ATE353217T1 - 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren - Google Patents

3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren

Info

Publication number
ATE353217T1
ATE353217T1 AT03757767T AT03757767T ATE353217T1 AT E353217 T1 ATE353217 T1 AT E353217T1 AT 03757767 T AT03757767 T AT 03757767T AT 03757767 T AT03757767 T AT 03757767T AT E353217 T1 ATE353217 T1 AT E353217T1
Authority
AT
Austria
Prior art keywords
inhibitors
phenylphenanthridine
pde
hydroxy
meanings
Prior art date
Application number
AT03757767T
Other languages
German (de)
English (en)
Inventor
Ulrich Kautz
Beate Schmidt
Dieter Flockerzi
Gerhard Grundler
Ruediger Nave
Rolf-Peter Hummel
Ernst Sturm
Armin Hatzelmann
Johannes Barsig
Degenhard Marx
Hans-Peter Kley
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE353217T1 publication Critical patent/ATE353217T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • AIDS & HIV (AREA)
AT03757767T 2002-08-29 2003-08-29 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren ATE353217T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02019336 2002-08-29

Publications (1)

Publication Number Publication Date
ATE353217T1 true ATE353217T1 (de) 2007-02-15

Family

ID=31970272

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03757767T ATE353217T1 (de) 2002-08-29 2003-08-29 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren

Country Status (9)

Country Link
US (2) US7423046B2 (https=)
EP (1) EP1536798B1 (https=)
JP (1) JP4587295B2 (https=)
AT (1) ATE353217T1 (https=)
AU (1) AU2003273805B8 (https=)
CA (1) CA2496459C (https=)
DE (1) DE60311662T2 (https=)
ES (1) ES2281658T3 (https=)
WO (1) WO2004019945A1 (https=)

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GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
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GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
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DE602008005140D1 (de) 2007-05-07 2011-04-07 Novartis Ag Organische verbindungen
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JP2011522860A (ja) 2008-06-10 2011-08-04 ノバルティス アーゲー 上皮性ナトリウムチャネルブロッカーとしてのピラジン誘導体
PT2391366E (pt) 2009-01-29 2013-02-05 Novartis Ag Benzimidazoles substituídos para o tratamento de astrocitomas
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
JP5781510B2 (ja) 2009-08-12 2015-09-24 ノバルティス アーゲー ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用
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MX2012004792A (es) 2009-10-22 2013-02-01 Vertex Pharma Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas.
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
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US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
EA026655B1 (ru) 2011-09-15 2017-05-31 Новартис Аг 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ
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CN108658778A (zh) * 2018-06-19 2018-10-16 上海华堇生物技术有限责任公司 一种3,4-二甲氧基-β-硝基苯乙烯的新制备方法
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