ATE350486T1 - Durch mechanischen stress induzierte gene, deren expressionsprodukte und deren verwendung. - Google Patents

Durch mechanischen stress induzierte gene, deren expressionsprodukte und deren verwendung.

Info

Publication number
ATE350486T1
ATE350486T1 AT99923223T AT99923223T ATE350486T1 AT E350486 T1 ATE350486 T1 AT E350486T1 AT 99923223 T AT99923223 T AT 99923223T AT 99923223 T AT99923223 T AT 99923223T AT E350486 T1 ATE350486 T1 AT E350486T1
Authority
AT
Austria
Prior art keywords
genes
expression products
mechanical stress
osteoporosis
processes
Prior art date
Application number
AT99923223T
Other languages
English (en)
Inventor
Paz Einat
Orna Mor
Rami Skaliter
Elena Feinstein
Alexander Faerman
Original Assignee
Quark Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quark Biotech Inc filed Critical Quark Biotech Inc
Application granted granted Critical
Publication of ATE350486T1 publication Critical patent/ATE350486T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT99923223T 1998-05-15 1999-05-14 Durch mechanischen stress induzierte gene, deren expressionsprodukte und deren verwendung. ATE350486T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8567398P 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
ATE350486T1 true ATE350486T1 (de) 2007-01-15

Family

ID=22193209

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99923223T ATE350486T1 (de) 1998-05-15 1999-05-14 Durch mechanischen stress induzierte gene, deren expressionsprodukte und deren verwendung.

Country Status (9)

Country Link
EP (1) EP1082463B1 (de)
JP (1) JP2002535956A (de)
AT (1) ATE350486T1 (de)
AU (1) AU4004699A (de)
CA (1) CA2332150A1 (de)
DE (1) DE69934688T2 (de)
IL (2) IL139637A0 (de)
WO (1) WO1999060164A1 (de)
ZA (1) ZA200006613B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151514A1 (en) * 1998-05-11 2002-10-17 Paz Einat Genes associated with mechanical stress, expression products therefrom, and uses thereof
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US7259253B2 (en) 1999-05-14 2007-08-21 Quark Biotech, Inc. Genes associated with mechanical stress, expression products therefrom, and uses thereof
US6528262B1 (en) 1999-10-06 2003-03-04 Quark Biotech, Inc. Method for enrichment of natural antisense messenger RNA
US6986988B2 (en) 1999-10-06 2006-01-17 Quark Biotech, Inc. Method for enrichment of natural antisense messenger RNA
US6468749B1 (en) 2000-03-30 2002-10-22 Quark Biotech, Inc. Sequence-dependent gene sorting techniques
AU2002221046A1 (en) * 2000-12-06 2002-06-18 Takara Shuzo Co., Ltd. Functional dna array
EP1370576A4 (de) * 2001-03-23 2005-06-01 Dana Farber Cancer Inst Inc Verfahren und zusammensetzungen zur modulation der tumorsuppression
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
BE1014949A3 (fr) 2001-08-14 2004-07-06 Probiox Procede de detection de stress oxydant et trousse pour sa mise en oeuvre.
EP1537140B1 (de) 2001-11-07 2013-01-02 Agensys, Inc. Zur behandlung und zum nachweis von krebs geeignete nukleinsäure und zugehöriges protein mit der bezeichnung 161p2f10b
EP1636388A2 (de) * 2003-06-06 2006-03-22 Wyeth Verfahren und materialien zur identifizierung von das knochen-remodeling modulierenden agentien und damit identifizierte agentien
CN101076348A (zh) 2004-10-08 2007-11-21 克里纽沃药物有限公司 用于在受试者中诱导黑素原生成的组合物和方法
BRPI0609655A2 (pt) 2005-03-31 2010-03-16 Agensys Inc anticorpos e moléculas relacionadas que ligam-se às proteìnas 161p2f10b
US8350009B2 (en) 2005-03-31 2013-01-08 Agensys, Inc. Antibodies and related molecules that bind to 161P2F10B proteins
ES2620789T3 (es) 2005-08-15 2017-06-29 Altimmune Inc. Inmunización de aves por administración de vacunas con vectores no replicantes
FR2893328B1 (fr) * 2005-11-17 2014-01-31 Lvmh Rech Procede pour depister des marqueurs impliques dans la resistance de keratinocytes a des deformations mecaniques.
PL2056855T3 (pl) 2006-08-31 2015-04-30 Clinuvel Pharmaceuticals Ltd Pochodne alfa-MSH do leczenia fotodermatoz
ES2550160T3 (es) 2008-03-27 2015-11-04 Clinuvel Pharmaceuticals Limited Terapia para el vitíligo
TWI504410B (zh) 2010-02-08 2015-10-21 Agensys Inc 結合至１６１ｐ２ｆ１０ｂ蛋白之抗體藥物結合物（ａｄｃ）
EP2487185A1 (de) 2011-02-11 2012-08-15 Clinuvel Pharmaceuticals Limited Hexapeptid mit verbesserter Aktivität bei der Reparatur von zellulärer DNA von Dermiszellen
WO2012129295A1 (en) 2011-03-21 2012-09-27 Vaxin Inc. Rapid and prolonged immunologic-therapeutic
LT2741740T (lt) 2011-08-12 2017-08-10 Merial, Inc. Biologinių produktų, ypatingai vakcinų, vakuuminis konservavimas
WO2014012090A1 (en) 2012-07-13 2014-01-16 The Broad Institute, Inc. Molecular sleds comprising a positively-charged amino acid sequence and a molecular cargo and uses thereof
JP2015527889A (ja) 2012-07-25 2015-09-24 ザ ブロード インスティテュート， インコーポレイテッド 誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用
WO2014121104A1 (en) * 2013-01-31 2014-08-07 The Regents Of The University Of California Pooled genetic perturbation effects
US11332719B2 (en) 2013-03-15 2022-05-17 The Broad Institute, Inc. Recombinant virus and preparations thereof
WO2015057671A1 (en) 2013-10-14 2015-04-23 The Broad Institute, Inc. Artificial transcription factors comprising a sliding domain and uses thereof
JP6545084B2 (ja) * 2015-11-11 2019-07-17 株式会社Adeka 潤滑油組成物及びその製造方法
EP3640329A1 (de) * 2018-10-18 2020-04-22 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Geneditierungsbasierte krebsbehandlung
US20240254510A1 (en) * 2021-03-19 2024-08-01 Washington University Methods for generating mechanically-responsive cells and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9204303A (es) * 1991-07-23 1993-11-01 Rhone Poulenc Rorer Int Factor regulador del crecimiento de osteoclasto.
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5834248A (en) * 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US5861249A (en) * 1996-04-23 1999-01-19 Cold Spring Harbor Laboratory Assays and reagents for identifying modulators of cdc25-mediated mitotic activation

Also Published As

Publication number Publication date
EP1082463A1 (de) 2001-03-14
AU4004699A (en) 1999-12-06
EP1082463B1 (de) 2007-01-03
ZA200006613B (en) 2002-02-14
IL139637A (en) 2009-09-22
DE69934688T2 (de) 2007-10-18
EP1082463A4 (de) 2003-05-21
JP2002535956A (ja) 2002-10-29
WO1999060164A1 (en) 1999-11-25
IL139637A0 (en) 2002-02-10
DE69934688D1 (de) 2007-02-15
CA2332150A1 (en) 1999-11-25

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