ATE360423T1 - Verwendung von chymase hemmern gegen vaskuläre lipidablagerung - Google Patents
Verwendung von chymase hemmern gegen vaskuläre lipidablagerungInfo
- Publication number
- ATE360423T1 ATE360423T1 AT00971729T AT00971729T ATE360423T1 AT E360423 T1 ATE360423 T1 AT E360423T1 AT 00971729 T AT00971729 T AT 00971729T AT 00971729 T AT00971729 T AT 00971729T AT E360423 T1 ATE360423 T1 AT E360423T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors against
- against vascular
- chymase inhibitors
- lipid deposit
- vascular lipid
- Prior art date
Links
- 239000003601 chymase inhibitor Substances 0.000 title abstract 3
- 150000002632 lipids Chemical class 0.000 title abstract 2
- 230000002792 vascular Effects 0.000 title 1
- 229940119334 Chymase inhibitor Drugs 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000004218 vascular function Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31125799 | 1999-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360423T1 true ATE360423T1 (de) | 2007-05-15 |
Family
ID=18014979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00971729T ATE360423T1 (de) | 1999-11-01 | 2000-11-01 | Verwendung von chymase hemmern gegen vaskuläre lipidablagerung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6921766B1 (de) |
| EP (1) | EP1142586B1 (de) |
| KR (1) | KR20010100004A (de) |
| CN (1) | CN1335778A (de) |
| AT (1) | ATE360423T1 (de) |
| AU (1) | AU784467B2 (de) |
| CA (1) | CA2358314A1 (de) |
| DE (1) | DE60034545T2 (de) |
| ES (1) | ES2281358T3 (de) |
| HU (1) | HUP0104952A3 (de) |
| WO (1) | WO2001032214A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60121695T2 (de) | 2000-02-22 | 2007-08-30 | Daiichi Asubio Pharma Co., Ltd. | Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen |
| AU3413501A (en) | 2000-02-22 | 2001-09-03 | Daiichi Asubio Pharma Co., Ltd. | Preventive or therapeutic drugs for various eosinophilia-related diseases containing chymase inhibitors as the active ingredient |
| KR20010108519A (ko) | 2000-02-22 | 2001-12-07 | 도리이 신이치로 | 키마제 억제제를 유효성분으로 하는 선유증의 예방 또는치료약 |
| WO2003007964A1 (en) * | 2001-07-18 | 2003-01-30 | Nippon Kayaku Kabushiki Kaisha | Remedial or preventive agent for cardiopathy or aneurysm containing chymase inhibitory compound |
| WO2004071531A1 (en) * | 2003-02-13 | 2004-08-26 | Licentia Oy | Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia |
| KR101278522B1 (ko) | 2004-12-02 | 2013-06-25 | 다이이찌 산쿄 가부시키가이샤 | 7원환 화합물 및 그 제조법 및 의약 용도 |
| JP5117382B2 (ja) | 2006-05-31 | 2013-01-16 | 第一三共株式会社 | ７員環化合物の製造方法 |
| WO2009096667A2 (ko) * | 2008-01-30 | 2009-08-06 | Shin Poong Pharmaceutical Co., Ltd. | 신규한 퀴나졸린-2,4-디온 유도체 및 이를 함유하는 뇌신경질환 예방 및 치료용 의약 조성물 |
| JP6364362B2 (ja) * | 2015-02-17 | 2018-07-25 | 学校法人福岡大学 | ヒトキマーゼ阻害剤および機能性食品、並びにヒトキマーゼの活性を阻害する方法 |
| US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5199279A (en) | 1991-08-13 | 1993-04-06 | Reynolds Martin M | Drum contact freezer system and method |
| JP2982454B2 (ja) | 1991-12-20 | 1999-11-22 | 王子製紙株式会社 | 感熱記録体 |
| JP2668003B2 (ja) | 1992-06-12 | 1997-10-27 | ファイザー インク． | ヒトの心臓キマーゼを含むアンギオテンシンｉキマーゼに関する阻害剤 |
| ES2155134T3 (es) | 1994-07-29 | 2001-05-01 | Suntory Ltd | Derivados de imidazolidina y su utilizacion. |
| CN1188401C (zh) | 1995-04-27 | 2005-02-09 | 三菱制药株式会社 | 杂环类酰胺化合物及其医药用途 |
| US5596111A (en) | 1995-06-05 | 1997-01-21 | North Dakota State University | Method for preparation of carboxylic acids |
| JP3992291B2 (ja) | 1995-09-28 | 2007-10-17 | アスビオファーマ株式会社 | キナゾリン誘導体 |
| EP0906273B1 (de) | 1996-05-24 | 2002-10-16 | Neurosearch A/S | Saure gruppen enthaltende phenylderivate, ihre herstellung und ihre verwendung als chloridkanalblocker |
| AUPO062696A0 (en) * | 1996-06-24 | 1996-07-18 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds |
| US6080738A (en) * | 1996-10-25 | 2000-06-27 | Yoshitomi Pharmaceuticals Industries, Ltd. | Heterocyclic amide compounds and medicinal uses thereof |
| WO1999041277A1 (en) | 1998-02-17 | 1999-08-19 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivative and use thereof |
| ATE326451T1 (de) * | 1998-08-21 | 2006-06-15 | Daiichi Asubio Pharma Co Ltd | Chinazolin derivate und therapeutische verwendungen davon |
| EP1136488A4 (de) * | 1998-12-01 | 2002-06-12 | Meiji Seika Kaisha | Sf2809-i, ii, iii. vi, v und vi-verbindungen mit chymase-inhibierender wirkung |
-
2000
- 2000-11-01 EP EP00971729A patent/EP1142586B1/de not_active Expired - Lifetime
- 2000-11-01 ES ES00971729T patent/ES2281358T3/es not_active Expired - Lifetime
- 2000-11-01 AT AT00971729T patent/ATE360423T1/de not_active IP Right Cessation
- 2000-11-01 WO PCT/JP2000/007706 patent/WO2001032214A1/ja not_active Ceased
- 2000-11-01 DE DE60034545T patent/DE60034545T2/de not_active Expired - Lifetime
- 2000-11-01 KR KR1020017008302A patent/KR20010100004A/ko not_active Ceased
- 2000-11-01 US US09/869,360 patent/US6921766B1/en not_active Expired - Fee Related
- 2000-11-01 CA CA002358314A patent/CA2358314A1/en not_active Abandoned
- 2000-11-01 HU HU0104952A patent/HUP0104952A3/hu unknown
- 2000-11-01 AU AU10536/01A patent/AU784467B2/en not_active Ceased
- 2000-11-01 CN CN00802476A patent/CN1335778A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU784467B2 (en) | 2006-04-06 |
| HUP0104952A3 (en) | 2006-02-28 |
| EP1142586A1 (de) | 2001-10-10 |
| AU1053601A (en) | 2001-05-14 |
| WO2001032214A1 (en) | 2001-05-10 |
| CA2358314A1 (en) | 2001-05-10 |
| KR20010100004A (ko) | 2001-11-09 |
| EP1142586B1 (de) | 2007-04-25 |
| EP1142586A4 (de) | 2003-03-19 |
| DE60034545T2 (de) | 2007-10-25 |
| US6921766B1 (en) | 2005-07-26 |
| HUP0104952A2 (en) | 2002-06-29 |
| ES2281358T3 (es) | 2007-10-01 |
| CN1335778A (zh) | 2002-02-13 |
| DE60034545D1 (de) | 2007-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |