Related
- 2010-12-23 US US12/977,497 patent/US8106171B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5831058A (en) | 1998-11-03 |
JPH09308492A (ja) | 1997-12-02 |
US8106171B2 (en) | 2012-01-31 |
US8048995B2 (en) | 2011-11-01 |
EP1860189A1 (de) | 2007-11-28 |
CA2200371A1 (en) | 1997-09-19 |
US20070111285A1 (en) | 2007-05-17 |
EP0796913A3 (de) | 2001-01-31 |
EP1295944B1 (de) | 2007-05-16 |
US7592438B2 (en) | 2009-09-22 |
EP0796913A2 (de) | 1997-09-24 |
US7674889B2 (en) | 2010-03-09 |
EP2361982A1 (de) | 2011-08-31 |
DE69737740T2 (de) | 2008-01-31 |
US7858754B2 (en) | 2010-12-28 |
EP1295944A3 (de) | 2004-04-21 |
DE69737740D1 (de) | 2007-06-28 |
US20110105718A1 (en) | 2011-05-05 |
EP1439230A3 (de) | 2004-09-22 |
EP2272960A1 (de) | 2011-01-12 |
JP3646191B2 (ja) | 2005-05-11 |
US20060134634A1 (en) | 2006-06-22 |
CA2641565A1 (en) | 1997-09-19 |
ES2284770T3 (es) | 2007-11-16 |
US20080032337A1 (en) | 2008-02-07 |
DK1295944T3 (da) | 2007-09-17 |
EP1439230A2 (de) | 2004-07-21 |
US20100048878A1 (en) | 2010-02-25 |
US20100160611A1 (en) | 2010-06-24 |
CA2200371C (en) | 2007-07-10 |
CA2641565C (en) | 2012-11-13 |
EP1295944A2 (de) | 2003-03-26 |
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