DK0730606T3 - Hu-B1.219, en hidtil ukendt human hæmatopoietinreceptor - Google Patents
Hu-B1.219, en hidtil ukendt human hæmatopoietinreceptorInfo
- Publication number
- DK0730606T3 DK0730606T3 DK95931007T DK95931007T DK0730606T3 DK 0730606 T3 DK0730606 T3 DK 0730606T3 DK 95931007 T DK95931007 T DK 95931007T DK 95931007 T DK95931007 T DK 95931007T DK 0730606 T3 DK0730606 T3 DK 0730606T3
- Authority
- DK
- Denmark
- Prior art keywords
- hematopoietin receptor
- relates
- novel human
- expression
- human hematopoietin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Physiology (AREA)
- Diabetes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/306,231 US5643748A (en) | 1994-09-14 | 1994-09-14 | HU-B1.219, a novel human hematopoietin receptor |
US08/355,888 US5763211A (en) | 1994-09-14 | 1994-12-14 | Isolated nucleic acid encoding Hu-B1.219, a novel human hematopoietin |
PCT/US1995/010965 WO1996008510A1 (en) | 1994-09-14 | 1995-08-30 | Hu-B1.219, A NOVEL HUMAN HEMATOPOIETIN RECEPTOR |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0730606T3 true DK0730606T3 (da) | 2005-06-06 |
Family
ID=23184398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95931007T DK0730606T3 (da) | 1994-09-14 | 1995-08-30 | Hu-B1.219, en hidtil ukendt human hæmatopoietinreceptor |
Country Status (11)
Country | Link |
---|---|
US (4) | US5643748A (da) |
EP (1) | EP0730606B1 (da) |
JP (2) | JP3479892B2 (da) |
AT (1) | ATE295374T1 (da) |
AU (1) | AU689948B2 (da) |
CA (1) | CA2176463C (da) |
DE (1) | DE69534196T2 (da) |
DK (1) | DK0730606T3 (da) |
ES (1) | ES2242960T3 (da) |
PT (1) | PT730606E (da) |
WO (1) | WO1996008510A1 (da) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6471956B1 (en) | 1994-08-17 | 2002-10-29 | The Rockefeller University | Ob polypeptides, modified forms and compositions thereto |
US6429290B1 (en) | 1994-08-17 | 2002-08-06 | The Rockefeller University | OB polypeptides, modified forms and derivatives |
US6001968A (en) * | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
US6350730B1 (en) | 1994-08-17 | 2002-02-26 | The Rockefeller University | OB polypeptides and modified forms as modulators of body weight |
US6124448A (en) * | 1994-08-17 | 2000-09-26 | The Rockfeller University | Nucleic acid primers and probes for the mammalian OB gene |
US6048837A (en) * | 1994-08-17 | 2000-04-11 | The Rockefeller University | OB polypeptides as modulators of body weight |
AUPN564195A0 (en) * | 1995-09-26 | 1995-10-19 | Walter And Eliza Hall Institute Of Medical Research, The | A novel haemopoietin receptor and genetic sequences encoding same |
US6287782B1 (en) | 1995-11-27 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Methods of using the Ob receptor to identify therapeutic compounds |
US6482927B1 (en) * | 1995-11-27 | 2002-11-19 | Millennium Pharmaceuticals, Inc. | Chimeric proteins comprising the extracellular domain of murine Ob receptor |
US6506877B1 (en) * | 1995-11-27 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Ob receptor |
US6977240B1 (en) * | 1995-11-27 | 2005-12-20 | Millenium Pharmaceuticals, Inc. | Methods of using the OB receptor antibodies to treat bodyweight disorders |
US6509189B1 (en) | 1995-11-27 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding the cytoplasmic domain of human Ob receptor |
US6548269B1 (en) * | 1995-11-27 | 2003-04-15 | Millennium Pharmaceuticals, Inc. | Ob receptor and methods for the diagnosis and treatment of body weight disorders, including obesity and cachexia |
US5972621A (en) * | 1995-11-27 | 1999-10-26 | Millennium Pharmaceuticals, Inc. | Methods of identifying compounds that modulate body weight using the OB receptor |
US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
EP0877803B1 (en) * | 1996-01-04 | 2005-08-31 | Amgen Inc., | Ob protein receptor and related compositions and methods |
US6541604B1 (en) * | 1996-01-08 | 2003-04-01 | Genentech, Inc. | Leptin receptor having a WSX motif |
US20050019325A1 (en) * | 1996-01-08 | 2005-01-27 | Carter Paul J. | WSX receptor agonist antibodies |
US7074397B1 (en) * | 1996-01-08 | 2006-07-11 | Genentech, Inc. | Method for enhancing proliferation or differentiation of a cell using ob protein |
ATE449849T1 (de) * | 1996-01-08 | 2009-12-15 | Genentech Inc | Ob rezeptor-variante und liganden |
US7148004B1 (en) | 1997-01-16 | 2006-12-12 | The Rockefeller University | Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight |
US7063958B1 (en) * | 1996-01-16 | 2006-06-20 | The Rockefeller University | Nucleic acids db, the receptor for leptin |
US7084252B1 (en) * | 1996-01-16 | 2006-08-01 | The Rockefeller University | DB, the receptor for leptin |
AU1833197A (en) * | 1996-01-18 | 1997-08-11 | Progenitor, Inc. | Detection of a leptin receptor variant and methods for regulating obesity |
ATE320479T1 (de) * | 1996-01-23 | 2006-04-15 | Indevus Pharmaceuticals Inc | Process zur verwendung des obese-gens und seines genprodukts zur stimulierung der entwicklung von haemotopoietischen zellen |
US7619079B2 (en) * | 1996-02-14 | 2009-11-17 | The Rockefeller University | Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof |
US6281346B1 (en) | 1996-03-22 | 2001-08-28 | Merck & Co., Inc. | Rat ob-receptors and nucleotides encoding them |
US6007998A (en) * | 1996-04-22 | 1999-12-28 | Merck & Co., Inc. | Leptin assay |
WO1997040380A1 (en) * | 1996-04-22 | 1997-10-30 | Merck & Co., Inc. | Leptin assay |
US6258944B1 (en) | 1996-05-06 | 2001-07-10 | Merck & Co., Inc. | OB receptor isoforms and nucleic acids encoding them |
WO1997042340A1 (en) * | 1996-05-06 | 1997-11-13 | Merck & Co., Inc. | Ob receptor isoforms and nucleic acids encoding them |
US6001816A (en) * | 1996-06-20 | 1999-12-14 | Merck & Co., Inc. | Gene therapy for leptin deficiency |
US20060205660A1 (en) * | 1996-06-20 | 2006-09-14 | Sauvage Frederic D | OB protein-immunoglobulin chimeras |
US5874535A (en) * | 1996-08-01 | 1999-02-23 | Incyte Pharmaceuticals, Inc. | Human leptin receptor gene-related protein |
US5789198A (en) * | 1996-08-01 | 1998-08-04 | Incyte Pharmaceuticals, Inc. | Human leptin receptor-related protein |
AUPO224696A0 (en) * | 1996-09-11 | 1996-10-03 | Amrad Operations Pty. Limited | A novel haemopoietin receptor and genetic sequences encoding same |
US5976838A (en) * | 1996-12-18 | 1999-11-02 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
EP0951564A1 (en) * | 1996-11-01 | 1999-10-27 | Smithkline Beecham Plc | Method for the detection of compounds that modulate the effects of the obese (ob) protein |
US20020081602A1 (en) * | 1996-11-01 | 2002-06-27 | Smithkline Beecham P.1.C. | Method for the detection of compounds that modulate the effects of the obese (ob) protein |
CA2273164A1 (en) | 1996-12-02 | 1998-06-11 | Merck & Co., Inc. | Mutant ob receptors and nucleotides encoding them |
AU5733898A (en) * | 1997-01-16 | 1998-08-07 | Genetics Institute Inc. | Member of the hematopoietin receptor superfamily |
NZ507293A (en) * | 1998-04-10 | 2003-12-19 | Inst Genetics Llc | U4, a member of the hematopoietin receptor superfamily |
US6770444B2 (en) | 1998-07-16 | 2004-08-03 | Synaptic Pharmaceutical Corporation | Methods of identifying or screening for agents that binds the Ob-Re |
US6743906B1 (en) * | 1998-10-02 | 2004-06-01 | Board Of Regents, The University Of Texas | PPP2R1B is a tumor suppressor |
US8034100B2 (en) | 1999-03-11 | 2011-10-11 | Endologix, Inc. | Graft deployment system |
US20030215423A1 (en) * | 1999-04-01 | 2003-11-20 | Merck & Co., Inc. | Gene therapy for obesity |
AU767068B2 (en) * | 1999-06-11 | 2003-10-30 | Baylor College Of Medicine | Methods and compositions for control of bone formation via modulation of leptin activity |
FR2836475B1 (fr) * | 2002-02-26 | 2007-02-23 | Aventis Pharma Sa | Procede de detection de ligands du recepteur de la leptine |
TWI752920B (zh) | 2015-10-12 | 2022-01-21 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
WO2018089532A1 (en) | 2016-11-08 | 2018-05-17 | Regeneron Pharmaceuticals, Inc. | Antigen-binding proteins that antagonize leptin receptor |
MX2020006508A (es) | 2017-12-18 | 2020-09-17 | Regeneron Pharma | Moleculas de union a antigeno biespecificas que se unen al receptor de leptina y/o gp130, y metodos para el uso de estas. |
CN112040980A (zh) | 2018-04-06 | 2020-12-04 | 瑞泽恩制药公司 | 用于治疗代谢功能障碍或低瘦蛋白血症的瘦蛋白受体激动剂抗体 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988002757A1 (en) * | 1986-10-17 | 1988-04-21 | Saramane Pty. Ltd.; | Hybrid proteins or polypeptides |
DE69029015T2 (de) * | 1989-07-20 | 1998-01-22 | Tadamitsu Kishimoto | Antikörper gegen menschlichen Interleukin-6-Rezeptor |
US5574136A (en) * | 1990-03-23 | 1996-11-12 | Osaka Bioscience Institute | DNA encoding granulocyte colony-stimulating factor receptor and protein thereof |
US5262522A (en) * | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
WO1996007737A1 (en) * | 1994-09-05 | 1996-03-14 | Amrad Operations Pty. Ltd. | A novel haemopoietin receptor |
US5972621A (en) * | 1995-11-27 | 1999-10-26 | Millennium Pharmaceuticals, Inc. | Methods of identifying compounds that modulate body weight using the OB receptor |
-
1994
- 1994-09-14 US US08/306,231 patent/US5643748A/en not_active Expired - Fee Related
-
1995
- 1995-08-30 DE DE69534196T patent/DE69534196T2/de not_active Expired - Fee Related
- 1995-08-30 AU AU34194/95A patent/AU689948B2/en not_active Ceased
- 1995-08-30 EP EP95931007A patent/EP0730606B1/en not_active Expired - Lifetime
- 1995-08-30 JP JP51021196A patent/JP3479892B2/ja not_active Expired - Fee Related
- 1995-08-30 PT PT95931007T patent/PT730606E/pt unknown
- 1995-08-30 CA CA002176463A patent/CA2176463C/en not_active Expired - Fee Related
- 1995-08-30 DK DK95931007T patent/DK0730606T3/da active
- 1995-08-30 ES ES95931007T patent/ES2242960T3/es not_active Expired - Lifetime
- 1995-08-30 AT AT95931007T patent/ATE295374T1/de not_active IP Right Cessation
- 1995-08-30 WO PCT/US1995/010965 patent/WO1996008510A1/en active IP Right Grant
-
1996
- 1996-08-05 US US08/693,697 patent/US5869610A/en not_active Expired - Fee Related
- 1996-08-05 US US08/693,696 patent/US6005080A/en not_active Expired - Fee Related
-
1999
- 1999-07-19 US US09/357,914 patent/US6524806B1/en not_active Expired - Fee Related
-
2002
- 2002-10-02 JP JP2002290121A patent/JP2003174895A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE295374T1 (de) | 2005-05-15 |
PT730606E (pt) | 2005-09-30 |
EP0730606A4 (en) | 1997-03-12 |
AU3419495A (en) | 1996-03-29 |
WO1996008510A1 (en) | 1996-03-21 |
AU689948B2 (en) | 1998-04-09 |
EP0730606A1 (en) | 1996-09-11 |
EP0730606B1 (en) | 2005-05-11 |
US5869610A (en) | 1999-02-09 |
ES2242960T3 (es) | 2005-11-16 |
US5643748A (en) | 1997-07-01 |
DE69534196T2 (de) | 2006-02-16 |
JP3479892B2 (ja) | 2003-12-15 |
US6524806B1 (en) | 2003-02-25 |
CA2176463C (en) | 2006-07-11 |
JP2003174895A (ja) | 2003-06-24 |
US6005080A (en) | 1999-12-21 |
JPH10511079A (ja) | 1998-10-27 |
CA2176463A1 (en) | 1996-03-21 |
DE69534196D1 (de) | 2005-06-16 |
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