CA2281205A1
(en)
|
1997-02-12 |
1998-08-13 |
Eugene Y. Chan |
Methods and products for analyzing polymers
|
US6780591B2
(en)
|
1998-05-01 |
2004-08-24 |
Arizona Board Of Regents |
Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|
US7875440B2
(en)
|
1998-05-01 |
2011-01-25 |
Arizona Board Of Regents |
Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|
US6818395B1
(en)
*
|
1999-06-28 |
2004-11-16 |
California Institute Of Technology |
Methods and apparatus for analyzing polynucleotide sequences
|
US7501245B2
(en)
*
|
1999-06-28 |
2009-03-10 |
Helicos Biosciences Corp. |
Methods and apparatuses for analyzing polynucleotide sequences
|
US6309836B1
(en)
*
|
1999-10-05 |
2001-10-30 |
Marek Kwiatkowski |
Compounds for protecting hydroxyls and methods for their use
|
US6664079B2
(en)
|
2000-10-06 |
2003-12-16 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
US9708358B2
(en)
|
2000-10-06 |
2017-07-18 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
AU2002227156A1
(en)
|
2000-12-01 |
2002-06-11 |
Visigen Biotechnologies, Inc. |
Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
|
DE10120798B4
(de)
*
|
2001-04-27 |
2005-12-29 |
Genovoxx Gmbh |
Verfahren zur Bestimmung der Genexpression
|
DE10120797B4
(de)
*
|
2001-04-27 |
2005-12-22 |
Genovoxx Gmbh |
Verfahren zur Analyse von Nukleinsäureketten
|
GB0129012D0
(en)
|
2001-12-04 |
2002-01-23 |
Solexa Ltd |
Labelled nucleotides
|
US7057026B2
(en)
*
|
2001-12-04 |
2006-06-06 |
Solexa Limited |
Labelled nucleotides
|
US20030153741A1
(en)
*
|
2002-02-08 |
2003-08-14 |
Marek Kwiatkowski |
Methods for separating oligonucleotides
|
DE10214395A1
(de)
*
|
2002-03-30 |
2003-10-23 |
Dmitri Tcherkassov |
Verfahren zur Analyse von Einzelnukleotidpolymorphismen
|
US20030228611A1
(en)
*
|
2002-05-01 |
2003-12-11 |
President And Fellows Of Harvard College |
Nucleic acid memory device
|
US11008359B2
(en)
|
2002-08-23 |
2021-05-18 |
Illumina Cambridge Limited |
Labelled nucleotides
|
DK3363809T3
(da)
|
2002-08-23 |
2020-05-04 |
Illumina Cambridge Ltd |
Modificerede nukleotider til polynukleotidsekvensering
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
DK1560838T3
(da)
|
2002-08-23 |
2009-09-07 |
Illumina Cambridge Ltd |
M rkede nuklotider
|
US7345163B2
(en)
*
|
2002-08-28 |
2008-03-18 |
Quiatech Ab |
Process for separating and deprotecting oligonucleotides
|
US20050170367A1
(en)
*
|
2003-06-10 |
2005-08-04 |
Quake Stephen R. |
Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
|
WO2005044836A2
(de)
|
2003-11-05 |
2005-05-19 |
Genovoxx Gmbh |
Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
|
US7169560B2
(en)
|
2003-11-12 |
2007-01-30 |
Helicos Biosciences Corporation |
Short cycle methods for sequencing polynucleotides
|
US20060172408A1
(en)
*
|
2003-12-01 |
2006-08-03 |
Quake Steven R |
Device for immobilizing chemical and biochemical species and methods of using same
|
ATE463584T1
(de)
|
2004-02-19 |
2010-04-15 |
Helicos Biosciences Corp |
Verfahren zur analyse von polynukleotidsequenzen
|
US20060046258A1
(en)
*
|
2004-02-27 |
2006-03-02 |
Lapidus Stanley N |
Applications of single molecule sequencing
|
US20050239085A1
(en)
*
|
2004-04-23 |
2005-10-27 |
Buzby Philip R |
Methods for nucleic acid sequence determination
|
US20070117104A1
(en)
*
|
2005-11-22 |
2007-05-24 |
Buzby Philip R |
Nucleotide analogs
|
US20070117103A1
(en)
*
|
2005-11-22 |
2007-05-24 |
Buzby Philip R |
Nucleotide analogs
|
EP1766090B1
(de)
*
|
2004-05-25 |
2011-04-27 |
Helicos Biosciences Corporation |
Verfahren zur nukleinsäureimmobilisierung
|
US7476734B2
(en)
*
|
2005-12-06 |
2009-01-13 |
Helicos Biosciences Corporation |
Nucleotide analogs
|
US20060024678A1
(en)
*
|
2004-07-28 |
2006-02-02 |
Helicos Biosciences Corporation |
Use of single-stranded nucleic acid binding proteins in sequencing
|
US20060118754A1
(en)
*
|
2004-12-08 |
2006-06-08 |
Lapen Daniel C |
Stabilizing a polyelectrolyte multilayer
|
US7220549B2
(en)
*
|
2004-12-30 |
2007-05-22 |
Helicos Biosciences Corporation |
Stabilizing a nucleic acid for nucleic acid sequencing
|
US20060172328A1
(en)
*
|
2005-01-05 |
2006-08-03 |
Buzby Philip R |
Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
|
JP2008526877A
(ja)
*
|
2005-01-05 |
2008-07-24 |
エージェンコート パーソナル ジェノミクス |
可逆的ヌクレオチドターミネーターおよびその使用
|
US7482120B2
(en)
*
|
2005-01-28 |
2009-01-27 |
Helicos Biosciences Corporation |
Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
|
EP2241637A1
(de)
|
2005-02-01 |
2010-10-20 |
AB Advanced Genetic Analysis Corporation |
Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
|
US20080003571A1
(en)
|
2005-02-01 |
2008-01-03 |
Mckernan Kevin |
Reagents, methods, and libraries for bead-based sequencing
|
US20060263790A1
(en)
*
|
2005-05-20 |
2006-11-23 |
Timothy Harris |
Methods for improving fidelity in a nucleic acid synthesis reaction
|
GB0517097D0
(en)
|
2005-08-19 |
2005-09-28 |
Solexa Ltd |
Modified nucleosides and nucleotides and uses thereof
|
US7666593B2
(en)
|
2005-08-26 |
2010-02-23 |
Helicos Biosciences Corporation |
Single molecule sequencing of captured nucleic acids
|
WO2007053719A2
(en)
|
2005-10-31 |
2007-05-10 |
The Trustees Of Columbia University In The City Of New York |
Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
|
WO2007053702A2
(en)
|
2005-10-31 |
2007-05-10 |
The Trustees Of Columbia University In The City Of New York |
Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods
|
US20070117102A1
(en)
*
|
2005-11-22 |
2007-05-24 |
Buzby Philip R |
Nucleotide analogs
|
US20070128610A1
(en)
*
|
2005-12-02 |
2007-06-07 |
Buzby Philip R |
Sample preparation method and apparatus for nucleic acid sequencing
|
EP2007907A2
(de)
*
|
2006-04-19 |
2008-12-31 |
Applera Corporation |
Reagenzien, verfahren und bibliotheken für gelfreie, perlenbasierte sequenzierung
|
WO2008037568A2
(en)
*
|
2006-09-04 |
2008-04-03 |
Quiatech Ab |
Reversible terminators for efficient sequencing by synthesis
|
US8399188B2
(en)
|
2006-09-28 |
2013-03-19 |
Illumina, Inc. |
Compositions and methods for nucleotide sequencing
|
WO2008069973A2
(en)
|
2006-12-01 |
2008-06-12 |
The Trustees Of Columbia University In The City Of New York |
Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
|
US8612161B2
(en)
|
2008-03-19 |
2013-12-17 |
Intelligent Biosystems Inc. |
Methods and compositions for base calling nucleic acids
|
US11940413B2
(en)
|
2007-02-05 |
2024-03-26 |
IsoPlexis Corporation |
Methods and devices for sequencing nucleic acids in smaller batches
|
US11035823B2
(en)
|
2009-03-17 |
2021-06-15 |
Qiagen Sciences, Llc |
Methods and devices for sequencing nucleic acids in smaller batches
|
US8481259B2
(en)
*
|
2007-02-05 |
2013-07-09 |
Intelligent Bio-Systems, Inc. |
Methods and devices for sequencing nucleic acids in smaller batches
|
US7881933B2
(en)
*
|
2007-03-23 |
2011-02-01 |
Verizon Patent And Licensing Inc. |
Age determination using speech
|
US20090062132A1
(en)
*
|
2007-08-29 |
2009-03-05 |
Borner Scott R |
Alternative nucleic acid sequencing methods
|
DK2725107T3
(da)
|
2007-10-19 |
2019-01-02 |
Univ Columbia |
DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
|
EP4310194A3
(de)
|
2007-10-19 |
2024-10-16 |
The Trustees of Columbia University in the City of New York |
Entwurf und synthese von spaltbaren fluoreszierenden nukleotiden als reversible terminatoren zur dna-sequenzierung durch synthese
|
US20090156412A1
(en)
*
|
2007-12-17 |
2009-06-18 |
Helicos Biosciences Corporation |
Surface-capture of target nucleic acids
|
US9017973B2
(en)
|
2008-03-19 |
2015-04-28 |
Intelligent Biosystems, Inc. |
Methods and compositions for incorporating nucleotides
|
CA2725239C
(en)
|
2008-05-27 |
2019-02-26 |
Trilink Biotechnologies |
Chemically modified nucleoside 5'-triphosphates for thermally initiated amplification of nucleic acid
|
WO2010003153A2
(en)
*
|
2008-07-03 |
2010-01-07 |
Life Technologies Corporation |
Methylation analysis of mate pairs
|
US10022454B2
(en)
|
2008-09-23 |
2018-07-17 |
Liposciences, Llc |
Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
|
EP2346883B1
(de)
*
|
2008-09-23 |
2016-03-23 |
Scott G. Petersen |
Selbstfreisetzende biolabile phosphatgeschützte pro-oligos für therapeutika auf oligonukleotidbasis und vermittlung von rna-interferenz
|
US20100330569A1
(en)
|
2009-04-23 |
2010-12-30 |
Intelligent Bio-Systems, Inc. |
Hydroxymethyl Linkers For Labeling Nucleotides
|
WO2010141390A2
(en)
|
2009-06-05 |
2010-12-09 |
Life Technologies Corporation |
Nucleotide transient binding for sequencing methods
|
KR101107315B1
(ko)
*
|
2009-09-29 |
2012-01-20 |
한국과학기술연구원 |
3′―하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 dna 염기서열 분석 방법
|
DE102010049607A1
(de)
|
2009-10-26 |
2011-06-30 |
Becker, Claus, Prof., 76470 |
Konjugate von Nukleotiden und Methoden zu deren Anwendung
|
DE102009046981A1
(de)
*
|
2009-11-23 |
2011-06-01 |
Ernst-Moritz-Arndt-Universität Greifswald |
Verfahren zur Herstellung von Trinukleotiden
|
DE102009046982A1
(de)
*
|
2009-11-23 |
2011-06-01 |
Ernst-Moritz-Arndt-Universität Greifswald |
Festphasengebundene Nukleoside
|
WO2012012703A2
(en)
|
2010-07-23 |
2012-01-26 |
Esoterix Genetic Laboratories, Llc |
Identification of differentially represented fetal or maternal genomic regions and uses thereof
|
US9994894B2
(en)
|
2011-04-27 |
2018-06-12 |
Agct Gmbh |
Method and components for detecting nucleic acid chains
|
US20150086981A1
(en)
|
2011-05-04 |
2015-03-26 |
Genovoxx Gmbh |
Nucleoside-triphosphate conjugate and methods for the use thereof
|
WO2012162429A2
(en)
|
2011-05-23 |
2012-11-29 |
The Trustees Of Columbia University In The City Of New York |
Dna sequencing by synthesis using raman and infrared spectroscopy detection
|
EP3248982A1
(de)
*
|
2011-07-19 |
2017-11-29 |
Wave Life Sciences Ltd. |
Thiosulfonate reagente zur synthese von funktionalisierten nukleinsäuren
|
EP2847353B1
(de)
|
2012-05-10 |
2022-01-19 |
The General Hospital Corporation |
Verfahren zur bestimmung einer nukleotidsequenz
|
US9146248B2
(en)
|
2013-03-14 |
2015-09-29 |
Intelligent Bio-Systems, Inc. |
Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
|
KR102230831B1
(ko)
|
2013-03-15 |
2021-03-22 |
일루미나 케임브리지 리미티드 |
변형된 뉴클레오사이드 또는 뉴클레오타이드
|
WO2014144883A1
(en)
|
2013-03-15 |
2014-09-18 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
US9591268B2
(en)
|
2013-03-15 |
2017-03-07 |
Qiagen Waltham, Inc. |
Flow cell alignment methods and systems
|
US8808989B1
(en)
|
2013-04-02 |
2014-08-19 |
Molecular Assemblies, Inc. |
Methods and apparatus for synthesizing nucleic acids
|
US9771613B2
(en)
|
2013-04-02 |
2017-09-26 |
Molecular Assemblies, Inc. |
Methods and apparatus for synthesizing nucleic acid
|
US11384377B2
(en)
|
2013-04-02 |
2022-07-12 |
Molecular Assemblies, Inc. |
Reusable initiators for synthesizing nucleic acids
|
US11331643B2
(en)
|
2013-04-02 |
2022-05-17 |
Molecular Assemblies, Inc. |
Reusable initiators for synthesizing nucleic acids
|
US9279149B2
(en)
|
2013-04-02 |
2016-03-08 |
Molecular Assemblies, Inc. |
Methods and apparatus for synthesizing nucleic acids
|
US10683536B2
(en)
|
2013-04-02 |
2020-06-16 |
Molecular Assemblies, Inc. |
Reusable initiators for synthesizing nucleic acids
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
CN106661612A
(zh)
|
2014-01-27 |
2017-05-10 |
通用医疗公司 |
制备用于测序的核酸的方法
|
EP3332790A1
(de)
|
2014-07-15 |
2018-06-13 |
Kymab Limited |
Antikörper zur verwendung bei der behandlung von erkrankungen im zusammenhang mit spezifischen pcsk9-varianten in bestimmten patientenpopulationen
|
EP4328245A3
(de)
|
2014-07-15 |
2024-06-05 |
Kymab Ltd. |
Antikörper zur verwendung bei der behandlung von erkrankungen im zusammenhang mit spezifischen pcsk9-varianten in bestimmten patientenpopulationen
|
DE202015009002U1
(de)
|
2014-07-15 |
2016-08-18 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
WO2016023916A1
(en)
|
2014-08-12 |
2016-02-18 |
Kymab Limited |
Treatment of disease using ligand binding to targets of interest
|
WO2016064880A1
(en)
|
2014-10-20 |
2016-04-28 |
Molecular Assemblies, Inc. |
Modified template-independent enzymes for polydeoxynucleotide systhesis
|
WO2016071701A1
(en)
|
2014-11-07 |
2016-05-12 |
Kymab Limited |
Treatment of disease using ligand binding to targets of interest
|
CN114989235A
(zh)
*
|
2015-09-28 |
2022-09-02 |
哥伦比亚大学董事会 |
用作dna合成测序的可逆终止物的基于新的二硫键接头的核苷酸的设计与合成
|
TWI664160B
(zh)
*
|
2015-11-06 |
2019-07-01 |
美商齊亞雋科學公司 |
核苷酸類似物
|
US11421264B2
(en)
|
2015-11-06 |
2022-08-23 |
IsoPlexis Corporation |
Thiol-containing cleave reagents and oxidative wash
|
WO2017205336A1
(en)
|
2016-05-23 |
2017-11-30 |
The Trustees Of Columbia University In The City Of New York |
Nucleotide derivatives and methods of use thereof
|
JP6997772B2
(ja)
|
2016-09-15 |
2022-01-18 |
アーチャーディーエックス, エルエルシー |
核酸サンプル調製の方法
|
AU2017328953B2
(en)
|
2016-09-15 |
2023-09-14 |
Archerdx, Llc |
Methods of nucleic acid sample preparation for analysis of cell-free DNA
|
ES2940620T3
(es)
|
2016-11-02 |
2023-05-09 |
Archerdx Llc |
Métodos de preparación de muestras de ácido nucleico para la secuenciación del repertorio inmunitario
|
CN110506121A
(zh)
*
|
2016-11-04 |
2019-11-26 |
奇根科学有限责任公司 |
含硫羟基的切割试剂和氧化洗涤剂
|
US11773133B2
(en)
*
|
2017-01-06 |
2023-10-03 |
The Charles Stark Draper Laboratory, Inc. |
Optically verified polymer synthesis
|
EP3596099B1
(de)
|
2017-03-06 |
2024-07-24 |
Singular Genomics Systems, Inc. |
Verfahren zur nukleinsäuresequenzierung durch synthese (sbs), die sbs-zyklusschritte kombinieren
|
CN110709089A
(zh)
*
|
2017-03-28 |
2020-01-17 |
哥伦比亚大学董事会 |
用于连接荧光标记与用于dna合成测序的碱基的具有不同可裂解连接子的3’-o-改性的核苷酸类似物
|
WO2019023924A1
(en)
|
2017-08-01 |
2019-02-07 |
Helitec Limited |
METHODS FOR ENRICHMENT AND DETERMINATION OF TARGET NUCLEOTIDE SEQUENCES
|
US10844430B2
(en)
|
2018-01-24 |
2020-11-24 |
Qiagen Sciences, Llc |
DNA sequencing reaction additive
|
CN113039191B
(zh)
|
2018-10-25 |
2024-07-16 |
奇异基因组学系统公司 |
核苷酸类似物
|
JP2022516684A
(ja)
|
2019-01-08 |
2022-03-01 |
シンギュラー・ゲノミクス・システムズ・インコーポレイテッド |
ヌクレオチドの開裂可能なリンカーおよびその使用
|
US11773422B2
(en)
|
2019-08-16 |
2023-10-03 |
Microsoft Technology Licensing, Llc |
Regulation of polymerase using cofactor oxidation states
|
US11795450B2
(en)
|
2019-09-06 |
2023-10-24 |
Microsoft Technology Licensing, Llc |
Array-based enzymatic oligonucleotide synthesis
|
EP4117682A4
(de)
|
2020-04-24 |
2023-09-13 |
Singular Genomics Systems, Inc. |
Modifizierte nukleotide und verwendungen davon
|
US11702683B2
(en)
|
2020-05-28 |
2023-07-18 |
Microsoft Technology Licensing, Llc |
De novo polynucleotide synthesis with substrate-bound polymerase
|
US11840715B2
(en)
|
2020-06-30 |
2023-12-12 |
Microsoft Technology Licensing, Llc |
Microelectrode array with a switchable hydrophilic surface
|
WO2022204321A1
(en)
|
2021-03-24 |
2022-09-29 |
Ambry Genetics Corporation |
Conservative concurrent evaluation of dna modifications
|
US20220372468A1
(en)
|
2021-05-19 |
2022-11-24 |
Microsoft Technology Licensing, Llc |
Real-time detection of errors in oligonucleotide synthesis
|
AU2022316209A1
(en)
|
2021-07-20 |
2024-02-22 |
Regeneron Pharmaceuticals, Inc. |
Butyrophilin-like 2 agents for treating inflammatory disorders
|