WO1996039511A3 - A c5a-like seven transmembrane receptor - Google Patents

A c5a-like seven transmembrane receptor Download PDF

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Publication number
WO1996039511A3
WO1996039511A3 PCT/US1996/008596 US9608596W WO9639511A3 WO 1996039511 A3 WO1996039511 A3 WO 1996039511A3 US 9608596 W US9608596 W US 9608596W WO 9639511 A3 WO9639511 A3 WO 9639511A3
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WO
WIPO (PCT)
Prior art keywords
calr
encode
transmembrane receptor
provides
present
Prior art date
Application number
PCT/US1996/008596
Other languages
French (fr)
Other versions
WO1996039511A2 (en
Inventor
Roger Coleman
Janice Au-Young
Olga Bandman
Jeffrey J Seilhamer
Original Assignee
Incyte Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc filed Critical Incyte Pharma Inc
Priority to AU63273/96A priority Critical patent/AU718311B2/en
Priority to EP96922382A priority patent/EP0832231A2/en
Priority to MX9709338A priority patent/MX9709338A/en
Priority to JP9501136A priority patent/JPH11507513A/en
Publication of WO1996039511A2 publication Critical patent/WO1996039511A2/en
Publication of WO1996039511A3 publication Critical patent/WO1996039511A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Laminated Bodies (AREA)
  • Diaphragms And Bellows (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides nucleotide and amino acid sequences that identify and encode a novel C5a-like seven transmembrane receptor (CALR) expressed in human mast cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode CALR, expression vectors for the production of purified CALR, antibodies capable of binding specifically to CALR, hybridization probes or oligonucleotides for the detection of CALR-encoding nucleotide sequences, diagnostic tests based on CALR-encoding nucleic acid molecules, genetically engineered host cells for the expression of CALR, and antagonists and inhibitors of the polypeptide CALR.
PCT/US1996/008596 1995-06-05 1996-06-03 A C5a-LIKE SEVEN TRANSMEMBRANE RECEPTOR WO1996039511A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU63273/96A AU718311B2 (en) 1995-06-05 1996-06-03 A C5a-like seven transmembrane receptor
EP96922382A EP0832231A2 (en) 1995-06-05 1996-06-03 A C5a-LIKE SEVEN TRANSMEMBRANE RECEPTOR
MX9709338A MX9709338A (en) 1995-06-05 1996-06-03 A C5a-LIKE SEVEN TRANSMEMBRANE RECEPTOR.
JP9501136A JPH11507513A (en) 1995-06-05 1996-06-03 C5a-like 7 transmembrane receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46235595A 1995-06-05 1995-06-05
US08/462,355 1995-12-01

Publications (2)

Publication Number Publication Date
WO1996039511A2 WO1996039511A2 (en) 1996-12-12
WO1996039511A3 true WO1996039511A3 (en) 1997-01-09

Family

ID=23836136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008596 WO1996039511A2 (en) 1995-06-05 1996-06-03 A C5a-LIKE SEVEN TRANSMEMBRANE RECEPTOR

Country Status (6)

Country Link
EP (1) EP0832231A2 (en)
JP (1) JPH11507513A (en)
AU (1) AU718311B2 (en)
CA (1) CA2223038A1 (en)
MX (1) MX9709338A (en)
WO (1) WO1996039511A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996025432A1 (en) * 1995-02-17 1996-08-22 Human Genome Sciences, Inc. Human g-protein coupled receptor
CA2244850A1 (en) * 1996-01-30 1997-08-07 The Scripps Research Institute A g protein-coupled receptor with an enlarged extracellular domain
JPH1087700A (en) * 1996-06-17 1998-04-07 Smithkline Beecham Corp Treatment and screening using c3a receptor and c3a
US6063596A (en) * 1997-12-11 2000-05-16 Incyte Pharmaceuticals, Inc. G-protein coupled receptors associated with immune response
WO2000008155A2 (en) * 1998-08-07 2000-02-17 Incyte Pharmaceuticals, Inc. Human receptor-associated proteins
EP1304921A2 (en) * 2000-06-29 2003-05-02 Deltagen, Inc. Transgenic mice containing targeted gene disruptions
NZ534399A (en) 2002-01-25 2008-08-29 G2 Therapies Ltd Monoclonal antibodies against extracellular loops of C5aR
CN104059149B (en) 2006-08-22 2017-04-12 诺沃诺蒂斯克股份有限公司 Anti-C5aR antibodies with improved properties
CN101970494B (en) 2008-02-20 2015-01-21 G2炎症私人有限公司 Humanized anti-c5ar antibodies
RU2616881C2 (en) 2011-06-06 2017-04-18 Ново Нордиск А/С Therapeutic antibodies
CA3026572A1 (en) * 2016-06-10 2017-12-14 Io Biotech Aps Calr and jak2 vaccine compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005695A1 (en) * 1992-09-10 1994-03-17 New York University Polypeptides of g-coupled receptor proteins, and compositions and methods thereof
WO1994012635A2 (en) * 1992-11-17 1994-06-09 Icos Corporation Novel seven transmembrane receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005695A1 (en) * 1992-09-10 1994-03-17 New York University Polypeptides of g-coupled receptor proteins, and compositions and methods thereof
WO1994012635A2 (en) * 1992-11-17 1994-06-09 Icos Corporation Novel seven transmembrane receptors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EMBL EST, Accession no R01558, Sequence reference ye79h02.r1, 17-APR-1995, Homo sapiens cDNA clone 123987 5'. *
EMBL EST, Accession no T49050, sequence reference yb08e05.r1, 25-FEB-95, Homo sapiens cDNA clone 70592 5' *
EMBL EST, Accession no T91438, Sequence reference ye01d06.r1, 11-APR-1995, Homo sapiens cDNA clone 116459 5'. *

Also Published As

Publication number Publication date
AU718311B2 (en) 2000-04-13
MX9709338A (en) 1998-02-28
CA2223038A1 (en) 1996-12-12
AU6327396A (en) 1996-12-24
WO1996039511A2 (en) 1996-12-12
JPH11507513A (en) 1999-07-06
EP0832231A2 (en) 1998-04-01

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