ATE291879T1 - Verfahren zur vermeidung von fluoreszenzlöschung - Google Patents

Verfahren zur vermeidung von fluoreszenzlöschung

Info

Publication number
ATE291879T1
ATE291879T1 AT01904884T AT01904884T ATE291879T1 AT E291879 T1 ATE291879 T1 AT E291879T1 AT 01904884 T AT01904884 T AT 01904884T AT 01904884 T AT01904884 T AT 01904884T AT E291879 T1 ATE291879 T1 AT E291879T1
Authority
AT
Austria
Prior art keywords
therapy
detection
imaging
dyes
useful
Prior art date
Application number
AT01904884T
Other languages
English (en)
Inventor
Samuel I Achilefu
Raghavan Rajagopalan
Richard B Dorshow
Joseph E Bugaj
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE291879T1 publication Critical patent/ATE291879T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01904884T 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung ATE291879T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/484,323 US6190641B1 (en) 2000-01-18 2000-01-18 Indocyanine dyes
PCT/US2001/001470 WO2001062156A1 (en) 2000-01-18 2001-01-17 Novel indocyanine dyes

Publications (1)

Publication Number Publication Date
ATE291879T1 true ATE291879T1 (de) 2005-04-15

Family

ID=23923670

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01904884T ATE291879T1 (de) 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung

Country Status (8)

Country Link
US (2) US6190641B1 (de)
EP (2) EP1250093B1 (de)
JP (1) JP2003523371A (de)
AT (1) ATE291879T1 (de)
AU (1) AU2001232820A1 (de)
DE (1) DE60109741T8 (de)
ES (1) ES2239123T3 (de)
WO (1) WO2001062156A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133445A (en) * 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US6190641B1 (en) * 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6485704B1 (en) * 2001-05-04 2002-11-26 Mallinckrodt Inc. Azo compound for type I pototherapy
US6761878B2 (en) * 2001-10-17 2004-07-13 Mallinckrodt, Inc. Pathological tissue detection and treatment employing targeted benzoindole optical agents
JP4749718B2 (ja) 2002-05-10 2011-08-17 カーネギー・メロン・ユニヴァーシティ 官能基を含有するキラルインドール中間体およびそれらの蛍光シアニン染料
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
ES2431520T3 (es) * 2003-01-25 2013-11-26 Seno Medical Instruments, Inc. Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
JP5349839B2 (ja) * 2007-06-22 2013-11-20 キヤノン株式会社 生体情報イメージング装置
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US9138492B2 (en) 2012-02-23 2015-09-22 Canon Kabushiki Kaisha Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919447A1 (de) * 1978-05-17 1979-11-22 Takeda Chemical Industries Ltd Tumorhemmendes mittel
JPS59192595A (ja) * 1983-04-16 1984-10-31 Tdk Corp 光記録媒体
JPS62220962A (ja) * 1986-03-24 1987-09-29 Oji Paper Co Ltd レ−ザ−光用電子写真感光体
JP3354975B2 (ja) * 1992-10-06 2002-12-09 イビデン株式会社 蛍光標識試薬および蛍光免疫測定法
JP3669752B2 (ja) * 1995-01-30 2005-07-13 第一化学薬品株式会社 診断用マーカー
DE69632244T2 (de) * 1995-01-30 2005-04-14 Daiichi Pure Chemicals Co. Ltd. Diagnostisches Markierungsmittel
JPH09227378A (ja) * 1996-02-20 1997-09-02 Fuji Photo Film Co Ltd 抗癌性組成物
JPH106653A (ja) * 1996-06-25 1998-01-13 Fuji Photo Film Co Ltd 情報記録媒体
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US6190641B1 (en) * 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes

Also Published As

Publication number Publication date
EP1250093A4 (de) 2003-05-07
US6264919B1 (en) 2001-07-24
EP1250093B1 (de) 2005-03-30
US6190641B1 (en) 2001-02-20
DE60109741T8 (de) 2006-04-27
EP1250093A1 (de) 2002-10-23
ES2239123T3 (es) 2005-09-16
EP1561425A1 (de) 2005-08-10
DE60109741T2 (de) 2006-02-23
AU2001232820A1 (en) 2001-09-03
DE60109741D1 (de) 2005-05-04
JP2003523371A (ja) 2003-08-05
WO2001062156A1 (en) 2001-08-30

Similar Documents

Publication Publication Date Title
ATE291878T1 (de) Verfahren zur vermeidung von fluoreszenzlöschung
ATE291879T1 (de) Verfahren zur vermeidung von fluoreszenzlöschung
Mahmood et al. Near-infrared optical imaging of protease activity for tumor detection
Keereweer et al. Optical image-guided cancer surgery: challenges and limitations
Keereweer et al. Optical image-guided surgery—where do we stand?
Walsh et al. Fluorescence imaging of nerves during surgery
Gioux et al. Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation
Celli et al. Imaging and photodynamic therapy: mechanisms, monitoring, and optimization
Zehri et al. Neurosurgical confocal endomicroscopy: a review of contrast agents, confocal systems, and future imaging modalities
DK1178830T3 (da) Cyanin- og indocyaninfarvestof-biokonjugater til biomedicinske anvendelser
Yim et al. Optimization of a protease activated probe for optical surgical navigation
He et al. Combination of fluorescence-guided surgery with photodynamic therapy for the treatment of cancer
Miwa The principle of ICG fluorescence method
DE60137453D1 (de) Fluoreszenz vermittelte molekulare tomographie
WO2005000218A3 (en) Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications
Zelmer et al. Noninvasive fluorescence imaging of small animals
Solomon et al. Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer–based molecular probe
Demos et al. Near-infrared autofluorescence imaging for detection of cancer
EP1250095A4 (de) Vielseitige hydrophile farbstoffe
Ntziachristos Clinical translation of optical and optoacoustic imaging
Keereweer et al. Translational optical imaging in diagnosis and treatment of cancer
Azar et al. Translational multimodality optical imaging
Hien et al. Noncontact recognition of fluorescently labeled objects in deep tissue via a novel optical light beam arrangement
WO2005058153A3 (en) Optical imaging contrast agents comprising a targeting vector linked to a fluorophore
Kirillin et al. Complementary bimodal approach to monitoring of photodynamic therapy with targeted nanoconstructs: numerical simulations

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties