WO1997000952A3 - A human edg-2 receptor homolog - Google Patents

A human edg-2 receptor homolog Download PDF

Info

Publication number
WO1997000952A3
WO1997000952A3 PCT/US1996/010618 US9610618W WO9700952A3 WO 1997000952 A3 WO1997000952 A3 WO 1997000952A3 US 9610618 W US9610618 W US 9610618W WO 9700952 A3 WO9700952 A3 WO 9700952A3
Authority
WO
WIPO (PCT)
Prior art keywords
hedg
molecules
encode
receptor homolog
nucleic acid
Prior art date
Application number
PCT/US1996/010618
Other languages
French (fr)
Other versions
WO1997000952A2 (en
Inventor
Roger Coleman
Karl J Guegler
Janice Au-Young
Olga Bandman
Jeffrey J Seilhamer
Original Assignee
Incyte Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc filed Critical Incyte Pharma Inc
Priority to AU63886/96A priority Critical patent/AU718269B2/en
Priority to JP9503937A priority patent/JPH11508135A/en
Priority to EP96945463A priority patent/EP0840787A2/en
Publication of WO1997000952A2 publication Critical patent/WO1997000952A2/en
Publication of WO1997000952A3 publication Critical patent/WO1997000952A3/en
Priority to MXPA/A/1997/010409A priority patent/MXPA97010409A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides nucleic acid and amino acid sequences that identify and encode a novel EDG-2 receptor homolog (hedg) expressed in human rheumatoid synovium. The present invention also provides for probes for the detection of nucleotide sequences encoding of HEDG or HEDG-like molecules, antisense molecules to the nucleotide sequences which encode HEDG, diagnostic tests based on HEDG encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified HEDG, antibodies capable of binding specifically to HEDG, and antagonists and inhibitors with specific binding activity for the polypeptide HEDG.
PCT/US1996/010618 1995-06-20 1996-06-20 A human edg-2 receptor homolog WO1997000952A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU63886/96A AU718269B2 (en) 1995-06-20 1996-06-20 A human EDG-2 receptor homolog
JP9503937A JPH11508135A (en) 1995-06-20 1996-06-20 Human EDG-2 receptor homolog
EP96945463A EP0840787A2 (en) 1995-06-20 1996-06-20 A human edg-2 receptor homolog
MXPA/A/1997/010409A MXPA97010409A (en) 1995-06-20 1997-12-18 Homologo de receptor de edg-2 hum

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35295P 1995-06-20 1995-06-20
US56781795A 1995-12-06 1995-12-06
US08/567,817 1995-12-06
US60/000,352 1995-12-06

Publications (2)

Publication Number Publication Date
WO1997000952A2 WO1997000952A2 (en) 1997-01-09
WO1997000952A3 true WO1997000952A3 (en) 1997-03-20

Family

ID=26667516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/010618 WO1997000952A2 (en) 1995-06-20 1996-06-20 A human edg-2 receptor homolog

Country Status (5)

Country Link
EP (1) EP0840787A2 (en)
JP (1) JPH11508135A (en)
AU (1) AU718269B2 (en)
CA (1) CA2224799A1 (en)
WO (1) WO1997000952A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2759374B1 (en) * 1997-02-13 1999-04-30 Inst Nat Sante Rech Med POLYPEPTIDE WITH OB25 RECEPTOR ACTIVITY SPECIFIC TO MYELINIZING CELLS IN RATS, APPLICATION TO SCREENING OF MEDICINAL PRODUCTS AND MEDICINAL PRODUCTS
FR2759375B1 (en) * 1997-02-13 1999-04-30 Inst Nat Sante Rech Med POLYPEPTIDE WITH OB25 RECEPTOR ACTIVITY SPECIFIC TO MYELINIZING CELLS IN RATS, APPLICATION TO SCREENING OF MEDICINAL PRODUCTS AND MEDICINAL PRODUCTS
US5912144A (en) * 1997-04-24 1999-06-15 Incyte Pharmaceuticals, Inc. Edg-1-receptor homolog
US6020158A (en) * 1997-05-22 2000-02-01 Allelix Biopharmaceuticals, Inc. Isolated polynucleotide for novel G-protein coupled receptor
WO1999019513A2 (en) * 1997-10-10 1999-04-22 Lxr Biotechnology, Inc. Methods for detecting compounds which modulate the activity of an lpa receptor
US6485922B1 (en) 1997-10-10 2002-11-26 Atairgin Technologies, Inc. Methods for detecting compounds which modulate the activity of an LPA receptor
EP1042471B1 (en) * 1997-12-30 2004-08-11 NPS Allelix Corp. Mammalian edg-7 receptor homologs
JP2002500041A (en) * 1997-12-30 2002-01-08 エヌピーエス アレリックス コーポレーション Identification of lysolipid receptor involved in inflammatory response
AU2659799A (en) * 1998-02-12 1999-08-30 Incyte Pharmaceuticals, Inc. Human receptor proteins
CA2340334A1 (en) * 1998-08-19 2000-03-02 Millenium Pharmaceuticals, Inc. 14274 receptor, a g-protein coupled receptor related to the edg receptor family
US6812335B1 (en) 1999-03-23 2004-11-02 The Regents Of The University Of California Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
AU2002246680A1 (en) * 2000-12-22 2002-07-30 University Of South Florida Sphingosine 1-phosphate receptor gene, sppr
AU2003278165A1 (en) * 2002-11-13 2004-06-03 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human endothelial differentiation, lysophosphatidic acid g-protein-coupled receptor 2 (edg2)
US20070003928A1 (en) * 2002-12-12 2007-01-04 Shuji Hinuma Novel use of edg receptors
WO2008153072A1 (en) * 2007-06-12 2008-12-18 Riken Gene sensitive to bone/joint disease and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015583A1 (en) * 1990-04-05 1991-10-17 The American National Red Cross A protein family related to immediate-early protein expressed by human endothelial cells during differentiation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015583A1 (en) * 1990-04-05 1991-10-17 The American National Red Cross A protein family related to immediate-early protein expressed by human endothelial cells during differentiation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARCHAM GJ ET AL: "Cloning and expression of a cDNA encoding ovine interleukin 7.", GENE, MAR 10 1995, 154 (2) P265-9, NETHERLANDS, XP002024554 *
BUCK L ET AL: "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.", CELL, APR 5 1991, 65 (1) P175-87, UNITED STATES, XP002024553 *
EMBL database Accession number U18405 28-12-1994 *
HLA T ET AL: "Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells.", BIOCHIM BIOPHYS ACTA, JAN 25 1995, 1260 (2) P227-9, NETHERLANDS, XP000609651 *
MASANA MI ET AL: "Cloning and characterization of a new member of the G-protein coupled receptor EDG family.", RECEPTORS CHANNELS, 1995, 3 (4) P255-62, SWITZERLAND, XP000610109 *
SWISSPROT DATABASE Accession number P46628 01-11-1995 *

Also Published As

Publication number Publication date
WO1997000952A2 (en) 1997-01-09
EP0840787A2 (en) 1998-05-13
MX9710409A (en) 1998-07-31
AU6388696A (en) 1997-01-22
AU718269B2 (en) 2000-04-13
CA2224799A1 (en) 1997-01-09
JPH11508135A (en) 1999-07-21

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