ATE357928T1 - Pharmazeutische zusammensetzung für thrombinpeptidderivaten - Google Patents
Pharmazeutische zusammensetzung für thrombinpeptidderivatenInfo
- Publication number
- ATE357928T1 ATE357928T1 AT04258191T AT04258191T ATE357928T1 AT E357928 T1 ATE357928 T1 AT E357928T1 AT 04258191 T AT04258191 T AT 04258191T AT 04258191 T AT04258191 T AT 04258191T AT E357928 T1 ATE357928 T1 AT E357928T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical composition
- thrombin peptide
- peptide derivatives
- thrombin
- disclosed
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 108090000190 Thrombin Proteins 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 229960004072 thrombin Drugs 0.000 title abstract 3
- 102000003790 Thrombin receptors Human genes 0.000 abstract 1
- 108090000166 Thrombin receptors Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53373003P | 2003-12-31 | 2003-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE357928T1 true ATE357928T1 (de) | 2007-04-15 |
Family
ID=34652502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04258191T ATE357928T1 (de) | 2003-12-31 | 2004-12-30 | Pharmazeutische zusammensetzung für thrombinpeptidderivaten |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7291596B2 (https=) |
| EP (1) | EP1559431B1 (https=) |
| JP (1) | JP5044829B2 (https=) |
| CN (1) | CN1913917B (https=) |
| AT (1) | ATE357928T1 (https=) |
| AU (1) | AU2004312090B2 (https=) |
| CA (1) | CA2551525C (https=) |
| DE (1) | DE602004005564T2 (https=) |
| DK (1) | DK1559431T3 (https=) |
| ES (1) | ES2287660T3 (https=) |
| PL (1) | PL1559431T3 (https=) |
| PT (1) | PT1559431E (https=) |
| WO (1) | WO2005065706A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003247848B2 (en) * | 2002-07-02 | 2006-12-21 | The Board Of Regents, The University Of Texas System | Thrombin peptide derivative dimers |
| HUE029994T2 (en) | 2005-12-08 | 2017-04-28 | Insmed Inc | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| CN101563102B (zh) * | 2006-09-22 | 2014-12-17 | 德克萨斯系统大学董事会 | 治疗内皮功能障碍的方法 |
| US8227412B2 (en) * | 2007-03-29 | 2012-07-24 | Tsopanoglou Nikos E | Bioactive parstatin peptides and methods of use |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| GB0710529D0 (en) | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
| AU2009229399A1 (en) * | 2008-03-26 | 2009-10-01 | Orthologic Corp. | Thrombin derived peptides for smooth muscle relaxation |
| JP2011515471A (ja) * | 2008-03-26 | 2011-05-19 | オーソロジック コーポレイション | 急性心筋梗塞を処置するための方法 |
| AU2009229395A1 (en) * | 2008-03-26 | 2009-10-01 | The Board Of Regents, The University Of Texas System | Method of treating degenerative diseases |
| CA2722620A1 (en) * | 2008-03-26 | 2009-10-01 | Orthologic Corp. | Method of treating peripheral arterial disease |
| WO2010033862A2 (en) * | 2008-09-19 | 2010-03-25 | The Board Of Regents, The University Of Texas System | Methods for treating cancer |
| GB0821806D0 (en) | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
| JP6025256B2 (ja) | 2010-02-23 | 2016-11-16 | コーニング インコーポレイテッド | ペプチド固定化表面をγ線劣化から保護するための修飾基板 |
| RU2018135921A (ru) * | 2012-11-29 | 2019-02-05 | Инсмед Инкорпорейтед | Стабилизированные составы ванкомицина |
| US11019824B2 (en) * | 2013-10-03 | 2021-06-01 | Luis Alberto Amestica Salazar | Biocidal resin composition including one or a plurality of resins selected from MF, UF, PF, MUF and phenolic resins; and more than one soluble copper salt |
| SMT202000516T1 (it) | 2014-05-15 | 2020-11-10 | Insmed Inc | Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari |
| US10220078B2 (en) | 2014-06-11 | 2019-03-05 | The Board Of Regents Of The University Of Texas System | Methods of using thrombin derivatives to treat medulloblastoma |
| CN105879010A (zh) * | 2015-01-17 | 2016-08-24 | 内蒙古天奇生物科技有限公司 | 一种能促进创伤愈合减轻创后瘢痕的多肽组合物及其制备方法 |
| EP3773505B1 (en) | 2018-03-30 | 2026-04-29 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| WO2019213398A1 (en) | 2018-05-02 | 2019-11-07 | Insmed Incorporated | Methods for the manufacture of liposomal drug formulations |
| EP3952991A4 (en) * | 2019-04-12 | 2023-08-09 | Affirmed Pharma, LLC | RUSALATIDE ACETATE COMPOSITIONS |
| JP2023139750A (ja) * | 2022-03-22 | 2023-10-04 | 株式会社東芝 | 抗酸化剤を用いたｆｅｔセンサ |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3019612A1 (de) * | 1980-05-22 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabilisiertes thrombinpraeparat |
| US5352664A (en) | 1986-10-31 | 1994-10-04 | Board Of Regents, The University Of Texas System | Thrombin derived polypeptides; compositions and methods for use |
| JP2000229882A (ja) * | 1998-12-10 | 2000-08-22 | Sankyo Co Ltd | 修飾シクロデキストリン含有トロンビン水性液剤 |
| GB9930768D0 (en) | 1999-12-29 | 2000-02-16 | Pfizer Ltd | Composition |
| TWI257307B (en) | 2000-07-12 | 2006-07-01 | Orthologic Corp | Pharmaceutical composition for cardiac tissue repair |
| DK1301196T3 (da) | 2000-07-19 | 2004-03-29 | Univ Texas | Stimulering af knoglevækst med peptidderivater af thrombin |
| WO2003061690A1 (en) | 2002-01-17 | 2003-07-31 | The Board Of Regents, The University Of Texas System | Stimulation of bone growth and cartilage formation with thrombing peptide derivatives |
| EP1259598B1 (en) | 2000-07-20 | 2004-09-22 | The Board of Regents, The University of Texas System | Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor |
| DE60113290D1 (de) * | 2000-11-17 | 2005-10-13 | Warner Lambert Co | Behandlung von sexueller funktionsstörung mit bombesin rezeptor antagonisten |
| EP2080771A3 (en) * | 2001-02-27 | 2010-01-06 | Maxygen Aps | New interferon beta-like molecules |
| EP1414487B1 (en) | 2001-07-27 | 2006-06-07 | Orthologic Corp. | Use of thrombin-derived peptides for the therapy of chronic dermal ulcers |
| CA2511223A1 (en) | 2002-01-16 | 2003-07-31 | The Board Of Regents, The University Of Texas System | Thrombin derived peptides for promoting cardiac tissue repair |
| JP5184738B2 (ja) * | 2002-05-03 | 2013-04-17 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 修飾第ｖｉｉ因子の安定化された固体組成物 |
| AU2003247848B2 (en) * | 2002-07-02 | 2006-12-21 | The Board Of Regents, The University Of Texas System | Thrombin peptide derivative dimers |
| EP1539214A4 (en) * | 2002-07-02 | 2008-01-02 | Orthologic Corp | Thrombin |
-
2004
- 2004-12-30 PL PL04258191T patent/PL1559431T3/pl unknown
- 2004-12-30 AU AU2004312090A patent/AU2004312090B2/en not_active Expired
- 2004-12-30 ES ES04258191T patent/ES2287660T3/es not_active Expired - Lifetime
- 2004-12-30 DK DK04258191T patent/DK1559431T3/da active
- 2004-12-30 DE DE602004005564T patent/DE602004005564T2/de not_active Expired - Lifetime
- 2004-12-30 AT AT04258191T patent/ATE357928T1/de active
- 2004-12-30 CA CA2551525A patent/CA2551525C/en not_active Expired - Lifetime
- 2004-12-30 US US11/027,923 patent/US7291596B2/en not_active Expired - Lifetime
- 2004-12-30 WO PCT/US2004/044012 patent/WO2005065706A1/en not_active Ceased
- 2004-12-30 CN CN2004800414872A patent/CN1913917B/zh not_active Expired - Fee Related
- 2004-12-30 EP EP04258191A patent/EP1559431B1/en not_active Expired - Lifetime
- 2004-12-30 JP JP2006547586A patent/JP5044829B2/ja not_active Expired - Lifetime
- 2004-12-30 PT PT04258191T patent/PT1559431E/pt unknown
-
2007
- 2007-09-25 US US11/903,877 patent/US7875588B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004312090A1 (en) | 2005-07-21 |
| DK1559431T3 (da) | 2007-07-30 |
| US7875588B2 (en) | 2011-01-25 |
| CA2551525A1 (en) | 2005-07-21 |
| EP1559431A1 (en) | 2005-08-03 |
| CA2551525C (en) | 2013-02-19 |
| CN1913917A (zh) | 2007-02-14 |
| CN1913917B (zh) | 2012-02-01 |
| HK1080390A1 (en) | 2006-04-28 |
| DE602004005564D1 (de) | 2007-05-10 |
| ES2287660T3 (es) | 2007-12-16 |
| JP5044829B2 (ja) | 2012-10-10 |
| US7291596B2 (en) | 2007-11-06 |
| US20050203017A1 (en) | 2005-09-15 |
| PT1559431E (pt) | 2007-07-02 |
| DE602004005564T2 (de) | 2007-12-13 |
| AU2004312090B2 (en) | 2008-08-14 |
| PL1559431T3 (pl) | 2007-10-31 |
| JP2007518724A (ja) | 2007-07-12 |
| EP1559431B1 (en) | 2007-03-28 |
| US20090054343A1 (en) | 2009-02-26 |
| WO2005065706A1 (en) | 2005-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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