ATE360392T1 - In vivo multiphoton diagnostische detektion und bilddarstellung einer neurodegenerativen erkrankung - Google Patents
In vivo multiphoton diagnostische detektion und bilddarstellung einer neurodegenerativen erkrankungInfo
- Publication number
- ATE360392T1 ATE360392T1 AT01999158T AT01999158T ATE360392T1 AT E360392 T1 ATE360392 T1 AT E360392T1 AT 01999158 T AT01999158 T AT 01999158T AT 01999158 T AT01999158 T AT 01999158T AT E360392 T1 ATE360392 T1 AT E360392T1
- Authority
- AT
- Austria
- Prior art keywords
- brain tissue
- fluorescence
- mammal
- neurodegenerative disease
- imaging
- Prior art date
Links
- 230000004770 neurodegeneration Effects 0.000 title abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 210000005013 brain tissue Anatomy 0.000 abstract 8
- 241000124008 Mammalia Species 0.000 abstract 5
- 230000003213 activating effect Effects 0.000 abstract 3
- 230000005284 excitation Effects 0.000 abstract 2
- 230000005855 radiation Effects 0.000 abstract 2
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1075—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/4064—Evaluating the brain
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24530600P | 2000-11-02 | 2000-11-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE360392T1 true ATE360392T1 (de) | 2007-05-15 |
Family
ID=22926133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01999158T ATE360392T1 (de) | 2000-11-02 | 2001-10-31 | In vivo multiphoton diagnostische detektion und bilddarstellung einer neurodegenerativen erkrankung |
Country Status (8)
Country | Link |
---|---|
US (1) | US7668586B2 (de) |
EP (1) | EP1347731B1 (de) |
JP (1) | JP2004518488A (de) |
AT (1) | ATE360392T1 (de) |
AU (1) | AU2002251682A1 (de) |
CA (1) | CA2427014A1 (de) |
DE (1) | DE60128138T2 (de) |
WO (1) | WO2002064084A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US7700751B2 (en) * | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US7534255B1 (en) | 2003-01-24 | 2009-05-19 | Photothera, Inc | Low level light therapy for enhancement of neurologic function |
US7303578B2 (en) | 2001-11-01 | 2007-12-04 | Photothera, Inc. | Device and method for providing phototherapy to the brain |
MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
AU2002951841A0 (en) | 2002-09-30 | 2002-10-24 | Swinburne University Of Technology | Apparatus |
RU2390350C2 (ru) * | 2003-02-01 | 2010-05-27 | Ньюралаб Лимитед | Активная иммунизация для создания антител к растворимому а-бета |
US7706863B2 (en) | 2004-01-21 | 2010-04-27 | University Of Washington | Methods for assessing a physiological state of a mammalian retina |
WO2005072386A2 (en) * | 2004-01-27 | 2005-08-11 | Cornell Research Foundation, Inc. | Nonlinear optical detection of fast cellular electrical activity |
US8184300B2 (en) * | 2004-12-13 | 2012-05-22 | Alexander Mazurenko | Method and apparatus for reducing probe wavelength in laser excited surface acoustic wave spectroscopy |
JP2008523815A (ja) * | 2004-12-15 | 2008-07-10 | エラン ファーマ インターナショナル リミテッド | 認知の改善における使用のためのヒト化アミロイドβ抗体 |
US20060293644A1 (en) * | 2005-06-21 | 2006-12-28 | Donald Umstadter | System and methods for laser-generated ionizing radiation |
US7801589B2 (en) | 2005-12-22 | 2010-09-21 | Olympus Corporation | In-vivo examination method and in-vivo examination apparatus |
US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
DE102006050886B4 (de) * | 2006-10-27 | 2016-12-22 | Siemens Healthcare Gmbh | Medizinisches Instrument und Einrichtung zur Erzeugung von Gewebeschnittbildern |
US20120059254A1 (en) * | 2007-03-14 | 2012-03-08 | Wang Lifan | Apparatus and method for phase-space reduction for imaging of fluorescing, scattering and/or absorbing structures |
BRPI0810118A8 (pt) * | 2007-04-18 | 2015-09-29 | Janssen Alzheimer Immunotherap | Método para tratar doença, método para efetuar profilaxia contra caa, uso de um agente, método para reduzir amilóide vascular em um paciente, e, kit para tratamento |
US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
ES2498040T3 (es) * | 2007-07-27 | 2014-09-24 | Janssen Alzheimer Immunotherapy | Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados |
JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
WO2009072123A2 (en) * | 2007-12-06 | 2009-06-11 | Technion Research & Development Foundation Ltd. | Method and system for optical stimulation of neurons |
US20090185980A1 (en) * | 2008-01-23 | 2009-07-23 | National Taiwan University | In vivo drug screening system |
US20120035444A1 (en) * | 2008-01-23 | 2012-02-09 | National Taiwan University | Intravital sample device for in vivo drug screening |
US8954133B1 (en) * | 2008-08-08 | 2015-02-10 | The United States Of America As Represented By The Department Of Veterans Affairs | Spectroscopic detection of brain damage |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US8748386B2 (en) | 2009-06-10 | 2014-06-10 | New York University | Immunological targeting of pathological Tau proteins |
JP5549728B2 (ja) * | 2010-03-18 | 2014-07-16 | 株式会社島津製作所 | ホルダ及びそれを用いた光計測装置 |
US8873827B2 (en) | 2012-06-29 | 2014-10-28 | General Electric Company | Determination of spatial proximity between features of interest in biological tissue |
JP6133053B2 (ja) * | 2012-12-21 | 2017-05-24 | 浜松ホトニクス株式会社 | アミロイドの凝集体の定量方法及びその定量装置 |
EP3166688A4 (de) | 2014-07-08 | 2017-12-20 | New York University | Tau-bildgebungsliganden und deren verwendung in der diagnose und behandlung von tauopathie |
WO2016141339A1 (en) | 2015-03-04 | 2016-09-09 | Aramco Services Company | Adaptive optics for imaging through highly scattering media in oil reservoir applications |
EP3334453A4 (de) | 2015-08-13 | 2019-02-06 | New York University | Antikörperbasierte, für das verkürzte asp421-epitop von tau spezifische moleküle und deren verwendungen in der diagnose und behandlung von tauopathie |
US10394008B2 (en) | 2016-10-19 | 2019-08-27 | Cornell University | Hyperspectral multiphoton microscope for biomedical applications |
WO2019173813A1 (en) * | 2018-03-09 | 2019-09-12 | Icahn School Of Medicine At Mount Sinai | Multiphoton microscopy assessment of neurologic tissue |
CN110313892A (zh) * | 2018-03-28 | 2019-10-11 | 上海交通大学 | 基于体表自发荧光判断帕金森病发生的方法及其应用 |
CN113008850B (zh) * | 2021-02-07 | 2022-02-25 | 首都医科大学宣武医院 | 诊断阿尔茨海默病的用途及诊断阿尔茨海默病的装置 |
CN113804166B (zh) * | 2021-11-19 | 2022-02-08 | 西南交通大学 | 一种基于无人机视觉的落石运动参数数字化还原方法 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4576173A (en) | 1982-06-28 | 1986-03-18 | The Johns Hopkins University | Electro-optical device and method for monitoring instanteous singlet oxygen concentration produced during photoradiation using a CW excitation source |
US4592361A (en) | 1982-06-28 | 1986-06-03 | The Johns Hopkins University | Electro-optical device and method for monitoring instantaneous singlet oxygen concentration produced during photoradiation using pulsed excitation and time domain signal processing |
JPS61159936A (ja) | 1985-07-02 | 1986-07-19 | 熊谷 博彰 | 生物組織の分光画像撮影装置 |
US4895156A (en) | 1986-07-02 | 1990-01-23 | Schulze John E | Sensor system using fluorometric decay measurements |
WO1990006718A1 (en) | 1988-12-21 | 1990-06-28 | Massachusetts Institute Of Technology | A method for laser induced fluorescence of tissue |
US5386827A (en) | 1993-03-30 | 1995-02-07 | Nim Incorporated | Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy |
US5119815A (en) | 1988-12-21 | 1992-06-09 | Nim, Incorporated | Apparatus for determining the concentration of a tissue pigment of known absorbance, in vivo, using the decay characteristics of scintered electromagnetic radiation |
SE8900612D0 (sv) | 1989-02-22 | 1989-02-22 | Jonas Johansson | Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium |
US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5034613A (en) | 1989-11-14 | 1991-07-23 | Cornell Research Foundation, Inc. | Two-photon laser microscopy |
US5127405A (en) | 1990-02-16 | 1992-07-07 | The Boc Group, Inc. | Biomedical fiber optic probe with frequency domain signal processing |
US5062428A (en) * | 1990-06-04 | 1991-11-05 | Nim Incorporated | Method and device for in vivo diagnosis detecting IR emission by body organ |
US5197470A (en) | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
US5438989A (en) | 1990-08-10 | 1995-08-08 | Hochman; Darryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
CA2042075C (en) | 1991-05-08 | 2001-01-23 | Branko Palcic | Endoscopic imaging system |
US5323775A (en) | 1991-09-13 | 1994-06-28 | Allergan, Inc. | Diagnostic method for determining precorneal retention time of ophthalmic formulations |
US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
US5736410A (en) * | 1992-09-14 | 1998-04-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5311013A (en) | 1992-10-15 | 1994-05-10 | Abbott Laboratories | Optical fiber distribution system for an optical fiber sensor in a luminescent sensor system |
US5333044A (en) | 1992-11-24 | 1994-07-26 | The United States Of America As Represented By The Department Of Energy | Fluorescent image tracking velocimeter |
US5341805A (en) | 1993-04-06 | 1994-08-30 | Cedars-Sinai Medical Center | Glucose fluorescence monitor and method |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
US5469653A (en) | 1994-04-28 | 1995-11-28 | Roehrick; Harry V. | Apparatus and method for pest control |
US6168776B1 (en) * | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US5579773A (en) | 1994-09-30 | 1996-12-03 | Martin Marietta Energy Systems, Inc. | Laser-induced differential normalized fluorescence method for cancer diagnosis |
US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5699795A (en) | 1995-03-31 | 1997-12-23 | Board Of Regents, The University Of Texas System | Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same |
US5628310A (en) | 1995-05-19 | 1997-05-13 | Joseph R. Lakowicz | Method and apparatus to perform trans-cutaneous analyte monitoring |
JPH10512959A (ja) | 1995-09-19 | 1998-12-08 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 多光子レーザ顕微鏡法 |
JP3621704B2 (ja) * | 1995-09-26 | 2005-02-16 | カール.ストルツ.ゲゼルシャフト.ミット.ベシュレンクテル.ハフツング.ウント.カンパニー | 光力学的診断用装置 |
US5720894A (en) | 1996-01-11 | 1998-02-24 | The Regents Of The University Of California | Ultrashort pulse high repetition rate laser system for biological tissue processing |
JP3796635B2 (ja) | 1996-03-06 | 2006-07-12 | 富士写真フイルム株式会社 | 蛍光検出装置 |
DE19622359B4 (de) | 1996-06-04 | 2007-11-22 | Carl Zeiss Jena Gmbh | Vorrichtung zur Einkopplung der Strahlung von Kurzpulslasern in einem mikroskopischen Strahlengang |
DE19649971A1 (de) * | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
WO1998040007A1 (en) | 1997-03-13 | 1998-09-17 | Biomax Technologies, Inc. | Methods and apparatus for detecting the rejection of transplanted tissue |
US6280386B1 (en) * | 1997-06-16 | 2001-08-28 | The Research Foundation Of The City University Of New York | Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same |
US5986271A (en) | 1997-07-03 | 1999-11-16 | Lazarev; Victor | Fluorescence imaging system |
US6238348B1 (en) | 1997-07-22 | 2001-05-29 | Scimed Life Systems, Inc. | Miniature spectrometer system and method |
US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
GB9813062D0 (en) | 1998-06-18 | 1998-08-19 | Univ Wales Medicine | An anthraquinone and its derivatives |
US6472541B2 (en) | 1998-11-20 | 2002-10-29 | The Regents Of The University Of California | Protecting groups with increased photosensitivities |
WO2001008552A1 (en) * | 1999-08-03 | 2001-02-08 | Biophysica, Llc | Spectroscopic systems and methods for detecting tissue properties |
US6680203B2 (en) * | 2000-07-10 | 2004-01-20 | Esperion Therapeutics, Inc. | Fourier transform mass spectrometry of complex biological samples |
US20020115717A1 (en) * | 2000-07-25 | 2002-08-22 | Francine Gervais | Amyloid targeting imaging agents and uses thereof |
WO2002010358A2 (en) * | 2000-07-31 | 2002-02-07 | Maxygen, Inc. | Nucleotide incorporating enzymes |
JP4853936B2 (ja) * | 2000-08-21 | 2012-01-11 | ザ ジェネラル ホスピタル コーポレイション | 神経変性状態の診断方法 |
HU230581B1 (hu) * | 2000-08-24 | 2017-01-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében |
US7270800B2 (en) * | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US6600947B2 (en) * | 2001-03-16 | 2003-07-29 | Nymox Corporation | Method of detecting amyloid-containing lesions by autofluorescence |
US20030194798A1 (en) * | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
WO2004013172A2 (en) * | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
WO2004087733A2 (en) * | 2003-03-28 | 2004-10-14 | New York University | Prevention and treatment of alzheimer amyloid deposition |
MXPA05012281A (es) * | 2003-05-14 | 2006-05-19 | Torreypines Therapeutics Inc | Compuestos y uso de los mismos en la modulacion beta amiloide. |
US20050048539A1 (en) * | 2003-06-13 | 2005-03-03 | The General Hospital Corporation | Methods to monitor molecule conformation and molecule/molecule proximity |
US20060034848A1 (en) * | 2003-11-07 | 2006-02-16 | Ayae Kinoshita | Methods and compositions for treating Alzheimer's disease |
WO2006026184A2 (en) * | 2004-08-20 | 2006-03-09 | Washington University | Blood brain barrier permeation peptides |
US8227621B2 (en) * | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
-
2001
- 2001-10-31 DE DE60128138T patent/DE60128138T2/de not_active Expired - Lifetime
- 2001-10-31 CA CA002427014A patent/CA2427014A1/en not_active Abandoned
- 2001-10-31 AT AT01999158T patent/ATE360392T1/de not_active IP Right Cessation
- 2001-10-31 WO PCT/US2001/045383 patent/WO2002064084A2/en active IP Right Grant
- 2001-10-31 US US10/001,643 patent/US7668586B2/en not_active Expired - Fee Related
- 2001-10-31 JP JP2002563881A patent/JP2004518488A/ja active Pending
- 2001-10-31 AU AU2002251682A patent/AU2002251682A1/en not_active Abandoned
- 2001-10-31 EP EP01999158A patent/EP1347731B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2427014A1 (en) | 2002-08-22 |
DE60128138T2 (de) | 2008-01-03 |
JP2004518488A (ja) | 2004-06-24 |
EP1347731B1 (de) | 2007-04-25 |
US20030009104A1 (en) | 2003-01-09 |
DE60128138D1 (de) | 2007-06-06 |
AU2002251682A1 (en) | 2002-08-28 |
EP1347731A2 (de) | 2003-10-01 |
WO2002064084A3 (en) | 2003-06-19 |
WO2002064084A2 (en) | 2002-08-22 |
EP1347731A4 (de) | 2004-09-08 |
US7668586B2 (en) | 2010-02-23 |
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